Modulation of the oxidative stress by metformin in the cerebrum of rats exposed to global cerebral ischemia and ischemia/reperfusion

European Review for Medical and Pharmacological Sciences

Volumn 18, Issue 16, 2014, Pages 2387-2392

  Abd Elsameea, A A ^a   Moustaf, A A ^a   Mohamed, A M ^a,b  

^a Zagazig University   (Egypt)

^b TAIF UNIVERSITY   (Saudi Arabia)

Author keywords

AMPK; Ischemia reperfusion; Metformin; Oxidative stress

Indexed keywords

CATALASE; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; METFORMIN; SUPEROXIDE DISMUTASE; NEUROPROTECTIVE AGENT;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN HOMOGENATE; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; MALE; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; ANIMAL; BRAIN; DRUG EFFECTS; METABOLISM; WISTAR RAT;

ANIMALS; BRAIN ISCHEMIA; CATALASE; CEREBRUM; GLUTATHIONE PEROXIDASE; MALE; MALONDIALDEHYDE; METFORMIN; NEUROPROTECTIVE AGENTS; OXIDATIVE STRESS; RATS, WISTAR; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 84907846028     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. SAIKI R, PARK H, ISHII I, YOSHIDA M, NISHIMURA K, TOIDA T, TATSUKAWA H, KOJIMA S, IKEGUCHI Y, PEGG AE, KASHIWAGU K, IGARASHI K. Brain infarction correlates more closely with acrolein than with reactive oxygen species. Biochem Biophys Res Commun 2011; 404: 1044-1049.
2. LI J, ZENG Z, VIOLLET B, RONNETT GV, MCCULLOUGH LD. Neuroprotective effects of adenosinemonophosphate- Activated protein kinase inhibition and gene deletion i stroke. Stroke 2007; 38: 2992-2999.
3. SCHALLER B, GRAF R. Cerebral ischemia and reperfusion: the pathophysiologic concept as a basis for clinical therapy. J Cereb Blood Flow Metab 2004; 24: 351-371.
4. NITA DA, NITA V, SPULBER S, MOLDOVAN M, POPA DP, ZAGREAN AM, ZAFREAN L. Oxidative damage following cerebral ischemia depends on reperfusion-a biochemical study in rat. J Cell Mol Med 2001; 5: 163-170.
5. TRAYSTMAN RJ, KIRSCH JR, KOEHLER RC. Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appl Physiol 1991; 71: 1185-1195.
6. FLOYD RA. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999; 222: 236-245.
7. KIRPICHNIKOV D, MCFARLANEM SI, SOWERS JR. Metformin: An update. Ann Intern Med 2002; 137: 25-33.
8. SELVIN E, HIRSCH AT. Contemporary risk factor control and walking dysfunction in individuals with peripheral arterial disease. Atherosclerosis 2008; 201: 425-433.
9. ABBASI F, CHU JW, MCLAUGHLIN T, LAMENDOLA C, LEARY ET, REAVEN GM. Effect of metformin treatment on multiple cardiovascular disease risk factors in patients with type 2 diabetes mellitus. Metabolism 2004; 53(Suppl 2): S159-S164.
10. MAHROUF M, OUSLIMANI N, PEYNET J, DJELIDI R, COUTURIER M, THEROND P, LEGRAND A, BEAUDEUX JL. Metformin reduces angiotensin-mediated intracellular production of reactive oxygen species in endothelial cells through the inhibition of protein kinase C. Biochem Pharmacol 2006; 72: 176-183.
11. LI J, BENASHSKI SE, VENNA VR, MCCULLOUGH LD. Effects of metformin in experimental stroke. Stroke 2010; 41: 2645-2652.
12. QUAILE MP, MELICH DH, JORDAN HL, NOLD JB, CHISM JP, POLLI JW, SMITH GA, RHODES MG. Toxicity and toxicokinetics of metformin in rats. Toxicol Appl Pharmacol 2010; 2433: 340-347.
13. ULRICH PT, KROPPENSTEDT S, HEIMANN A, KEMPSKI O. Laser-Doppler scanning of local cerebral blood flow and reserve capacity and testing of motor and memory functions in a chronic 2-vessel occlusion model in rats. Stroke 1998; 29: 2412-2420.
14. WONG BS, LIU T, LI RL, PAN T, PETERSEN RB, SMITH MA. Increased levels of oxidative stress markers detected in the brains of prion knock-out mice. J Neurochem 2001; 76: 565-572.
