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Volumn 13, Issue 9, 2013, Pages 1332-1343

Colorectal cancer in elderly patients: From best supportive care to cure

Author keywords

Cancer; Chemotherapy; Colorectal; Elderly; Treatment

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MITOMYCIN; OXALIPLATIN; PANITUMUMAB; UFT; ANTINEOPLASTIC AGENT;

EID: 84888214777     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/18715206113136660350     Document Type: Article
Times cited : (22)

References (124)
  • 1
    • 16244392389 scopus 로고    scopus 로고
    • Never too old? Age should not be a barrier to enrolment in cancer clinical trials
    • Aapro, M.S.; Kohne, C.H.; Cohen, H.J.; Extermann, M. Never too old? Age should not be a barrier to enrolment in cancer clinical trials. Oncologist, 2005, 10, 198-204.
    • (2005) Oncologist , vol.10 , pp. 198-204
    • Aapro, M.S.1    Kohne, C.H.2    Cohen, H.J.3    Extermann, M.4
  • 3
    • 0037622579 scopus 로고    scopus 로고
    • Adjuvant chemotherapy in the elderly
    • Biganzoli, L.; Aapro, M. Adjuvant chemotherapy in the elderly. Ann. Oncol., 2003, 14 (Suppl 3), iii1-iii3.
    • (2003) Ann. Oncol , vol.14 , Issue.SUPPL. 3
    • Biganzoli, L.1    Aapro, M.2
  • 4
    • 34047181030 scopus 로고    scopus 로고
    • The illness trajectory of elderly cancer patients across cultures: SIOG position paper
    • Surbone, A.; Kagawa-Singer, M.; Terret, C.; Baider, L. The illness trajectory of elderly cancer patients across cultures: SIOG position paper. Ann. Oncol., 2007, 18, 633-638.
    • (2007) Ann. Oncol , vol.18 , pp. 633-638
    • Surbone, A.1    Kagawa-Singer, M.2    Terret, C.3    Baider, L.4
  • 5
    • 0029809147 scopus 로고    scopus 로고
    • Are the elderly receiving appropriate treatment for cancer
    • Fentiman, I.S. Are the elderly receiving appropriate treatment for cancer? Ann. Oncol., 1996, 7, 657-658.
    • (1996) Ann. Oncol , vol.7 , pp. 657-658
    • Fentiman, I.S.1
  • 6
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of patients 65 years of age or older in cancer-treatment trials
    • Hutchins, L.F.; Unger, J.M.; Crowley, J.J.; Coltman, C.A. Jr.; Albain, K.S. Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N. Engl. J. Med., 1999, 341, 2061-2067.
    • (1999) N. Engl. J. Med , vol.341 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3    Coltman Jr., C.A.4    Albain, K.S.5
  • 9
    • 0036270715 scopus 로고    scopus 로고
    • Oncopaz Cooperative Group Associated Hospitals. Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: An active and low toxicity regimen
    • Feliu, J; Mel, J.R.; Camps, C.; Escudero, P.; Aparicio, J.; Menéndez, D.; García Girón, C.; Rodriguez, M.R.; Sánchez, J.J.; González Barón, M.; Oncopaz Cooperative Group Associated Hospitals. Raltitrexed in the treatment of elderly patients with advanced colorectal cancer: an active and low toxicity regimen. Eur. J. Cancer, 2002, 38, 1204-1211.
    • (2002) Eur. J. Cancer , vol.38 , pp. 1204-1211
    • Feliu, J.1    Mel, J.R.2    Camps, C.3    Escudero, P.4    Aparicio, J.5    Menéndez, D.6    García girón, C.7    Rodriguez, M.R.8    Sánchez, J.J.9    González, B.M.10
  • 11
    • 0036220622 scopus 로고    scopus 로고
    • Palliative 5-fluorouracil-based chemotherapy for advanced colorectal cancer in the elderly. Results of a 10-year experience
    • Magné, N.; François, E.; Broisin, L.; Guardiola, E.; Ramaïoli, A.; Ferrero, J.M.; Namer, M. Palliative 5-fluorouracil-based chemotherapy for advanced colorectal cancer in the elderly. Results of a 10-year experience. Am. J. Clin. Oncol., 2002, 25, 126-130.
    • (2002) Am. J. Clin. Oncol , vol.25 , pp. 126-130
    • Magné, N.1    François, E.2    Broisin, L.3    Guardiola, E.4    Ramaïoli, A.5    Ferrero, J.M.6    Namer, M.7
  • 13
    • 4143089333 scopus 로고    scopus 로고
    • Predictive factors of survival in patients with advanced colorectal cancer: An individual data analysis of 602 patients included in irinotecan phase III trials
    • Mitry, E.; Douillard, J.Y.; Van Cutsem, E.; Cunningham, D.; Magherini, E.; Mery-Mignard, D.; Awad, L.; Rougier, P. Predictive factors of survival in patients with advanced colorectal cancer: an individual data analysis of 602 patients included in irinotecan phase III trials. Ann. Oncol., 2004, 15, 1013-1017.
    • (2004) Ann. Oncol , vol.15 , pp. 1013-1017
    • Mitry, E.1    Douillard, J.Y.2    van Cutsem, E.3    Cunningham, D.4    Magherini, E.5    Mery-Mignard, D.6    Awad, L.7    Rougier, P.8
  • 14
    • 25444443120 scopus 로고    scopus 로고
    • Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients
    • Rosati, G.; Cordio, S.; Tucci, A.; Blanco, G.; Bordonaro, R.; Reggiardo, G.; Manzione, L. Phase II trial of oxaliplatin and tegafur/uracil and oral folinic acid for advanced or metastatic colorectal cancer in elderly patients. Oncology, 2005, 69, 122-129.
    • (2005) Oncology , vol.69 , pp. 122-129
    • Rosati, G.1    Cordio, S.2    Tucci, A.3    Blanco, G.4    Bordonaro, R.5    Reggiardo, G.6    Manzione, L.7
  • 15
    • 20644437768 scopus 로고    scopus 로고
    • Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study
    • Cooperative Group for the Treatment of Digestive Tumors
    • Sastre, J.; Marcuello, E.; Masutti, B.; Navarro, M.; Gil, S.; Antón, A.; Abad, A.; Aranda, E.; Maurel, J.; Valladares, M.; Maestu, I.; Carrato, A.; Vicent, J.M.; Díaz-Rubio, E.; Cooperative Group for the Treatment of Digestive Tumors. Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: a Spanish Cooperative Group for the Treatment of Digestive Tumors study. J. Clin. Oncol., 2005, 23, 3545-3551.
