Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease

Pain

Volumn 156, Issue 4, 2015, Pages 722-730

  Cataldo, Giuseppe ^a   Rajput, Sugandha ^b   Gupta, Kalpna ^b   Simone, Donald A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b Division of Hematology   (United States)

Author keywords

Central sensitization; Electrophysiology; Mouse; Pain; Sickle cell disease; Spinal cord

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42; PROTEIN P44; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; HEMOGLOBIN A; MITOGEN ACTIVATED PROTEIN KINASE KINASE;

ACTION POTENTIAL; ADULT; AFTERDISCHARGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGICAL PROCEDURES; EXCITABILITY; HYPERALGESIA; IMMUNOBLOTTING; MALE; MECHANICAL HYPERALGESIA; MECHANICAL STIMULATION; MOUSE; NERVE CELL; NONHUMAN; PAIN; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTIVE FIELD; SENSITIZATION; SICKLE CELL ANEMIA; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD DORSAL HORN; SPINAL CORD NERVE CELL; TRANSGENIC ORGANISM; ANIMAL; CASE CONTROL STUDY; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MEMBRANE POTENTIAL; METABOLISM; MOTOR ACTIVITY; MUTATION; PAIN MEASUREMENT; PAIN RECEPTOR; PAIN THRESHOLD; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANEMIA, SICKLE CELL; ANIMALS; CASE-CONTROL STUDIES; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; GENE EXPRESSION REGULATION; HEMOGLOBIN A; HUMANS; HYPERALGESIA; MALE; MEMBRANE POTENTIALS; MICE; MICE, TRANSGENIC; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MOTOR ACTIVITY; MUTATION; NOCICEPTORS; PAIN; PAIN MEASUREMENT; PAIN THRESHOLD; SPINAL CORD;

EID: 85003045651     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000104     Document Type: Article

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