-
2
-
-
10644220306
-
Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity
-
Browning JD, Szczepaniak LS, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity. Hepatology. 2004;40:1387–1395.
-
(2004)
Hepatology
, vol.40
, pp. 1387-1395
-
-
Browning, J.D.1
Szczepaniak, L.S.2
Dobbins, R.3
-
3
-
-
78650486196
-
Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
-
Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology. 2011;140:124–131.
-
(2011)
Gastroenterology
, vol.140
, pp. 124-131
-
-
Williams, C.D.1
Stengel, J.2
Asike, M.I.3
-
4
-
-
84877900838
-
Gastrointestinal complications of obesity: non-alcoholic fatty liver disease (NAFLD) and its sequelae
-
Karlas T, Wiegand J, Berg T. Gastrointestinal complications of obesity: non-alcoholic fatty liver disease (NAFLD) and its sequelae. Best Pract Res Clin Endocrinol Metab. 2013;27:195–208.
-
(2013)
Best Pract Res Clin Endocrinol Metab
, vol.27
, pp. 195-208
-
-
Karlas, T.1
Wiegand, J.2
Berg, T.3
-
5
-
-
77952529040
-
A position statement on NAFLD/NASH based on the EASL 2009 special conference
-
Ratziu V, Bellentani S, Cortez-Pinto H, Day C, Marchesini G. A position statement on NAFLD/NASH based on the EASL 2009 special conference. J Hepatol. 2010;53:372–384.
-
(2010)
J Hepatol
, vol.53
, pp. 372-384
-
-
Ratziu, V.1
Bellentani, S.2
Cortez-Pinto, H.3
Day, C.4
Marchesini, G.5
-
6
-
-
80053581540
-
Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States
-
Charlton MR, Burns JM, Pedersen RA, Watt KD, Heimbach JK, Dierkhising RA. Frequency and outcomes of liver transplantation for nonalcoholic steatohepatitis in the United States. Gastroenterology. 2011;141:1249–1253.
-
(2011)
Gastroenterology
, vol.141
, pp. 1249-1253
-
-
Charlton, M.R.1
Burns, J.M.2
Pedersen, R.A.3
Watt, K.D.4
Heimbach, J.K.5
Dierkhising, R.A.6
-
7
-
-
77955625142
-
Population-based risk factors and resource utilization for HCC: US perspective
-
Sanyal A, Poklepovic A, Moyneur E, Barghout V. Population-based risk factors and resource utilization for HCC: US perspective. Curr Med Res Opin. 2010;26:2183–2191.
-
(2010)
Curr Med Res Opin
, vol.26
, pp. 2183-2191
-
-
Sanyal, A.1
Poklepovic, A.2
Moyneur, E.3
Barghout, V.4
-
8
-
-
84925374835
-
Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop
-
Sanyal AJ, Friedman SL, McCullough AJ, Dimick-Santos L. Challenges and opportunities in drug and biomarker development for nonalcoholic steatohepatitis: findings and recommendations from an American Association for the Study of Liver Diseases-U.S. Food and Drug Administration Joint Workshop. Hepatology. 2015;61:1392–1405.
-
(2015)
Hepatology
, vol.61
, pp. 1392-1405
-
-
Sanyal, A.J.1
Friedman, S.L.2
McCullough, A.J.3
Dimick-Santos, L.4
-
9
-
-
84895508097
-
Diets and nonalcoholic fatty liver disease: the good and the bad
-
Asrih M, Jornayvaz FR. Diets and nonalcoholic fatty liver disease: the good and the bad. Clin Nutr. 2014;33:186–190.
-
(2014)
Clin Nutr
, vol.33
, pp. 186-190
-
-
Asrih, M.1
Jornayvaz, F.R.2
-
10
-
-
84894327806
-
Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease
-
Lambert JE, Ramos-Roman MA, Browning JD, Parks EJ. Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease. Gastroenterology. 2014;146:726–735.
-
(2014)
Gastroenterology
, vol.146
, pp. 726-735
-
-
Lambert, J.E.1
Ramos-Roman, M.A.2
Browning, J.D.3
Parks, E.J.4
-
11
-
-
38649111018
-
Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease
-
Fabbrini E, Mohammed BS, Magkos F, Korenblat KM, Patterson BW, Klein S. Alterations in adipose tissue and hepatic lipid kinetics in obese men and women with nonalcoholic fatty liver disease. Gastroenterology. 2008;134:424–431.