    • (2005) J. Clin. Oncol , vol.23 , pp. 3545-3551
    • Sastre, J.1    Masutti, B.2    Navarro, M.3    Gil, S.4    Antón, A.5    Abad, A.6    Aranda, E.7    Maurel, J.8    Valladares, M.9    Maestu, I.10    Carrato, A.11    Vicent, J.M.12    Díaz-Rubio, E.13
  • 19
    • 1842569206 scopus 로고    scopus 로고
    • A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer
    • Goldberg, R.M.; Sargent, D.J.; Morton, R.F.; Fuchs, C.S.; Ramanathan, R.K.; Williamson, S.K.; Findlay, B.P.; Pitot, H.C.; Alberts, S.R. A randomized controlled trial of fluorouracil plus leucovorin, irinotecan, and oxaliplatin combinations in patients with previously untreated metastatic colorectal cancer. J. Clin. Oncol., 2004, 22(1), 23-30.
    • (2004) J. Clin. Oncol , vol.22 , Issue.1 , pp. 23-30
    • Goldberg, R.M.1    Sargent, D.J.2    Morton, R.F.3    Fuchs, C.S.4    Ramanathan, R.K.5    Williamson, S.K.6    Findlay, B.P.7    Pitot, H.C.8    Alberts, S.R.9
  • 20
    • 33745147264 scopus 로고    scopus 로고
    • Management of cancer in the elderly
    • Balducci, L. Management of cancer in the elderly. Oncology, 2006, 20, 135-143.
    • (2006) Oncology , vol.20 , pp. 135-143
    • Balducci, L.1
  • 22
    • 0037022820 scopus 로고    scopus 로고
    • Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with nodepositive colon cancer
    • Sundararajan, V.; Mitra, N.; Jacobson, J.S.; Grann, V.R.; Heitjan, D.F.; Neugut, A.I. Survival associated with 5-fluorouracil-based adjuvant chemotherapy among elderly patients with nodepositive colon cancer. Ann. Intern. Med., 2002, 136, 349-357.
    • (2002) Ann. Intern. Med , vol.136 , pp. 349-357
    • Sundararajan, V.1    Mitra, N.2    Jacobson, J.S.3    Grann, V.R.4    Heitjan, D.F.5    Neugut, A.I.6
  • 23
    • 28844482345 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for stage III colon cancer: Implications of race/ethnicity, age, and differentiation
    • Jessup, J.M.; Stewart, A.; Greene, F.L.; Minsky, B.D. Adjuvant chemotherapy for stage III colon cancer: implications of race/ethnicity, age, and differentiation. J.A.M.A., 2005, 294, 2703-2711.
    • (2005) J.A.M.A , vol.294 , pp. 2703-2711
    • Jessup, J.M.1    Stewart, A.2    Greene, F.L.3    Minsky, B.D.4
  • 25
    • 20044370090 scopus 로고    scopus 로고
    • Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomics status, gender, and comorbidity
    • Lemmens, V.E.P.P.; van Halteren, A.H.; Janssen-Heijnen, M.L.G.; Vreugdenhil, G.; Repelaer van Driel, O.J.; Coebergh, W.W. Adjuvant treatment for elderly patients with stage III colon cancer in the southern Netherlands is affected by socioeconomics status, gender, and comorbidity. Ann. Oncol., 2005, 16(5), 767-772.
    • (2005) Ann. Oncol , vol.16 , Issue.5 , pp. 767-772
    • Lemmens, V.E.P.P.1    van Halteren, A.H.2    Janssen-Heijnen, M.L.G.3    Vreugdenhil, G.4    van Driel, R.O.J.5    Coebergh, W.W.6
  • 27
    • 0032792959 scopus 로고    scopus 로고
    • Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
    • Popescu, R.A.; Norman, A.; Ross, P.J.; Parikh, B.; Cunningham, D. Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J. Clin. Oncol., 1999, 17, 2412-2418.
    • (1999) J. Clin. Oncol , vol.17 , pp. 2412-2418
    • Popescu, R.A.1    Norman, A.2    Ross, P.J.3    Parikh, B.4    Cunningham, D.5
  • 28
    • 33748669385 scopus 로고    scopus 로고
    • Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer
    • Goldberg, R.M.; Tabah-Fisch, I.; Bleiberg, H.; de Gramont, A.; Tournigand, C.; Andre, T.; Rothenberg, M.L.; Green, E.; Sargent, D.J. Pooled analysis of safety and efficacy of oxaliplatin plus fluorouracil/leucovorin administered bimonthly in elderly patients with colorectal cancer. J. Clin. Oncol., 2006, 24, 4085-4091.
    • (2006) J. Clin. Oncol , vol.24 , pp. 4085-4091
    • Goldberg, R.M.1    Tabah-Fisch, I.2    Bleiberg, H.3    de Gramont, A.4    Tournigand, C.5    Andre, T.6    Rothenberg, M.L.7    Green, E.8    Sargent, D.J.9
  • 30
    • 36849064682 scopus 로고    scopus 로고
    • Adjuvant chemotherapy versus observation in patients with colorectal cancer: A randomised study
    • Quasar Collaborative Group
    • Quasar Collaborative Group; Gray, R.; Barnwell, J.; McConkey, C.; Hills, R.K.; Williams, N.S.; Kerr, D.J. Adjuvant chemotherapy versus observation in patients with colorectal cancer: a randomised study. Lancet, 2007, 370, 2020-2029.
    • (2007) Lancet , vol.370 , pp. 2020-2029
    • Gray, R.1    Barnwell, J.2    McConkey, C.3    Hills, R.K.4    Williams, N.S.5    Kerr, D.J.6
  • 31
    • 77953359926 scopus 로고    scopus 로고
    • Adjuvant chemotherapy in elderly patients with colorectal cancer. A retrospective analysis of the implementation of tumor board recommendations in a single institution
    • Kurtz, J.E.; Heitz, D.; Serra, S.; Brigand, C.; Juif, V.; Podelski, V.; Meyer, P.; Litique, V.; Bergerat, J.P.; Rohr, S.; Dufour, P. Adjuvant chemotherapy in elderly patients with colorectal cancer. A retrospective analysis of the implementation of tumor board recommendations in a single institution. Crit. Rev. Oncol. Hematol., 2010, 74(3), 211-217.
