Akt1 gene deletion and stroke

Journal of the Neurological Sciences

Volumn 269, Issue 1-2, 2008, Pages 105-112

  Li, Jun ^a   Lang, Jesse ^a   Zeng, Zhiyuan ^a   McCullough, Louise D ^a  

^a UNIVERSITY OF CONNECTICUT HEALTH CENTER   (United States)

Author keywords

Akt; Estrogen; Stroke; Triciribine

Indexed keywords

ESTROGEN; PROTEIN KINASE AKT1; PROTEIN KINASE B; TRICIRIBINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; GENE DELETION; MALE; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; STROKE;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; ESTRADIOL; ESTROGENS; FEMALE; GENE EXPRESSION REGULATION; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVARIECTOMY; PROTO-ONCOGENE PROTEINS C-AKT; SEVERITY OF ILLNESS INDEX; TIME FACTORS;

EID: 43049109830     PISSN: 0022510X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jns.2007.12.034     Document Type: Article

References (34)

1. Luo H.R., Hattori H., Hossain M.A., Hester L., Huang Y., Lee-Kwon W., et al. Akt as a mediator of cell death. Proc Natl Acad Sci U S A 100 (2003) 11712-11717
2. Brazil D.P., Yang Z.Z., and Hemmings B.A. Advances in protein kinase B signalling: AKTion on multiple fronts. Trends Biochem Sci 29 (2004) 233-242
3. Datta S.R., Brunet A., and Greenberg M.E. Cellular survival: a play in three Akts. Genes Dev 13 (1999) 2905-2927
4. Franke T.F., Hornik C.P., Segev L., Shostak G.A., and Sugimoto C. PI3K/Akt and apoptosis: size matters. Oncogene 22 (2003) 8983-8998
5. Manning B.D., and Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 129 (2007) 1261-1274
6. Noshita N., Lewen A., Sugawara T., and Chan P.H. Evidence of phosphorylation of Akt and neuronal survival after transient focal cerebral ischemia in mice. J Cereb Blood Flow Metab 21 (2001) 1442-1450
7. Friguls B., Petegnief V., Justicia C., Pallas M., and Planas A.M. Activation of ERK and Akt signaling in focal cerebral ischemia: modulation by TGF-alpha and involvement of NMDA receptor. Neurobiol Dis 11 (2002) 443-456
8. Jin G., Omori N., Li F., Nagano I., Manabe Y., Shoji M., et al. Protection against ischemic brain damage by GDNF affecting cell survival and death signals. Neurol Res 25 (2003) 249-253
9. Janelidze S., Hu B.R., Siesjo P., and Siesjo B.K. Alterations of Akt1 (PKBalpha) and p70(S6K) in transient focal ischemia. Neurobiol Dis 8 (2001) 147-154
10. Noshita N., Sugawara T., Lewen A., Hayashi T., and Chan P.H. Copper-zinc superoxide dismutase affects Akt activation after transient focal cerebral ischemia in mice. Stroke 34 (2003) 1513-1518
11. Limbourg F.P., Huang Z., Plumier J.C., Simoncini T., Fujioka M., Tuckermann J., et al. Rapid nontranscriptional activation of endothelial nitric oxide synthase mediates increased cerebral blood flow and stroke protection by corticosteroids. J Clin Invest 110 (2002) 1729-1738
12. Kamada H., Nito C., Endo H., and Chan P.H. Bad as a converging signaling molecule between survival PI3-K/Akt and death JNK in neurons after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 27 (2007) 521-533
13. Amaravadi R., and Thompson C.B. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 115 (2005) 2618-2624
14. Ohba N., Kiryu-Seo S., Maeda M., Muraoka M., Ishii M., and Kiyama H. Transgenic mouse overexpressing the Akt reduced the volume of infarct area after middle cerebral artery occlusion. Neurosci Lett 359 (2004) 159-162
15. Kitano H., Young J.M., Cheng J., Wang L., Hurn P.D., and Murphy S.J. Gender-specific response to isoflurane preconditioning in focal cerebral ischemia. J Cereb Blood Flow Metab 27 (2007) 1377-1386
16. Amantea D., Russo R., Bagetta G., and Corasaniti M.T. From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens. Pharmacol Res 52 (2005) 119-132
