메뉴 건너뛰기




Volumn 1, Issue 4, 2013, Pages 265-275

Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma

Author keywords

Angiogenesis; GDC 0449; Hedgehog; Hepatocellular carcinoma; VEGF

Indexed keywords

SONIC HEDGEHOG PROTEIN; VASCULOTROPIN A;

EID: 85006226117     PISSN: 20506406     EISSN: 20506414     Source Type: Journal    
DOI: 10.1177/2050640613496605     Document Type: Article
Times cited : (29)

References (54)
  • 2
    • 3042777392 scopus 로고    scopus 로고
    • Systemic treatment and liver transplantation for hepatocellular carcinoma: Two ends of the therapeutic spectrum
    • Burroughs A, Hochhauser D and Meyer T. Systemic treatment and liver transplantation for hepatocellular carcinoma: two ends of the therapeutic spectrum. Lancet Oncol 2004; 5: 409–418.
    • (2004) Lancet Oncol , vol.5 , pp. 409-418
    • Burroughs, A.1    Hochhauser, D.2    Meyer, T.3
  • 3
    • 83155175343 scopus 로고    scopus 로고
    • Clinical characteristics of patients with hepatocellular carcinoma in Austria – is there a need for a structured screening program?
    • Hucke F, Sieghart W, Schoniger-Hekele M, et al. Clinical characteristics of patients with hepatocellular carcinoma in Austria – is there a need for a structured screening program? Wien Klin Wochenschr 2001; 123: 542–551.
    • (2001) Wien Klin Wochenschr , vol.123 , pp. 542-551
    • Hucke, F.1    Sieghart, W.2    Schoniger-Hekele, M.3
  • 4
    • 84858658381 scopus 로고    scopus 로고
    • EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma
    • European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer
    • European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol 2012; 56: 908–943.
    • (2012) J Hepatol , vol.56 , pp. 908-943
  • 5
    • 84863728459 scopus 로고    scopus 로고
    • Austrian Joint OGGH-OGIR-OGHO-ASSO position statement on the use of transarterial chemoembolization (TACE) in hepatocellular carcinoma
    • Peck-Radosavljevic M, Sieghart W, Kolblinger C, et al. Austrian Joint OGGH-OGIR-OGHO-ASSO position statement on the use of transarterial chemoembolization (TACE) in hepatocellular carcinoma. Wien Klin Wochenschr 2012; 124: 104–110.
    • (2012) Wien Klin Wochenschr , vol.124 , pp. 104-110
    • Peck-Radosavljevic, M.1    Sieghart, W.2    Kolblinger, C.3
  • 6
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, et al. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med 2008; 359: 378–390.
    • (2008) N Engl J Med , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 7
    • 34548306769 scopus 로고    scopus 로고
    • Patching the gaps in Hedgehog signalling
    • Rohatgi R and Scott MP. Patching the gaps in Hedgehog signalling. Nat Cell Biol 2007; 9: 1005–1009.
    • (2007) Nat Cell Biol , vol.9 , pp. 1005-1009
    • Rohatgi, R.1    Scott, M.P.2
  • 8
    • 33947254016 scopus 로고    scopus 로고
    • Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: A new paradigm for combination therapy in solid cancers
    • Feldmann G, Dhara S, Fendrich V, et al. Blockade of hedgehog signaling inhibits pancreatic cancer invasion and metastases: a new paradigm for combination therapy in solid cancers. Cancer Res 2007; 67: 2187–2196.
    • (2007) Cancer Res , vol.67 , pp. 2187-2196
    • Feldmann, G.1    Dhara, S.2    Fendrich, V.3
  • 9
    • 33845927886 scopus 로고    scopus 로고
    • Molecular pathways regulating pro-migratory effects of Hedgehog signaling
    • Hochman E, Castiel A, Jacob-Hirsch J, et al. Molecular pathways regulating pro-migratory effects of Hedgehog signaling. J Biol Chem 2006; 281: 33860–33870.
    • (2006) J Biol Chem , vol.281 , pp. 33860-33870
    • Hochman, E.1    Castiel, A.2    Jacob-Hirsch, J.3
  • 10
    • 40949137792 scopus 로고    scopus 로고
    • Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway
    • Yoo YA, Kang MH, Kim JS, et al. Sonic hedgehog signaling promotes motility and invasiveness of gastric cancer cells through TGF-beta-mediated activation of the ALK5-Smad 3 pathway. Carcinogenesis 2008; 29: 480–490.
