메뉴 건너뛰기




Volumn 9, Issue 2, 2012, Pages 139-147

HIV and inflammation: Mechanisms and consequences

Author keywords

Antiretroviral therapy; Co infections; HIV; Inflammation; Microbial translocation; Non AIDS morbidity; Non AIDS mortality; T cell activation

Indexed keywords

C REACTIVE PROTEIN; D DIMER; FATTY ACID BINDING PROTEIN 2; HYALURONIC ACID; INTERLEUKIN 6; MITOCHONDRIAL DNA; RALTEGRAVIR; VALGANCICLOVIR; VIRUS RNA; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIINFLAMMATORY AGENT;

EID: 84863991281     PISSN: 15483568     EISSN: 15483576     Source Type: Journal    
DOI: 10.1007/s11904-012-0118-8     Document Type: Article
Times cited : (321)

References (95)
  • 1
    • 0019782357 scopus 로고
    • Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. Evidence of a new acquired cellular immunodeficiency
    • Gottlieb MS, Schroff R, Schanker HM, et al. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men: evidence of a new acquired cellular immunodeficiency. N Engl J Med. 1981;305(24):1425- 31. (Pubitemid 12240076)
    • (1981) New England Journal of Medicine , vol.305 , Issue.24 , pp. 1425-1431
    • Gottlieb, M.S.1    Schroff, R.2    Schanker, H.M.3
  • 2
    • 0032504919 scopus 로고    scopus 로고
    • Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements
    • DOI 10.1097/00002030-199813000-00004
    • Fahey JL, Taylor JM, Manna B, et al. Prognostic significance of plasma markers of immune activation, HIV viral load and CD4 T-cell measurements. AIDS. 1998;12(13):1581-90. (Pubitemid 28418327)
    • (1998) AIDS , vol.12 , Issue.13 , pp. 1581-1590
    • Fahey, J.L.1    Taylor, J.M.G.2    Manna, B.3    Nishanian, P.4    Aziz, N.5    Giorgi, J.V.6    Detels, R.7
  • 3
    • 0027965585 scopus 로고
    • CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: Development of HLA-DR+CD38-CD8+ cells is associated with subsequent stable CD4+ cell levels
    • The Multicenter AIDS Cohort Study Group
    • Giorgi JV, Ho HN, Hirji K, et al. CD8+ lymphocyte activation at human immunodeficiency virus type 1 seroconversion: development of HLA-DR+CD38-CD8+ cells is associated with subsequent stable CD4+ cell levels. The Multicenter AIDS Cohort Study Group. J Infect Dis. 1994;170(4):775-81.
    • (1994) J Infect Dis. , vol.170 , Issue.4 , pp. 775-781
    • Giorgi, J.V.1    Ho, H.N.2    Hirji, K.3
  • 7
    • 0030668834 scopus 로고    scopus 로고
    • Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multi-center AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression
    • Liu Z, Cumberland WG, Hultin LE, et al. Elevated CD38 antigen expression on CD8+ T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multi-center AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16 (2):83-92.
    • (1997) J Acquir Immune Defic Syndr Hum Retrovirol , vol.16 , Issue.2 , pp. 83-92
    • Liu, Z.1    Cumberland, W.G.2    Hultin, L.E.3
  • 9
    • 19344370239 scopus 로고    scopus 로고
    • Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection
    • Papagno L, Spina CA, Marchant A, et al. Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection. PLoS Biol. 2004;2(2):E20.
    • (2004) PLoS Biol. , vol.2 , Issue.2
    • Papagno, L.1    Spina, C.A.2    Marchant, A.3
  • 11
    • 79957940339 scopus 로고    scopus 로고
    • Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy
    • Burdo TH, Lentz MR, Autissier P, et al. Soluble CD163 made by monocyte/macrophages is a novel marker of HIV activity in early and chronic infection prior to and after anti-retroviral therapy. J Infect Dis 2011, 204(1): p. 154-63.
    • (2011) J Infect Dis , vol.204 , Issue.1 , pp. 154-163
    • Burdo, T.H.1    Lentz, M.R.2    Autissier, P.3
  • 13
    • 77953901782 scopus 로고    scopus 로고
    • Nonprogressive and progressive primate immunodeficiency lentivirus infections
    • Brenchley JM, Silvestri G, Douek DC. Nonprogressive and progressive primate immunodeficiency lentivirus infections. Immunity. 2010;32(6):737-42.
