Windup leads to characteristics of central sensitization

Pain

Volumn 79, Issue 1, 1999, Pages 75-82

  Li, Jun ^a   Simone, Donald A ^a   Larson, Alice A ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Dorsal horn neuron; Electrophysiology; Hyperalgesia; Hyperexcitability; Pain

Indexed keywords

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONDITIONING; CONTROLLED STUDY; ELECTROPHYSIOLOGY; ELECTROSTIMULATION; EXCITABILITY; HYPERALGESIA; INFLAMMATION; MALE; NERVE FIBER C; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SPINAL CORD DORSAL HORN; TISSUE INJURY;

AFFERENT PATHWAYS; ANIMALS; ELECTRIC STIMULATION; EVOKED POTENTIALS; HYPERALGESIA; MALE; NERVE FIBERS; NEURONAL PLASTICITY; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD;

EID: 0032945956     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3959(98)00154-7     Document Type: Article

References (41)

1. Budai D. A computer-controlled system for post-stimulus time histogram and wind-up studies. J. Neurosci. Methods. 51:1994;205-221.
2. Budai D., Larson A.A. Role of substance P in the modulation of C-fiber-evoked responses of spinal dorsal horn neurons. Brain Res. 710:1996;197-203.
3. Campbell J.N., Meyer R.A., LaMotte R.H. Sensitization of myelinated nociceptive afferents that innervate monkey hand. J. Neurophysiol. 42:1979;1669-1679.
4. Cervero F., Shouenborg J., Sjölund B.H., Waddell P.J. Cutaneous inputs to dorsal horn neurones in adult rats treated at birth with capsaicin. Brain Res. 301:1984;45-57.
5. Cook A.J., Woolf C.J., Wall P.D., McMahon S.B. Dynamic receptive field plasticity in rat spinal dorsal horn following C-primary afferent input. Nature. 325:1987;151-153.
6. Davar G., Hama A., Deykin A., Vos B., Maciewicz R. MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy. Brain Res. 553:1991;327-330.
7. Davies S.N., Lodge D. Evidence for involvement of N-methyl-D-aspartate receptors in 'wind-up' of class 2 neurons in the dorsal horn of the rat. Brain Res. 424:1987;402-406.
8. Dickenson A.H., Sullivan A.F. Evidence for a role of the NMDA receptor in the frequency dependent potentiation of the deep rat dorsal horn nociceptive neurons following C fiber stimulation. Neuropharmacology. 26:1987;1235-1238.
9. Dickenson A.H., Sullivan A.F. Differential effects of excitatory amino-acid antagonists on nociceptive neurons in the rat. Brain Res. 506:1990;31-39.
10. Dougherty P.M., Willis W.D. Enhancement of spinothalamic neuron responses to chemical and mechanical stimuli following combined micro-iontophoretic application of N-methyl-D-aspartic acid and substance P. Pain. 47:1991;85-93.
11. Dubner R., Ruda M.A. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci. 15:1992;96-103.
12. Fitzgerald M., Lynn B. The sensitization of high threshold mechanoreceptors with myelinated axons by repeated heating. J. Physiol. 265:1977;549-563.
13. Hardy J.D., Wolff H.G., Goodell H. Experimental evidence on the nature of cutaneous hyperalgesia. J. Clin. Invest. 29:1950;115-140.
14. Hylden J.L.K., Nahin R.L., Traub R.J., Dubner R. Expansion of receptive fields of spinal lamina I projection neurones in rats with unilateral adjuvant-induced inflammation: the contribution of central dorsal horn mechanisms. Pain. 37:1989;229-243.
15. LaMotte R.H., Thalhammer J.G., Torebjörk H.E., Robinson C.J. Peripheral neural mechanisms of cutaneous hyperalgesia following mild injury by heat. J. Neurosci. 2:1982;765-781.
16. LaMotte R.H., Thalhammer J.G., Robinson C.J. Peripheral neural correlates of magnitude of cutaneous pain and hyperalgesia: a comparison of neural events in monkey with sensory judgements in human. J. Neurophysiol. 50:1983;1-26.
17. Lewis T. Experiments relating to cutaneous hyperalgesia and its spread through somatic nerves. Clin. Sci. 2:1936;373-423.
18. Li J., Simone D.A., Larson A.A. C-Fiber responses of dorsal horn neurons are facilitated following stimulation outside their receptive field. Soc. Neurosci. Abstr. 22:1996;861.