-
(2008)
Gastroenterology
, vol.134
, pp. 424-431
-
-
Fabbrini, E.1
Mohammed, B.S.2
Magkos, F.3
Korenblat, K.M.4
Patterson, B.W.5
Klein, S.6
-
12
-
-
77955690182
-
Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites
-
Neuschwander-Tetri BA. Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites. Hepatology. 2010;52:774–788.
-
(2010)
Hepatology
, vol.52
, pp. 774-788
-
-
Neuschwander-Tetri, B.A.1
-
13
-
-
56649085036
-
Abnormalities of lipid metabolism in nonalcoholic fatty liver disease
-
Cheung O, Sanyal AJ. Abnormalities of lipid metabolism in nonalcoholic fatty liver disease. Semin Liver Dis. 2008;28:351–359.
-
(2008)
Semin Liver Dis
, vol.28
, pp. 351-359
-
-
Cheung, O.1
Sanyal, A.J.2
-
15
-
-
84861901590
-
The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
-
Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Am J Gastroenterol. 2012;107:811–826.
-
(2012)
Am J Gastroenterol
, vol.107
, pp. 811-826
-
-
Chalasani, N.1
Younossi, Z.2
Lavine, J.E.3
-
16
-
-
19144372447
-
One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study
-
Huang MA, Greenson JK, Chao C, et al. One-year intense nutritional counseling results in histological improvement in patients with non-alcoholic steatohepatitis: a pilot study. Am J Gastroenterol. 2005;100:1072–1081.
-
(2005)
Am J Gastroenterol
, vol.100
, pp. 1072-1081
-
-
Huang, M.A.1
Greenson, J.K.2
Chao, C.3
-
17
-
-
58949102847
-
Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial
-
Harrison SA, Fecht W, Brunt EM, Neuschwander-Tetri BA. Orlistat for overweight subjects with nonalcoholic steatohepatitis: a randomized, prospective trial. Hepatology. 2009;49:80–86.
-
(2009)
Hepatology
, vol.49
, pp. 80-86
-
-
Harrison, S.A.1
Fecht, W.2
Brunt, E.M.3
Neuschwander-Tetri, B.A.4
-
18
-
-
73449116035
-
Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
-
Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology. 2010;51:121–129.
-
(2010)
Hepatology
, vol.51
, pp. 121-129
-
-
Promrat, K.1
Kleiner, D.E.2
Niemeier, H.M.3
-
19
-
-
84929354082
-
Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis
-
e365; quiz e314–365
-
Vilar-Gomez E, Martinez-Perez Y, Calzadilla-Bertot L, et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015;149:367–378. e365; quiz e314–365.
-
(2015)
Gastroenterology
, vol.149
, pp. 367-378
-
-
Vilar-Gomez, E.1
Martinez-Perez, Y.2
Calzadilla-Bertot, L.3
-
20
-
-
81855169560
-
A two-year randomized trial of obesity treatment in primary care practice
-
Wadden TA, Volger S, Sarwer DB, et al. A two-year randomized trial of obesity treatment in primary care practice. N Engl J Med. 2011;365:1969–1979.
-
(2011)
N Engl J Med
, vol.365
, pp. 1969-1979
-
-
Wadden, T.A.1
Volger, S.2
Sarwer, D.B.3
-
22
-
-
33846623798
-
Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets
-
Brown JD, Plutzky J. Peroxisome proliferator-activated receptors as transcriptional nodal points and therapeutic targets. Circulation. 2007;115:518–533.
-
(2007)
Circulation
, vol.115
, pp. 518-533
-
-
Brown, J.D.1
Plutzky, J.2
-
24
-
-
77954239704
-
A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
-
Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology. 2010;52:79–104.
-
(2010)
Hepatology
, vol.52
, pp. 79-104
-
-
Musso, G.1
Gambino, R.2
Cassader, M.3
Pagano, G.4
-
25
-
-
84875190733
-
Peroxisome proliferator-activated receptor delta: a multifaceted metabolic player
-
Bojic LA, Huff MW. Peroxisome proliferator-activated receptor delta: a multifaceted metabolic player. Curr Opin Lipidol. 2013;24:171–177.
-
(2013)
Curr Opin Lipidol
, vol.24
, pp. 171-177
-
-
Bojic, L.A.1
Huff, M.W.2
-
26
-
-
39649101196
-
Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men
-
Riserus U, Sprecher D, Johnson T, et al. Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. Diabetes. 2008;57:332–339.
-
(2008)
Diabetes
, vol.57
, pp. 332-339
-
-
Riserus, U.1
Sprecher, D.2
Johnson, T.3
-
27
-
-
84885405205
-
Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects
-
Cariou B, Hanf R, Lambert-Porcheron S, et al. Dual peroxisome proliferator-activated receptor alpha/delta agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. Diabetes Care. 2013;36:2923–2930.