    • (2010) Immunity , vol.32 , Issue.6 , pp. 737-742
    • Brenchley, J.M.1    Silvestri, G.2    Douek, D.C.3
  • 14
    • 0037343278 scopus 로고    scopus 로고
    • Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia
    • DOI 10.1016/S1074-7613(03)00060-8
    • Silvestri G, Sodora DL, Koup RA, et al. Nonpathogenic SIV infection of sooty mangabeys is characterized by limited bystander immunopathology despite chronic high-level viremia. Immunity. 2003;18(3):441-52. (Pubitemid 36351522)
    • (2003) Immunity , vol.18 , Issue.3 , pp. 441-452
    • Silvestri, G.1    Sodora, D.L.2    Koup, R.A.3    Paiardini, M.4    O'Neil, S.P.5    McClure, H.M.6    Staprans, S.I.7    Feinberg, M.B.8
  • 15
    • 70449494637 scopus 로고    scopus 로고
    • The level of monocyte turnover predicts disease progression in the macaque model of AIDS
    • Hasegawa A, Liu H, Ling B, et al. The level of monocyte turnover predicts disease progression in the macaque model of AIDS. Blood. 2009;114(14):2917-25.
    • (2009) Blood , vol.114 , Issue.14 , pp. 2917-2925
    • Hasegawa, A.1    Liu, H.2    Ling, B.3
  • 16
    • 53549103852 scopus 로고    scopus 로고
    • Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections
    • Mandl JN, Barry AP, Vanderford TH, et al. Divergent TLR7 and TLR9 signaling and type I interferon production distinguish pathogenic and nonpathogenic AIDS virus infections. Nat Med. 2008;14 (10):1077-87.
    • (2008) Nat Med. , vol.14 , Issue.10 , pp. 1077-1087
    • Mandl, J.N.1    Barry, A.P.2    Vanderford, T.H.3
  • 17
    • 72849132344 scopus 로고    scopus 로고
    • Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys
    • Bosinger SE, Li Q, Gordon SN, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest. 2009;119(12):3556-72.
    • (2009) J Clin Invest. , vol.119 , Issue.12 , pp. 3556-3572
    • Bosinger, S.E.1    Li, Q.2    Gordon, S.N.3
  • 18
    • 53449093632 scopus 로고    scopus 로고
    • Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections
    • Brenchley JM, Paiardini M, Knox KS, et al. Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections. Blood. 2008;112(7):2826-35.
    • (2008) Blood , vol.112 , Issue.7 , pp. 2826-2835
    • Brenchley, J.M.1    Paiardini, M.2    Knox, K.S.3
  • 19
    • 61449115882 scopus 로고    scopus 로고
    • Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection
    • Favre D, Lederer S, Kanwar B, et al. Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog. 2009;5(2):e1000295.
    • (2009) PLoS Pathog. , vol.5 , Issue.2
    • Favre, D.1    Lederer, S.2    Kanwar, B.3
  • 21
    • 77952977625 scopus 로고    scopus 로고
    • Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease
    • Favre D, Mold J, Hunt PW, et al. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2010;2 (32):32ra36.
    • (2010) Sci Transl Med , vol.2 , Issue.32
    • Favre, D.1    Mold, J.2    Hunt, P.W.3
  • 22
    • 0037183954 scopus 로고    scopus 로고
    • Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease
    • Valdez H, Connick E, Smith KY, et al. Limited immune restoration after 3 years' suppression of HIV-1 replication in patients with moderately advanced disease. AIDS. 2002;16(14):1859-66.
