Expression of Toll-like receptor 9 in mouse and human lungs

Journal of Anatomy

Volumn 222, Issue 5, 2013, Pages 495-503

  Schneberger, David ^a   Caldwell, Sarah ^a   Kanthan, Rani ^b   Singh, Baljit ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Alveolar macrophages; Immunocytochemistry; in situ hybridization; TLR9

Indexed keywords

TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRONCHUS MUCOSA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOELECTRON MICROSCOPY; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LUNG ALVEOLUS MACROPHAGE; LUNG PARENCHYMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM;

ANIMALS; HUMANS; LUNG; MICE; MICE, INBRED C3H; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, MESSENGER; TOLL-LIKE RECEPTOR 9;

MUS;

EID: 84876426643     PISSN: 00218782     EISSN: 14697580     Source Type: Journal    
DOI: 10.1111/joa.12039     Document Type: Article

References (36)

1. An H, Xu H, Yu Y, et al. (2002) Up-regulation of TLR9 gene expression by LPS in mouse macrophages via activation of NF-kappaB, ERK and p38 MAPK signal pathways. Immunol Lett 81, 165-169.
2. Assaf A, Esteves H, Curnow SJ, et al. (2009) A threshold level of TLR9 mRNA predicts cellular responsiveness to CpG-ODN in haematological and non-haematological tumour cell lines. Cell Immunol 259, 90-99.
3. Bhan U, Trujillo G, Lyn-Kew K, et al. (2008) Toll-like receptor 9 regulates the lung macrophage phenotype and host immunity in murine pneumonia caused by Legionella pneumophila. Infect Immun 76, 2895-2904.
4. Bowden DH (1984) The alveolar macrophage. Environ Health Perspect 55, 327-341.
5. Chen L, Arora M, Yarlagadda M, et al. (2006) Distinct responses of lung and spleen dendritic cells to the TLR9 agonist CpG oligodeoxynucleotide. J Immunol 177, 2373-2383.
6. Droemann D, Albrecht D, Gerdes J, et al. (2005) Human lung cancer cells express functionally active Toll-like receptor 9. Respir Res 6, 1-10.
7. Fernandez S, Jose P, Avdiushko MG, et al. (2004) Inhibition of IL-10 receptor function in alveolar macrophages by Toll-like receptor agonists. J Immunol 172, 2613-2620.
8. Hemmi H, Takeuchi O, Kawai T, et al. (2000) A Toll-like receptor recognizes bacterial DNA. Nature 408, 740-745.
9. Hornung V, Rothenfusser S, Britsch S, et al. (2002) Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 168, 4531-4537.
10. Ilmarinen P, Hasala H, Sareila O, et al. (2009) Bacterial DNA delays human eosinophil apoptosis. Pulm Pharmacol Ther 22, 167-176.
11. Jozsef L, Khreiss T, Filep JG (2004) CpG motifs in bacterial DNA delay apoptosis of neutrophil granulocytes. FASEB J 18, 1776-1778.
12. Kadowaki N, Ho S, Antonenko S, et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 194, 863-869.
13. Kalis C, Gumenscheimer M, Freudenberg N, et al. (2005) Requirement for TLR9 in the immunomodulatory activity of Propionibacterium acnes. J Immunol 174, 4295-4300.
14. Kawabata K, Takakura Y, Hashida M (1995) The fate of plasmid DNA after intravenous injection in mice: involvement of scavenger receptors in its hepatic uptake. Pharm Res 12, 825-830.
15. Kiemer AK, Senaratne RH, Hoppstadter J, et al. (2008) Attenuated activation of macrophage TLR9 by DNA from virulent mycobacteria. J Innate Immun 1, 29-45.
16. Knuefermann P, Baumgarten G, Koch A, et al. (2007) CpG oligonucleotide activates Toll-like receptor 9 and causes lung inflammation in vivo. Respir Res 8, 72-80.
17. Krieg AM (2002) CpG motifs in bacterial DNA and their immune effects. Ann Rev Immunol 20, 709-760.
18. Krieg AM, Yi AK, Matson S, et al. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374, 546-549.
19. Kuramoto E, Yano O, Kimura Y, et al. (1992) Oligonucleotide sequences required for natural killer cell activation. Jpn J Cancer Res 83, 1128-1131.
20. Li J, Ma Z, Tang ZL, et al. (2004) CpG DNA-mediated immune response in pulmonary endothelial cells. Am J Physiol Lung Cell Mol Physiol 287, L552-L558.
21. O'Mahony DS, Pham U, Iyer R, et al. (2008) Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages. Int J Med Sci 5, 1-8.
22. Parbhakar OP, Duke T, Townsend HGG, et al. (2004) Immunophenotypic characterization and depletion of pulmonary intravascular macrophages of horses. Vet Res 35, 39-51.
23. Parilla NW, Hughes VS, Lierl KM, et al. (2006) CpG DNA modulates interleukin 1β-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells. Respir Res 7, 84-92.
24. Platz J, Beisswenger C, Dalpke A, et al. (2004) Microbial DNA induces a host defense reaction of human respiratory epithelial cells. J Immunol 173, 1219-1223.
25. Rutz M, Metzger J, Gellert T, et al. (2004) Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner. Eur J Immunol 34, 2541-2550.
26. Samara KD, Antoniou KM, Karagiannis K, et al. (2012) Expression profiles of Toll-like receptors in non-small cell lung cancer and idiopathic pulmonary fibrosis. Int J Onco 40, 1397-1404.
27. Schaumann F, Müller M, Braun A, et al. (2008) Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma. Am J Respir Crit Care Med 177, 1307-1313.
28. Schneberger D, Caldwell S, Suri SS, et al. (2009) Expression of toll-like receptor 9 in horse lungs. Anat Rec (Hoboken) 292, 1068-1077.
29. Schneberger D, Aharonson-Raz K, Singh B (2011a) Monocyte and macrophage heterogeneity and Toll-like receptors in the lung. Cell Tissue Res 343, 97-106.
30. Schneberger D, Lewis D, Caldwell S, et al. (2011b) Expression of toll-like receptor 9 in lungs of pigs, dogs and cattle. Int J Exp Pathol 92, 1-7.
31. Schwartz DA, Quinn TJ, Thorne PS, et al. (1997) CpG motifs in bacterial DNA cause inflammation in the lower respiratory tract. J Clin Invest 100, 68-73.
32. Schwartz DA, Wohlford-Lenane CL, Quinn TJ, et al. (1999) Bacterial DNA or oligonucleotides containing unmethylated CpG motifs can minimize lipopolysaccharide-induced inflammation in the lower respiratory tract through an IL-12-dependent pathway. J Immunol 163, 224-231.
33. Senthilselvan A, Dosman JA, Chenard L, et al. (2009) Toll-like receptor 4 variants reduce airway response in human subjects at high endotoxin levels in a swine facility. J Allergy Clin Immunol, 123, 1034-1040, 1040.e1-2.
34. Staub NC (1994) Pulmonary intravascular macrophages. Annu Rev Physiol 56, 47-67.
35. Suzuki K, Suda T, Naito T, et al. (2005) Impaired toll-like receptor 9 expression in alveolar macrophages with no sensitivity to CpG DNA. Am J Respir Crit Care Med 171, 707-713.
36. Wong CK, Cheung PFY, Ip WK, et al. (2007) Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Resp Cell Mol Biol 37, 85-96.