Genetically decreased Vitamin D and risk of Alzheimer disease

Neurology

Volumn 87, Issue 24, 2016, Pages 2567-2574

  Mokry, Lauren E ^a   Ross, Stephanie ^a   Morris, John A ^a,b   Manousaki, Despoina ^a,b   Forgetta, Vincenzo ^a   Richards, J Brent ^a,b,c  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; COLECALCIFEROL 24 HYDROXYLASE; CYP 2R1 PROTEIN; DHCRY 7 PROTEIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; VITAMIN D BINDING PROTEIN; VITAMIN D;

ALZHEIMER DISEASE; ARTICLE; CLINICAL DEMENTIA RATING; DSM-IV; GENE LINKAGE DISEQUILIBRIUM; GENE MAPPING; GENETIC ASSOCIATION; GENOME-WIDE ASSOCIATION STUDY; HUMAN; MAJOR CLINICAL STUDY; MENDELIAN RANDOMIZATION ANALYSIS; MINI MENTAL STATE EXAMINATION; PLEIOTROPY; PRIORITY JOURNAL; RISK ASSESSMENT; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN D METABOLISM; BLOOD; CANADA; DIETARY SUPPLEMENT; GENETICS; OSTEOPOROSIS; PHENOTYPE; PROCEDURES; RISK FACTOR;

ALZHEIMER DISEASE; CANADA; DIETARY SUPPLEMENTS; HUMANS; MENDELIAN RANDOMIZATION ANALYSIS; OSTEOPOROSIS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; VITAMIN D;

EID: 85006062715     PISSN: 00283878     EISSN: 1526632X     Source Type: Journal    
DOI: 10.1212/WNL.0000000000003430     Document Type: Article

References (38)

