Deregulation of apoptotic factors Bcl-xL and Bax confers apoptotic resistance to myeloid-derived suppressor cells and contributes to their persistence in cancer

Journal of Biological Chemistry

Volumn 288, Issue 26, 2013, Pages 19103-19115

  Hu, Xiaolin ^a   Bardhan, Kankana ^a   Paschall, Amy V ^a   Yang, Dafeng ^a   Waller, Jennifer L ^a   Park, Mary Anne ^a   Nayak Kapoor, Asha ^a   Samuel, Thomas A ^a   Abrams, Scott I ^b   Liu, Kebin ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS PATHWAYS; APOPTOTIC FACTORS; CANCER THERAPY; CYTOTOXIC T LYMPHOCYTES; DOWN-REGULATION; EXPRESSION LEVELS; INFLAMMATORY MEDIATORS; TUMOR PROGRESSIONS;

CELL DEATH; CELL MEMBRANES; DISEASES; MAMMALS; TUMORS;

DIAGNOSIS;

4 [4 (4' CHLORO 2 BIPHENYLYLMETHYL) 1 PIPERAZINYL] N [4 [3 DIMETHYLAMINO 1 (PHENYLTHIOMETHYL)PROPYLAMINO] 3 NITROBENZENESULFONYL]BENZAMIDE; CASPASE 8; CD69 ANTIGEN; FAS ANTIGEN; FAS LIGAND; FLICE INHIBITORY PROTEIN; GRANZYME; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; PERFORIN; PROTEIN BAX; PROTEIN BCL XL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BONE MARROW CELL; BREAST CANCER; BREAST CARCINOMA; CD8+ T LYMPHOCYTE; CELL SURFACE; COLON TUMOR; COLORECTAL CANCER; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; DRUG CYTOTOXICITY; GENE REPRESSION; HUMAN; HUMAN CELL; MOUSE; MYELOID DERIVED SUPPRESSOR CELL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; UPREGULATION;

APOPTOSIS; BAX; BCL-2 FAMILY; FAS; MYELOID CELL;

ANIMALS; ANTIGENS, CD95; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 8; CD8-POSITIVE T-LYMPHOCYTES; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERFERON REGULATORY FACTORS; MICE; MICE, INBRED BALB C; MYELOID CELLS; NEOPLASMS;

MUS;

EID: 84879592535     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.434530     Document Type: Article

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