Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors

Molecular Pain

Volumn 8, Issue , 2012, Pages

  Garrison, Sheldon R ^a   Kramer, Audra A ^a   Gerges, Nashaat Z ^a   Hillery, Cheryl A ^b,c   Stucky, Cheryl L ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b Children's Hospital of Wisconsin   (United States)

^c BLOOD RESEARCH INSTITUTE   (United States)

Author keywords

Allodynia; Anxiety; Nociception; Open field test; Pain; Primary afferents

Indexed keywords

HEMOGLOBIN A; HEMOGLOBIN S;

ACTION POTENTIAL; ALLODYNIA; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; CELL STIMULATION; CELLULAR STRESS RESPONSE; COMPARATIVE STUDY; CONTROLLED STUDY; COTTON; DISEASE SEVERITY; HAIR CELL; MALE; MECHANICAL ALLODYNIA; MECHANORECEPTOR; MOUSE; NERVE CELL; NERVE CONDUCTION; NONHUMAN; PAIN RECEPTOR; PERCEPTIVE THRESHOLD; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAPIDLY ADAPTING ABETA HAIR FIBER; RAPIDLY ADAPTING ASIGMA D HAIR FIBER; SENSITIZATION; SENSORY NERVE; SENSORY NERVE CELL; SICKLE CELL ANEMIA; SKIN RECEPTOR; SLOWLY ADAPTING ABETA AFFERENT NERVE; TOUCH;

ACTION POTENTIALS; ANEMIA, SICKLE CELL; ANIMALS; HUMANS; HYPERALGESIA; MECHANORECEPTORS; MICE; MOTOR ACTIVITY; NERVE FIBERS; NEURONS, AFFERENT; PHYSICAL STIMULATION; SKIN; TOUCH;

EID: 84865847334     PISSN: None     EISSN: 17448069     Source Type: Journal    
DOI: 10.1186/1744-8069-8-62     Document Type: Article

References (21)

1. Hillery CA, Panepinto JA. Pathophysiology of stroke in sickle cell disease. Microcirculation 2004, 11:195-208.
2. Platt OS, Thorington BD, Brambilla DJ, Milner PF, Rosse WF, Vichinsky E, Kinney TR. Pain in sickle cell disease. Rates and risk factors. N Engl J Med 1991, 325:11-16. 10.1056/NEJM199107043250103, 1710777.
3. Kohli DR, Li Y, Khasabov SG, Gupta P, Kehl LJ, Ericson ME, Nguyen J, Gupta V, Hebbel RP, Simone DA, Gupta K. Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood 2010, 116:456-465. 10.1182/blood-2010-01-260372, 2913454, 20304807.
4. Paszty C, Brion CM, Manci E, Witkowska HE, Stevens ME, Mohandas N, Rubin EM. Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science 1997, 278:876-878. 10.1126/science.278.5339.876, 9346488.
5. Hillery CA, Kerstein PC, Vilceanu D, Barabas ME, Retherford D, Brandow AM, Wandersee NJ, Stucky CL. Transient receptor potential vanilloid 1 mediates pain in mice with severe sickle cell disease. Blood 2011, 118:3376-3383. 10.1182/blood-2010-12-327429, 3179403, 21708890.
6. Nolan VG, Zhang Y, Lash T, Sebastiani P, Steinberg MH. Association between wind speed and the occurrence of sickle cell acute painful episodes: results of a case-crossover study. Br J Haematol 2008, 143:433-438. 10.1111/j.1365-2141.2008.07354.x, 18729854.
7. Garrison SR, Dietrich A, Stucky CL. TRPC1 contributes to light-touch sensation and mechanical responses in low-threshold cutaneous sensory neurons. J Neurophysiol 2012, 107:913-922. 10.1152/jn.00658.2011, 22072513.
8. Kwan KY, Glazer JM, Corey DP, Rice FL, Stucky CL. TRPA1 modulates mechanotransduction in cutaneous sensory neurons. J Neurosci 2009, 29:4808-4819. 10.1523/JNEUROSCI.5380-08.2009, 2744291, 19369549.
9. Djouhri L, Lawson SN. Abeta-fiber nociceptive primary afferent neurons: a review of incidence and properties in relation to other afferent A-fiber neurons in mammals. Brain Res Brain Res Rev 2004, 46:131-145.
10. Pells J, Edwards CL, McDougald CS, Wood M, Barksdale C, Jonassaint J, Leach-Beale B, Byrd G, Mathis M, Harrison MO, Feliu M, Edwards LY, Whitfield KE, Rogers L. Fear of movement (kinesiophobia), pain, and psychopathology in patients with sickle cell disease. Clin J Pain 2007, 23:707-713. 10.1097/AJP.0b013e31814da3eb, 17885350.
11. Jones S, Duncan ER, Thomas N, Walters J, Dick MC, Height SE, Stephens AD, Thein SL, Rees DC. Windy weather and low humidity are associated with an increased number of hospital admissions for acute pain and sickle cell disease in an urban environment with a maritime temperate climate. Br J Haematol 2005, 131:530-533. 10.1111/j.1365-2141.2005.05799.x, 16281945.
12. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain 1991, 44:293-299. 10.1016/0304-3959(91)90100-C, 1828878.
13. Carlson JD, Maire JJ, Martenson ME, Heinricher MM. Sensitization of pain-modulating neurons in the rostral ventromedial medulla after peripheral nerve injury. J Neurosci 2007, 27:13222-13231. 10.1523/JNEUROSCI.3715-07.2007, 18045916.
14. Shortland P, Woolf CJ. Morphology and somatotopy of the central arborizations of rapidly adapting glabrous skin afferents in the rat lumbar spinal cord. J Comp Neurol 1992, 329:491-511.
15. Zhu YF, Henry JL. Excitability of Abeta sensory neurons is altered in an animal model of peripheral neuropathy. BMC Neurosci 2012, 13:15. 10.1186/1471-2202-13-15, 3292996, 22289651.
16. Pitcher GM, Henry JL. Governing role of primary afferent drive in increased excitation of spinal nociceptive neurons in a model of sciatic neuropathy. Exp Neurol 2008, 214:219-228. 10.1016/j.expneurol.2008.08.003, 18773893.
17. Elg S, Marmigere F, Mattsson JP, Ernfors P. Cellular subtype distribution and developmental regulation of TRPC channel members in the mouse dorsal root ganglion. J Comp Neurol 2007, 503:35-46. 10.1002/cne.21351, 17480026.
18. Alessandri-Haber N, Dina OA, Chen X, Levine JD. TRPC1 and TRPC6 channels cooperate with TRPV4 to mediate mechanical hyperalgesia and nociceptor sensitization. J Neurosci 2009, 29:6217-6228. 10.1523/JNEUROSCI.0893-09.2009, 2726836, 19439599.
19. Page AJ, Brierley SM, Martin CM, Price MP, Symonds E, Butler R, Wemmie JA, Blackshaw LA. Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory function. Gut 2005, 54:1408-1415. 10.1136/gut.2005.071084, 1774697, 15987792.
20. Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, et al. Piezo proteins are pore-forming subunits of mechanically activated channels. Nature 2012, 483:176-181. 10.1038/nature10812, 3297710, 22343900.
21. Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 2010, 330:55-60. 10.1126/science.1193270, 3062430, 20813920.