Autophagy protects against cholesterol-induced apoptosis in pancreatic β-cells

Biochemical and Biophysical Research Communications

Volumn 482, Issue 4, 2017, Pages 678-685

  Wu, Jiahua ^a   Kong, Feijuan ^a   Pan, Qianqian ^a   Du, Ying ^a   Ye, Jun ^b   Zheng, Fenping ^a   Li, Hong ^a   Zhou, Jiaqiang ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b Hanggang Hospital   (China)

Author keywords

Apoptosis; Autophagy; Cholesterol; LC3 II; cell

Indexed keywords

ALOXISTATIN; BAFILOMYCIN A1; CHOLESTEROL; PEPSTATIN; RAPAMYCIN; CASPASE 3; FLUORESCENT DYE; MACROLIDE; MAP1LC3 PROTEIN, MOUSE; MICROTUBULE ASSOCIATED PROTEIN; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOLYSOSOME; AUTOPHAGY; CELL DAMAGE; CONTROLLED STUDY; IMMUNOFLUORESCENCE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; RAT; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; HOMEOSTASIS; INSULIN RESISTANCE; INSULINOMA; METABOLISM;

ANIMALS; APOPTOSIS; AUTOPHAGY; CASPASE 3; CELL SURVIVAL; CHOLESTEROL; FLUORESCENT DYES; HOMEOSTASIS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; INSULINOMA; MACROLIDES; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROTUBULE-ASSOCIATED PROTEINS; PEPSTATINS; RATS; TOR SERINE-THREONINE KINASES;

EID: 85007366073     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2016.11.093     Document Type: Article

References (31)

