Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease

Science

Volumn 278, Issue 5339, 1997, Pages 876-878

  Pászty, Chris ^a   Brion, Catherine M ^a   Manci, Elizabeth ^b   Witkowska, H Ewa ^c   Stevens, Mary E ^a   Mohandas, Narla ^a   Rubin, Edward M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Pathology   (United States)

^c CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA GLOBIN; BETA GLOBIN; HEMOGLOBIN S;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD ANALYSIS; BREEDING; CONTROLLED STUDY; DELETION MUTANT; EXTRAMEDULLARY HEMATOPOIESIS; GENE EXPRESSION; GENETIC DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; SICKLE CELL; SICKLE CELL ANEMIA; TRANSGENIC MOUSE;

ANEMIA, SICKLE CELL; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GLOBINS; HEMOGLOBIN, SICKLE; HUMANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 1842408336     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.278.5339.876     Document Type: Article

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27. We thank P. Cooper, F. Kuypers, B.-C. Lau, M. Sorette, B. Bookchin, B. Mentzer, J. Zhang, P. Donohue, J. Hanneman, and K. Brinkley for their contribution to this work. Supported by National Heart, Lung, and Blood Institute (NHLBI) grants HL31579 and HL20985 to the Northern California Comprehensive Sickle Cell Center, a Red Cell Program Project Grant (DK32094) from the National Institute of Diabetes, Digestive and Kidney Diseases, a NHLBI contract (NO1-HB-07086) to the Sickle Cell Disease Centralized Pathology Unit, and an NIH Shared Instrumentation Grant (VGBioQ mass spectrometer). Care of experimental animals was in accordance with institutional guidelines. Informed consent was obtained for human blood samples.