    • (2010) Crit. Rev. Oncol. Hematol , vol.74 , Issue.3 , pp. 211-217
    • Kurtz, J.E.1    Heitz, D.2    Serra, S.3    Brigand, C.4    Juif, V.5    Podelski, V.6    Meyer, P.7    Litique, V.8    Bergerat, J.P.9    Rohr, S.10    Dufour, P.11
  • 32
  • 33
    • 2542615200 scopus 로고    scopus 로고
    • Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • André, T.; Boni, C.; Mounedji-Boudiaf, L.; Navarro, M.; Tabernero, J.; Hickish, T.; Topham, C.; Zaninelli, M.; Clingan, P.; Bridgewater, J.; Tabah-Fisch, I.; de Gramont, A.; Multicenter International Study of Oxaliplatin/5-Fluorouracil/Leucovorin in the Adjuvant Treatment of Colon Cancer (MOSAIC) Investigators. Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N. Engl. J. Med., 2004, 350(23), 2343-2351.
    • (2004) N. Engl. J. Med , vol.350 , Issue.23 , pp. 2343-2351
    • André, T.1    Boni, C.2    Mounedji-Boudiaf, L.3    Navarro, M.4    Tabernero, J.5    Hickish, T.6    Topham, C.7    Zaninelli, M.8    Clingan, P.9    Bridgewater, J.10    Tabah-Fisch, I.11    de Gramont, A.12
  • 35
    • 70350177864 scopus 로고    scopus 로고
    • Impact of older age on the efficacy of newer adjuvant therapies in >12,500 patients (pts) with stage II/III colon cancer: Findings from the ACCENT Database
    • and The ACCENT Collaborative Group
    • Jackson McCleary, N.A.; Meyerhardt, J.; Green, E.; Yothers, G.; de Gramont, A.; Van Cutsem, E.; O'Connell, M.; Twelves, C.; Saltz, L.; Sargent, D.; and The ACCENT Collaborative Group. Impact of older age on the efficacy of newer adjuvant therapies in >12,500 patients (pts) with stage II/III colon cancer: Findings from the ACCENT Database. Proc. Am. Soc. Clin. Oncol. J. Clin. Oncol., 2009, 27(15S), 4010. (Abstract).
    • (2009) Proc. Am. Soc. Clin. Oncol. J. Clin. Oncol , vol.27 , Issue.15 S , pp. 4010
    • Jackson, M.N.A.1    Meyerhardt, J.2    Green, E.3    Yothers, G.4    de Gramont, A.5    van Cutsem, E.6    O'Connell, M.7    Twelves, C.8    Saltz, L.9    Sargent, D.10
  • 37
    • 84866745407 scopus 로고    scopus 로고
    • Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer. Subgroup analyses of the multicenter international study of oxaliplatin, fluorouracil, and leucovorin in the adjuvant treatment of colon cancer trial
    • Tourningard, C.; Andrè, T.; Bonnetain, F.; Chibaudel, B.; Lledo, G.; Hickish, T.; Tabernero, J.; Boni, C.; Bachet, J.B.; Teixeira, L.; de Gramnt, A. Adjuvant therapy with fluorouracil and oxaliplatin in stage II and elderly patients (between ages 70 and 75 years) with colon cancer. Subgroup analyses of the multicenter international study of oxaliplatin, fluorouracil, and leucovorin in the adjuvant treatment of colon cancer trial. J. Clin. Oncol., 2012, 30, 3353-3360.
    • (2012) J. Clin. Oncol , vol.30 , pp. 3353-3360
    • Tourningard, C.1    Andrè, T.2    Bonnetain, F.3    Chibaudel, B.4    Lledo, G.5    Hickish, T.6    Tabernero, J.7    Boni, C.8    Bachet, J.B.9    Teixeira, L.10    de Gramnt, A.11
  • 38
    • 17644382288 scopus 로고    scopus 로고
    • Critical evaluation of current treatments in metastatic colorectal cancer
    • Venook, A. Critical evaluation of current treatments in metastatic colorectal cancer. Oncologist, 2005, 10, 250-261.
    • (2005) Oncologist , vol.10 , pp. 250-261
    • Venook, A.1
  • 42
    • 0038518557 scopus 로고    scopus 로고
    • Enrollment of older patients in cancer treatment trials in Canada: Why is age a barrier
    • Yee, K.W.; Pater, J.L.; Pho, L.; Zee, B.; Siu, L.L. Enrollment of older patients in cancer treatment trials in Canada: why is age a barrier? J. Clin. Oncol., 2003, 21, 1618-1623.
    • (2003) J. Clin. Oncol , vol.21 , pp. 1618-1623
    • Yee, K.W.1    Pater, J.L.2    Pho, L.3    Zee, B.4    Siu, L.L.5
  • 44
    • 48749102117 scopus 로고    scopus 로고
    • Irinotecan/5-FU/FA (I-FU) or FU/FA (FU) first-line therapy in older and younger patients with metastatic colorectal cancer: Combined analysis of 2.691 patients in randomized controlled trials
    • and Irinotecan Meta-analysis Group
    • Folprecht, G.; Seymour, T.; Saltz, L.; Douillard, J.Y.; Stephens, R.J.; Van Cutsem, E.; Rougier, P.; Maughan, T.S.; Kohne, C.H.; and Irinotecan Meta-analysis Group. Irinotecan/5-FU/FA (I-FU) or FU/FA (FU) first-line therapy in older and younger patients with metastatic colorectal cancer: combined analysis of 2.691 patients in randomized controlled trials. Proc. Am. Soc. Clin. Oncol. J. Clin. Oncol., 2007, 25(18S), 4071. (Abstract).
    • (2007) Proc. Am. Soc. Clin. Oncol. J. Clin. Oncol , vol.25 , Issue.18 S , pp. 4071
    • Folprecht, G.1    Seymour, T.2    Saltz, L.3    Douillard, J.Y.4    Stephens, R.J.5    van Cutsem, E.6    Rougier, P.7    Maughan, T.S.8    Kohne, C.H.9
  • 45
    • 0027997825 scopus 로고
    • Age and clinical decision making in oncology patients
    • Yellen, S.B.; Cella, D.F.; Leslie, W.T. Age and clinical decision making in oncology patients. J. Natl. Canc. Inst., 1994, 86, 1766-1770.
    • (1994) J. Natl. Canc. Inst , vol.86 , pp. 1766-1770
    • Yellen, S.B.1    Cella, D.F.2    Leslie, W.T.3
  • 46
    • 2642529751 scopus 로고    scopus 로고
    • Is age a prognostic factor of toxicity and efficacy in patients with metastatic colorectal cancer receiving irinotecan in combination with 5FU/folinic acid (FA)
    • abstract 1072
    • Rougier, P.; Mitry, E.; Cunningham, D.; Roth, A.; Clavero-Fabri, M.C.; Magherini, E.; Mery-Mignard, D.; Awad, L.; Douillard, J.Y. Is age a prognostic factor of toxicity and efficacy in patients with metastatic colorectal cancer receiving irinotecan in combination with 5FU/folinic acid (FA). Proc. Am. Soc. Clin. Oncol., 2003, 21, 267. abstract 1072.
