A sensitive and rapid liquid chromatography-tandem mass spectrometry method for the quantification of the novel neurokinin-1 receptor antagonist aprepitant in rhesus macaque plasma, and cerebral spinal fluid, and human plasma with application in translational NeuroAIDs research

Journal of Pharmaceutical and Biomedical Analysis

Volumn 49, Issue 3, 2009, Pages 739-745

  Wu, Di ^a   Paul, Dustin J ^b   Zhao, Xianguo ^c   Douglas, Steven D ^a,d   Barrett, Jeffrey S ^a,d  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c PharmaOn LLC   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Aprepitant; Cerebral spinal fluid; Liquid chromatography tandem mass spectrometry; Plasma; Translational research

Indexed keywords

ACETONITRILE; APREPITANT; FORMIC ACID; METHANOL; WATER;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; CEREBROSPINAL FLUID; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG MONITORING; ELECTROSPRAY; ELUTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACACA; NONHUMAN; PLASMA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SIMIAN IMMUNODEFICIENCY VIRUS; TANDEM MASS SPECTROMETRY;

AIDS DEMENTIA COMPLEX; ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COST-BENEFIT ANALYSIS; HIV INFECTIONS; HUMANS; MACACA MULATTA; MORPHOLINES; QUALITY CONTROL; RECEPTORS, NEUROKININ-1; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 61449238029     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.12.005     Document Type: Article

References (6)

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6. Food and Drug Administration, US Department of Health and Human Services, Guidance for Industry: Bioanalytical Method Validation. May 2001, Available at: http://www.fda.gov/cder/guidance/4252fnl.pdf. Accessed August 19, 2008.