1. Littlejohns TJ, Henley WE, Lang IA, et al. Vitamin D and the risk of dementia and Alzheimer disease. Neurology 2014;83:920-928
2. Afzal S, Bojesen SE, Nordestgaard BG. Reduced 25-hydroxyvitamin D and risk of Alzheimer's disease and vascular dementia. Alzheimers Dement 2014;10: 296-302
3. Annweiler C, Llewellyn DJ, Beauchet O. Low serum vitamin D concentrations in Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis 2013;33: 659-674
4. Shen L, Ji H-F. Vitamin D deficiency is associated with increased risk of Alzheimer's disease and dementia: evidence from meta-analysis. Nutr J 2015;14:76
5. Balion C, Griffith LE, Strifler L, et al. Vitamin D, cognition, and dementia: a systematic review and meta-analysis. Neurology 2012;79:1397-1405
6. Looker AC, Pfeiffer CM, Lacher DA, Schleicher RL, Picciano MF, Yetley EA. Serum 25-hydroxyvitamin D status of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr 2008;88:1519-1527
7. Yetley EA. Assessing the vitamin D status of the US population. Am J Clin Nutr 2008;88:558S-564S
8. Smith GD, Ebrahim S. "Mendelian randomization": can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22
9. Wang TJ, Zhang F, Richards JB, et al. Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet 2010;376:180-188
10. Lambert JC, Ibrahim-Verbaas CA, Harold D, et al. Metaanalysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet 2013;45: 1452-1458
11. Holick MF. Vitamin D status: measurement, interpretation, and clinical application. Ann Epidemiol 2009;19: 73-78
12. Mokry LE, Ross S, Ahmad OS, et al. Vitamin D and risk of multiple sclerosis: a mendelian randomization study. PLoS Med 2015;12:e1001866
13. Manousaki D, Mokry LE, Ross S, Goltzman D, Richards JB. Mendelian randomization studies do not support a role for vitamin D in coronary artery disease. Circ Cardiovasc Genet 2016;9:349-356
14. Berry DJ, Vimaleswaran KS, Whittaker JC, Hingorani AD, Hyppönen E. Evaluation of genetic markers as instruments for mendelian randomization studies on vitamin D. PLoS One 2012;7:e37465
15. Walter K, Min JL, Huang J, et al. The UK10K project identifies rare variants in health and disease. Nature 2015; 526:82-90
16. Huckins LM, Boraska V, Franklin CS, et al. Using ancestry-informative markers to identify fine structure across 15 populations of European origin. Eur J Hum Genet 2014;22:1190-1200
17. Burgess S, Butterworth A, Thompson SG. Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 2013;37: 658-665
18. Brion MJ, Shakhbazov K, Visscher PM. Calculating statistical power in mendelian randomization studies. Int J Epidemiol 2013;42:1497-1501
19. mRnd: power calculations for mendelian randomization [online]. Available at: http://cnsgenomics.com/shiny/ mRnd/. Accessed March 23, 2016
20. Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 2012;380: 2095-2128
21. Nowaczyk MJM, Irons MB. Smith-Lemli-Opitz syndrome: phenotype, natural history, and epidemiology. Am J Med Genet C Semin Med Genet 2012;160: 250-262
22. Ostergaard SD, Mukherjee S, Sharp SJ, et al. Associations between potentially modifiable risk factors and Alzheimer disease: a mendelian randomization study. PLoS Med 2015;12:e1001841
23. Willer CJ, Schmidt EM, Sengupta S, et al. Discovery and refinement of loci associated with lipid levels. Nat Genet 2013;45:1274-1283
24. Zhang J, Sokal I, Peskind ER, et al. CSF multianalyte profile distinguishes Alzheimer and Parkinson diseases. Am J Clin Pathol 2008;129:526-529
25. Moon M, Song H, Hong HJ, et al. Vitamin D-binding protein interacts with Ab and suppresses Ab-mediated pathology. Cell Death Differ 2013;20:630-638
26. Ehret GB, Munroe PB, Rice KM, et al. Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature 2011;478:103-109
27. Vimaleswaran KS, Cavadino A, Berry DJ, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol 2014;2:719-729
28. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement 2013;9: 63-75.e2
29. Mithal A, Wahl DA, Bonjour J-P, et al. Global vitamin D status and determinants of hypovitaminosis D. Osteoporos Int 2009;20:1807-1820
30. Alzheimer's Association. 2015 Alzheimer's disease facts and figures. Alzheimers Dement 2015;11:332-384
31. Takizawa C, Thompson PL, van Walsem A, Faure C,Maier WC. Epidemiological and economic burden of Alzheimer's disease: a systematic literature review of data across Europe and the United States of America. J Alzheimers Dis 2015; 43:1271-1284
32. Ross AC. Dietary reference intakes for calcium and vitamin D-Institute of Medicine [online]. Available at: https://www. ncbi.nlm.nih.gov/books/NBK56070/. Accessed March 23, 2016
33. Verboven C, Rabijns A, De Maeyer M, Van Baelen H, Bouillon R, De Ranter C. A structural basis for the unique binding features of the human vitamin D-binding protein. Nat Struct Biol 2002;9:131-136
34. Bikle DD, Siiteri PK, Ryzen E, Haddad JG. Serum protein binding of 1,25-dihydroxyvitamin D: a reevaluation by direct measurement of free metabolite levels. J Clin Endocrinol Metab 1985;61:969-975
35. White P, Cooke N. The multifunctional properties and characteristics of vitamin D-binding protein. Trends Endocrinol Metab 2000;11:320-327
36. Wilson RT, Bortner JD, Roff A, et al. Genetic and environmental influences on plasma vitamin D binding protein concentrations. Transl Res 2015;165:667-676
37. Dastani Z, Berger C, Langsetmo L, et al. In healthy adults, biological activity of vitamin D, as assessed by serum PTH, is largely independent of DBP concentrations. J Bone Miner Res 2013;29:494-499
38. Ooi EM, Afzal S, Nordestgaard BG. Elevated remnant cholesterol in 25-hydroxyvitamin D deficiency in the general population: mendelian randomization study. Circ Cardiovasc Genet 2014;7:650-658