Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation

Particle and Fibre Toxicology

Volumn 13, Issue 1, 2016, Pages

  Hiraku, Yusuke ^a   Guo, Feiye ^a   Ma, Ning ^b   Yamada, Tatsuhiko ^a   Wang, Shumin ^a   Kawanishi, Shosuke ^b   Murata, Mariko ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b SUZUKA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

8 nitroguanine; Carbon nanotube; Carcinogenesis; Cytotoxicity; DNA damage; Endocytosis; High mobility group box 1; Nitric oxide; Receptor for advanced glycation end products; Toll like receptor

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ANTIBODY; DOUBLE STRANDED DNA; GLUTATHIONE; HIGH MOBILITY GROUP B1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MULTI WALLED NANOTUBE; NITRIC OXIDE; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 9; 8-NITROGUANINE; AGER PROTEIN, HUMAN; CARBON NANOTUBE; GUANINE; HMGB1 PROTEIN, HUMAN; REACTIVE NITROGEN SPECIES; TLR9 PROTEIN, HUMAN;

A-549 CELL LINE; ARTICLE; CELL LINE; CELLULAR DISTRIBUTION; CO-IMMUNOPRECIPITATION; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENDOCYTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUOROMETRY; GENE ACTIVATION; HBEPC CELL LINE; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IMMUNOPRECIPITATION; LYSOSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; ACUTE LUNG INJURY; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CHEMICALLY INDUCED; CPG ISLAND; DOSE RESPONSE; DOUBLE STRANDED DNA BREAK; DRUG EFFECTS; EPITHELIUM CELL; GENETIC TRANSFECTION; GENETICS; IMMUNOLOGY; LUNG; METABOLISM; NECROSIS; PARTICLE SIZE; PATHOLOGY; RISK ASSESSMENT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE;

ACUTE LUNG INJURY; ADVANCED GLYCOSYLATION END PRODUCT-SPECIFIC RECEPTOR; ANTIBODIES; CELL LINE, TUMOR; CPG ISLANDS; DNA BREAKS, DOUBLE-STRANDED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; EPITHELIAL CELLS; GUANINE; HMGB1 PROTEIN; HUMANS; LUNG; LYSOSOMES; NANOTUBES, CARBON; NECROSIS; NITRIC OXIDE; PARTICLE SIZE; REACTIVE NITROGEN SPECIES; RISK ASSESSMENT; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TIME FACTORS; TOLL-LIKE RECEPTOR 9; TRANSFECTION;

EID: 85007504704     PISSN: None     EISSN: 17438977     Source Type: Journal    
DOI: 10.1186/S12989-016-0127-7     Document Type: Article

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