Chronic hepatitis C infection-induced liver fibrogenesis is associated with M2 macrophage activation

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Bility, Moses T ^a   Nio, Kouki ^b,c   Li, Feng ^b,c   McGivern, David R ^b,c   Lemon, Stanley M ^b,c   Feeney, Eoin R ^d,e   Chung, Raymond T ^e,f   Su, Lishan ^b,c  

^a UNIVERSITY OF PITTSBURGH GRADUATE SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e MASSACHUSETTS GENERAL HOSPITAL   (United States)

^f HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT;

ANIMAL; CHRONIC DISEASE; CHRONIC HEPATITIS C; COMPLICATION; CYTOLOGY; DISEASE MODEL; HEPACIVIRUS; HEPATIC STELLATE CELL; HUMAN; IMMUNE SYSTEM; INFLAMMATION; LIVER; LIVER CIRRHOSIS; MACROPHAGE; MACROPHAGE ACTIVATION; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; CHRONIC DISEASE; DISEASE MODELS, ANIMAL; HEPACIVIRUS; HEPATIC STELLATE CELLS; HEPATITIS C, CHRONIC; HUMANS; IMMUNE SYSTEM; INFLAMMATION; LIVER; LIVER CIRRHOSIS; MACROPHAGE ACTIVATION; MACROPHAGES; MICE;

EID: 85006987461     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep39520     Document Type: Article

References (31)