-
(2013)
Diabetes Care
, vol.36
, pp. 2923-2930
-
-
Cariou, B.1
Hanf, R.2
Lambert-Porcheron, S.3
-
28
-
-
84960140218
-
Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening
-
e1145
-
Ratziu V, Harrison SA, Francque S, et al. Elafibranor, an agonist of the peroxisome proliferator-activated receptor-alpha and -delta, induces resolution of nonalcoholic steatohepatitis without fibrosis worsening. Gastroenterology. 2016;150:1147–1159. e1145.
-
(2016)
Gastroenterology
, vol.150
, pp. 1147-1159
-
-
Ratziu, V.1
Harrison, S.A.2
Francque, S.3
-
29
-
-
20044374023
-
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
-
Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41:1313–1321.
-
(2005)
Hepatology
, vol.41
, pp. 1313-1321
-
-
Kleiner, D.E.1
Brunt, E.M.2
Van Natta, M.3
-
30
-
-
33751545838
-
A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis
-
Belfort R, Harrison SA, Brown K, et al. A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis. N Engl J Med. 2006;355:2297–2307.
-
(2006)
N Engl J Med
, vol.355
, pp. 2297-2307
-
-
Belfort, R.1
Harrison, S.A.2
Brown, K.3
-
31
-
-
1442355447
-
A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis
-
Promrat K, Lutchman G, Uwaifo GI, et al. A pilot study of pioglitazone treatment for nonalcoholic steatohepatitis. Hepatology. 2004;39:188–196.
-
(2004)
Hepatology
, vol.39
, pp. 188-196
-
-
Promrat, K.1
Lutchman, G.2
Uwaifo, G.I.3
-
32
-
-
77951874018
-
Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
-
Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. 2010;362:1675–1685.
-
(2010)
N Engl J Med
, vol.362
, pp. 1675-1685
-
-
Sanyal, A.J.1
Chalasani, N.2
Kowdley, K.V.3
-
33
-
-
34548590934
-
Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials
-
Lincoff AM, Wolski K, Nicholls SJ, Nissen SE. Pioglitazone and risk of cardiovascular events in patients with type 2 diabetes mellitus: a meta-analysis of randomized trials. JAMA. 2007;298:1180–1188.
-
(2007)
JAMA
, vol.298
, pp. 1180-1188
-
-
Lincoff, A.M.1
Wolski, K.2
Nicholls, S.J.3
Nissen, S.E.4
-
34
-
-
84900559988
-
A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of saroglitazar 2 and 4 mg compared to pioglitazone 45 mg in diabetic dyslipidemia (PRESS V)
-
Pai V, Paneerselvam A, Mukhopadhyay S, et al. A multicenter, prospective, randomized, double-blind study to evaluate the safety and efficacy of saroglitazar 2 and 4 mg compared to pioglitazone 45 mg in diabetic dyslipidemia (PRESS V). J Diabetes Sci Technol. 2014;8:132–141.
-
(2014)
J Diabetes Sci Technol
, vol.8
, pp. 132-141
-
-
Pai, V.1
Paneerselvam, A.2
Mukhopadhyay, S.3
-
35
-
-
84988462353
-
Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease
-
Rotman Y, Sanyal AJ. Current and upcoming pharmacotherapy for non-alcoholic fatty liver disease. Gut. 2016; doi: 10.1136/gutjnl-2016-312431
-
(2016)
Gut
-
-
Rotman, Y.1
Sanyal, A.J.2
-
36
-
-
85047694456
-
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
-
Watanabe M, Houten SM, Wang L, et al. Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c. J Clin Investig. 2004;113:1408–1418.
-
(2004)
J Clin Investig
, vol.113
, pp. 1408-1418
-
-
Watanabe, M.1
Houten, S.M.2
Wang, L.3
-
37
-
-
84864861866
-
Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease
-
Porez G, Prawitt J, Gross B, Staels B. Bile acid receptors as targets for the treatment of dyslipidemia and cardiovascular disease. J Lipid Res. 2012;53:1723–1737.
-
(2012)
J Lipid Res
, vol.53
, pp. 1723-1737
-
-
Porez, G.1
Prawitt, J.2
Gross, B.3
Staels, B.4
-
38
-
-
84929266699
-
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
-
Neuschwander-Tetri BA, Loomba R, Sanyal AJ, et al. Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial. Lancet. 2015;385:956–965.