    • (2003) Proc. Am. Soc. Clin. Oncol , vol.21 , pp. 267
    • Rougier, P.1    Mitry, E.2    Cunningham, D.3    Roth, A.4    Clavero-Fabri, M.C.5    Magherini, E.6    Mery-Mignard, D.7    Awad, L.8    Douillard, J.Y.9
  • 51
    • 29144469349 scopus 로고    scopus 로고
    • Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial
    • Souglakos, J.; Pallis, A.; Kakolyris, S.; Mavroudis, D.; Androulakis, N.; Kouroussis, C.; Agelaki, S.; Xenidis, N.; Milaki, G.; Georgoulias, V. Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: a phase II trial. Oncology, 2005, 69, 384-390.
    • (2005) Oncology , vol.69 , pp. 384-390
    • Souglakos, J.1    Pallis, A.2    Kakolyris, S.3    Mavroudis, D.4    Androulakis, N.5    Kouroussis, C.6    Agelaki, S.7    Xenidis, N.8    Milaki, G.9    Georgoulias, V.10
  • 53
    • 0001015790 scopus 로고    scopus 로고
    • Should we consider weekly (w) chemotherapy with 5-fluorouracil (F) + racemic folinic acid (f) a standard treatment for carcinoma of the digestive tract (DTD) in elderly patients
    • Beretta, G.; Bollina, R.; Cozzi, C.; Beretta, G. Should we consider weekly (w) chemotherapy with 5-fluorouracil (F) + racemic folinic acid (f) a standard treatment for carcinoma of the digestive tract (DTD) in elderly patients. Proc. Am. Soc. Clin. Oncol., 1997, 920.
    • (1997) Proc. Am. Soc. Clin. Oncol , pp. 920
    • Beretta, G.1    Bollina, R.2    Cozzi, C.3    Beretta, G.4
  • 55
    • 42149125461 scopus 로고    scopus 로고
    • Discrimninating factors in treatment decisons for chemotherapy in elderly patients with colorectal cancer
    • Barton, M.; Gabriel, G.; Alam, M.; Eek, R. Discrimninating factors in treatment decisons for chemotherapy in elderly patients with colorectal cancer. Cancer Forum, 2008, 32(1), 22-26.
    • (2008) Cancer Forum , vol.32 , Issue.1 , pp. 22-26
    • Barton, M.1    Gabriel, G.2    Alam, M.3    Eek, R.4
  • 56
    • 84888230893 scopus 로고    scopus 로고
    • Commission on Cancer
    • National Cancer database, Benchmark Reports, v1.1, October 1
    • National Cancer database. Commission on Cancer. ACoS. Benchmark Reports, v1.1, October 1, 2007.
    • (2007) ACoS
  • 57
    • 33644839465 scopus 로고    scopus 로고
    • Outcomes in elderly patients with advanced colorectal cancer treated with capecitabine: A population-based analysis
    • Ho, C.; Ng, K.; O'Reilly, S.; Gill, S. Outcomes in elderly patients with advanced colorectal cancer treated with capecitabine: a population-based analysis. Clin. Colorectal. Cancer, 2005, 5(4), 279-282.
    • (2005) Clin. Colorectal. Cancer , vol.5 , Issue.4 , pp. 279-282
    • Ho, C.1    Ng, K.2    O'Reilly, S.3    Gill, S.4
  • 59
    • 0028819554 scopus 로고
    • Age and sex are independent predictors of 5-fluorouracil toxicity. Analysis of a large scale phase III trial
    • Stein, B.N.; Petrelli, N.J.; Douglass, H.O.; Driscoll, D.L.; Arcangeli, G.; Meropol, N.J. Age and sex are independent predictors of 5-fluorouracil toxicity. Analysis of a large scale phase III trial. Cancer, 1995, 75(1), 11-17.
    • (1995) Cancer , vol.75 , Issue.1 , pp. 11-17
    • Stein, B.N.1    Petrelli, N.J.2    Douglass, H.O.3    Driscoll, D.L.4    Arcangeli, G.5    Meropol, N.J.6
  • 61
    • 84856026641 scopus 로고    scopus 로고
    • Targeted agents: Review of toxicity in the elderly metastatic colorectal cancer patients
    • Kyriakou, F.; Kountourakis, P.; Papamichael, D. Targeted agents: review of toxicity in the elderly metastatic colorectal cancer patients. Target Oncol., 2011, 6(4), 245-251.
    • (2011) Target Oncol , vol.6 , Issue.4 , pp. 245-251
    • Kyriakou, F.1    Kountourakis, P.2    Papamichael, D.3
  • 65
    • 0035871538 scopus 로고    scopus 로고
    • Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: Results of a randomized phase III study
    • Hoff, P.M.; Ansari, R.; Batist, G.; Cox, J.; Kocha, W.; Kuperminc, M.; Maroun, J.; Walde, D.; Weaver, C.; Harrison, E.; Burger, H.U.; Osterwalder, B.; Wong, A.O.; Wong, R. Comparison of oral capecitabine versus intravenous fluorouracil plus leucovorin as first-line treatment in 605 patients with metastatic colorectal cancer: results of a randomized phase III study. J. Clin. Oncol., 2001, 19, 2282-2292.
    • (2001) J. Clin. Oncol , vol.19 , pp. 2282-2292
    • Hoff, P.M.1    Ansari, R.2    Batist, G.3    Cox, J.4    Kocha, W.5    Kuperminc, M.6    Maroun, J.7    Walde, D.8    Weaver, C.9    Harrison, E.10    Burger, H.U.11    Osterwalder, B.12    Wong, A.O.13    Wong, R.14
  • 67
    • 77957785821 scopus 로고    scopus 로고
    • Patients with locally advanced and metastatic colorectal cancer treated with capecitabine versus 5-fluorouracil as monotherapy or combination therapy with oxaliplatin: A cost comparison
    • Chu, E.; Schulman, K.L.; McKenna, E.F. Jr., Cartwright, T. Patients with locally advanced and metastatic colorectal cancer treated with capecitabine versus 5-fluorouracil as monotherapy or combination therapy with oxaliplatin: a cost comparison. Clin. Colorectal Cancer., 2010, 9(4), 229-237.
