Disease Model of GATA4 Mutation Reveals Transcription Factor Cooperativity in Human Cardiogenesis

Cell

Volumn 167, Issue 7, 2016, Pages 1734-1749.e22

  Ang, Yen Sin ^a,b   Rivas, Renee N ^a,b   Ribeiro, Alexandre J S ^c   Srivas, Rohith ^d   Rivera, Janell ^a   Stone, Nicole R ^a,b   Pratt, Karishma ^a   Mohamed, Tamer M A ^a,b   Fu, Ji Dong ^a   Spencer, C Ian ^a   Tippens, Nathaniel D ^e   Li, Molong ^a   Narasimha, Anil ^d   Radzinsky, Ethan ^a   Moon Grady, Anita J ^b   Yu, Haiyuan ^e   Pruitt, Beth L ^c   Snyder, Michael P ^d   Srivastava, Deepak ^a,b  

^a GLADSTONE INSTITUTE OF CARDIOVASCULAR DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Stanford University   (United States)

^d STANFORD UNIVERSITY   (United States)

^e Program on Infrastructure Policy   (United States)

Author keywords

birth defect; cardiomyopathy; congenital heart defects; disease modeling; epigenetics; GATA4; gene regulation; heart development; systems biology; TBX5

Indexed keywords

CALCIUM; TRANSCRIPTION FACTOR GATA 4; TRANSCRIPTION FACTOR TBX5; CHROMATIN; GATA4 PROTEIN, HUMAN; PHOSPHATIDYLINOSITOL 3 KINASE; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR 5;

ARTICLE; CARDIAC MUSCLE CELL; CARDIOMYOPATHY; CHROMATIN; CONGENITAL HEART MALFORMATION; ENHANCER REGION; GENE EXPRESSION; GENE REPRESSION; HEART MUSCLE CONTRACTILITY; HEART SEPTUM DEFECT; HETEROZYGOTE; HUMAN; HUMAN CELL; MISSENSE MUTATION; PRIORITY JOURNAL; PROTEIN DNA INTERACTION; PROTEIN PROTEIN INTERACTION; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEART; INDUCED PLURIPOTENT STEM CELL; MALE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

CHROMATIN; ENHANCER ELEMENTS, GENETIC; FEMALE; GATA4 TRANSCRIPTION FACTOR; HEART; HEART DEFECTS, CONGENITAL; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MUTATION, MISSENSE; MYOCYTES, CARDIAC; PHOSPHATIDYLINOSITOL 3-KINASES; SIGNAL TRANSDUCTION; T-BOX DOMAIN PROTEINS;

EID: 85006302151     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.11.033     Document Type: Article

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