Substance P (SP)-neurokinin-1 receptor (NK-1R) alters adipose tissue responses to high-fat diet and insulin action

Endocrinology

Volumn 152, Issue 6, 2011, Pages 2197-2205

  Karagiannides, Iordanes ^a   Stavrakis, Dimitris ^a   Bakirtzi, Kyriaki ^a   Kokkotou, Efi ^b   Pirtskhalava, Tamara ^c   Nayeb Hashemi, Hamed ^a   Bowe, Collin ^a   Bugni, James M ^a   Nuño, Miriam ^d   Lu, Bao ^e   Gerard, Norma P ^e   Leeman, Susan E ^f   Kirkland, James L ^c   Pothoulakis, Charalabos ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MAYO CLINIC   (United States)

^d CEDARS SINAI MEDICAL CENTER   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN RECEPTOR; INSULIN; LEPTIN; MESSENGER RNA; NEUROKININ 1 RECEPTOR; PROTEIN KINASE C THETA; STRESS ACTIVATED PROTEIN KINASE; SUBSTANCE P;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL STIMULATION; CONTROLLED STUDY; EMBRYO; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; INSULIN RESISTANCE; LIPID DIET; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; WEIGHT GAIN; WILD TYPE;

ADIPOSE TISSUE; ANIMALS; DIETARY FATS; FEMALE; GLUCOSE; HUMANS; INSULIN; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OBESITY; RATS; RATS, INBRED F344; RECEPTORS, NEUROKININ-1; SIGNAL TRANSDUCTION; SUBSTANCE P; WEIGHT GAIN;

EID: 79956313745     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-1345     Document Type: Article

References (42)