    • (2010) Clin. Colorectal Cancer , vol.9 , Issue.4 , pp. 229-237
    • Chu, E.1    Schulman, K.L.2    McKenna Jr., E.F.3    Cartwright, T.4
  • 68
    • 0031864830 scopus 로고    scopus 로고
    • Oxaliplatin: Mechanism of action and antineoplastic activity
    • Raymond, E.; Faivre, S.; Woynarowski, J.M.; Chaney, S.G. Oxaliplatin: mechanism of action and antineoplastic activity. Semin. Oncol., 1998, 25, 4-12.
    • (1998) Semin. Oncol , vol.25 , pp. 4-12
    • Raymond, E.1    Faivre, S.2    Woynarowski, J.M.3    Chaney, S.G.4
  • 69
    • 38449099720 scopus 로고    scopus 로고
    • An update on treatment advances for the first-line therapy of metastatic colorectal cancer
    • Lee, J.J.; Chu, E. An update on treatment advances for the first-line therapy of metastatic colorectal cancer. Cancer J., 2007, 13, 276-282.
    • (2007) Cancer J , vol.13 , pp. 276-282
    • Lee, J.J.1    Chu, E.2
  • 71
    • 0037531121 scopus 로고    scopus 로고
    • Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: Interim results of a phase III trial
    • Rothenberg, M.L.; Oza, A.M.; Bigelow, R.H.; Berlin, J.D.; Marshall, J.L.; Ramanathan, R.K.; Hart, L.L.; Gupta, S.; Garay, C.A.; Burger, B.G.; Le Bail, N.; Haller, D.G. Superiority of oxaliplatin and fluorouracil-leucovorin compared with either therapy alone in patients with progressive colorectal cancer after irinotecan and fluorouracil-leucovorin: interim results of a phase III trial. J. Clin. Oncol., 2003, 21(11), 2059-2069.
    • (2003) J. Clin. Oncol , vol.21 , Issue.11 , pp. 2059-2069
    • Rothenberg, M.L.1    Oza, A.M.2    Bigelow, R.H.3    Berlin, J.D.4    Marshall, J.L.5    Ramanathan, R.K.6    Hart, L.L.7    Gupta, S.8    Garay, C.A.9    Burger, B.G.10    Le Bail, N.11    Haller, D.G.12
  • 74
    • 34249776143 scopus 로고    scopus 로고
    • Efficacy of reduced intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer
    • 3720.[abstract]
    • Oh, D.-Y.; Kim, Y.-J.; Han, S.-W.; Choi, I.-S.; Kim, J.H.; Kim, D.-W.; Im, S.-A.; Kim, T.-Y.; Heo, D.S.; Bang, Y.-J., Kim, N.K. Efficacy of reduced intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer. J. Clin. Oncol., 2005, 23(16S), 300s, 3720.[abstract].
    • (2005) J. Clin. Oncol , vol.23 , Issue.16 S
    • Oh, D.-Y.1    Kim, Y.-J.2    Han, S.-W.3    Choi, I.-S.4    Kim, J.H.5    Kim, D.-W.6    Im, S.-A.7    Kim, T.-Y.8    Heo, D.S.9    Bang, Y.-J.10    Kim, N.K.11
  • 75
    • 0010521320 scopus 로고    scopus 로고
    • Oxaliplatin/5FU/LV is feasible, safe and active in elderly colorectal cancer (CRC) patients
    • Tabash-Fisch, I.; Maindrault-Goebel, F.; Benavides, M. Oxaliplatin/5FU/LV is feasible, safe and active in elderly colorectal cancer (CRC) patients, Proc. Am. Soc. Clin. Oncol., 2002, 21, 556.
    • (2002) Proc. Am. Soc. Clin. Oncol , vol.21 , pp. 556
    • Tabash-Fisch, I.1    Maindrault-Goebel, F.2    Benavides, M.3
  • 76
    • 8444224072 scopus 로고    scopus 로고
    • Age-independent benefit of chemotherapy with 5-fluorouracil, leucovorin, and oxaliplatin in patients with metastatic colorectal cancer within multi center randomized phase III trials
    • Levi, F.; Zidani, R.; Focan, C. Age-independent benefit of chemotherapy with 5-fluorouracil, leucovorin, and oxaliplatin in patients with metastatic colorectal cancer within multi center randomized phase III trials. Proc. Am. Soc. Clin. Oncol., 2002, 21, 1431.
    • (2002) Proc. Am. Soc. Clin. Oncol , vol.21 , pp. 1431
    • Levi, F.1    Zidani, R.2    Focan, C.3
  • 77
    • 27944509513 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin: A phase II study with a new schedule of administration in elderly patients with advanced colorectal cancer
    • 3681
    • Comandone, A.; Pochettino, P.; Bergnolo, P.; Boglione, A.; Dal Canton, O.; Chiado Cutin, S.; Garetto, F.; Biscardi, M.; Oliva, C. Capecitabine and oxaliplatin: A phase II study with a new schedule of administration in elderly patients with advanced colorectal cancer. J. Clin. Oncol., 2005, 23(16S), 291s, 3681.
    • (2005) J. Clin. Oncol , vol.23 , Issue.16 S
    • Comandone, A.1    Pochettino, P.2    Bergnolo, P.3    Boglione, A.4    Dal, C.O.5    Chiado, C.S.6    Garetto, F.7    Biscardi, M.8    Oliva, C.9
  • 79
    • 7944223833 scopus 로고    scopus 로고
    • Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy
    • Chau, I.; Norman, A.R.; Cunningham, D.; Waters, J.S.; Topham, C.; Middleton, G.; Hill, M.; Ross, P.J.; Katopodis, R.; Stewart, G.; Oates, J.R. Elderly patients with fluoropyrimidine and thymidylate synthase inhibitor-resistant advanced colorectal cancer derive similar benefit without excessive toxicity when treated with irinotecan monotherapy. Br. J. Cancer, 2004, 91(8), 1453-1458.
    • (2004) Br. J. Cancer , vol.91 , Issue.8 , pp. 1453-1458
    • Chau, I.1    Norman, A.R.2    Cunningham, D.3    Waters, J.S.4    Topham, C.5    Middleton, G.6    Hill, M.7    Ross, P.J.8    Katopodis, R.9    Stewart, G.10    Oates, J.R.11
  • 82
    • 45449119254 scopus 로고    scopus 로고
    • Phase III trial of chemotherapy with or without irinotecan in the front-line treatment of metastatic colorectal cancer in elderly patients (FFCD 2001-02 trial): Results of a planned interim analysis
    • Available at, (Abstr 281)
    • Mitry, E.; Phelip, J.M.; Bonnetain, F. Phase III trial of chemotherapy with or without irinotecan in the front-line treatment of metastatic colorectal cancer in elderly patients (FFCD 2001-02 trial): Results of a planned interim analysis. ASCO Gastrointestinal Cancers Symposium. Available at: www.asco.org 2008 (Abstr 281).