-
(2015)
Lancet
, vol.385
, pp. 956-965
-
-
Neuschwander-Tetri, B.A.1
Loomba, R.2
Sanyal, A.J.3
-
39
-
-
79953129095
-
FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis
-
Kir S, Beddow SA, Samuel VT, et al. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science. 2011;331:1621–1624.
-
(2011)
Science
, vol.331
, pp. 1621-1624
-
-
Kir, S.1
Beddow, S.A.2
Samuel, V.T.3
-
40
-
-
84962606933
-
Fibroblast growth factor signaling in metabolic regulation
-
Nies VJ, Sancar G, Liu W, et al. Fibroblast growth factor signaling in metabolic regulation. Front Endocrinol. 2015;6:193.
-
(2015)
Front Endocrinol
, vol.6
, pp. 193
-
-
Nies, V.J.1
Sancar, G.2
Liu, W.3
-
41
-
-
84922726981
-
A nontumorigenic variant of FGF19 treats cholestatic liver diseases
-
Luo J, Ko B, Elliott M, et al. A nontumorigenic variant of FGF19 treats cholestatic liver diseases. Sci Transl Med. 2014;6:247ra100.
-
(2014)
Sci Transl Med
, vol.6
, pp. 247ra100
-
-
Luo, J.1
Ko, B.2
Elliott, M.3
-
42
-
-
85007598260
-
Treatment with Ngm282 significantly improves liver histopathology in a mouse model of non-alcoholic steatohepatitis (Nash)
-
Luo J, Ko B, To C, et al. Treatment with Ngm282 significantly improves liver histopathology in a mouse model of non-alcoholic steatohepatitis (Nash). J Hepatol. 2015;62:S694.
-
(2015)
J Hepatol
, vol.62
, pp. S694
-
-
Luo, J.1
Ko, B.2
To, C.3
-
43
-
-
84867235842
-
Stearoyl-CoA desaturase: rogue or innocent bystander?
-
Hodson L, Fielding BA. Stearoyl-CoA desaturase: rogue or innocent bystander? Prog Lipid Res. 2013;52:15–42.
-
(2013)
Prog Lipid Res
, vol.52
, pp. 15-42
-
-
Hodson, L.1
Fielding, B.A.2
-
44
-
-
0029077405
-
The regulation of stearoyl-CoA desaturase (SCD)
-
Ntambi JM. The regulation of stearoyl-CoA desaturase (SCD). Prog Lipid Res. 1995;34:139–150.
-
(1995)
Prog Lipid Res
, vol.34
, pp. 139-150
-
-
Ntambi, J.M.1
-
45
-
-
36448991861
-
Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
-
Miyazaki M, Flowers MT, Sampath H, et al. Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis. Cell Metab. 2007;6:484–496.
-
(2007)
Cell Metab
, vol.6
, pp. 484-496
-
-
Miyazaki, M.1
Flowers, M.T.2
Sampath, H.3
-
46
-
-
69249213918
-
Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models
-
Issandou M, Bouillot A, Brusq JM, et al. Pharmacological inhibition of stearoyl-CoA desaturase 1 improves insulin sensitivity in insulin-resistant rat models. Eur J Pharmacol. 2009;618:28–36.
-
(2009)
Eur J Pharmacol
, vol.618
, pp. 28-36
-
-
Issandou, M.1
Bouillot, A.2
Brusq, J.M.3
-
47
-
-
84962019076
-
Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity
-
Walle P, Takkunen M, Mannisto V, et al. Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity. Metabolism. 2016;65:655–666.
-
(2016)
Metabolism
, vol.65
, pp. 655-666
-
-
Walle, P.1
Takkunen, M.2
Mannisto, V.3
-
48
-
-
84918843434
-
The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease
-
e2081
-
Safadi R, Konikoff FM, Mahamid M, et al. The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2014;12:2085–2091. e2081.
-
(2014)
Clin Gastroenterol Hepatol
, vol.12
, pp. 2085-2091
-
-
Safadi, R.1
Konikoff, F.M.2
Mahamid, M.3
-
49
-
-
84897970506
-
2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines
-
Stone NJ, Robinson JG, Lichtenstein AH, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S1–S45.
-
(2014)
Circulation
, vol.129
, Issue.25
, pp. S1-S45
-
-
Stone, N.J.1
Robinson, J.G.2
Lichtenstein, A.H.3
-
50
-
-
84991052058
-
Management of dyslipidemia in patients with hypertension, diabetes, and metabolic syndrome
-
Srikanth S, Deedwania P. Management of dyslipidemia in patients with hypertension, diabetes, and metabolic syndrome. Curr Hypertens Rep. 2016;18:76.
