Reduction of soluble CD163, substance P, programmed death 1 and inflammatory markers: Phase 1B trial of aprepitant in HIV-1-infected adults

AIDS

Volumn 29, Issue 8, 2015, Pages 931-939

  Tebas, Pablo ^a   Spitsin, Sergei ^b   Barrett, Jeffrey S ^b   Tuluc, Florin ^b   Elci, Okan ^c   Korelitz, James J ^c   Wagner, Wayne ^a   Winters, Angela ^b   Kim, Deborah ^a   Catalano, Renae ^c   Evans, Dwight L ^a   Douglas, Steven D ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^c WESTAT   (United States)

Author keywords

aprepitant; CD163; HIV 1; Inflammation; Neurokinin 1 receptor; Neurokinin 1 receptor antagonists; Substance P

Indexed keywords

APREPITANT; CD163 ANTIGEN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; PLACEBO; PROGRAMMED DEATH 1 RECEPTOR; SUBSTANCE P; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIOLOGICAL MARKER; CELL SURFACE RECEPTOR; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; MORPHOLINE DERIVATIVE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CD4+ T LYMPHOCYTE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL DISEASE; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFLAMMATION; MALE; MONOCYTE; NEUROLOGIC DISEASE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RANDOMIZED CONTROLLED TRIAL; SKIN DISEASE; SYSTEMIC DISEASE; TOTAL CHOLESTEROL LEVEL; URINARY TRACT DISEASE; VIREMIA; VIRUS LOAD; BLOOD; CD4 LYMPHOCYTE COUNT; CLINICAL TRIAL; DOSE RESPONSE; HIV INFECTIONS; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; MIDDLE AGED; YOUNG ADULT;

ADULT; ANTI-HIV AGENTS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; BIOMARKERS; CD4 LYMPHOCYTE COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; LIPOPROTEINS, HDL; LIPOPROTEINS, LDL; MALE; MIDDLE AGED; MORPHOLINES; NEUROKININ-1 RECEPTOR ANTAGONISTS; PROGRAMMED CELL DEATH 1 RECEPTOR; PROSPECTIVE STUDIES; RECEPTORS, CELL SURFACE; RECEPTORS, NEUROKININ-1; SUBSTANCE P; YOUNG ADULT;

EID: 85003044948     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000638     Document Type: Article

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