    • (2008) ASCO Gastrointestinal Cancers Symposium
    • Mitry, E.1    Phelip, J.M.2    Bonnetain, F.3
  • 85
    • 33846042717 scopus 로고    scopus 로고
    • Comparison of the tolerance and efficacy of LV5FU2-CPT11 and FOLFIRI regimens in front-line treatment of advanced colorectal cancer-a pooled analysis of 254 patients included in 2 randomised trials
    • Mitry, E.; Tournigand, C.; Andre, T.; Douillard, J.Y.Y.; Louvet, C.; Cunningham, D.; Magherini, E.; Mery-Mignard, D.; De Gramont, A.; Rougier, P. Comparison of the tolerance and efficacy of LV5FU2-CPT11 and FOLFIRI regimens in front-line treatment of advanced colorectal cancer-a pooled analysis of 254 patients included in 2 randomised trials. Proc. Am. Soc. Clin. Oncol., 2004, 22, 3576.
    • (2004) Proc. Am. Soc. Clin. Oncol , vol.22 , pp. 3576
    • Mitry, E.1    Tournigand, C.2    Andre, T.3    Douillard, J.Y.Y.4    Louvet, C.5    Cunningham, D.6    Magherini, E.7    Mery-Mignard, D.8    de Gramont, A.9    Rougier, P.10
  • 86
    • 33745928751 scopus 로고    scopus 로고
    • Management of advanced colorectal cancer: State of the art
    • Saunders, M.; Iveson, T. Management of advanced colorectal cancer: State of the art. Br. J. Cancer, 2006, 95, 131-138.
    • (2006) Br. J. Cancer , vol.95 , pp. 131-138
    • Saunders, M.1    Iveson, T.2
  • 87
    • 29144469349 scopus 로고    scopus 로고
    • Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial
    • Souglakos, J.; Pallis, A.; Kakolyris, S.; Mavroudis, D.; Androulakis, N.; Kouroussis, C.; Agelaki, S.; Xenidis, N.; Milaki, G.; Georgoulias, V. Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial. Oncology, 2005, 69, 384-390.
    • (2005) Oncology , vol.69 , pp. 384-390
    • Souglakos, J.1    Pallis, A.2    Kakolyris, S.3    Mavroudis, D.4    Androulakis, N.5    Kouroussis, C.6    Agelaki, S.7    Xenidis, N.8    Milaki, G.9    Georgoulias, V.10
  • 88
    • 33751073739 scopus 로고    scopus 로고
    • Irinotecan in first line therapy of elderly and non-elderly patients with metastatic colorectal cancer: Metaanalysis of three trials investigating 5-FU and irinotecan
    • Folprecht, G.; Rougier, P.; Saltz, L.; Van Cutsem, E.; Douillard, J.Y.; Sastre, J.; Mitry, E.; Hecker, H.; Schubert, U.; Kohne, C.H. Irinotecan in first line therapy of elderly and non-elderly patients with metastatic colorectal cancer: Metaanalysis of three trials investigating 5-FU and irinotecan. Proc. Am. Soc. Clin. Oncol., 2006, 24, 3578.
    • (2006) Proc. Am. Soc. Clin. Oncol , vol.24 , pp. 3578
    • Folprecht, G.1    Rougier, P.2    Saltz, L.3    van Cutsem, E.4    Douillard, J.Y.5    Sastre, J.6    Mitry, E.7    Hecker, H.8    Schubert, U.9    Kohne, C.H.10
  • 92
    • 84888233728 scopus 로고    scopus 로고
    • Genentech, Inc, Available at
    • Genentech, Inc., United States Securities and Exchange Commission. Available at: http://www.sec.gov/Archives/edgar/data/318771/000031877109000003/form10-k_2008.htm.
    • United States Securities and Exchange Commission
  • 93
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain, R.K. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat. Med., 2001, 7, 987-989.
    • (2001) Nat. Med , vol.7 , pp. 987-989
    • Jain, R.K.1
  • 94
    • 20044375603 scopus 로고    scopus 로고
    • Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro
    • Wang, Y.; Fei, D.; Vanderlaan, M.A. Song. Biological activity of bevacizumab, a humanized anti-VEGF antibody in vitro. Angiogenesis, 2004, 7(4), 335-345.
    • (2004) Angiogenesis , vol.7 , Issue.4 , pp. 335-345
    • Wang, Y.1    Fei, D.2    Vanderlaan, M.A.3
  • 95
    • 8844276697 scopus 로고    scopus 로고
    • Translating angiogenesis research into the clinic: The challenges ahead
    • Spec No
    • Augustin, H.G. Translating angiogenesis research into the clinic: the challenges ahead. Brit. J. Radiol., 2003, 76 (Spec No 1), S3-S10.
    • (2003) Brit. J. Radiol , vol.76 , Issue.1
    • Augustin, H.G.1
  • 96
    • 34447329590 scopus 로고    scopus 로고
    • Spectrum of activity and mechanism of action of VEGF/PDGF inhibitors
    • Homsi, J.; Daud, A.I. Spectrum of activity and mechanism of action of VEGF/PDGF inhibitors. Cancer Control J. Moffitt Cancer Center, 2007, 14, 285-294.
    • (2007) Cancer Control J. Moffitt Cancer Center , vol.14 , pp. 285-294
    • Homsi, J.1    Daud, A.I.2
  • 99
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar, F.F.; Schulz, J.; McCleod, M.; Patel, T.; Hamm, J.T.; Hecht, J.R.; Mass, R.; Perrou, B.; Nelson, B.; Novotny, W.F. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J. Clin. Oncol., 2005, 23(16), 3697-3705.
    • (2005) J. Clin. Oncol , vol.23 , Issue.16 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3    Patel, T.4    Hamm, J.T.5    Hecht, J.R.6    Mass, R.7    Perrou, B.8    Nelson, B.9    Novotny, W.F.10
  • 100
    • 58249088835 scopus 로고    scopus 로고
    • Addition of bevacizumab to fluorouracil-based first-line treatment of metastaticcolorectal cancer: Pooled analysis of cohorts of older patients from two randomized clinical trials
    • Kabbinavar, F.F.; Hurwitz, H.I.; Yi, J.; Sarkar, S.; Rosen, O. Addition of bevacizumab to fluorouracil-based first-line treatment of metastaticcolorectal cancer: pooled analysis of cohorts of older patients from two randomized clinical trials. J. Clin. Oncol., 2009, 27(2), 199-205.
