Pathology of Berkeley sickle cell mice: Similarities and differences with human sickle cell disease

Blood

Volumn 107, Issue 4, 2006, Pages 1651-1658

  Manci, Elizabeth A ^a   Hillery, Cheryl A ^b   Bodian, Carol A ^b   Zhang, Zheng G ^b   Lutty, Gerard A ^b   Coller, Barry S ^b  

^a USA Children's and Women's Hospital   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BERKELEY SICKLE CELL; BLEEDING; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CARDIOMEGALY; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GLOMERULOSCLEROSIS; HEMATOPOIESIS; HEMOSIDEROSIS; HISTOPATHOLOGY; HYPERPLASIA; INTRAVASCULAR HEMOLYSIS; LUNG DISEASE; MALE; MOUSE; MULTIPLE ORGAN FAILURE; NONHUMAN; PRIORITY JOURNAL; RETINA DEGENERATION; SICKLE CELL; SPECIES DIFFERENCE; SPLENOMEGALY; TRANSGENIC MOUSE; WILD TYPE;

EID: 32644437616     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-07-2839     Document Type: Article

References (49)

1. Paszty C. Transgenic and gene knock-out mouse models of sickle cell anemia and the thalassemias. Curr Opin Hematol. 1997;4:88-93.
2. Paszty C, Brion CM, Manci E, et al. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science. 1997;278:876-878.
3. de Jong K, Emerson RK, Butler J, Bastacky J, Mohandas N, Kuypers FA. Short survival of phosphatidylserine-exposing red blood cells in murine sickle cell anemia. Blood. 2001;98:1577-1584.
4. Fabry ME, Suzuka SM, Weinberg RS, et al. Second generation knockout sickle mice: the effect of HbF. Blood. 2001;97:410-418.
5. Kean LS, Manci EA, Perry J, et al. Chimerism and cure: hematologic and pathologic correction of murine sickle cell disease. Blood. 2003;102:4582-4593.
6. Lutty GA, McLeod DS. A new technique for visualization of the human retinal vasculature. Arch Ophthalmol. 1992;110:267-276.
7. Zhang Z, Davies K, Prostak J, Fenstermacher J, Chopp M. Quantitation of microvascular plasma perfusion and neuronal microtubule-associated protein in ischemic mouse brain by laser-scanning confocal microscopy. J Cereb Blood Flow Metab. 1999;19:68-78.
8. Pittler SJ, Baehr W. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. Proc Natl Acad Sci U S A. 1991;88:8322-8326.
9. Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci. 1978;17:489-498.
10. Chang B, Hawes NL, Hurd RE, Davisson MT, Nusinowitz S, Heckenlively JR. Retinal degeneration mutants in the mouse. Vision Res. 2002;42:517-525.
11. Driscoll MC, Hurlet A, Styles L, et al. Stroke risk in siblings with sickle cell anemia. Blood. 2003;101:2401-2404.
12. Fabry ME, Suzuka SM, Aggarwal S, Nagel RL. Unexpected impact of HbF on mean survival time of BERK sickle transgenic mice expressing exclusively human hemoglobins [abstract]. Blood. 2002;100:2617a.
13. Noguchi CT, Gladwin MT, Diwan B, et al. Developing a useful model for sickle cell disease: hemizygotes for the mouse beta-globin gene [abstract]. Blood. 2000;96:598a.
14. Noguchi CT, Gladwin M, Diwan B, et al. Pathophysiology of a sickle cell trait mouse model: human alpha(beta)(S) transgenes with one mouse beta-globin allele. Blood Cells Mol Dis. 2001;27:971-977.
15. Diwan BA, Gladwin MT, Noguchi CT, Ward JM, Fitzhugh AL, Buzard GS. Renal pathology in hemizygous sickle cell mice. Toxicol Pathol. 2002;30:254-262.
16. Song J. Pathology of Sickle Cell Disease. Springfield, IL: Charles C. Thomas; 1971.
17. Rogers DW, Vaidya S, Serjeant GR. Early splenomegaly in homozygous sickle-cell disease: an indicator of susceptibility to infection. Lancet. 1978;2:963-965.
18. Stevens MC, Hayes RJ, Vaidya S, Serjeant GR. Fetal hemoglobin and clinical severity of homozygous sickle cell disease in early childhood. J Pediatr. 1981;98:37-41.
19. Mankad VN, Yang YM, Williams JP, Brogdon BG. Magnetic resonance imaging of bone marrow in sickle cell patients. Am J Pediatr Hematol Oncol. 1988;10:344-347.
20. Keeley K, Buchanan GR. Acute infarction of long bones in children with sickle cell anemia. J Pediatr. 1982;101:170-175.
21. Morgan AG, Shah DJ, Williams W. Renal pathology in adults over 40 with sickle-cell disease. West Indian Med J. 1987;36:241-250.
22. Pitcock JA, Muirhead EE, Hatch FE, Johnson JG, Kelly BJ. Early renal changes in sickle cell anemia. Arch Pathol. 1970;90:403-410.
