Vaccinia Virus Protein C6 Inhibits Type I IFN Signalling in the Nucleus and Binds to the Transactivation Domain of STAT2

PLoS Pathogens

Volumn 12, Issue 12, 2016, Pages

  Stuart, Jennifer H ^a   Sumner, Rebecca P ^a,b   Lu, Yongxu ^a   Snowden, Joseph S ^a   Smith, Geoffrey L ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; I KAPPA B KINASE EPSILON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERFERON STIMULATED GENE FACTOR 3; JANUS KINASE; MESSENGER RNA; PROTEIN SERINE THREONINE KINASE; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; VACCINIA VIRUS PROTEIN C6; VIRAL PROTEIN; STAT2 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONFOCAL LASER SCANNING MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INTRACELLULAR SIGNALING; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RNA EXTRACTION; TRANSACTIVATION; VACCINIA VIRUS; VIRUS INFECTION; WESTERN BLOTTING; CELL LINE; CELL NUCLEUS; CONFOCAL MICROSCOPY; HOST PATHOGEN INTERACTION; IMMUNOLOGY; IMMUNOPRECIPITATION; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

CELL LINE; CELL NUCLEUS; FLOW CYTOMETRY; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNITY, INNATE; IMMUNOPRECIPITATION; INTERFERON TYPE I; MICROSCOPY, CONFOCAL; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STAT2 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION; VACCINIA VIRUS; VIRAL PROTEINS;

EID: 85007579741     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005955     Document Type: Article

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