    • (2009) J. Clin. Oncol , vol.27 , Issue.2 , pp. 199-205
    • Kabbinavar, F.F.1    Hurwitz, H.I.2    Yi, J.3    Sarkar, S.4    Rosen, O.5
  • 101
    • 77950494294 scopus 로고    scopus 로고
    • Effect of bevacizumab in older patients with metastatic colorectal cancer: Pooled analysis of four randomized studies
    • Cassidy, J.; Saltz, L.B.; Giantonio, B.J.; Kabbinavar, F.F.; Hurwitz, H.I.; Rohr, U.P. Effect of bevacizumab in older patients with metastatic colorectal cancer: pooled analysis of four randomized studies. J. Cancer. Res. Clin. Oncol., 2010, 136(5), 737-743.
    • (2010) J. Cancer. Res. Clin. Oncol , vol.136 , Issue.5 , pp. 737-743
    • Cassidy, J.1    Saltz, L.B.2    Giantonio, B.J.3    Kabbinavar, F.F.4    Hurwitz, H.I.5    Rohr, U.P.6
  • 102
    • 70349413045 scopus 로고    scopus 로고
    • Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: The BRiTE observational cohort study
    • Investigators of the BRiTE study
    • Kozloff, M.; Yood, M.U.; Berlin, J.; Flynn, P.J.; Kabbinavar, F.F.; Purdie, D.M.; Ashby, M.A.; Dong, W.; Sugrue, M.M.; Grothey, A.; Investigators of the BRiTE study. Clinical outcomes associated with bevacizumab-containing treatment of metastatic colorectal cancer: the BRiTE observational cohort study. Oncologist, 2009, 14(9), 862-870.
    • (2009) Oncologist , vol.14 , Issue.9 , pp. 862-870
    • Kozloff, M.1    Yood, M.U.2    Berlin, J.3    Flynn, P.J.4    Kabbinavar, F.F.5    Purdie, D.M.6    Ashby, M.A.7    Dong, W.8    Sugrue, M.M.9    Grothey, A.10
  • 103
    • 77956072936 scopus 로고    scopus 로고
    • Clinical outcomes in elderly patients with metastatic colorectal cancer receiving bevacizumab and chemotherapy: Results from the BRiTE observational cohort study
    • Kozloff, M.F.; Berlin, J.; Flynn, P.J.; Kabbinavar, F.; Ashby, M.; Dong, W.; Sing, A.P.; Grothey, A. Clinical outcomes in elderly patients with metastatic colorectal cancer receiving bevacizumab and chemotherapy: results from the BRiTE observational cohort study. Oncology, 2010, 78(5-6), 329-339.
    • (2010) Oncology , vol.78 , Issue.5-6 , pp. 329-339
    • Kozloff, M.F.1    Berlin, J.2    Flynn, P.J.3    Kabbinavar, F.4    Ashby, M.5    Dong, W.6    Sing, A.P.7    Grothey, A.8
  • 106
    • 84861724011 scopus 로고    scopus 로고
    • Bevacizumab is equally effective and no more toxic in elderly patients with advanced colorectal cancer: A subgroup analysis from the AGITG MAX trial: An international randomized controlled trial of Capecitabine, Bevacizumab and Mitomycin C
    • Price, T.J.; Zannino, D.; Wilson, K.; Simes, R.J.; Cassidy, J.; Van Hazel, G.A.; Robinson, B.A.; Broad, A.; Ganju, V.; Ackland, S.P.; Tebbutt, N.C. Bevacizumab is equally effective and no more toxic in elderly patients with advanced colorectal cancer: a subgroup analysis from the AGITG MAX trial: an international randomized controlled trial of Capecitabine, Bevacizumab and Mitomycin C. Ann. Oncol., 2012, 23(6), 1531-1536.
    • (2012) Ann. Oncol , vol.23 , Issue.6 , pp. 1531-1536
    • Price, T.J.1    Zannino, D.2    Wilson, K.3    Simes, R.J.4    Cassidy, J.5    van Hazel, G.A.6    Robinson, B.A.7    Broad, A.8    Ganju, V.9    Ackland, S.P.10    Tebbutt, N.C.11
  • 107
    • 84878577857 scopus 로고    scopus 로고
    • Safety and effectiveness of bevacizumab in combination with chemotherapy in elderly patients with metastatic colorectal cancer: Results from a large Czech observational registry
    • Kubala, E.; Bartos, J.; Petruzelka, L.B. Safety and effectiveness of bevacizumab in combination with chemotherapy in elderly patients with metastatic colorectal cancer: results from a large Czech observational registry. In: Gastrointestinal Cancers Symposium, 2010, 467.
    • (2010) Gastrointestinal Cancers Symposium , pp. 467
    • Kubala, E.1    Bartos, J.2    Petruzelka, L.B.3
  • 108
    • 84872316412 scopus 로고    scopus 로고
    • XELOX and bevacizumab followed by single-agent bevacizumab as maintnenace therapy as first-line treatment in elderly patients with advanced colorectal cancer: The boxe study
    • Rosati, G.; Avallone, A.; Aprile, G.; Butera, A.; Reggiardo, G.; Bilancia, D. XELOX and bevacizumab followed by single-agent bevacizumab as maintnenace therapy as first-line treatment in elderly patients with advanced colorectal cancer: the boxe study. Cancer Chemother. Pharmacol., 2013, 71, 257-264.
    • (2013) Cancer Chemother. Pharmacol , vol.71 , pp. 257-264
    • Rosati, G.1    Avallone, A.2    Aprile, G.3    Butera, A.4    Reggiardo, G.5    Bilancia, D.6
  • 109
    • 84878449640 scopus 로고    scopus 로고
    • Bevacizumab use and risk of cardiovascular adverse events among elderly patients with colorectal cancer receiving chemotherapy: A population-based study
    • Feb. 27, [Epub ahead of print]
    • Tsai, H.-T.; Marshall, J.L.; Weiss, S.R; Huang, C.-Y; Warren, J.L.; Freedman, A.N.; Fu, A.Z.; Sansbury, L.B.; Potosky, A.L. Bevacizumab use and risk of cardiovascular adverse events among elderly patients with colorectal cancer receiving chemotherapy: a population-based study. Ann. Oncol., 2013, Feb. 27. [Epub ahead of print].