1. [1] Boden, G., Shulman, G.I., Free fatty acids in obesity and type 2 diabetes, defining their role in the development of insulin resistance and beta-cell dysfunction. Eur. J. Clin. Investig. 32:Suppl 3 (2002), 14–23.
2. [2] Lupi, R., Dotta, F., Marselli, L., Del, G.S., Masini, M., Santangelo, C., Patane, G., Boggi, U., Piro, S., Anello, M., Bergamini, E., Mosca, F., Di, M.U., Del, P.S., Marchetti, P., Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that beta-cell death is caspase mediated,partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51 (2002), 1437–1442.
3. [3] Kashyap, S., Belfort, R., Gastaldelli, A., Pratipanawatr, T., Berria, R., Pratipanawatr, W., Bajaj, M., Mandarino, L., DeFronzo, R., Cusi, K., A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes 52 (2003), 2461–2474.
4. [4] Turner, R.C., Millns, H., Neil, H.A., Stratton, I.M., Manley, S.E., Matthews, D.R., Holman, R.R., Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus, United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ 316 (1998), 823–828.
5. [5] Chahil, T.J., Ginsberg, H.N., Diabetic dyslipidemia. Endocrinol. Metab. Clin. North Am. 35 (2006), 491–510 (vii-viii).
6. [6] Hao, M., Head, W.S., Gunawardana, S.C., Hasty, A.H., Piston, D.W., Direct effect of cholesterol on insulin secretion, a novel mechanism for pancreatic beta-cell dysfunction. Diabetes 56 (2007), 2328–2338.
7. [7] Zhou, J., Wu, J., Zheng, F., Jin, M., Li, H., Glucagon-like peptide-1 analog-mediated protection against cholesterol-induced apoptosis via mammalian target of rapamycin activation in pancreatic betaTC-6 cells -1mTORbetaTC-6. J. Diabetes 7 (2015), 231–239.
8. [8] Zhao, Y.F., Wang, L., Lee, S., Sun, Q., Tuo, Y., Wang, Y., Pei, J., Chen, C., Cholesterol induces mitochondrial dysfunction and apoptosis in mouse pancreatic beta-cell line MIN6 cells. Endocrine 37 (2010), 76–82.
9. [9] Lu, X., Liu, J., Hou, F., Liu, Z., Cao, X., Seo, H., Gao, B., Cholesterol induces pancreatic beta cell apoptosis through oxidative stress pathway. Cell Stress Chaperones 16 (2011), 539–548.
10. [10] Mizushima, N., Komatsu, M., Autophagy, renovation of cells and tissues. Cell 147 (2011), 728–741.
11. [11] Kaniuk, N.A., Kiraly, M., Bates, H., Vranic, M., Volchuk, A., Brumell, J.H., Ubiquitinated-protein aggregates form in pancreatic beta-cells during diabetes-induced oxidative stress and are regulated by autophagy. Diabetes 56 (2007), 930–939.
12. [12] Ebato, C., Uchida, T., Arakawa, M., Komatsu, M., Ueno, T., Komiya, K., Azuma, K., Hirose, T., Tanaka, K., Kominami, E., Kawamori, R., Fujitani, Y., Watada, H., Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 8 (2008), 325–332.
13. [13] Klionsky, D.J., Abeliovich, H., Agostinis, P., Agrawal, D.K., Aliev, G., Askew, D.S., et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4 (2008), 151–175.
14. [14] Ravikumar, B., Vacher, C., Berger, Z., Davies, J.E., Luo, S., Oroz, L.G., Scaravilli, F., Easton, D.F., Duden, R., O'Kane, C.J., Rubinsztein, D.C., Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat. Genet. 36 (2004), 585–595.
15. [15] Choe, S.S., Choi, A.H., Lee, J.W., Kim, K.H., Chung, J.J., Park, J., Lee, K.M., Park, K.G., Lee, I.K., Kim, J.B., Chronic activation of liver X receptor induces beta-cell apoptosis through hyperactivation of lipogenesis: liver X receptor-mediated lipotoxicity in pancreatic beta-cells. Diabetes 56 (2007), 1534–1543.
16. [16] Kusminski, C.M., Shetty, S., Orci, L., Unger, R.H., Scherer, P.E., Diabetes and apoptosis: lipotoxicity. Apoptosis 14 (2009), 1484–1495.
17. [17] Bergman, R.N., Ader, M., Free fatty acids and pathogenesis of type 2 diabetes mellitus. Trends Endocrinol. Metab. 11 (2000), 351–356.
18. [18] Maiuri, M.C., Zalckvar, E., Kimchi, A., Kroemer, G., Self-eating and self-killing: crosstalk between autophagy and apoptosis. Nat. Rev. Mol. Cell Biol. 8 (2007), 741–752.
19. [19] Rodriguez-Enriquez, S., Kim, I., Currin, R.T., Lemasters, J.J., Tracker dyes to probe mitochondrial autophagy (mitophagy) in rat hepatocytes. Autophagy 2 (2006), 39–46.
20. [20] Thorburn, A., Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 13 (2008), 1–9.
21. [21] El-Khattouti, A., Selimovic, D., Haikel, Y., Hassan, M., Crosstalk between apoptosis and autophagy: molecular mechanisms and therapeutic strategies in cancer. J. Cell Death 6 (2013), 37–55.
22. [22] Su, M., Mei, Y., Sinha, S., Role of the crosstalk between autophagy and apoptosis in Cancer. J. Oncol., 2013, 2013, 102735.
23. [23] Jaishy, B., Abel, E.D., AUID- oho, lipids, lysosomes and Autophagy. J. Lipid Res. 57 (2016), 1619–1635.
24. [24] Klionsky, D.J., Abdalla, F.C., Abeliovich, H., Abraham, R.T., Acevedo-Arozena, A., Adeli, K., et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 8 (2012), 445–544.
25. [25] Gordy, C., He, Y.W., The crosstalk between autophagy and apoptosis: where does this lead. Protein Cell 3 (2012), 17–27.
26. [26] Wu, H., Che, X., Zheng, Q., Wu, A., Pan, K., Shao, A., Wu, Q., Zhang, J., Hong, Y., Caspases: a molecular switch node in the crosstalk between autophagy and apoptosis. Int. J. Biol. Sci. 10 (2014), 1072–1083.
27. [27] Kelley, D.E., He, J., Menshikova, E.V., Ritov, V.B., Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes 51 (2002), 2944–2950.
28. [28] Okamoto, K., Kondo-Okamoto, N., Mitochondria and autophagy, critical interplay between the two homeostats. Biochim. Biophys. Acta 1820 (2012), 595–600.
29. [29] Meira, M.L.A., Vieira, M.Q., Ilha, M., de Vasconcelos, M., Biehl, H.B., Lima, D.B., Schein, V., Barbe-Tuana, F., Borojevic, R., Guma, F.C., The interplay between apoptosis, mitophagy and mitochondrial biogenesis induced by resveratrol can determine activated hepatic stellate cells death or survival. Cell Biochem. Biophys. 721 (2015), 657–672.
30. [30] Jung, M., Lee, J., Seo, H.Y., Lim, J.S., Kim, E.K., Cathepsin inhibition-induced lysosomal dysfunction enhances pancreatic beta-cell apoptosis in high glucose. PLoS One, 10, 2015, e0116972.
31. [31] Jung, H.S., Chung, K.W., Won, K.J., Kim, J., Komatsu, M., Tanaka, K., Nguyen, Y.H., Kang, T.M., Yoon, K.H., Kim, J.W., Jeong, Y.T., Han, M.S., Lee, M.K., Kim, K.W., Shin, J., Lee, M.S., Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab. 8 (2008), 318–324.