23. Walker BR, Alexander F, Birdsall TR, Warren RL. Glomerular lesions in sickle cell nephropathy. JAMA. 1971;215:437-440.
24. Tejani A, Phadke K, Adamson O, Nicastri A, Chen CK, Sen D. Renal lesions in sickle cell nephropathy in children. Nephron. 1985;39:352-355.
25. Verani RR, Conley SB. Sickle cell glomerulopathy with focal segmental glomerulosclerosis. Child Nephrol Urol. 1991;11:206-208.
26. Omata M, Johnson CS, Tong M, Tatter D. Pathological spectrum of liver diseases in sickle cell disease. Dig Dis Sci. 1986;31:247-256.
27. Mills LR, Mwakyusa D, Milner PF. Histopathologic features of liver biopsy specimens in sickle cell disease. Arch Pathol Lab Med. 1988;112:290-294.
28. Bauer TW, Moore GW, Hutchins GM. The liver in sickle cell disease: a clinicopathologic study of 70 patients. Am J Med. 1980;69:833-837.
29. Gerry JL, Bulkley BH, Hutchins GM. Clinicopathologic analysis of cardiac dysfunction in 52 patients with sickle cell anemia. Am J Cardiol. 1978;42:211-216.
30. Hardison JE, Rogers CM. Cardiovascular manifestations of sickle cell anemia. In: Hurst JW, ed. The Heart. New York, NY: McGraw-Hill; 1979:195.
31. Martin CR, Johnson CS, Cobb C, Tatter D, Haywood LJ. Myocardial infarction in sickle cell disease. J Natl Med Assoc. 1996;88:428-432.
32. Vichinsky EP, Styles LA, Colangelo LH, Wright EC, Castro O, Nickerson B. Acute chest syndrome in sickle cell disease: clinical presentation and course: Cooperative Study of Sickle Cell Disease. Blood. 1997;89:1787-1792.
33. Vichinsky EP, Neumayr LD, Earles AN, et al. Causes and outcomes of the acute chest syndrome in sickle cell disease: National Acute Chest Syndrome Study Group. N Engl J Med. 2000;342:1855-1865.
34. Haupt HM, Moore GW, Bauer TW, Hutchins GM. The lung in sickle cell disease. Chest. 1982;81:332-337.
35. Belcher JD, Bryant CJ, Nguyen J, et al. Transgenic sickle mice have vascular inflammation. Blood. 2003;101:3953-3959.
36. Merkel KH, Ginsberg PL, Parker JC Jr, Post MJ. Cerebrovascular disease in sickle cell anemia: a clinical, pathological and radiological correlation. Stroke. 1978;9:45-52.
37. Tuohy AM, McKie V, Manci EA, Adams RJ. Internal carotid artery occlusion in a child with sickle cell disease: case report and immunohistochemical study. J Pediatr Hematol Oncol. 1997;19:455-458.
38. Manci EA, Culberson DE, Gardner JM, et al. Perivascular fibrosis in the bone marrow in sickle cell disease. Arch Pathol Lab Med. 2004;128:634-639.
39. Baird R, Weiss D, Ferguson A, French J, Scott R. Studies in sickle cell anemia, XXI: clinicopathological aspects of neurological manifestations. Pediatrics. 1964;34:92-100.
40. Ohene-Frempong K, Weiner SJ, Sleeper LA, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998;91:288-294.
41. Rothman S, Nelson JS. Stenosis of large caliber intracranial arteries and cerebral infarctions in sickle cell anaemia. Lab Invest. 1978;38:392.
42. Stockman JA, Nigro MA, Mishkin MM, Oski FA. Occlusion of large cerebral vessels in sickle-cell anemia. N Engl J Med. 1972;287:846-849.
43. Koshy M, Thomas C, Goodwin J. Vascular lesions in the central nervous system in sickle cell disease (neuropathology). J Assoc Acad Minor Phys. 1990;1:71-78.
44. Mankad VN, Williams JP, Harpen MD, et al. Magnetic resonance imaging of bone marrow in sickle cell disease: clinical, hematologic, and pathologic correlations. Blood. 1990;75:274-283.
45. Rothman SM, Fulling KH, Nelson JS. Sickle cell anemia and central nervous system infarction: a neuropathological study. Ann Neurol. 1986;20:684-690.
46. Adams RJ, McKie VC, Hsu L, et al. Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography. N Engl J Med. 1998;339:5-11.
47. Romayanada N, Goldberg MF, Green WR. Histopathology of sickle cell retinopathy. Trans Am Acad Ophthalmol Otolaryngol. 1973;77:OP642-OP676.
48. Welch RB, Goldberg MF. Sickle-cell hemoglobin and its relation to fundus abnormality. Arch Ophthalmol. 1966;75:353-362.
49. Asdourian G, Nagpal KC, Goldbaum M, Patrianakos D, Goldberg MF, Rabb M. Evolution of the retinal black sunburst in sickling haemoglobinopathies. Br J Ophthalmol. 1975;59:710-716.