    • (2013) Ann. Oncol
    • Tsai, H.-T.1    Marshall, J.L.2    Weiss, S.R.3    Huang, C.-Y.4    Warren, J.L.5    Freedman, A.N.6    Fu, A.Z.7    Sansbury, L.B.8    Potosky, A.L.9
  • 112
    • 78650396059 scopus 로고    scopus 로고
    • Comorbidity, age and overall survival in cetuximab-treated patients with advanced colorectal cancer (ACRC)-results from NCIC CTG CO.17: A phase III trial of cetuximab versus best supportive care
    • Asmis, T.R.; Powell, E.; Karapetis, C.S.; Jonker, D.J.; Tu, D.; Jeffery, M.; Pavlakis, N.; Gibbs, P.; Zhu, L.; Dueck, D.A.; Whittom, R.; Langer, C.; O'Callaghan, C.J. Comorbidity, age and overall survival in cetuximab-treated patients with advanced colorectal cancer (ACRC)-results from NCIC CTG CO.17: a phase III trial of cetuximab versus best supportive care. Ann. Oncol., 2011, 22(1), 118-126.
    • (2011) Ann. Oncol , vol.22 , Issue.1 , pp. 118-126
    • Asmis, T.R.1    Powell, E.2    Karapetis, C.S.3    Jonker, D.J.4    Tu, D.5    Jeffery, M.6    Pavlakis, N.7    Gibbs, P.8    Zhu, L.9    Dueck, D.A.10    Whittom, R.11    Langer, C.12    O'Callaghan, C.J.13
  • 115
    • 78650309129 scopus 로고    scopus 로고
    • First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD)
    • Sastre, J.; Aranda, E.; Grávalos, C.; Massutí, B.; Varella-Garcia, M.; Rivera, F.; Soler, G.; Carrato, A.; Manzano, J.L.; Díaz-Rubio, E.; Hidalgo, M. First-line single-agent cetuximab in elderly patients with metastatic colorectal cancer. A phase II clinical and molecular study of the Spanish group for digestive tumor therapy (TTD). Crit. Rev. Oncol. Hematol., 2011, 77 (1), 78-84.
    • (2011) Crit. Rev. Oncol. Hematol , vol.77 , Issue.1 , pp. 78-84
    • Sastre, J.1    Aranda, E.2    Grávalos, C.3    Massutí, B.4    Varella-Garcia, M.5    Rivera, F.6    Soler, G.7    Carrato, A.8    Manzano, J.L.9    Díaz-Rubio, E.10    Hidalgo, M.11
  • 117
    • 67650702948 scopus 로고    scopus 로고
    • Risk of high-grade skin rash in cancer patients treated with cetuximab-an antibody against epidermal growth factor receptor: Systemic review and meta-analysis
    • Su, X.; Lacouture, M.E.; Jia, Y.; Wu, S. Risk of high-grade skin rash in cancer patients treated with cetuximab-an antibody against epidermal growth factor receptor: systemic review and meta-analysis. Oncology, 2009, 77(2), 124-133.
    • (2009) Oncology , vol.77 , Issue.2 , pp. 124-133
    • Su, X.1    Lacouture, M.E.2    Jia, Y.3    Wu, S.4
  • 119
    • 77950196196 scopus 로고    scopus 로고
    • Reduced incidence of infusion-related reactions in metastatic colorectal cancer during treatment with cetuximab plus irinotecan with combined corticosteroid and antihistamine premedication
    • Siena, S.; Glynne-Jones, R.; Adenis, A.; Thaler, J.; Preusser, P.; Aguilar, E.A.; Aapro, M.S.; Loos, A.H.; Esser, R.; Wilke, H. Reduced incidence of infusion-related reactions in metastatic colorectal cancer during treatment with cetuximab plus irinotecan with combined corticosteroid and antihistamine premedication. Cancer, 2010, 116(7), 1827-1837.
    • (2010) Cancer , vol.116 , Issue.7 , pp. 1827-1837
    • Siena, S.1    Glynne-Jones, R.2    Adenis, A.3    Thaler, J.4    Preusser, P.5    Aguilar, E.A.6    Aapro, M.S.7    Loos, A.H.8    Esser, R.9    Wilke, H.10
  • 120
    • 34247224987 scopus 로고    scopus 로고
    • Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: A prospective study
    • Tejpar, S.; Piessevaux, H.; Claes, K.; Piront, P.; Hoenderop, J.G.; Verslype, C.; Van Cutsem, E. Magnesium wasting associated with epidermal-growth-factor receptor-targeting antibodies in colorectal cancer: a prospective study. Lancet Oncol., 2007, 8(5), 387-394.
    • (2007) Lancet Oncol , vol.8 , Issue.5 , pp. 387-394
    • Tejpar, S.1    Piessevaux, H.2    Claes, K.3    Piront, P.4    Hoenderop, J.G.5    Verslype, C.6    van Cutsem, E.7
  • 121
    • 23844555670 scopus 로고    scopus 로고
    • Cetuximab therapy and symptomatic hypomagnesemia
    • Schrag, D.; Chung, K.Y.; Flombaum, C.; Saltz, L. Cetuximab therapy and symptomatic hypomagnesemia. J. Natl. Cancer Inst., 2005, 97(16), 1221-1224.
    • (2005) J. Natl. Cancer Inst , vol.97 , Issue.16 , pp. 1221-1224
    • Schrag, D.1    Chung, K.Y.2    Flombaum, C.3    Saltz, L.4
  • 122
    • 84856026641 scopus 로고    scopus 로고
    • Targeted agents: Review of toxicity in the elderly metastatic colorectal cancer patients
    • Kyriakou, F.; Kountourakis, P.; Papamichael, D. Targeted agents: review of toxicity in the elderly metastatic colorectal cancer patients. Targ. Oncol., 2011, 6, 245-251.
    • (2011) Targ. Oncol , vol.6 , pp. 245-251
    • Kyriakou, F.1    Kountourakis, P.2    Papamichael, D.3
  • 123
    • 34250372165 scopus 로고    scopus 로고
    • Treatment with panitumumab after a severe infusion reaction to cetuximab in a patient with metastatic colorectal cancer: A case report
    • Heun, J.; Holen, K. Treatment with panitumumab after a severe infusion reaction to cetuximab in a patient with metastatic colorectal cancer: a case report. Clin. Colorectal Cancer, 2007, 6(7), 529-531.
    • (2007) Clin. Colorectal Cancer , vol.6 , Issue.7 , pp. 529-531
    • Heun, J.1    Holen, K.2
  • 124
    • 44449130999 scopus 로고    scopus 로고
    • Successful administration of panitumumab alone after severe infusion reaction to cetuximab in a patient with metastatic colorectal cancer
    • Cartwright, T.H.; Genther, R. Successful administration of panitumumab alone after severe infusion reaction to cetuximab in a patient with metastatic colorectal cancer. Clin. Colorectal Cancer, 2008, 7(3), 202-203.
    • (2008) Clin. Colorectal Cancer , vol.7 , Issue.3 , pp. 202-203
    • Cartwright, T.H.1    Genther, R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.