    • (2002) AIDS , vol.16 , Issue.14 , pp. 1859-1866
    • Valdez, H.1    Connick, E.2    Smith, K.Y.3
  • 23
    • 0038701685 scopus 로고    scopus 로고
    • + T cell gains in human immunodeficiency vires-infected patients with sustained viral suppression during antiretroviral therapy
    • DOI 10.1086/374786
    • Hunt PW, Martin JN, Sinclair E, et al. T cell activation is associated with lower CD4+ T cell gains in human immunodeficiency virus-infected patients with sustained viral suppression during antiretroviral therapy. J Infect Dis. 2003;187(10):1534-43. (Pubitemid 36578959)
    • (2003) Journal of Infectious Diseases , vol.187 , Issue.10 , pp. 1534-1543
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3    Bredt, B.4    Hagos, E.5    Lampiris, H.6    Deeks, S.G.7
  • 24
    • 33745214932 scopus 로고    scopus 로고
    • Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: Association of immune activation, T cell maturation markers, and cellular HIV-1 DNA
    • Goicoechea M, Smith DM, Liu L, et al. Determinants of CD4+ T cell recovery during suppressive antiretroviral therapy: association of immune activation, T cell maturation markers, and cellular HIV-1 DNA. J Infect Dis. 2006;194(1):29-37.
    • (2006) J Infect Dis. , vol.194 , Issue.1 , pp. 29-37
    • Goicoechea, M.1    Smith, D.M.2    Liu, L.3
  • 26
    • 80055049890 scopus 로고    scopus 로고
    • Impact of CD8+ T Cell activation on CD4+ T cell recovery and mortality in HIV-infected ugandans initiating antiretroviral therapy
    • Hunt PW, Cao H, Muzoora C, et al. Impact of CD8+ T Cell Activation on CD4+ T Cell Recovery and Mortality in HIV-infected Ugandans Initiating Antiretroviral Therapy. AIDS, 2011;25(17):2123-31.
    • (2011) AIDS , vol.25 , Issue.17 , pp. 2123-2131
    • Hunt, P.W.1    Cao, H.2    Muzoora, C.3
  • 27
    • 77950947891 scopus 로고    scopus 로고
    • CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART
    • Massanella M, Negredo E, Perez-Alvarez N, et al. CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART AIDS. 2010;24 (7):959-68.
    • (2010) AIDS , vol.24 , Issue.7 , pp. 959-968
    • Massanella, M.1    Negredo, E.2    Perez-Alvarez, N.3
  • 28
    • 77950979658 scopus 로고    scopus 로고
    • Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 Tcell recovery in virologically suppressed HIV-infected patients: Clinical implications
    • Negredo E, Massanella M, Puig J, et al. Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 Tcell recovery in virologically suppressed HIV-infected patients: clinical implications. Clin Infect Dis. 2010;50 (9):1300-8.
    • (2010) Clin Infect Dis. , vol.50 , Issue.9 , pp. 1300-1308
    • Negredo, E.1    Massanella, M.2    Puig, J.3
  • 29
    • 80052882129 scopus 로고    scopus 로고
    • Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
    • Lederman MM, Calabrese L, Funderburg NT, et al. Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells. J Infect Dis. 2011;204 (8):1217-26.
    • (2011) J Infect Dis. , vol.204 , Issue.8 , pp. 1217-1226
    • Lederman, M.M.1    Calabrese, L.2    Funderburg, N.T.3
  • 30
    • 70349433735 scopus 로고    scopus 로고
    • Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells
    • French MA, King MS, Tschampa JM, et al. Serum immune activation markers are persistently increased in patients with HIV infection after 6 years of antiretroviral therapy despite suppression of viral replication and reconstitution of CD4+ T cells. J Infect Dis. 2009;200(8):1212-5.
    • (2009) J Infect Dis. , vol.200 , Issue.8 , pp. 1212-1215
    • French, M.A.1    King, M.S.2    Tschampa, J.M.3
  • 31
    • 77952571995 scopus 로고    scopus 로고
    • Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection
    • Neuhaus J, Jacobs DR Jr., Baker JV, et al. Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. J Infect Dis 2010;201(12):1788-95.
    • (2010) J Infect Dis , vol.201 , Issue.12 , pp. 1788-1795
    • Neuhaus, J.1    Jacobs Jr., D.R.2    Baker, J.V.3
  • 32
    • 84879169421 scopus 로고    scopus 로고
    • Antiretroviral Therapy Initiation during Acute/Early HIV Infection vs. Later ART Initiation is Associated with Improved Immunologic and Virologic Parameters during Suppressive ART
    • Boston, MA, Abstract #517
    • Jain V, Hartogensis W, Bacchetti P, et al. Antiretroviral Therapy Initiation during Acute/Early HIV Infection vs. Later ART Initiation is Associated with Improved Immunologic and Virologic Parameters during Suppressive ART. in In the Program and Abstracts of the 18th Conference on Retroviruses and Opportunistic Infections, Boston, MA, Abstract #517. 2011.