17. McEwen B.S. Clinical review 108: the molecular and neuroanatomical basis for estrogen effects in the central nervous system. J Clin Endocrinol Metab 84 (1999) 1790-1797
18. Won C.K., Ji H.H., and Koh P.O. Estradiol prevents the focal cerebral ischemic injury-induced decrease of forkhead transcription factors phosphorylation. Neurosci Lett 398 (2006) 39-43
19. Wang R., Zhang Q.G., Han D., Xu J., Lu Q., and Zhang G.Y. Inhibition of MLK3-MKK4/7-JNK1/2 pathway by Akt1 in exogenous estrogen-induced neuroprotection against transient global cerebral ischemia by a non-genomic mechanism in male rats. J Neurochem 99 (2006) 1543-1554
20. Yang L., Dan H.C., Sun M., Liu Q., Sun X.M., Feldman R.I., et al. Akt/protein kinase B signaling inhibitor-2, a selective small molecule inhibitor of Akt signaling with antitumor activity in cancer cells overexpressing Akt. Cancer Res 64 (2004) 4394-4399
21. Cho H., Thorvaldsen J.L., Chu Q., Feng F., and Birnbaum M.J. Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem 276 (2001) 38349-38352
22. McCullough L.D., Blizzard K., Simpson E.R., Oz O.K., and Hurn P.D. Aromatase cytochrome P450 and extragonadal estrogen play a role in ischemic neuroprotection. J Neurosci 23 (2003) 8701-8705
23. McCullough L.D., Zeng Z., Li H., Landree L.E., McFadden J., and Ronnett G.V. Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. J Biol Chem 280 (2005) 20493-20502
24. Ouyang Y.B., Tan Y., Comb M., Liu C.L., Martone M.E., Siesjo B.K., et al. Survival-and death-promoting events after transient cerebral ischemia: phosphorylation of Akt, release of cytochrome C and Activation of caspase-like proteases. J Cereb Blood Flow Metab 19 (1999) 1126-1135
25. Namura S., Nagata I., Kikuchi H., Andreucci M., and Alessandrini A. Serine-threonine protein kinase Akt does not mediate ischemic tolerance after global ischemia in the gerbil. J Cereb Blood Flow Metab 20 (2000) 1301-1305
26. Yano S., Morioka M., Fukunaga K., Kawano T., Hara T., Kai Y., et al. Activation of Akt/protein kinase B contributes to induction of ischemic tolerance in the CA1 subfield of gerbil hippocampus. J Cereb Blood Flow Metab 21 (2001) 351-360
27. Yoshimoto T., Uchino H., He Q.P., Li P.A., and Siesjo B.K. Cyclosporin A, but not FK506, prevents the downregulation of phosphorylated Akt after transient focal ischemia in the rat. Brain Res 899 (2001) 148-158
28. Nilsen J., and Diaz Brinton R. Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression. Proc Natl Acad Sci U S A 100 (2003) 2842-2847
29. Toran-Allerand C.D., Tinnikov A.A., Singh R.J., and Nethrapalli I.S. 17alpha-estradiol: a brain-active estrogen?. Endocrinology 146 (2005) 3843-3850
30. McCullough L.D., Alkayed N.J., Traystman R.J., Williams M.J., and Hurn P.D. Postischemic estrogen reduces hypoperfusion and secondary ischemia after experimental stroke. Stroke 32 (2001) 796-802
31. Liu X., Shi Y., Birnbaum M.J., Ye K., De Jong R., Oltersdorf T., et al. Quantitative analysis of anti-apoptotic function of Akt in Akt1 and Akt2 double knock-out mouse embryonic fibroblast cells under normal and stressed conditions. J Biol Chem 281 (2006) 31380-31388
32. Workman P. Inhibiting the phosphoinositide 3-kinase pathway for cancer treatment. Biochem Soc Trans 32 (2004) 393-396
33. Hillion J.A., Li Y., Maric D., Takanohashi A., Klimanis D., Barker J.L., et al. Involvement of Akt in preconditioning-induced tolerance to ischemia in PC12 cells. J Cereb Blood Flow Metab 26 (2006) 1323-1331
34. Cheng J.Q., Lindsley C.W., Cheng G.Z., Yang H., and Nicosia S.V. The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 24 (2005) 7482-7492