15. POLIDORI M, CHERUBINI A, NELLES O, RORDORF G, KEANEY JFK. Increased plasma levels of lipid hyclroperoxides in patients with ischemic stroke. Free Radic Bio Med 1998; 25: 561-556.
16. ABEI C. CATALASE. In: Bergmeyer HD, (editor). Methods of Enzymatic analysis. New York: Academic press, 1974; pp. 631-384.
17. MARKLUND S, MARKLUND G. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974; 47: 469-474.
18. LAWRENCE RA, BURK RE. Assay for glutathione peroxidase in selenium deficient rat liver. Biochem Biophys Res Commun 1976; 71: 952-958.
19. LIPTON P. Ischemic cell death in brain neurons. Physiol Rev 1999; 79: 1431-1568.
20. GHONEIM AI, ABDEL-NAIM AB, KHALIFA AE, EL-DENSHARY S. Protective effects of curcumin against ischaemia/reperfusion insult in rat forebrain. Pharmacol Res 2002; 46: 273-279.
21. EKLOF, B., SIESJO, B.K. The effect of bilateral carotid artery ligation upon the blood flow and the energy state of the rat brain. Acta Physiol Scand 1972; 86: 155-165.
22. VANELLA A, SORRENTI V, GAMBERA G, CASTORINA C, DIGIACOMO C, CAMPISI A, SALVA M, PEREZ-POLO JR. Lipid peroxidation in rat cerebral cortex during post ischemic reperfusion: effect of exogenous antioxidants and Ca(++)-antagonist drugs. Ital J Biochem 1990; 39: 196A-198A.
23. SAKAMOTO A, OHNISHI ST, OHNISHI T, OGAWA R. Relationship between free radical production and lipid peroxidation during ischemia-reperfusion injury in the rat brain. Brain Res 1991; 554: 186-192.
24. MALINSKI T, BAILEY F, ZHANG ZG, CHOPP M. Nitric oxide measured by a porphyrinic acid microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 1993; 13: 355-358.
25. FRIDOVICH, I. Superoxide radicals and superoxide dismutase. Ann Rev Biochem 1995; 44, 147-159.
26. BLAKE DR, ALLEN RE, LUNEC J. Free radicals in biological systems: A review oriented to the inflammatory process. Br Med Bull 1987; 43: 371-385.
27. HOU X, SONG J, LI XN, ZHANG L, WANG X, CHEN L, SHEN YH. Metformin reduces intracellular reactive oxygen species levels by upregulating expression of the antioxidant thioredoxin via the AMPKFOXO3 pathway. Biochem Biophys Res Commun 2010; 396: 199-205.
28. MARTHA SN. Pancreatic hormones and antidiabetic drugs. In: katzung BG, Masters SB, Trevor AJ, editors. Basic and Clinical Pharmacology. New York: Mc Graw Hill Medical, 2012; pp. 743-768.
29. HARADA S, FUJITA W, SHICHI K, TOKUYAMA S. The development of glucose intolerance after focal cerebral ischemia participates in subsequent neuronal damage. Brain Res 2009; 1279: 174-181.
30. BELLIN C, DE-WIZA DH, WIERNSPERGER NF, ROSEN P. Generation of reactive oxygen species by endothelial and smooth muscle cells: influence of hyperglycemia and metformin. Horm Metab Res 2006; 38: 732-739.
31. GUO D, CHIEN S, SHYY JY. Regulation of endothelial cell cycle by laminar versus oscillatory flow: distinct modes of interactions of AMP-activated protein kinase and Akt pathways. Circ Res 2007; 100: 564-571.
32. GASKIN FS, KAMADA K, YUSOF M, KORTHUIS RJ. AMPactivated protein kinase activation prevents postischemic leukocyte-endothelial cell adhesive interactions. Am J Physiol Heart Circ Physiol 2007; 292: 326-332.
33. ARPITA C, SUBHANKAR C, MAITREE B. Effect of metformin on oxidative stress, nitrosative stress and inflammatory biomarkers in type 2 diabetes patients. Diabetes Res Clin Pract 2011; 93: 56-62.
34. YUMEI Y, JOSE R, PEREZ P, DAVID A, YOCHAI B. The potential effects of anti-diabetic medications on myocardial ischemia-reperfusion injury. Basic Res Cardiol 2011; 106: 925-952.
35. WANG J, GALLAGHER D, DE-VITO LM, CANCINO G, TSUI D, HE L, KELLER GM, FRANKLAND PW, KAPLAN DR, MILLER FD. Metformin activates an atypical PKCCBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 2012; 11: 23-35.