    • (2011) The Program and Abstracts of the 18th Conference on Retroviruses and Opportunistic Infections
    • Jain, V.1    Hartogensis, W.2    Bacchetti, P.3
  • 34
    • 80051633217 scopus 로고    scopus 로고
    • Prevention of HIV-1 infection with early antiretroviral therapy
    • Cohen MS, Chen YQ, McCauley M, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med. 2011;365 (6):493-505.
    • (2011) N Engl J Med. , vol.365 , Issue.6 , pp. 493-505
    • Cohen, M.S.1    Chen, Y.Q.2    McCauley, M.3
  • 36
    • 77953916742 scopus 로고    scopus 로고
    • Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals
    • van Sighem AI, Gras LA, Reiss P, et al. Life expectancy of recently diagnosed asymptomatic HIV-infected patients approaches that of uninfected individuals. AIDS. 2010;24(10):1527-35.
    • (2010) AIDS , vol.24 , Issue.10 , pp. 1527-1535
    • Van Sighem, A.I.1    Gras, L.A.2    Reiss, P.3
  • 37
    • 47649115323 scopus 로고    scopus 로고
    • Life expectancy of individuals on combination antiretroviral therapy in high-income countries: A collaborative analysis of 14 cohort studies
    • The Antiretroviral Therapy Cohort Collaboration
    • The Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet. 2008;372(9635):293-9.
    • (2008) Lancet , vol.372 , Issue.9635 , pp. 293-299
  • 38
    • 53549129725 scopus 로고    scopus 로고
    • Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy
    • Marchetti G, Bellistri GM, Borghi E, et al. Microbial translocation is associated with sustained failure in CD4+ T-cell reconstitution in HIV-infected patients on long-term highly active antiretroviral therapy. AIDS. 2008;22(15):2035-8.
    • (2008) AIDS , vol.22 , Issue.15 , pp. 2035-2038
    • Marchetti, G.1    Bellistri, G.M.2    Borghi, E.3
  • 39
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Lederman MM, Hunt P, et al. Plasma Levels of Bacterial DNA Correlate with Immune Activation and the Magnitude of Immune Restoration in Persons with Antiretroviral-Treated HIV Infection. J Infect Dis 2009;199(8):1177-1185.
    • (2009) J Infect Dis , vol.199 , Issue.8 , pp. 1177-1185
    • Jiang, W.1    Lederman, M.M.2    Hunt, P.3
  • 41
    • 34247584237 scopus 로고    scopus 로고
    • ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia
    • Maldarelli F, Palmer S, King MS, et al. ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia. PLoS Pathog. 2007;3(4):e46.
    • (2007) PLoS Pathog. , vol.3 , Issue.4
    • Maldarelli, F.1    Palmer, S.2    King, M.S.3
  • 43
    • 67249121143 scopus 로고    scopus 로고
    • Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy
    • Dinoso JB, Kim SY, Wiegand AM, et al. Treatment intensification does not reduce residual HIV-1 viremia in patients on highly active antiretroviral therapy. Proc Natl Acad Sci USA. 2009;106 (23):9403-8.
    • (2009) Proc Natl Acad Sci USA , vol.106 , Issue.23 , pp. 9403-9408
    • Dinoso, J.B.1    Kim, S.Y.2    Wiegand, A.M.3
  • 44
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi RT, Zheng L, Bosch RJ, et al. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PLoS Med 2010, 7(8):e1000321.
    • (2010) PLoS Med , vol.7 , Issue.8
    • Gandhi, R.T.1    Zheng, L.2    Bosch, R.J.3
  • 45
    • 79953000877 scopus 로고    scopus 로고
    • A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response
    • Hatano H, Hayes TL, Dahl V, et al. A randomized, controlled trial of raltegravir intensification in antiretroviral-treated, HIV-infected patients with a suboptimal CD4+ T cell response. J Infect Dis. 2011;203(7):960-8.
    • (2011) J Infect Dis. , vol.203 , Issue.7 , pp. 960-968
    • Hatano, H.1    Hayes, T.L.2    Dahl, V.3
  • 46
    • 77950537810 scopus 로고    scopus 로고
    • HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects
    • Buzon MJ, Massanella M, Llibre JM, et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAART-suppressed subjects. Nat Med. 2010;16(4):460-5.