    • (2008) Carcinogenesis , vol.29 , pp. 480-490
    • Yoo, Y.A.1    Kang, M.H.2    Kim, J.S.3
  • 11
    • 79959333446 scopus 로고    scopus 로고
    • Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
    • Chen W, Tang T, Eastham-Anderson J, et al. Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells. Proc Natl Acad Sci USA 2011; 108: 9589–9594.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 9589-9594
    • Chen, W.1    Tang, T.2    Eastham-Anderson, J.3
  • 12
    • 77749249596 scopus 로고    scopus 로고
    • Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells
    • Nakamura K, Sasajima J, Mizukami Y, et al. Hedgehog promotes neovascularization in pancreatic cancers by regulating Ang-1 and IGF-1 expression in bone-marrow derived pro-angiogenic cells. PLoS One 2010; 5: 8824.
    • (2010) Plos One , vol.5 , pp. 8824
    • Nakamura, K.1    Sasajima, J.2    Mizukami, Y.3
  • 13
    • 57049089995 scopus 로고    scopus 로고
    • Hedgehog signaling in development and cancer
    • Jiang J and Hui CC. Hedgehog signaling in development and cancer. Dev Cell 2008; 15: 801–812.
    • (2008) Dev Cell , vol.15 , pp. 801-812
    • Jiang, J.1    Hui, C.C.2
  • 14
    • 0242268525 scopus 로고    scopus 로고
    • Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours
    • Berman DM, Karhadkar SS, Maitra A, et al. Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature 2003; 425: 846–851.
    • (2003) Nature , vol.425 , pp. 846-851
    • Berman, D.M.1    Karhadkar, S.S.2    Maitra, A.3
  • 15
    • 78751585439 scopus 로고    scopus 로고
    • Hedgehog signaling in the liver
    • Omenetti A, Choi S, Michelotti G, et al. Hedgehog signaling in the liver. J Hepatol 2011; 54: 366–373.
    • (2011) J Hepatol , vol.54 , pp. 366-373
    • Omenetti, A.1    Choi, S.2    Michelotti, G.3
  • 16
    • 41549118422 scopus 로고    scopus 로고
    • The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, andcancer
    • Omenetti A and Diehl AM. The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, andcancer. Am J Physiol Gastrointest Liver Physiol 2008; 294: G595–598.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. 595-598
    • Omenetti, A.1    Diehl, A.M.2
  • 17
    • 58949088366 scopus 로고    scopus 로고
    • Liver stem cells and hepatocellular carcinoma
    • Mishra L, Banker T, Murray J, et al. Liver stem cells and hepatocellular carcinoma. Hepatology 2009; 49: 318–329.
    • (2009) Hepatology , vol.49 , pp. 318-329
    • Mishra, L.1    Banker, T.2    Murray, J.3
  • 18
    • 33745634379 scopus 로고    scopus 로고
    • Activation of the hedgehog pathway in human hepatocellular carcinomas
    • Huang S, He J, Zhang X, et al. Activation of the hedgehog pathway in human hepatocellular carcinomas. Carcinogenesis 2006; 27: 1334–1340.
    • (2006) Carcinogenesis , vol.27 , pp. 1334-1340
    • Huang, S.1    He, J.2    Zhang, X.3
  • 19
    • 32544437230 scopus 로고    scopus 로고
    • Hedgehog signaling in human hepatocellular carcinoma
    • Patil MA, Zhang J, Ho C, et al. Hedgehog signaling in human hepatocellular carcinoma. Cancer Biol Ther 2006; 5: 111–117.
    • (2006) Cancer Biol Ther , vol.5 , pp. 111-117
    • Patil, M.A.1    Zhang, J.2    Ho, C.3
  • 20
    • 33645371509 scopus 로고    scopus 로고
    • Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis
    • Sicklick JK, Li YX, Jayaraman A, et al. Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. Carcinogenesis 2006; 27: 748–757.
    • (2006) Carcinogenesis , vol.27 , pp. 748-757
    • Sicklick, J.K.1    Li, Y.X.2    Jayaraman, A.3
  • 21
    • 79954611501 scopus 로고    scopus 로고
    • Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
    • LoRusso PM, Rudin CM, Reddy JC, et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res 2011; 17: 2502–2511.
    • (2011) Clin Cancer Res , vol.17 , pp. 2502-2511
    • Lorusso, P.M.1    Rudin, C.M.2    Reddy, J.C.3
  • 22
    • 70349244812 scopus 로고    scopus 로고
    • Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
    • Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009; 361: 1173–1178.
    • (2009) N Engl J Med , vol.361 , pp. 1173-1178
    • Rudin, C.M.1    Hann, C.L.2    Laterra, J.3
  • 23
    • 70349238733 scopus 로고    scopus 로고
    • Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
    • Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009; 361: 1164–1172.