-
(2016)
Curr Hypertens Rep
, vol.18
, pp. 76
-
-
Srikanth, S.1
Deedwania, P.2
-
51
-
-
84969961723
-
Non-alcoholic fatty liver disease and dyslipidemia: an update
-
Katsiki N, Mikhailidis DP, Mantzoros CS. Non-alcoholic fatty liver disease and dyslipidemia: an update. Metabolism. 2016;65:1109–1123.
-
(2016)
Metabolism
, vol.65
, pp. 1109-1123
-
-
Katsiki, N.1
Mikhailidis, D.P.2
Mantzoros, C.S.3
-
52
-
-
84919632658
-
The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease
-
Pastori D, Polimeni L, Baratta F, Pani A, Del Ben M, Angelico F. The efficacy and safety of statins for the treatment of non-alcoholic fatty liver disease. Dig Liver Dis. 2015;47:4–11.
-
(2015)
Dig Liver Dis
, vol.47
, pp. 4-11
-
-
Pastori, D.1
Polimeni, L.2
Baratta, F.3
Pani, A.4
Del Ben, M.5
Angelico, F.6
-
53
-
-
84952066804
-
Statins are underutilized in patients with nonalcoholic fatty liver disease and dyslipidemia
-
Blais P, Lin M, Kramer JR, El-Serag HB, Kanwal F. Statins are underutilized in patients with nonalcoholic fatty liver disease and dyslipidemia. Dig Dis Sci. 2016;61:1714–1720.
-
(2016)
Dig Dis Sci
, vol.61
, pp. 1714-1720
-
-
Blais, P.1
Lin, M.2
Kramer, J.R.3
El-Serag, H.B.4
Kanwal, F.5
-
54
-
-
84939268765
-
Statin use and non-alcoholic steatohepatitis in at risk individuals
-
Dongiovanni P, Petta S, Mannisto V, et al. Statin use and non-alcoholic steatohepatitis in at risk individuals. J Hepatol. 2015;63:705–712.
-
(2015)
J Hepatol
, vol.63
, pp. 705-712
-
-
Dongiovanni, P.1
Petta, S.2
Mannisto, V.3
-
55
-
-
84936806639
-
Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome
-
Kargiotis K, Athyros VG, Giouleme O, et al. Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome. World J Gastroenterol. 2015;21:7860–7868.
-
(2015)
World J Gastroenterol
, vol.21
, pp. 7860-7868
-
-
Kargiotis, K.1
Athyros, V.G.2
Giouleme, O.3
-
56
-
-
33846006173
-
The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet. 2006;368:1696–1705.
-
(2006)
Lancet
, vol.368
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
57
-
-
33644618433
-
The biology of incretin hormones
-
Drucker DJ. The biology of incretin hormones. Cell Metab. 2006;3:153–165.
-
(2006)
Cell Metab
, vol.3
, pp. 153-165
-
-
Drucker, D.J.1
-
58
-
-
66749102158
-
Clinical review: the extrapancreatic effects of glucagon-like peptide-1 and related peptides
-
Abu-Hamdah R, Rabiee A, Meneilly GS, Shannon RP, Andersen DK, Elahi D. Clinical review: the extrapancreatic effects of glucagon-like peptide-1 and related peptides. J Clin Endocrinol Metab. 2009;94:1843–1852.
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1843-1852
-
-
Abu-Hamdah, R.1
Rabiee, A.2
Meneilly, G.S.3
Shannon, R.P.4
Andersen, D.K.5
Elahi, D.6
-
59
-
-
84956914555
-
Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis
-
Carbone LJ, Angus PW, Yeomans ND. Incretin-based therapies for the treatment of non-alcoholic fatty liver disease: a systematic review and meta-analysis. J Gastroenterol Hepatol. 2016;31:23–31.
-
(2016)
J Gastroenterol Hepatol
, vol.31
, pp. 23-31
-
-
Carbone, L.J.1
Angus, P.W.2
Yeomans, N.D.3
-
60
-
-
33947156808
-
Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials
-
Buse JB, Klonoff DC, Nielsen LL, et al. Metabolic effects of two years of exenatide treatment on diabetes, obesity, and hepatic biomarkers in patients with type 2 diabetes: an interim analysis of data from the open-label, uncontrolled extension of three double-blind, placebo-controlled trials. Clin Ther. 2007;29:139–153.