    • (2010) Nat Med. , vol.16 , Issue.4 , pp. 460-465
    • Buzon, M.J.1    Massanella, M.2    Llibre, J.M.3
  • 47
    • 84860345691 scopus 로고    scopus 로고
    • Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: A randomized 48-week study
    • Llibre JM, Buzon MJ, Massanella M, et al. Treatment intensification with raltegravir in subjects with sustained HIV-1 viraemia suppression: a randomized 48-week study. Antivir Ther 2012;17(2):355-64.
    • (2012) Antivir Ther , vol.17 , Issue.2 , pp. 355-364
    • Llibre, J.M.1    Buzon, M.J.2    Massanella, M.3
  • 50
    • 0142092389 scopus 로고    scopus 로고
    • + T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy
    • DOI 10.1128/JVI.77.21.11708-11717.2003
    • Guadalupe M, Reay E, Sankaran S, et al. Severe CD4+ T-cell depletion in gut lymphoid tissue during primary human immunodeficiency virus type 1 infection and substantial delay in restoration following highly active antiretroviral therapy. J Virol. 2003;77 (21):11708-17. (Pubitemid 37271669)
    • (2003) Journal of Virology , vol.77 , Issue.21 , pp. 11708-11717
    • Guadalupe, M.1    Reay, E.2    Sankaran, S.3    Prindiville, T.4    Flamm, J.5    McNeil, A.6    Dandekar, S.7
  • 52
    • 37349078686 scopus 로고    scopus 로고
    • Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration
    • DOI 10.1128/JVI.01449-07
    • Sankaran S, George MD, Reay E, et al. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. J Virol. 2008;82 (1):538-45. (Pubitemid 350309168)
    • (2008) Journal of Virology , vol.82 , Issue.1 , pp. 538-545
    • Sankaran, S.1    George, M.D.2    Reay, E.3    Guadalupe, M.4    Flamm, J.5    Prindiville, T.6    Dandekar, S.7
  • 54
    • 58949102533 scopus 로고    scopus 로고
    • Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients
    • Epple HJ, Schneider T, Troeger H, et al. Impairment of the intestinal barrier is evident in untreated but absent in suppressively treated HIV-infected patients. Gut. 2009;58(2):220-7.
    • (2009) Gut , vol.58 , Issue.2 , pp. 220-227
    • Epple, H.J.1    Schneider, T.2    Troeger, H.3
  • 56
    • 77955690397 scopus 로고    scopus 로고
    • Persistent mcrobial translocation and immune activation in HIV-1-infected south Africans receiving combination antiretroviral therapy
    • Cassol E, Malfeld S, Mahasha P, et al. Persistent Mcrobial Translocation and Immune Activation in HIV-1-Infected South Africans Receiving Combination Antiretroviral Therapy. J Infect Dis. 2010;202 (5):723-33.
    • (2010) J Infect Dis. , vol.202 , Issue.5 , pp. 723-733
    • Cassol, E.1    Malfeld, S.2    Mahasha, P.3
  • 57
    • 75649127335 scopus 로고    scopus 로고
    • Increased tissue factor expression on circulating monocytes in chronic HIV infection: Relationship to in vivo coagulation and immune activation
    • Funderburg NT, Mayne E, Sieg SF, et al. Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation. Blood 2010;115(2):161-7.
    • (2010) Blood , vol.115 , Issue.2 , pp. 161-167
    • Funderburg, N.T.1    Mayne, E.2    Sieg, S.F.3
  • 58
    • 80054739868 scopus 로고    scopus 로고
    • Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: A randomized controlled trial
    • Byakwaga H, Kelly M, Purcell DF, et al. Intensification of antiretroviral therapy with raltegravir or addition of hyperimmune bovine colostrum in HIV-infected patients with suboptimal CD4+ T-cell response: A randomized controlled trial. J Infect Dis 2011;204(10): 1532-40.
    • (2011) J Infect Dis , vol.204 , Issue.10 , pp. 1532-1540
    • Byakwaga, H.1    Kelly, M.2    Purcell, D.F.3
  • 59
    • 84860390171 scopus 로고    scopus 로고
    • Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: Results of the "COPA" pilot randomized trial
    • Gori A, Rizzardini G, Van't Land B, et al. Specific prebiotics modulate gut microbiota and immune activation in HAART-naive HIV-infected adults: results of the "COPA" pilot randomized trial. Mucosal Immunol 2011;4(5):554-63.
