Liver Regeneration Signature in Hepatitis B Virus (HBV)-Associated Acute Liver Failure Identified by Gene Expression Profiling

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Nissim, Oriel ^a   Melis, Marta ^a   Diaz, Giacomo ^b   Kleiner, David E ^c   Tice, Ashley ^a   Fantola, Giovanni ^d   Zamboni, Fausto ^d   Mishra, Lopa ^e   Farci, Patrizia ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF CAGLIARI   (Italy)

^c NATIONAL CANCER INSTITUTE   (United States)

^d BROTZU HOSPITAL   (Italy)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKERATIN 19; CYTOKERATIN 7; EPITHELIAL CELL ADHESION MOLECULE;

ACUTE LIVER FAILURE; ADULT; ARTICLE; CASE REPORT; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CK19 GENE; CK7 GENE; EPCAM GENE; FEMALE; GENE EXPRESSION PROFILING; HEPATIC STEM CELL; HEPATITIS B VIRUS ASSOCIATED ACUTE LIVER FAILURE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER CELL; LIVER NECROSIS; LIVER REGENERATION; LIVER TRANSPLANTATION; MALE; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; ORGAN DONOR; STEM CELL; UPREGULATION;

ADULT; CLUSTER ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, VIRAL; HEPATITIS B; HEPATITIS B VIRUS; HEPATOCYTES; HUMANS; LIVER; LIVER CIRRHOSIS; LIVER FAILURE, ACUTE; LIVER REGENERATION; MALE; MIDDLE AGED; NECROSIS; STEM CELLS;

HEPATITIS B VIRUS;

EID: 84869798298     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0049611     Document Type: Article

References (44)