    • (2009) N Engl J Med , vol.361 , pp. 1164-1172
    • Von Hoff, D.D.1    Lorusso, P.M.2    Rudin, C.M.3
  • 24
    • 84861856844 scopus 로고    scopus 로고
    • Efficacy and safety of vismodegib in advanced basal-cell carcinoma
    • Sekulic A, Migden MR, Oro AE, et al. Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med 2012; 366: 2171–2179.
    • (2012) N Engl J Med , vol.366 , pp. 2171-2179
    • Sekulic, A.1    Migden, M.R.2    Oro, A.E.3
  • 25
    • 84859321979 scopus 로고    scopus 로고
    • Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential
    • Guha M. Hedgehog inhibitor gets landmark skin cancer approval, but questions remain for wider potential. Nat Rev Drug Discov 2012; 11: 257–258.
    • (2012) Nat Rev Drug Discov , vol.11 , pp. 257-258
    • Guha, M.1
  • 26
    • 0034960583 scopus 로고    scopus 로고
    • The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
    • Pola R, Ling LE, Silver M, et al. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat Med 2001; 7: 706–711.
    • (2001) Nat Med , vol.7 , pp. 706-711
    • Pola, R.1    Ling, L.E.2    Silver, M.3
  • 27
    • 64349092619 scopus 로고    scopus 로고
    • Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors
    • Soleti R, Benameur T, Porro C, et al. Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors. Carcinogenesis 2009; 30: 580–588.
    • (2009) Carcinogenesis , vol.30 , pp. 580-588
    • Soleti, R.1    Benameur, T.2    Porro, C.3
  • 28
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D and Weinberg RA. The hallmarks of cancer. Cell 2000; 100: 57–70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 29
    • 84865107387 scopus 로고    scopus 로고
    • Erlotinib and Sorafenib in an orthotopic rat model of hepatocellular carcinoma
    • Sieghart W, Pinter M, Dauser B, et al. Erlotinib and Sorafenib in an orthotopic rat model of hepatocellular carcinoma. J Hepatol 2012; 57: 592–599.
    • (2012) J Hepatol , vol.57 , pp. 592-599
    • Sieghart, W.1    Pinter, M.2    Dauser, B.3
  • 30
    • 34047118033 scopus 로고    scopus 로고
    • Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma
    • Semela D, Piguet AC, Kolev M, et al. Vascular remodeling and antitumoral effects of mTOR inhibition in a rat model of hepatocellular carcinoma. J Hepatol 2007; 46: 840–848.
    • (2007) J Hepatol , vol.46 , pp. 840-848
    • Semela, D.1    Piguet, A.C.2    Kolev, M.3
  • 31
    • 28844437366 scopus 로고    scopus 로고
    • Mcl-1 overexpression in hepatocellular carcinoma: A potential target for antisense therapy
    • Sieghart W, Losert D, Strommer S, et al. Mcl-1 overexpression in hepatocellular carcinoma: a potential target for antisense therapy. J Hepatol 2006; 44: 151–157.
    • (2006) J Hepatol , vol.44 , pp. 151-157
    • Sieghart, W.1    Losert, D.2    Strommer, S.3
  • 32
    • 11244302427 scopus 로고    scopus 로고
    • Dietary lipid hydroperoxides induce expression of vascular endothelial growth factor (VEGF) in human colorectal tumor cells
    • Jurek D, Udilova N, Jozkowicz A, et al. Dietary lipid hydroperoxides induce expression of vascular endothelial growth factor (VEGF) in human colorectal tumor cells. Faseb J 2005; 19: 97–99.
    • (2005) Faseb J , vol.19 , pp. 97-99
    • Jurek, D.1    Udilova, N.2    Jozkowicz, A.3
  • 33
    • 0031042108 scopus 로고    scopus 로고
    • Focal adhesion kinase and phospholipase C gamma involvement in adhesion and migration of human hepatic stellate cells
    • Carloni V, Romanelli RG, Pinzani M, et al. Focal adhesion kinase and phospholipase C gamma involvement in adhesion and migration of human hepatic stellate cells. Gastroenterology 1997; 112: 522–531.