    • (2011) Mucosal Immunol , vol.4 , Issue.5 , pp. 554-563
    • Gori, A.1    Rizzardini, G.2    Van't Land, B.3
  • 60
    • 78049505077 scopus 로고    scopus 로고
    • Reduction of immune activation during chronic hiv infection with chloroquine therapy
    • Murray SM, Down CM, Boulware DR, et al. Reduction of immune activation during chronic hiv infection with chloroquine therapy. J Virol 2010;84(22):12082-6.
    • (2010) J Virol , vol.84 , Issue.22 , pp. 12082-12086
    • Murray, S.M.1    Down, C.M.2    Boulware, D.R.3
  • 61
    • 80053203528 scopus 로고    scopus 로고
    • Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders
    • Piconi S, Parisotto S, Rizzardini G, et al. Hydroxychloroquine drastically reduces immune activation in HIV-infected, antiretroviral therapy-treated immunologic nonresponders. Blood 2011;118 (12):3263-72.
    • (2011) Blood , vol.118 , Issue.12 , pp. 3263-3272
    • Piconi, S.1    Parisotto, S.2    Rizzardini, G.3
  • 63
    • 77952507646 scopus 로고    scopus 로고
    • Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease
    • Naeger DM, Martin JN, Sinclair E, et al. Cytomegalovirus-specific T cells persist at very high levels during long-term antiretroviral treatment of HIV disease. PLoS One. 2010;5(1):e8886.
    • (2010) PLoS One , vol.5 , Issue.1
    • Naeger, D.M.1    Martin, J.N.2    Sinclair, E.3
  • 65
    • 79955028940 scopus 로고    scopus 로고
    • Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy
    • Hunt PW, Martin JN, Sinclair E, et al. Valganciclovir reduces T cell activation in HIV-infected individuals with incomplete CD4+ T cell recovery on antiretroviral therapy. J Infect Dis 2011;203(10):1474-83.
    • (2011) J Infect Dis , vol.203 , Issue.10 , pp. 1474-1483
    • Hunt, P.W.1    Martin, J.N.2    Sinclair, E.3
  • 69
    • 0035916309 scopus 로고    scopus 로고
    • Cardiovascular disease, interleukin-6, and risk of mortality in older women: The women's health and aging study
    • Volpato S, Guralnik JM, Ferrucci L, et al. Cardiovascular disease, interleukin-6, and risk of mortality in older women: the women's health and aging study. Circulation. 2001;103(7):947-53. (Pubitemid 32183799)
    • (2001) Circulation , vol.103 , Issue.7 , pp. 947-953
    • Volpato, S.1    Guralnik, J.M.2    Ferrucci, L.3    Balfour, J.4    Chaves, P.5    Fried, L.P.6    Harris, T.B.7
  • 72
    • 55949084601 scopus 로고    scopus 로고
    • Inflammatory and coagulation biomarkers and mortality in patients with HIV infection
    • Kuller LH, Tracy R, Belloso W, et al. Inflammatory and coagulation biomarkers and mortality in patients with HIV infection. PLoS Medicine. 2008;5(10):e203.
    • (2008) PLoS Medicine , vol.5 , Issue.10
    • Kuller, L.H.1    Tracy, R.2    Belloso, W.3
  • 74
    • 77952556107 scopus 로고    scopus 로고
    • Pretreatment levels of soluble cellular receptors and interleukin-6 are associated with HIV disease progression in subjects treated with highly active antiretroviral therapy
    • Kalayjian RC, Machekano RN, Rizk N, et al. Pretreatment levels of soluble cellular receptors and interleukin-6 are associated with HIV disease progression in subjects treated with highly active antiretroviral therapy. J Infect Dis. 2010;201(12):1796-805.
    • (2010) J Infect Dis. , vol.201 , Issue.12 , pp. 1796-1805
    • Kalayjian, R.C.1    Machekano, R.N.2    Rizk, N.3
  • 75
    • 79956196632 scopus 로고    scopus 로고
    • Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death
    • Boulware DR, Hullsiek KH, Puronen CE, et al. Higher levels of CRP, D-dimer, IL-6, and hyaluronic acid before initiation of antiretroviral therapy (ART) are associated with increased risk of AIDS or death. J Infect Dis 2011;203(11):1637-46.