1. Fausto N, Campbell JS, Riehle KJ (2006) Liver regeneration. Hepatology. 2006/02/01 ed. S45-53.
2. Riehle KJ, Dan YY, Campbell JS, Fausto N, (2011) New concepts in liver regeneration. J Gastroenterol Hepatol 26 (Suppl 1):: 203-212.
3. Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, et al. (1999) The canals of Hering and hepatic stem cells in humans. Hepatology 30: 1425-1433.
4. Yoon SM, Gerasimidou D, Kuwahara R, Hytiroglou P, Yoo JE, et al. (2011) Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Hepatology 53: 964-973.
5. Gouw AS, Clouston AD, Theise ND, (2011) Ductular reactions in human liver: diversity at the interface. Hepatology 54: 1853-1863.
6. Turner R, Lozoya O, Wang Y, Cardinale V, Gaudio E, et al. (2011) Human hepatic stem cell and maturational liver lineage biology. Hepatology 53: 1035-1045.
7. Yovchev MI, Grozdanov PN, Zhou H, Racherla H, Guha C, et al. (2008) Identification of adult hepatic progenitor cells capable of repopulating injured rat liver. Hepatology 47: 636-647.
8. Roskams TA, Libbrecht L, Desmet VJ, (2003) Progenitor cells in diseased human liver. Semin Liver Dis 23: 385-396.
9. Lowes KN, Brennan BA, Yeoh GC, Olynyk JK, (1999) Oval cell numbers in human chronic liver diseases are directly related to disease severity. Am J Pathol 154: 537-541.
10. Sancho-Bru P, Altamirano J, Rodrigo-Torres D, Coll M, Millan C, et al. (2012) Liver progenitor cell markers correlate with liver damage and predict short-term mortality in patients with alcoholic hepatitis. Hepatology 55: 1931-1941.
11. Lee WM, (1993) Acute liver failure. N Engl J Med 329: 1862-1872.
12. Michalopoulos GK, DeFrances MC, (1997) Liver regeneration. Science 276: 60-66.
13. Craig CE, Quaglia A, Selden C, Lowdell M, Hodgson H, et al. (2004) The histopathology of regeneration in massive hepatic necrosis. Semin Liver Dis 24: 49-64.
14. Farci P, Diaz G, Chen Z, Govindarajan S, Tice A, et al. (2010) B cell gene signature with massive intrahepatic production of antibodies to hepatitis B core antigen in hepatitis B virus-associated acute liver failure. Proc Natl Acad Sci U S A 107: 8766-8771.
15. Trey C, (1972) The fulminant hepatic failure surveillance study. Brief review of the effects of presumed etiology and age of survival. Can Med Assoc J 106: 525-528.
16. Wang E, Miller LD, Ohnmacht GA, Liu ET, Marincola FM, (2000) High-fidelity mRNA amplification for gene profiling. Nat Biotechnol 18: 457-459.
17. Korn EL, Li MC, McShane LM, Simon R, (2007) An investigation of two multivariate permutation methods for controlling the false discovery proportion. Stat Med 26: 4428-4440.
18. Perk J, Iavarone A, Benezra R, (2005) Id family of helix-loop-helix proteins in cancer. Nat Rev Cancer 5: 603-614.
19. Nakayama M, Matsumoto K, Tatsumi N, Yanai M, Yokouchi Y, (2006) Id3 is important for proliferation and differentiation of the hepatoblasts during the chick liver development. Mech Dev 123: 580-590.
20. Spee B, Carpino G, Schotanus BA, Katoonizadeh A, Vander Borght S, et al. (2010) Characterisation of the liver progenitor cell niche in liver diseases: potential involvement of Wnt and Notch signalling. Gut 59: 247-257.
21. Boulter L, Govaere O, Bird TG, Radulescu S, Ramachandran P, et al. (2012) Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease. Nat Med 18: 572-579.
22. Wray J, Hartmann C, (2012) WNTing embryonic stem cells. Trends Cell Biol 22: 159-168.
23. Kopan R, Ilagan MX, (2009) The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137: 216-233.
24. Friedman SL, (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev 88: 125-172.
25. Hernandez-Gea V, Friedman SL, (2011) Pathogenesis of liver fibrosis. Annu Rev Pathol 6: 425-456.
26. Kordes C, Sawitza I, Muller-Marbach A, Ale-Agha N, Keitel V, et al. (2007) CD133+ hepatic stellate cells are progenitor cells. Biochem Biophys Res Commun 352: 410-417.
27. Fujishima S, Shiomi T, Yamashita S, Yogo Y, Nakano Y, et al. (2010) Production and activation of matrix metalloproteinase 7 (matrilysin 1) in the lungs of patients with idiopathic pulmonary fibrosis. Arch Pathol Lab Med 134: 1136-1142.
28. Huang CC, Chuang JH, Chou MH, Wu CL, Chen CM, et al. (2005) Matrilysin (MMP-7) is a major matrix metalloproteinase upregulated in biliary atresia-associated liver fibrosis. Mod Pathol 18: 941-950.
29. Mishra L, Banker T, Murray J, Byers S, Thenappan A, et al. (2009) Liver stem cells and hepatocellular carcinoma. Hepatology 49: 318-329.
30. Scholzen T, Gerdes J, (2000) The Ki-67 protein: from the known and the unknown. J Cell Physiol 182: 311-322.
31. Pi L, Oh SH, Shupe T, Petersen BE, (2005) Role of connective tissue growth factor in oval cell response during liver regeneration after 2-AAF/PHx in rats. Gastroenterology 128: 2077-2088.
32. Ho JC, Ip YC, Cheung ST, Lee YT, Chan KF, et al. (2008) Granulin-epithelin precursor as a therapeutic target for hepatocellular carcinoma. Hepatology 47: 1524-1532.
33. Schiodt FV, Ostapowicz G, Murray N, Satyanarana R, Zaman A, et al. (2006) Alpha-fetoprotein and prognosis in acute liver failure. Liver Transpl 12: 1776-1781.
34. Diehl AM, (2012) Neighborhood watch orchestrates liver regeneration. Nat Med 18: 497-499.
35. Dechene A, Sowa JP, Gieseler RK, Jochum C, Bechmann LP, et al. (2010) Acute liver failure is associated with elevated liver stiffness and hepatic stellate cell activation. Hepatology 52: 1008-1016.
36. Shiomi T, Okada Y, (2003) MT1-MMP and MMP-7 in invasion and metastasis of human cancers. Cancer Metastasis Rev 22: 145-152.
37. Chiu CC, Sheu JC, Chen CH, Lee CZ, Chiou LL, et al. (2009) Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents. Histochem Cell Biol 132: 479-489.
38. Dvorak HF, (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315: 1650-1659.
39. Riss J, Khanna C, Koo S, Chandramouli GV, Yang HH, et al. (2006) Cancers as wounds that do not heal: differences and similarities between renal regeneration/repair and renal cell carcinoma. Cancer Res 66: 7216-7224.
40. Lee JS, Heo J, Libbrecht L, Chu IS, Kaposi-Novak P, et al. (2006) A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med 12: 410-416.
41. Liu Z, Yan R, Al-Salman A, Shen Y, Bu Y, et al. (2012) Epidermal growth factor induces tumour marker AKR1B10 expression through activator protein-1 signalling in hepatocellular carcinoma cells. Biochem J 442: 273-282.
42. Hyndman D, Flynn TG, (1999) The aldo-keto reductases and their role in cancer. Adv Exp Med Biol 463: 427-434.
43. Heringlake S, Hofdmann M, Fiebeler A, Manns MP, Schmiegel W, et al. (2010) Identification and expression analysis of the aldo-ketoreductase1-B10 gene in primary malignant liver tumours. J Hepatol 52: 220-227.
44. Kung JW, Currie IS, Forbes SJ, Ross JA, (2010) Liver development, regeneration, and carcinogenesis. J Biomed Biotechnol 2010: 984248.