-
(2007)
Clin Ther
, vol.29
, pp. 139-153
-
-
Buse, J.B.1
Klonoff, D.C.2
Nielsen, L.L.3
-
61
-
-
84872864369
-
Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program
-
Armstrong MJ, Houlihan DD, Rowe IA, et al. Safety and efficacy of liraglutide in patients with type 2 diabetes and elevated liver enzymes: individual patient data meta-analysis of the LEAD program. Aliment Pharmacol Ther. 2013;37:234–242.
-
(2013)
Aliment Pharmacol Ther
, vol.37
, pp. 234-242
-
-
Armstrong, M.J.1
Houlihan, D.D.2
Rowe, I.A.3
-
62
-
-
84957840942
-
Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study
-
Armstrong MJ, Gaunt P, Aithal GP, et al. Liraglutide safety and efficacy in patients with non-alcoholic steatohepatitis (LEAN): a multicentre, double-blind, randomised, placebo-controlled phase 2 study. Lancet. 2016;387:679–690.
-
(2016)
Lancet
, vol.387
, pp. 679-690
-
-
Armstrong, M.J.1
Gaunt, P.2
Aithal, G.P.3
-
63
-
-
84863555133
-
Effects of sitagliptin in diabetic patients with nonalcoholic steatohepatitis
-
Yilmaz Y, Yonal O, Deyneli O, Celikel CA, Kalayci C, Duman DG. Effects of sitagliptin in diabetic patients with nonalcoholic steatohepatitis. Acta Gastroenterol Belg. 2012;75:240–244.
-
(2012)
Acta Gastroenterol Belg
, vol.75
, pp. 240-244
-
-
Yilmaz, Y.1
Yonal, O.2
Deyneli, O.3
Celikel, C.A.4
Kalayci, C.5
Duman, D.G.6
-
64
-
-
84902687972
-
Efficacy and safety of sitagliptin for the treatment of nonalcoholic fatty liver disease with type 2 diabetes mellitus
-
Fukuhara T, Hyogo H, Ochi H, et al. Efficacy and safety of sitagliptin for the treatment of nonalcoholic fatty liver disease with type 2 diabetes mellitus. Hepatogastroenterology. 2014;61:323–328.
-
(2014)
Hepatogastroenterology
, vol.61
, pp. 323-328
-
-
Fukuhara, T.1
Hyogo, H.2
Ochi, H.3
-
65
-
-
84930824303
-
Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes
-
Kato H, Nagai Y, Ohta A, et al. Effect of sitagliptin on intrahepatic lipid content and body fat in patients with type 2 diabetes. Diabetes Res Clin Pract. 2015;109:199–205.
-
(2015)
Diabetes Res Clin Pract
, vol.109
, pp. 199-205
-
-
Kato, H.1
Nagai, Y.2
Ohta, A.3
-
66
-
-
84969801284
-
Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial
-
Cui J, Philo L, Nguyen P, et al. Sitagliptin vs. placebo for non-alcoholic fatty liver disease: a randomized controlled trial. J Hepatol. 2016;65:369–376.
-
(2016)
J Hepatol
, vol.65
, pp. 369-376
-
-
Cui, J.1
Philo, L.2
Nguyen, P.3
-
67
-
-
14944359845
-
A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis
-
Sanyal AJ, Mofrad PS, Contos MJ, et al. A pilot study of vitamin E versus vitamin E and pioglitazone for the treatment of nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol. 2004;2:1107–1115.
-
(2004)
Clin Gastroenterol Hepatol
, vol.2
, pp. 1107-1115
-
-
Sanyal, A.J.1
Mofrad, P.S.2
Contos, M.J.3
-
68
-
-
79955446251
-
Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial
-
Lavine JE, Schwimmer JB, Van Natta ML, et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA. 2011;305:1659–1668.
-
(2011)
JAMA
, vol.305
, pp. 1659-1668
-
-
Lavine, J.E.1
Schwimmer, J.B.2
Van Natta, M.L.3
-
69
-
-
84968924846
-
Efficacy and safety of vitamin E in nonalcoholic steatohepatitis patients with and without diabetes: pooled analysis from the PIVENS and FLINT NIDDK NASH CRN trials
-
Kowdley K, Wilson L, Van Natta M, et al. Efficacy and safety of vitamin E in nonalcoholic steatohepatitis patients with and without diabetes: pooled analysis from the PIVENS and FLINT NIDDK NASH CRN trials. Hepatology. 2015;62:264A–264A.