    • (2011) J Infect Dis , vol.203 , Issue.11 , pp. 1637-1646
    • Boulware, D.R.1    Hullsiek, K.H.2    Puronen, C.E.3
  • 76
    • 79952335046 scopus 로고    scopus 로고
    • Plasma levels of soluble CD14 independently predict mortality in HIV infection
    • Sandler NG, Wand H, Roque A, et al. Plasma levels of soluble CD14 independently predict mortality in HIV infection. J Infect Dis 2011;203(6):780-90.
    • (2011) J Infect Dis , vol.203 , Issue.6 , pp. 780-790
    • Sandler, N.G.1    Wand, H.2    Roque, A.3
  • 78
    • 84861052801 scopus 로고    scopus 로고
    • Immunologic basis of cardiovascular disease in HIV-infected adults
    • in press
    • Hsue PY, Deeks SG, Hunt PW. Immunologic Basis of Cardiovascular Disease in HIV-Infected Adults. J Infect Dis 2012, in press.
    • (2012) J Infect Dis
    • Hsue, P.Y.1    Deeks, S.G.2    Hunt, P.W.3
  • 80
    • 80055054267 scopus 로고    scopus 로고
    • Inflammation predicts changes in high-density lipoprotein particles and apolipoprotein A1 following initiation of antiretroviral therapy
    • Baker JV, Neuhaus J, Duprez D, et al. Inflammation predicts changes in high-density lipoprotein particles and apolipoprotein A1 following initiation of antiretroviral therapy. AIDS. 2011;25 (17):2133-42.
    • (2011) AIDS , vol.25 , Issue.17 , pp. 2133-2142
    • Baker, J.V.1    Neuhaus, J.2    Duprez, D.3
  • 81
    • 78650682935 scopus 로고    scopus 로고
    • Changes in inflammatory and coagulation biomarkers: A randomized comparison of immediate versus deferred antiretroviral therapy in patients with HIV infection
    • Baker JV, Neuhaus J, Duprez D, et al. Changes in inflammatory and coagulation biomarkers: a randomized comparison of immediate versus deferred antiretroviral therapy in patients with HIV infection. J Acquir Immune Defic Syndr. 2011;56(1):36-43.
    • (2011) J Acquir Immune Defic Syndr. , vol.56 , Issue.1 , pp. 36-43
    • Baker, J.V.1    Neuhaus, J.2    Duprez, D.3
  • 82
    • 79953766478 scopus 로고    scopus 로고
    • Markers of endothelial dysfunction, coagulation and tissue fibrosis independently predict venous thromboembolism in HIV
    • Musselwhite LW, Sheikh V, Norton TD, et al. Markers of endothelial dysfunction, coagulation and tissue fibrosis independently predict venous thromboembolism in HIV AIDS. 2011;25(6):787-95.
    • (2011) AIDS , vol.25 , Issue.6 , pp. 787-795
    • Musselwhite, L.W.1    Sheikh, V.2    Norton, T.D.3
  • 83
    • 79951716000 scopus 로고    scopus 로고
    • Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy
    • Brown TT, Tassiopoulos K, Bosch RJ, et al. Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy. Diabetes Care 2010;33(10):2244-9.
    • (2010) Diabetes Care , vol.33 , Issue.10 , pp. 2244-2249
    • Brown, T.T.1    Tassiopoulos, K.2    Bosch, R.J.3
  • 84
    • 79960102823 scopus 로고    scopus 로고
    • B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma
    • Breen EC, Hussain SK, Magpantay L, et al. B-cell stimulatory cytokines and markers of immune activation are elevated several years prior to the diagnosis of systemic AIDS-associated non-Hodgkin B-cell lymphoma. Cancer Epidemiol Biomarkers Prev 2011;20(7):1303-14.
    • (2011) Cancer Epidemiol Biomarkers Prev , vol.20 , Issue.7 , pp. 1303-1314
    • Breen, E.C.1    Hussain, S.K.2    Magpantay, L.3
  • 87
    • 73549093387 scopus 로고    scopus 로고
    • Towards a combined prognostic index for survival in HIV infection: The role of 'non-HIV biomarkers
    • Justice AC, McGinnis KA, Skanderson M, et al. Towards a combined prognostic index for survival in HIV infection: the role of 'non-HIV biomarkers. HIV Med. 2010;11(2):143-51.
