Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease

Immunity

Volumn 45, Issue 6, 2016, Pages 1311-1326

  Ito, Ayaka ^a   Hong, Cynthia ^a   Oka, Kazuhiro ^e   Salazar, Jon V ^a   Diehl, Cody ^d   Witztum, Joseph L ^d   Diaz, Mercedes ^c   Castrillo, Antonio ^c   Bensinger, Steven J ^b   Chan, Lawrence ^e   Tontonoz, Peter ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

autoantibodies; autoimmune disease; LXR; reverse cholesterol transport

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN E; APRIL PROTEIN; AUTOANTIBODY; B CELL ACTIVATING FACTOR; CD4 ANTIGEN; CD8 ANTIGEN; CHOLESTEROL; GLYCOPROTEIN P 15095; HIGH DENSITY LIPOPROTEIN; LIPID; LIVER X RECEPTOR ALPHA; LIVER X RECEPTOR BETA; LIVER X RECEPTOR; TRANSCRIPTOME;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; B LYMPHOCYTE; BIOACCUMULATION; CELL EXPANSION; CHOLESTEROL DIET; CHOLESTEROL METABOLISM; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; HEMATOPOIETIC CELL; HOMEOSTASIS; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; IMMUNE DYSREGULATION; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOMODULATION; LYMPHOID ORGAN; METABOLIC REGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD11C; AUTOIMMUNE DISEASES; CHOLESTEROL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HYPERCHOLESTEROLEMIA; LIVER X RECEPTORS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; TRANSCRIPTOME;

EID: 85006797835     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.11.008     Document Type: Article

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