crystal structure of unlinked NS2B-NS3 protease from Zika virus

Science

Volumn 354, Issue 6319, 2016, Pages 1597-1600

  Zhang, Zhenzhen ^a,b   Li, Yan ^c   Loh, Ying Ru ^c   Phoo, Wint Wint ^a,b,d   Hung, Alvin W ^c   Kang, CongBao ^c   Luo, Dahai ^a,b  

^a NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c Agency for Science   (Singapore)

^d NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 2B; NONSTRUCTURAL PROTEIN 3; PEPTIDE; PROTEINASE; UNCLASSIFIED DRUG; NS2B PROTEIN, FLAVIVIRUS; NS3 PROTEIN, FLAVIVIRUS; OLIGOPEPTIDE; PROTEIN BINDING; RNA HELICASE; SERINE PROTEINASE; VIRAL PROTEIN;

CHEMICAL BINDING; CHEMICAL REACTION; DRUG; ENZYME ACTIVITY; GENE; GENETIC ANALYSIS; PROTEIN; VIRUS;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DENGUE VIRUS; ENCEPHALITIS VIRUS; ENDOPLASMIC RETICULUM MEMBRANE; ENZYME CONFORMATION; HETERONUCLEAR NUCLEAR MAGNETIC RESONANCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROGEN BOND; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; STEREOSPECIFICITY; WEST NILE VIRUS; ZIKA VIRUS; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; PROTEIN CONFORMATION; PROTEIN DEGRADATION; X RAY CRYSTALLOGRAPHY;

ZIKA VIRUS;

CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; OLIGOPEPTIDES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEOLYSIS; RNA HELICASES; SERINE ENDOPEPTIDASES; SUBSTRATE SPECIFICITY; VIRAL NONSTRUCTURAL PROTEINS; ZIKA VIRUS;

EID: 85006428027     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aai9309     Document Type: Article

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