Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats

Physiology and Behavior

Volumn 170, Issue , 2017, Pages 115-123

  Ge, Xu Hua ^a   Zhu, Guo Ji ^b   Geng, De Qin ^c   Zhang, Han Zhi ^a   He, Juan Mei ^a   Guo, Ai Zhen ^a   Ma, Lin Lin ^a   Yu, De Hua ^a  

^a TONGJI UNIVERSITY   (China)

^b CHILDREN S HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c XUZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Akt; Caspase 3; Ischemia reperfusion; JNK3; Metformin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; METFORMIN; MITOGEN ACTIVATED PROTEIN KINASE 10; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SERINE THREONINE KINASE; AKT1 PROTEIN, RAT; CASP3 PROTEIN, RAT; ENZYME INHIBITOR; NEUROPROTECTIVE AGENT; PROTEIN KINASE B;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY DISORDER; APOPTOSIS; ARTICLE; CELL SURVIVAL; COGNITIVE DEFECT; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; EXPLORATORY BEHAVIOR; HIPPOCAMPAL CA1 REGION; IMMUNOBLOTTING; MALE; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SPATIAL LEARNING; SPATIAL MEMORY; STAINING; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; ANXIETY; BRAIN ISCHEMIA; COGNITION DISORDERS; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; MAZE TEST; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; ANXIETY; APOPTOSIS; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; CASPASE 3; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; MALE; MAZE LEARNING; METFORMIN; MITOGEN-ACTIVATED PROTEIN KINASE 10; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRAMIDAL CELLS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

EID: 85007044942     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2016.12.021     Document Type: Article

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