-
(2015)
Hepatology
, vol.62
, pp. 264A
-
-
Kowdley, K.1
Wilson, L.2
Van Natta, M.3
-
70
-
-
79954494392
-
Vitamin E and all-cause mortality: a meta-analysis
-
Abner EL, Schmitt FA, Mendiondo MS, Marcum JL, Kryscio RJ. Vitamin E and all-cause mortality: a meta-analysis. Curr Aging Sci. 2011;4:158–170.
-
(2011)
Curr Aging Sci
, vol.4
, pp. 158-170
-
-
Abner, E.L.1
Schmitt, F.A.2
Mendiondo, M.S.3
Marcum, J.L.4
Kryscio, R.J.5
-
71
-
-
33847378451
-
Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis
-
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA. 2007;297:842–857.
-
(2007)
JAMA
, vol.297
, pp. 842-857
-
-
Bjelakovic, G.1
Nikolova, D.2
Gluud, L.L.3
Simonetti, R.G.4
Gluud, C.5
-
72
-
-
80053954605
-
Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
-
Klein EA, Thompson IM Jr, Tangen CM, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. 2011;306:1549–1556.
-
(2011)
JAMA
, vol.306
, pp. 1549-1556
-
-
Klein, E.A.1
Thompson, I.M.2
Tangen, C.M.3
-
73
-
-
84881317939
-
Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials
-
Schurks M, Glynn RJ, Rist PM, Tzourio C, Kurth T. Effects of vitamin E on stroke subtypes: meta-analysis of randomised controlled trials. BMJ. 2010;341:c5702.
-
(2010)
BMJ
, vol.341
, pp. c5702
-
-
Schurks, M.1
Glynn, R.J.2
Rist, P.M.3
Tzourio, C.4
Kurth, T.5
-
75
-
-
70349972775
-
Apoptosis and cytokines in non-alcoholic steatohepatitis
-
Syn WK, Choi SS, Diehl AM. Apoptosis and cytokines in non-alcoholic steatohepatitis. Clin Liver Dis. 2009;13:565–580.
-
(2009)
Clin Liver Dis
, vol.13
, pp. 565-580
-
-
Syn, W.K.1
Choi, S.S.2
Diehl, A.M.3
-
76
-
-
21344458172
-
Apoptosis in alcoholic and nonalcoholic steatohepatitis
-
Feldstein AE, Gores GJ. Apoptosis in alcoholic and nonalcoholic steatohepatitis. Front Biosci. 2005;10:3093–3099.
-
(2005)
Front Biosci
, vol.10
, pp. 3093-3099
-
-
Feldstein, A.E.1
Gores, G.J.2
-
77
-
-
34548336791
-
Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C
-
Pockros PJ, Schiff ER, Shiffman ML, et al. Oral IDN-6556, an antiapoptotic caspase inhibitor, may lower aminotransferase activity in patients with chronic hepatitis C. Hepatology. 2007;46:324–329.
-
(2007)
Hepatology
, vol.46
, pp. 324-329
-
-
Pockros, P.J.1
Schiff, E.R.2
Shiffman, M.L.3
-
78
-
-
0030433858
-
Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline
-
D'Hellencourt CL, Diaw L, Cornillet P, Guenounou M. Differential regulation of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta, and IL-10 by pentoxifylline. Int J Immunopharmacol. 1996;18:739–748.
-
(1996)
Int J Immunopharmacol
, vol.18
, pp. 739-748
-
-
D'Hellencourt, C.L.1
Diaw, L.2
Cornillet, P.3
Guenounou, M.4
-
79
-
-
84896906165
-
Pentoxifylline in liver ischemia and reperfusion
-
Genoves P, Garcia D, Cejalvo D, et al. Pentoxifylline in liver ischemia and reperfusion. J Invest Surg. 2014;27:114–124.
-
(2014)
J Invest Surg
, vol.27
, pp. 114-124
-
-
Genoves, P.1
Garcia, D.2
Cejalvo, D.3
-
80
-
-
84928494212
-
Prednisolone or pentoxifylline for alcoholic hepatitis
-
Thursz MR, Richardson P, Allison M, et al. Prednisolone or pentoxifylline for alcoholic hepatitis. N Engl J Med. 2015;372:1619–1628.
-
(2015)
N Engl J Med
, vol.372
, pp. 1619-1628
-
-
Thursz, M.R.1
Richardson, P.2
Allison, M.3
-
81
-
-
84883734359
-
Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial
-
Mathurin P, Louvet A, Duhamel A, et al. Prednisolone with vs without pentoxifylline and survival of patients with severe alcoholic hepatitis: a randomized clinical trial. JAMA. 2013;310:1033–1041.