1. Chang MM, Leeman SE 1970 Isolation of a sialogogic peptide from bovine hypothalamic tissue and its characterization as substance P. J Biol Chem 245:4784-4790
2. Aliakbari J, Sreedharan SP, Turck CW, Goetzl EJ 1987 Selective localization of vasoactive intestinal peptide and substance P in human eosinophils. Biochem Biophys Res Commun 148:1440-1445 (Pubitemid 18074676)
3. Ho WZ, Lai JP, Zhu XH, Uvaydova M, Douglas SD 1997 Human monocytes and macrophages express substance P and neurokinin-1 receptor. J Immunol 159:5654-5660 (Pubitemid 127470097)
4. Holzer P 1988 Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24:739-768
5. Lai JP, Douglas SD, Ho WZ 1998 Human lymphocytes express substance P and its receptor. J Neuroimmunol 86:80-86 (Pubitemid 28293952)
6. Lundberg JM 1996 Pharmacology of cotransmission in the autonomic nervous system: integrative aspects on amines, neuropeptides, adenosine triphosphate, amino acids and nitric oxide. Pharmacol Rev 48:113-178 (Pubitemid 26108946)
7. Pascual DW, Bost KL 1990 Substance P production by P388D1 macrophages: a possible autocrine function for this neuropeptide. Immunology 71:52-56 (Pubitemid 20296071)
8. Patak EN, Pennefather JN, Story ME 2000 Effects of tachykinins on uterine smooth muscle. Clin Exp Pharmacol Physiol 27:922-927
9. Karagiannides I, Kokkotou E, Tansky M, Tchkonia T, Giorgadze N, O'Brien M, Leeman SE, Kirkland JL, Pothoulakis C 2006 Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes. Proc Natl Acad Sci USA 103:5207-5212
10. Pothoulakis C, Castagliuolo I, Leeman SE, Wang CC, Li H, Hoffman BJ, Mezey E 1998 Substance P receptor expression in intestinal epithelium in clostridium difficile toxin A enteritis in rats. Am J Physiol 275:G68-G75
11. Stewart-Lee A, Burnstock G 1989 Actions of tachykinins on the rabbit mesenteric artery: substance P and [Glp6,L-Pro9]SP6-11 are potent agonists for endothelial neurokinin-1 receptors. Br J Pharmacol 97:1218-1224 (Pubitemid 20051937)
12. Tsuchida K, Shigemoto R, Yokota Y, Nakanishi S 1990 Tissue distribution and quantitation of the mRNAs for three rat tachykinin receptors. Eur J Biochem 193:751-757 (Pubitemid 20381706)
13. Tansky MF, Pothoulakis C, Leeman SE 2007 Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci USA 104:10691-10696 (Pubitemid 47185726)
14. Holzer P, Holzer-Petsche U 1997 Tachykinins in the gut. Part I. Expression, release and motor function. Pharmacol Ther 73:173-217
15. Pothoulakis C, Castagliuolo I, LaMont JT, Jaffer A, O'Keane JC, Snider RM, Leeman SE 1994 CP-96,345, a substance P antagonist, inhibits rat intestinal responses to Clostridium difficile toxin A but not cholera toxin. Proc Natl Acad Sci USA 91:947-951 (Pubitemid 24048485)
16. Castagliuolo I, Valenick L, Liu J, Pothoulakis C 2000 Epidermal growth factor receptor transactivation mediates substance P-induced mitogenic responses in U-373 MG cells. J Biol Chem 275:26545-26550
17. Riegler M, Castagliuolo I, So PT, Lotz M, Wang C, Wlk M, Sogukoglu T, Cosentini E, Bischof G, Hamilton G, Teleky B, Wenzl E, Matthews JB, Pothoulakis C 1999 Effects of substance P on human colonic mucosa in vitro. Am J Physiol 276:G1473-G1483 (Pubitemid 29323454)
18. Koon HW, Pothoulakis C 2006 Immunomodulatory properties of substance P: the gastrointestinal system as a model. Ann NY Acad Sci 1088:23-40 (Pubitemid 47092045)
19. Lazar MA 2005 How obesity causes diabetes: not a tall tale. Science 307:373-375 (Pubitemid 40139971)
20. Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E 2008 Substance P as a novel anti-obesity target. Gastroenterology 134:747-755
21. Hotamisligil GS 2006 Inflammation and metabolic disorders. Nature 444:860-867 (Pubitemid 46024993)
22. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil GS 2002 A central role for JNK in obesity and insulin resistance. Nature 420:333-336 (Pubitemid 35398190)
23. Kim JK, Fillmore JJ, Sunshine MJ, Albrecht B, Higashimori T, Kim DW, Liu ZX, Soos TJ, Cline GW, O'Brien WR, Littman DR, Shulman GI 2004 PKC-theta knockout mice are protected from fat-induced insulin resistance. J Clin Invest 114:823-827 (Pubitemid 39578741)
24. Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, Shoelson SE 2005 Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB. Nat Med 11:183-190 (Pubitemid 40321354)
25. Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE 2001 Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkβ. Science 293:1673-1677 (Pubitemid 32807849)
26. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T 2003 Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 423:762-769 (Pubitemid 36735700)
27. Antoniades C, Antonopoulos AS, Tousoulis D, Stefanadis C 2009 Adiponectin: from obesity to cardiovascular disease. Obesity Reviews 10:269-279
28. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA 2001 Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab 86:1930-1935 (Pubitemid 32472900)
29. Bozic CR, Lu B, Höpken UE, Gerard C, Gerard NP 1996 Neurogenic amplification of immune complex inflammation. Science 273:1722-1725 (Pubitemid 26317790)
30. Holland PM, Abramson RD, Watson R, Gelfand DH 1991 Detection of specific polymerase chain reaction product by utilizing the 5′-3′ exonuclease activity of Thermus aquaticus DNA polymerase. Proc Natl Acad Sci USA 88:7276-7280 (Pubitemid 21915133)
31. Karagiannides I, Tchkonia T, Dobson DE, Steppan CM, Cummins P, Chan G, Salvatori K, Hadzopoulou-Cladaras M, Kirkland JL 2001 Altered expression of C/EBP family members results in decreased adipogenesis with aging. Am J Physiol Regul Integr Comp Physiol 280:R1772-R1780
32. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considine RV 1996 Leptin: the tale of an obesity gene. Diabetes 45:1455-1462 (Pubitemid 26357535)
33. Aguirre V, Uchida T, Yenush L, Davis R, White MF 2000 The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275:9047-9054
34. Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM 1996 IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science 271:665-668 (Pubitemid 26052915)
35. Gross K, Karagiannides I, Thomou T, Koon HW, Bowe C, Kim H, Giorgadze N, Tchkonia T, Pirtskhalava T, Kirkland JL, Pothoulakis C 2009 Substance P promotes expansion of human mesenteric preadipocytes through proliferative and antiapoptotic pathways. Am J Physiol Gastrointest Liver Physiol 296:G1012-G1019
36. Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K 2006 Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784-1792 (Pubitemid 44033298)
37. Yamauchi T, Kadowaki T 2008 Physiological and pathophysiological roles of adiponectin and adiponectin receptors in the integrated regulation of metabolic and cardiovascular diseases. Int J Obes 32(Suppl 7):S13-S18
38. Baroncelli GI, Bertelloni S, Buggiani B, Papini A, Gualtieri M, Saggese G 1989 Evidence of increased levels of substance P in obese children. Funct Neurol 4:183-184 (Pubitemid 19126067)
39. Badman MK, Flier JS 2005 The gut and energy balance: visceral allies in the obesity wars. Science 307:1909-1914 (Pubitemid 40404693)
40. Neels JG, Badeanlou L, Hester KD, Samad F 2009 Keratinocyte-derived chemokine in obesity: expression and role in adipose macrophage infiltration and glucose homeostasis. J Biol Chem 284:20692-20698
41. Bartness TJ, Shrestha YB, Vaughan CH, Schwartz GJ, Song CK 2010 Sensory and sympathetic nervous system control of white adipose tissue lipolysis. Mol Cell Endocrinol 318:34-43
42. Shi H, Song CK, Giordano A, Cinti S, Bartness TJ 2005 Sensory or sympathetic white adipose tissue denervation differentially affects depot growth and cellularity. Am J Physiol-Reg I 288:R1028-R1037 (Pubitemid 40404180)