Pre-treatment with metformin activates Nrf2 antioxidant pathways and inhibits inflammatory responses through induction of AMPK after transient global cerebral ischemia

Metabolic Brain Disease

Volumn 30, Issue 3, 2015, Pages 747-754

  Ashabi, Ghorbangol ^a   Khalaj, Leila ^b   Khodagholi, Fariba ^c   Goudarzvand, Mahdi ^b   Sarkaki, Alireza ^a  

^a AHVAZ JUNDISHAPUR UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b ALBORZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

AMPK; Antioxidant; Global cerebral ischemia; Inflammation; Metformin; Nrf2

Indexed keywords

ANTIOXIDANT; AUTACOID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; METFORMIN; NFE2L2 PROTEIN, RAT; TRANSCRIPTION FACTOR NRF2;

ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; DRUG EFFECTS; ENZYME INDUCTION; ISCHEMIC ATTACK, TRANSIENT; MALE; METABOLISM; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIOXIDANTS; ENZYME INDUCTION; INFLAMMATION MEDIATORS; ISCHEMIC ATTACK, TRANSIENT; MALE; METFORMIN; NF-E2-RELATED FACTOR 2; RATS; SIGNAL TRANSDUCTION;

EID: 84939977745     PISSN: 08857490     EISSN: 15737365     Source Type: Journal    
DOI: 10.1007/s11011-014-9632-2     Document Type: Article

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