Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

Cell Stem Cell

Volumn 20, Issue 2, 2017, Pages 191-204.e5

  Latil, Mathilde ^a   Nassar, Dany ^a   Beck, Benjamin ^a   Boumahdi, Soufiane ^a   Wang, Li ^b   Brisebarre, Audrey ^a   Dubois, Christine ^a   Nkusi, Erwin ^a   Lenglez, Sandrine ^a   Checinska, Agnieszka ^a   Vercauteren Drubbel, Alizée ^a   Devos, Michael ^c,d   Declercq, Wim ^c,d   Yi, Rui ^b   Blanpain, Cédric ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF COLORADO   (United States)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

cancer cell of origin; cancer cell plasticity; cellular reprogramming; EMT; epigenetic; gene regulatory network; skin cancer; transcription factors; tumor heterogeneity

Indexed keywords

CADHERIN 11; CALVASCULIN; CONNECTIVE TISSUE GROWTH FACTOR; EPITHELIAL CELL ADHESION MOLECULE; K RAS PROTEIN; KALLIKREIN 5; KRUPPEL LIKE FACTOR 4; KRUPPEL LIKE FACTOR 5; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; OCTAMER TRANSCRIPTION FACTOR 6; PROTEIN P53; PROTEIN P63; SMAD2 PROTEIN; STROMELYSIN 3; TRANSCRIPTION FACTOR 7 LIKE 1; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR ETS 1; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR RUNX2; TRANSCRIPTION FACTOR SOX2; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; TWIST RELATED PROTEIN 1; TWIST RELATED PROTEIN 2; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN; CHROMATIN; PHOSPHOPROTEIN; REPRESSOR PROTEIN; TRANSACTIVATOR PROTEIN; TRP63 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOMA CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL LINEAGE; CELL TYPE SPECIFIC CHROMATIN; CHROMATIN; CLONOGENESIS; CONTROLLED STUDY; EPIDERMIS; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE REGULATORY NETWORK; GENE REPRESSION; HAIR FOLLICLE; INTERFOLLICULAR EPIDERMIS; MALE; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN MOTIF; SKIN CARCINOGENESIS; SQUAMOUS CELL SKIN CARCINOMA; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; CANCER STEM CELL; CARCINOGENESIS; CELL CLONE; EPITHELIUM CELL; GENETIC EPIGENESIS; GENETIC TRANSCRIPTION; GENETICS; HEK293 CELL LINE; HUMAN; METABOLISM; METASTASIS; NUCLEOTIDE SEQUENCE; PATHOLOGY; SKIN TUMOR; SQUAMOUS CELL CARCINOMA;

ANIMALS; BASE SEQUENCE; CARCINOGENESIS; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; CELL LINEAGE; CHROMATIN; CLONE CELLS; EPIGENESIS, GENETIC; EPITHELIAL CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; HAIR FOLLICLE; HEK293 CELLS; HUMANS; MICE; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; PHOSPHOPROTEINS; REPRESSOR PROTEINS; SKIN NEOPLASMS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 85007268713     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.10.018     Document Type: Article

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