19. Ma, Q.P. and Woolf, C.J., Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones, J. Physiol., 484 (1995a) 769-777.
20. Ma, Q.P. and Woolf, C.J., Noxious stimuli induce an N-methyl-D-aspartate receptor-dependent hypersensitivity of the flexion withdrawal reflex to touch: implications for the treatment of mechanical allodynia, Pain, 61 (1995b) 383-390.
21. McMahon, S.B., Lewin, G.R. and Wall, P.D., Central hyperexcitability triggered by noxious input, Curr. Opin. Neurobiol., 3 (1993) 602-610.
22. Mao J., Price D.D., Hayes R.L., Lu J., Mayer D.J. Differential roles of NMDA and non-NMDA receptor activation in induction and maintenance of thermal hyperalgesia in rats with painful peripheral mononeuropathy. Brain Res. 598:1992;271-278.
23. Mendell L.M. Physiological properties of unmyelinated fiber projection to the spinal cord. Exp. Neurol. 16:1966;316-332.
24. Meyer R.A., Campbell J.N. Myelinated nociceptive afferents account for hyperalgesia that follows a burn to the hand. Science. 213:1981;1527-1529.
25. Neugebauer V., Lucke T., Schaible H.G. N-Methyl-D-aspartate (NMDA) and non-NMDA receptor antagonists block the hyperexcitability of dorsal horn neurons during development of acute arthritis in rat's knee joint. J. Neurophysiol. 70(4):1993;1365-1377.
26. Palecek J., Dougherty P.M., Kim S.H., Paleckova V., Lekan H., Chung J.M., Carlton S.M., Willis W.D. Responses of spinothalamic tract neurons to mechanical and thermal stimuli in an experimental model of peripheral neuropathy in primates. J. Neurophysiol. 68:1992;1951-1966.
27. Price D.D., Mao J., Frenk H., Mayer D.J. The N-methyl-D-aspartate receptor antagonist dextromethorphan selectively reduces temporal summation of second pain in man. Pain. 59:1994;165-174.
28. Pubols L.M., Fogelsong M.E., Vahle-Hinz C. Electrical stimulation reveals relatively ineffective sural nerve projections to dorsal horn neurons in the cat. Brain Res. 371:1986;109-122.
29. Ren K., Hylden J.L., Williams G.M., Ruda M.A., Dubner R. The effects of a non-competitive NMDA receptor antagonist, MK-801, on behavioral hyperalgesia and dorsal horn neuronal activity in rats with unilateral inflammation. Pain. 50:1992;331-344.
30. Ren K., Dubner R. NMDA receptor antagonists attenuate mechanical hyperalgesia in rats with unilateral inflammation of the hindpaw. Neurosci. Lett. 163:1993;22-26.
31. Salter M.W., Henry J.L. Responses of functionally identified neurons in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin. Neuroscience. 43:1991;601-610.
32. Simone D.A., Sorkin L.S., Oh U., Chung J.M., Owens C., LaMotte R.H., Willis W.D. Jr. Neurogenic hyperalgesia: central neural correlates in responses of spinothalamic tract neurons. J. Neurophysiol. 66:1991;228-246.
33. Traub R.J. The spinal contribution of substance P to the generation and maintenance of inflammatory hyperalgesia in the rat. Pain. 67:1996;151-161.
34. Urban L., Randic M. Slow excitatory transmission in the rat dorsal horn: possible mediation by peptides. Brain Res. 290:1984;336-341.
35. Urban, L., Thompson, S.W. and Dray, A., Modulation of spinal excitability: co-operation between neurokinin and excitatory amino acid transmitters, Trends Neurosci., 17 (1994) 432-438.
36. Wall P.D. Recruitment of ineffective synapses injury. In: S.G. Waxman (Ed.). Advances in Neurology, Raven, New York. 47:1988;387-400.
37. Woolf C.J. Evidence of central component of post-injury pain hypersensitivity. Nature. 306:1983;686-688.
38. Woolf C.J. Wind-up and central sensitization are not equivalent. Pain. 66:1996;105-108.
39. Woolf C.J., Doubell T.P. The pathophysiology of chronic pain-increased sensitivity to low threshold A beta-fibre inputs. Curr. Opin. Neurobiol. 4:1994;525-534.
40. Woolf C.J., King A.E. Dynamic alteration in the cutaneous mechanoreceptive fields of dorsal horn neurons in the rat spinal cord. J. Neurosci. 10:1990;2717-2726.
41. Woolf C.J., Thompson S.W.N. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of post-injury pain hypersensitivity states. Pain. 44:1991;293-299.