    • (1997) Gastroenterology , vol.112 , pp. 522-531
    • Carloni, V.1    Romanelli, R.G.2    Pinzani, M.3
  • 34
    • 34249867843 scopus 로고    scopus 로고
    • Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
    • Lauth M, Bergstrom A, Shimokawa T, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci USA 2007; 104: 8455–8460.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 8455-8460
    • Lauth, M.1    Bergstrom, A.2    Shimokawa, T.3
  • 35
    • 79955580873 scopus 로고    scopus 로고
    • HCC and angiogenesis: Possible targets and future directions
    • Zhu AX, Duda DG, Sahani DV, et al. HCC and angiogenesis: possible targets and future directions. Nat Rev Clin Oncol 2011; 8: 292–301.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 292-301
    • Zhu, A.X.1    Duda, D.G.2    Sahani, D.V.3
  • 36
    • 84859212951 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Forner A, Llovet JM and Bruix J. Hepatocellular carcinoma. Lancet 2012; 379: 1245–1255.
    • (2012) Lancet , vol.379 , pp. 1245-1255
    • Forner, A.1    Llovet, J.M.2    Bruix, J.3
  • 37
    • 0031955570 scopus 로고    scopus 로고
    • Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma
    • Li XM, Tang ZY, Zhou G, et al. Significance of vascular endothelial growth factor mRNA expression in invasion and metastasis of hepatocellular carcinoma. J Exp Clin Cancer Res 1998; 17: 13–17.
    • (1998) J Exp Clin Cancer Res , vol.17 , pp. 13-17
    • Li, X.M.1    Tang, Z.Y.2    Zhou, G.3
  • 38
    • 0031807538 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor in human hepatocellular carcinoma
    • Yamaguchi R, Yano H, Iemura A, et al. Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatology 1998; 28: 68–77.
    • (1998) Hepatology , vol.28 , pp. 68-77
    • Yamaguchi, R.1    Yano, H.2    Iemura, A.3
  • 39
    • 0033986802 scopus 로고    scopus 로고
    • Expression of plateletderived endothelial cell growth factor and vascular endothelial growth factor in hepatocellular carcinoma and portal vein tumor thrombus
    • Zhou J, Tang ZY, Fan J, et al. Expression of plateletderived endothelial cell growth factor and vascular endothelial growth factor in hepatocellular carcinoma and portal vein tumor thrombus. J Cancer Res Clin Oncol 2000; 126: 57–61.
    • (2000) J Cancer Res Clin Oncol , vol.126 , pp. 57-61
    • Zhou, J.1    Tang, Z.Y.2    Fan, J.3
  • 40
    • 0035132143 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: A prospective study
    • Poon RT, Ng IO, Lau C, et al. Serum vascular endothelial growth factor predicts venous invasion in hepatocellular carcinoma: a prospective study. Ann Surg 2001; 233: 227–235.
    • (2001) Ann Surg , vol.233 , pp. 227-235
    • Poon, R.T.1    Ng, I.O.2    Lau, C.3
  • 41
    • 46449091500 scopus 로고    scopus 로고
    • Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma
    • Siegel AB, Cohen EI, Ocean A, et al. Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol 2008; 26: 2992–2998.
    • (2008) J Clin Oncol , vol.26 , pp. 2992-2998
    • Siegel, A.B.1    Cohen, E.I.2    Ocean, A.3
  • 42
    • 4644289324 scopus 로고    scopus 로고
    • Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level
    • Li X, Feng GS, Zheng CS, et al. Expression of plasma vascular endothelial growth factor in patients with hepatocellular carcinoma and effect of transcatheter arterial chemoembolization therapy on plasma vascular endothelial growth factor level. World J Gastroenterol 2004; 10: 2878–2882.
    • (2004) World J Gastroenterol , vol.10 , pp. 2878-2882
    • Li, X.1    Feng, G.S.2    Zheng, C.S.3
  • 43
    • 41949113329 scopus 로고    scopus 로고
    • Transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): The role of angiogenesis and invasiveness
    • Sergio A, Cristofori C, Cardin R, et al. Transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC): the role of angiogenesis and invasiveness. Am J Gastroenterol 2008; 103: 914–921.
    • (2008) Am J Gastroenterol , vol.103 , pp. 914-921
    • Sergio, A.1    Cristofori, C.2    Cardin, R.3
  • 44
    • 0043163428 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery
    • Chao Y, Li CP, Chau GY, et al. Prognostic significance of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin in patients with resectable hepatocellular carcinoma after surgery. Ann Surg Oncol 2003; 10: 355–362.
    • (2003) Ann Surg Oncol , vol.10 , pp. 355-362
    • Chao, Y.1    Li, C.P.2    Chau, G.Y.3
  • 45
    • 34249900712 scopus 로고    scopus 로고
    • High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: Importance of tumor biomarker in ablative therapies
    • Poon RT, Lau C, Pang R, et al. High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies. Ann Surg Oncol 2007; 14: 1835–1845.