1. Ciesek, S. & Manns, M. P. Hepatitis in 2010: the dawn of a new era in HCV therapy. Nat Rev Gastroenterol Hepatol 8, 69-71, doi: 10.1038/nrgastro.2010.219 (2011).
2. Gilgenkrantz, H. [Humanized mice for the study of hepatitis C]. Med Sci (Paris) 27, 587-589, doi: 10.1051/medsci/2011276009 (2011).
3. de Jong, Y. P., Rice, C. M. & Ploss, A. New horizons for studying human hepatotropic infections. J Clin Invest 120, 650-653, doi: 10.1172/JCI42338 (2010).
4. Brezillon, N. et al. Antiviral Activity of Bay 41-4109 on Hepatitis B Virus in Humanized Alb-uPA/SCID Mice. PLoS One 6, e25096, doi: 10.1371/journal.pone.0025096 (2011).
5. Washburn, M. L. et al. A humanized mouse model to study hepatitis C virus infection, immune response, and liver disease. Gastroenterology 140, 1334-1344, doi: 10.1053/j.gastro.2011.01.001 (2011).
6. Robinet, E. & Baumert, T. F. A first step towards a mouse model for hepatitis C virus infection containing a human immune system. J Hepatol 55, 718-720, doi: 10.1016/j.jhep.2011.02.038 (2011).
7. Revie, D. & Salahuddin, S. Z. Role of macrophages and monocytes in hepatitis C virus infections. World J Gastroenterol 20, 2777-2784, doi: 10.3748/wjg.v20.i11.2777 (2014).
8. Heydtmann, M. Macrophages in hepatitis B and hepatitis C virus infections. J Virol 83, 2796-2802, doi: 10.1128/JVI.00996-08 (2009).
9. Braga, T. T. et al. MyD88 Signaling Pathway Is Involved in Renal Fibrosis by Favoring a T(H)2 Immune Response and Activating Alternative M2 Macrophages. Mol Med 18, 1231-1239, doi: 10.2119/molmed. 2012.00131 (2012).
10. Glim, J. E., Niessen, F. B., Everts, V., van Egmond, M. & Beelen, R. H. Platelet derived growth factor-CC secreted by M2 macrophages induces alpha-smooth muscle actin expression by dermal and gingival fibroblasts. Immunobiology 6, 924-929, doi: 10.1016/j. imbio.2012.10.004 (2012).
11. Pereira, T. A. et al. Macrophage-derived hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni. Liver international : official journal of the International Association for the Study of the Liver 33, 149-161, doi: 10.1111/liv.12016 (2013).
12. Kurahara, H. et al. M2-Polarized Tumor-Associated Macrophage Infiltration of Regional Lymph Nodes Is Associated With Nodal Lymphangiogenesis and Occult Nodal Involvement in pN0 Pancreatic Cancer. Pancreas 42, 155-159, doi: 10.1097/MPA.0b013e318254f2d1 (2013).
13. Shirabe, K. et al. Role of tumor-associated macrophages in the progression of hepatocellular carcinoma. Surg Today 42, 1-7, doi: 10.1007/s00595-011-0058-8 (2012).
14. Murray, P. J. & Wynn, T. A. Protective and pathogenic functions of macrophage subsets. Nature reviews. Immunology 11, 723-737, doi: 10.1038/nri3073 (2011).
15. Mas, V. R. et al. Genes involved in viral carcinogenesis and tumor initiation in hepatitis C virus-induced hepatocellular carcinoma. Mol Med 15, 85-94, doi: 10.2119/molmed.2008.00110 (2009).
16. Andersen, E. S. et al. Macrophage-related serum biomarkers soluble CD163 (sCD163) and soluble mannose receptor (sMR) to differentiate mild liver fibrosis from cirrhosis in patients with chronic hepatitis C: a pilot study. Eur J Clin Microbiol Infect Dis 33, 117-122, doi: 10.1007/s10096-013-1936-3 (2014).
17. Kazankov, K. et al. Soluble CD163, a macrophage activation marker, is independently associated with fibrosis in patients with chronic viral hepatitis B and C. Hepatology 60, doi: 10.1002/hep.27129 (2014).
18. Meissner, E. G. et al. Endogenous intrahepatic IFNs and association with IFN-free HCV treatment outcome. J Clin Invest 124, 3352-3363, doi: 10.1172/JCI75938 (2014).
19. Lee, C. H. et al. Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages. Virology 279, 271-279, doi: 10.1006/viro.2000.0694 (2001).
20. Eisen-Vandervelde, A. L. et al. Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation. The Journal of biological chemistry 279, 43479-43486, doi: 10.1074/jbc.M407640200 (2004).
21. Brady, M. T., MacDonald, A. J., Rowan, A. G. & Mills, K. H. Hepatitis C virus non-structural protein 4 suppresses Th1 responses by stimulating IL-10 production from monocytes. Eur J Immunol 33, 3448-3457, doi: 10.1002/eji.200324251 (2003).
22. Tu, Z. et al. Hepatitis C virus core protein subverts the antiviral activities of human Kupffer cells. Gastroenterology 138, 305-314, doi: 10.1053/j.gastro.2009.09.009 (2010).
23. Friedman, S. L. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88, 125-172, doi: 10.1152/physrev.00013.2007 (2008).
24. Bility, M. T. et al. Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages. PLoS pathogens 10, e1004032, doi: 10.1371/journal.ppat.1004032 (2014).
25. Bility, M. T. & Sripa, B. Chronic Opisthorchis viverrini infection and associated hepatobiliary disease is associated with iron loaded M2-like macrophages. The Korean journal of parasitology 52, 695-699, doi: 10.3347/kjp.2014.52.6.695 (2014).
26. Farci, P. et al. B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virusassociated acute liver failure. Proceedings of the National Academy of Sciences of the United States of America 107, 8766-8771, doi: 10.1073/pnas.1003854107 (2010).
27. Nissim, O. et al. Liver regeneration signature in hepatitis B virus (HBV)-associated acute liver failure identified by gene expression profiling. PloS one 7, e49611, doi: 10.1371/journal.pone.0049611 (2012).
28. Jiang, Q. et al. FoxP3+ CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/-mice in vivo. Blood 112, 2858-2868, doi: 10.1182/blood-2008-03-145946 (2008).
29. Zhang, L., Kovalev, G. I. & Su, L. HIV-1 infection and pathogenesis in a novel humanized mouse model. Blood 109, 2978-2981, doi: 10.1182/blood-2006-07-033159 (2007).
30. Olthoff, K. M. et al. Outcomes of adult living donor liver transplantation: comparison of the Adult-to-adult Living Donor Liver Transplantation Cohort Study and the national experience. Liver transplantation: official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 17, 789-797, doi: 10.1002/lt.22288 (2011).
31. Osinusi, A. et al. Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial. Jama 310, 804-811, doi: 10.1001/jama.2013.109309 (2013).