    • (2010) HIV Med. , vol.11 , Issue.2 , pp. 143-151
    • Justice, A.C.1    McGinnis, K.A.2    Skanderson, M.3
  • 88
    • 84858132523 scopus 로고    scopus 로고
    • Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?
    • Justice AC, Freiberg MS, Tracy R, et al. Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV? Clin Infect Dis 2012;54(7):984-994.
    • (2012) Clin Infect Dis , vol.54 , Issue.7 , pp. 984-994
    • Justice, A.C.1    Freiberg, M.S.2    Tracy, R.3
  • 89
    • 84870806164 scopus 로고    scopus 로고
    • Frailty in HIV-1 infected individuals is associated with immune activation and inflammation but not immune senescence
    • Treatment and Prevention, Rome, Italy, Abstract #TULBPE029
    • Erlandson K, Allshouse A, MaWhinney S, et al. Frailty in HIV-1 infected individuals is associated with immune activation and inflammation but not immune senescence. in in the Program and Abstracts from the 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention, Rome, Italy, Abstract #TULBPE029. 2011.
    • (2011) The Program and Abstracts from the 6th IAS Conference on HIV Pathogenesis
    • Erlandson, K.1    Allshouse, A.2    MaWhinney, S.3
  • 90
    • 63149194327 scopus 로고    scopus 로고
    • Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men
    • Desquilbet L, Margolick JB, Fried LP, et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr. 2009;50(3):299-306.
    • (2009) J Acquir Immune Defic Syndr. , vol.50 , Issue.3 , pp. 299-306
    • Desquilbet, L.1    Margolick, J.B.2    Fried, L.P.3
  • 92
    • 79960930133 scopus 로고    scopus 로고
    • Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations
    • Payne BA, Wilson IJ, Hateley CA, et al. Mitochondrial aging is accelerated by anti-retroviral therapy through the clonal expansion of mtDNA mutations. Nat Genet. 2011;43(8):806-10.
    • (2011) Nat Genet. , vol.43 , Issue.8 , pp. 806-810
    • Payne, B.A.1    Wilson, I.J.2    Hateley, C.A.3
  • 93
    • 11144243979 scopus 로고    scopus 로고
    • Modification of the incidence of drug-associated symmetrical peripheral neuropathy by host and disease factors in the HIV outpatient study cohort
    • DOI 10.1086/426076
    • Lichtenstein KA, Armon C, Baron A, et al. Modification of the incidence of drug-associated symmetrical peripheral neuropathy by host and disease factors in the HIV outpatient study cohort. Clin Infect Dis. 2005;40(1):148-57. (Pubitemid 40053473)
    • (2005) Clinical Infectious Diseases , vol.40 , Issue.1 , pp. 148-157
    • Lichtenstein, K.A.1    Armon, C.2    Baron, A.3    Moorman, A.C.4    Wood, K.C.5    Holmberg, S.D.6
  • 94
    • 79952341800 scopus 로고    scopus 로고
    • High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: Results of a double-blind randomized placebo controlled clinical trial
    • Ganesan A, Crum-Cianflone N, Higgins J, et al. High dose atorvastatin decreases cellular markers of immune activation without affecting HIV-1 RNA levels: results of a double-blind randomized placebo controlled clinical trial. J Infect Dis. 2011;203(6):756-64.
    • (2011) J Infect Dis. , vol.203 , Issue.6 , pp. 756-764
    • Ganesan, A.1    Crum-Cianflone, N.2    Higgins, J.3
  • 95
    • 80052059246 scopus 로고    scopus 로고
    • An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: Downregulated immune activation and improved T Cell-dependent vaccine responses
    • Pettersen FO, Torheim EA, Dahm AE, et al. An exploratory trial of cyclooxygenase type 2 inhibitor in HIV-1 infection: downregulated immune activation and improved T Cell-dependent vaccine responses. J Virol. 2011;85(13):6557-66.
    • (2011) J Virol. , vol.85 , Issue.13 , pp. 6557-6566
    • Pettersen, F.O.1    Torheim, E.A.2    Dahm, A.E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.