    • (2007) Ann Surg Oncol , vol.14 , pp. 1835-1845
    • Poon, R.T.1    Lau, C.2    Pang, R.3
  • 46
    • 54949109005 scopus 로고    scopus 로고
    • Association between increment of serum VEGF level and prognosis after transcatheter arterial chemoembolization in hepatocellular carcinoma patients
    • Shim JH, Park JW, Kim JH, et al. Association between increment of serum VEGF level and prognosis after transcatheter arterial chemoembolization in hepatocellular carcinoma patients. Cancer Sci 2008; 99: 2037–2044.
    • (2008) Cancer Sci , vol.99 , pp. 2037-2044
    • Shim, J.H.1    Park, J.W.2    Kim, J.H.3
  • 47
    • 70350506052 scopus 로고    scopus 로고
    • High serum levels of vascular endothelial growth factor after hepatectomy are associated with poor prognosis in hepatocellular carcinoma
    • Tamesa T, Iizuka N, Mori N, et al. High serum levels of vascular endothelial growth factor after hepatectomy are associated with poor prognosis in hepatocellular carcinoma. Hepatogastroenterology 2009; 56: 1122–1126.
    • (2009) Hepatogastroenterology , vol.56 , pp. 1122-1126
    • Tamesa, T.1    Iizuka, N.2    Mori, N.3
  • 48
    • 4444366693 scopus 로고    scopus 로고
    • Effect of c-myc, Ki–67, MMP–2 and VEGF expression on prognosis of hepatocellular carcinoma patients undergoing tumor resection
    • Cui J, Dong BW, Liang P, et al. Effect of c-myc, Ki–67, MMP–2 and VEGF expression on prognosis of hepatocellular carcinoma patients undergoing tumor resection. World J Gastroenterol 2004; 10: 1533–1536.
    • (2004) World J Gastroenterol , vol.10 , pp. 1533-1536
    • Cui, J.1    Dong, B.W.2    Liang, P.3
  • 49
    • 1542685212 scopus 로고    scopus 로고
    • Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: A prospective study
    • Jeng KS, Sheen IS, Wang YC, et al. Prognostic significance of preoperative circulating vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma: a prospective study. World J Gastroenterol 2004; 10: 643–648.
    • (2004) World J Gastroenterol , vol.10 , pp. 643-648
    • Jeng, K.S.1    Sheen, I.S.2    Wang, Y.C.3
  • 50
    • 1542790444 scopus 로고    scopus 로고
    • Is the vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma of prognostic value after resection?
    • Jeng KS, Sheen IS, Wang YC, et al. Is the vascular endothelial growth factor messenger RNA expression in resectable hepatocellular carcinoma of prognostic value after resection? World J Gastroenterol 2004; 10: 676–681.
    • (2004) World J Gastroenterol , vol.10 , pp. 676-681
    • Jeng, K.S.1    Sheen, I.S.2    Wang, Y.C.3
  • 51
    • 79958742182 scopus 로고    scopus 로고
    • Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma
    • Piguet AC, Saar B, Hlushchuk R, et al. Everolimus augments the effects of sorafenib in a syngeneic orthotopic model of hepatocellular carcinoma. Mol Cancer Ther 2011; 10: 1007–1017.
    • (2011) Mol Cancer Ther , vol.10 , pp. 1007-1017
    • Piguet, A.C.1    Saar, B.2    Hlushchuk, R.3
  • 52
    • 26644471951 scopus 로고    scopus 로고
    • Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors
    • Casanovas O, Hicklin DJ, Bergers G, et al. Drug resistance by evasion of antiangiogenic targeting of VEGF signaling in late-stage pancreatic islet tumors. Cancer Cell 2005; 8: 299–309.
    • (2005) Cancer Cell , vol.8 , pp. 299-309
    • Casanovas, O.1    Hicklin, D.J.2    Bergers, G.3
  • 53
    • 80052420490 scopus 로고    scopus 로고
    • Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer
    • Philips GM, Chan IS, Swiderska M, et al. Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. PLoS One 2011; 6: 23943.
    • (2011) Plos One , vol.6 , pp. 23943
    • Philips, G.M.1    Chan, I.S.2    Swiderska, M.3
  • 54
    • 84863264746 scopus 로고    scopus 로고
    • Polymeric nanoparticleencapsulated Hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma
    • Xu Y, Chenna V, Hu C, et al. Polymeric nanoparticleencapsulated Hedgehog pathway inhibitor HPI-1 (NanoHHI) inhibits systemic metastases in an orthotopic model of human hepatocellular carcinoma. Clin Cancer Res 2012; 18: 1291–1302.
    • (2012) Clin Cancer Res , vol.18 , pp. 1291-1302
    • Xu, Y.1    Chenna, V.2    Hu, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.