Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloidderived suppressor cells

Oncotarget

Volumn 7, Issue 51, 2016, Pages 83907-83925

  Liu, Feiyan ^a   Li, Xia ^a   Lu, Chunwan ^b,c   Bai, Aiping ^d   Bielawski, Jacek ^d   Bielawska, Alicja ^d   Marshall, Brendan ^b   Schoenlein, Patricia V ^b   Lebedyeva, Iryna O ^e   Liu, Kebin ^b,c  

^a ZHEJIANG UNIVERSITY   (China)

^b MEDICAL COLLEGE OF GEORGIA   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e AUGUSTA UNIVERSITY   (United States)

Author keywords

Autophagy flux; Cathepsin; Ceramide; Immune response; Immunity; Immunology and Microbiology Section; Lysosomal cell death; MDSCs

Indexed keywords

BECLIN 1; BIM PROTEIN; CATHEPSIN B; CATHEPSIN D; CD11B ANTIGEN; CERAMIDASE; CERAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAK; PROTEIN BCL XL; PUMA PROTEIN; SPHINGOLIPID; ACID CERAMIDASE; ANTINEOPLASTIC AGENT; ASAH1 PROTEIN, MOUSE; CTSB PROTEIN, MOUSE; CTSD PROTEIN, MOUSE; ENZYME INHIBITOR; N-PALMITOYLSPHINGOSINE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CANCER GROWTH; CANCER IMMUNOTHERAPY; CD3+ T LYMPHOCYTE; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; IN VITRO STUDY; IN VIVO STUDY; LYSOSOME; MITOCHONDRION; MOUSE; MYELOID-DERIVED SUPPRESSOR CELL; NATURAL KILLER CELL; NECROPTOSIS; NONHUMAN; TUMOR ESCAPE; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; IMMUNOLOGY; METABOLISM; PATHOLOGY; SARCOMA; SIGNAL TRANSDUCTION; TIME FACTOR; TUMOR CELL LINE;

ACID CERAMIDASE; ANIMALS; ANTINEOPLASTIC AGENTS; AUTOPHAGY; CATHEPSIN B; CATHEPSIN D; CELL LINE, TUMOR; CERAMIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITORS; LYSOSOMES; MICE, INBRED BALB C; MYELOID-DERIVED SUPPRESSOR CELLS; SARCOMA; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 85007482646     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.13438     Document Type: Article

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