-
(2013)
JAMA
, vol.310
, pp. 1033-1041
-
-
Mathurin, P.1
Louvet, A.2
Duhamel, A.3
-
82
-
-
84867165316
-
Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism
-
Zein CO, Lopez R, Fu X, et al. Pentoxifylline decreases oxidized lipid products in nonalcoholic steatohepatitis: new evidence on the potential therapeutic mechanism. Hepatology. 2012;56:1291–1299.
-
(2012)
Hepatology
, vol.56
, pp. 1291-1299
-
-
Zein, C.O.1
Lopez, R.2
Fu, X.3
-
83
-
-
0028955572
-
Pentoxifylline. A hydroxyl radical scavenger
-
Freitas JP, Filipe PM. Pentoxifylline. A hydroxyl radical scavenger. Biol Trace Elem Res. 1995;47:307–311.
-
(1995)
Biol Trace Elem Res
, vol.47
, pp. 307-311
-
-
Freitas, J.P.1
Filipe, P.M.2
-
84
-
-
4644224457
-
Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet
-
Koppe SW, Sahai A, Malladi P, Whitington PF, Green RM. Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. J Hepatol. 2004;41:592–598.
-
(2004)
J Hepatol
, vol.41
, pp. 592-598
-
-
Koppe, S.W.1
Sahai, A.2
Malladi, P.3
Whitington, P.F.4
Green, R.M.5
-
85
-
-
84906535982
-
Roles for chemokines in liver disease
-
e571
-
Marra F, Tacke F. Roles for chemokines in liver disease. Gastroenterology. 2014;147:577–594. e571.
-
(2014)
Gastroenterology
, vol.147
, pp. 577-594
-
-
Marra, F.1
Tacke, F.2
-
86
-
-
84866376202
-
The role of chemokines in acute liver injury
-
Saiman Y, Friedman SL. The role of chemokines in acute liver injury. Front Physiol. 2012;3:213.
-
(2012)
Front Physiol
, vol.3
, pp. 213
-
-
Saiman, Y.1
Friedman, S.L.2
-
87
-
-
78149450628
-
Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients
-
Bertola A, Bonnafous S, Anty R, et al. Hepatic expression patterns of inflammatory and immune response genes associated with obesity and NASH in morbidly obese patients. PLoS ONE. 2010;5:e13577.
-
(2010)
PLoS ONE
, vol.5
-
-
Bertola, A.1
Bonnafous, S.2
Anty, R.3
-
88
-
-
84861197530
-
Gut–liver axis: the impact of gut microbiota on non alcoholic fatty liver disease
-
Compare D, Coccoli P, Rocco A, et al. Gut–liver axis: the impact of gut microbiota on non alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2012;22:471–476.
-
(2012)
Nutr Metab Cardiovasc Dis
, vol.22
, pp. 471-476
-
-
Compare, D.1
Coccoli, P.2
Rocco, A.3
-
89
-
-
84871637171
-
Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH
-
Mizrahi M, Shabat Y, Ben Ya'acov A, et al. Alleviation of insulin resistance and liver damage by oral administration of Imm124-E is mediated by increased Tregs and associated with increased serum GLP-1 and adiponectin: results of a phase I/II clinical trial in NASH. J Inflamm Res. 2012;5:141–150.
-
(2012)
J Inflamm Res
, vol.5
, pp. 141-150
-
-
Mizrahi, M.1
Shabat, Y.2
Ben Ya'acov, A.3
-
90
-
-
33646483917
-
A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease
-
Zelber-Sagi S, Kessler A, Brazowsky E, et al. A double-blind randomized placebo-controlled trial of orlistat for the treatment of nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 2006;4:639–644.
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 639-644
-
-
Zelber-Sagi, S.1
Kessler, A.2
Brazowsky, E.3
-
91
-
-
84928209634
-
Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
-
Ekstedt M, Hagstrom H, Nasr P, et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up. Hepatology. 2015;61:1547–1554.
-
(2015)
Hepatology
, vol.61
, pp. 1547-1554
-
-
Ekstedt, M.1
Hagstrom, H.2
Nasr, P.3
-
92
-
-
77956425361
-
Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment
-
Barry-Hamilton V, Spangler R, Marshall D, et al. Allosteric inhibition of lysyl oxidase-like-2 impedes the development of a pathologic microenvironment. Nat Med. 2010;16:1009–1017.
-
(2010)
Nat Med
, vol.16
, pp. 1009-1017
-
-
Barry-Hamilton, V.1
Spangler, R.2
Marshall, D.3
|