Substance p stimulates production of inflammatory cytokines in human disc cells

Spine

Volumn 38, Issue 21, 2013, Pages

  Kepler, Christopher K ^a   Markova, Dessislava Z ^a   Hilibrand, Alan S ^a   Vaccaro, Alexander R ^a   Risbud, Makarand V ^a   Albert, Todd J ^a   Anderson, Greg ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Human intervertebral disc cells; Interleukin 1 ; Interleukin 6; Interleukin 8; Neuropeptides; RANTES; Substance P; Tumor necrosis factor

Indexed keywords

ALGINIC ACID; COMPLEMENTARY DNA; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; RANTES; SUBSTANCE P; SUBSTANCE P RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANNULUS FIBROSUS; ARTICLE; CARTILAGE CELL; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATION; INTERVERTEBRAL DISK; MEDIATOR; MONOLAYER CULTURE; NUCLEUS PULPOSUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; UPREGULATION;

ADULT; CHEMOKINE CCL5; CYTOKINES; GENE EXPRESSION; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; INTERLEUKIN-6; INTERLEUKIN-8; INTERVERTEBRAL DISC; MIDDLE AGED; RECEPTORS, NEUROKININ-1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBSTANCE P; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84888646102     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e3182a42bc2     Document Type: Article

References (29)

1. Boden SD, Davis DO, Dina TS, et al. Abnormal magnetic-resonance scans of the lumbar spine in asymptomatic subjects. A prospective investigation . J Bone Joint Surg Am 1990; 72 : 403 - 8 .
2. Boden SD, McCowin PR, Davis DO, et al. Abnormal magneticresonance scans of the cervical spine in asymptomatic subjects. A prospective investigation . J Bone Joint Surg Am 1990; 72 : 1178 - 84 .
3. Chernova I, Lai JP, Li H, et al. Substance P (SP) enhances CCL5- induced chemotaxis and intracellular signaling in human monocytes, which express the truncated neurokinin-1 receptor (NK1R) . J Leukoc Biol 2009; 85 : 154 - 64 .
4. Douglas SD, Leeman SE . Neurokinin-1 receptor: functional significance in the immune system in reference to selected infections and inflammation . Ann N Y Acad Sci 2011; 1217 : 83 - 95 .
5. Satake H, Kawada T . Overview of the primary structure, tissue distribution, and functions of tachykinins and their receptors . Curr Drug Targets 2006; 7 : 963 - 74 .
6. Yamaguchi M, Kojima T, Kanekawa M, et al. Neuropeptides stimulate production of interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha in human dental pulp cells . Inflamm Res 2004; 53 : 199 - 204 .
7. VEuler US, Gaddum JH . An unidentified depressor substance in certain tissue extracts . J Physiol 1931; 72 : 74 - 87 .
8. Choi JY, Khansaheb M, Joo NS, et al. Substance P stimulates human airway submucosal gland secretion mainly via a CFTR-dependent process . J Clin Invest 2009; 119 : 1189 - 200 .
9. Bogduk N, Windsor M, Inglis A . The innervation of the cervical intervertebral discs . Spine 1988; 13 : 2 - 8 .
10. Freemont AJ, Peacock TE, Goupille P, et al. Nerve in growth into diseased inter vertebral disc in chronic back pain . Lancet 1997; 350 : 178 - 81 .
11. Richardson SM, Doyle P, Minogue BM, et al. Increased expression of matrix metalloproteinase-10, nerve growth factor and Substance P in the painful degenerate inter vertebral disc . Arthritis Res Ther 2009; 11 : R126 .
12. Purmessur D, Freemont AJ, Hoyland JA . Expression and regulation of neurotrophins in the non degenerate and degenerate human inter vertebral disc . Arthritis Res Ther 2008; 10 : R99 .
13. Beaman DN, Graziano GP, Glover RA, et al. Substance P innervation of lumbar spine facet joints . Spine 1993; 18 : 1044 - 9 .
14. Pfirrmann CW, Metzdorf A, Zanetti M, et al. Magnetic resonance classification of lumbar inter vertebral disc degeneration . Spine 2001; 26 : 1873 - 8 .
15. Ashton IK, Roberts S, Jaffray DC, et al. Neuropeptides in the human inter vertebral disc . J Orthop Res 1994; 12 : 186 - 92 .
16. Coppes MH, Marani E, Thomeer RT, et al. Innervation of "painful" lumbar discs . Spine 1997; 22 : 2342 - 9; discussion 2349-50.
17. Kokubo Y, Uchida K, Kobayashi S, et al. Herniated and spondylotic inter vertebral discs of the human cervical spine: histological and immunohistological fi ndings in 500 en bloc surgical samples. Laboratory investigation . J Neurosurg Spine 2008; 9 : 285 - 95 .
18. Sio SW, Puthia MK, Lu J, et al. The neuropeptide Substance P is a critical mediator of burn-induced acute lung injury . J Immunol 2008; 180 : 8333 - 41 .
19. Ramnath RD, Sun J, Bhatia M . Role of calcium in Substance P-induced chemokine synthesis in mouse pancreatic acinar cells . Br J Pharmacol 2008; 154 : 1339 - 48 .
20. Halliday DA, McNeil JD, Betts WH, et al. The Substance P fragment SP-(7-11) increases prostaglandin E2, intracellular Ca 2 + and collagenase production in bovine articular chondrocytes . Biochem J 1993; 292 : 57 - 62 .
21. Millward-Sadler SJ, Mackenzie A, Wright MO, et al. Tachykinin expression in cartilage and function in human articular chondrocyte mechanotransduction . Arthritis Rheum 2003; 48 : 146 - 56 .
22. Im HJ, Li X, Muddasani P, et al. Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes . J Cell Physiol 2008; 215 : 452 - 63 .
23. Lui PP, Chan LS, Fu SC, et al. Expression of sensory neuropeptides in tendon is associated with failed healing and activity-related tendon pain in collage nase-induced tendon injury . Am J Sports Med 2010; 38 : 757 - 64 .
24. Shih C, Bernard GW . Neurogenic Substance P stimulates osteogenesis in vitro . Peptides 1997; 18 : 323 - 6 .
25. Wang L, Zhao R, Shi X, et al. Substance P stimulates bone marrow stromal cell osteogenic activity, osteoclast differentiation, and resorption activity in vitro . Bone 2009; 45 : 309 - 20 .
26. Kepler CK, Markova DZ, Dibra F, et al. The expression and relationship of pro-infl ammatory chemokine RANTES/CCL5 and cytokine IL-1beta in painful human intervertebral discs [published online ahead of print January 15, 2013] . Spine . doi: 10.1097/BRS.0b013e318285ae08.
27. Grimsholm O, Guo Y, Ny T, et al. Are neuropeptides important in arthritis? Studies on the importance of bombesin/GRP and Substance P in a murine arthritis model . Ann N Y Acad Sci 2007; 1110 : 525 - 38 .
28. Hernanz A, De Miguel E, Romera N, et al. Calcitonin generelated peptide II, Substance P and vasoactive intestinal peptide in plasma and synovial fluid from patients with inflammatory joint disease . Br J Rheumatol 1993; 32 : 31 - 5 .
29. Arnalich F, de Miguel E, Perez-Ayala C, et al. Neuropeptides and interleukin-6 in human joint inflammation relationship between intraarticular Substance P and interleukin-6 concentrations . Neurosci Lett 1994; 170 : 251 - 4 .