Long-term multilineage engraftment of autologous genome-edited hematopoietic stem cells in nonhuman primates

Blood

Volumn 127, Issue 20, 2016, Pages 2416-2426

  Peterson, Christopher W ^a   Wang, Jianbin ^b   Norman, Krystin K ^a   Norgaard, Zachary K ^a   Humbert, Olivier ^a   Tse, Collette K ^b   Yan, Jenny J ^b   Trimble, Richard G ^b   Shivak, David A ^b   Rebar, Edward J ^b   Gregory, Philip D ^b   Holmes, Michael C ^b   Kiem, Hans Peter ^a,c,d  

^a Fred Hutchinson Cancer Research Center   (United States)

^b SANGAMO BIOSCIENCES INC   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; MESSENGER RNA; ZINC FINGER NUCLEASE; ZINC FINGER PROTEIN;

ANIMAL CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL LINEAGE; CONTROLLED STUDY; ELECTROPORATION; ENGRAFTMENT; FEASIBILITY STUDY; GENE DISRUPTION; GENE EDITING; GENE LOCUS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LENTIVIRINAE; MACACA NEMESTRINA; MEMORY T LYMPHOCYTE; MULTILINEAGE ENGRAFTMENT; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; PROGENY; T LYMPHOCYTE SUBPOPULATION; THROMBOCYTE COUNT; WESTERN BLOTTING; AMINO ACID SEQUENCE; ANIMAL; AUTOTRANSPLANTATION; BONE MARROW TRANSPLANTATION; CELL LINE; CYTOLOGY; DEFICIENCY; DNA SEQUENCE; GENE SILENCING; GENETICS; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; METABOLISM; MOLECULAR GENETICS; MUTATION; POLYMERASE CHAIN REACTION; PROCEDURES; TRANSPLANTATION CONDITIONING; WHOLE BODY RADIATION;

AMINO ACID SEQUENCE; ANIMALS; BONE MARROW TRANSPLANTATION; CELL LINE; CELL LINEAGE; ELECTROPORATION; FEASIBILITY STUDIES; GENE EDITING; GENE KNOCKDOWN TECHNIQUES; GRAFT SURVIVAL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; MACACA NEMESTRINA; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; RECEPTORS, CCR5; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, AUTOLOGOUS; WHOLE-BODY IRRADIATION; ZINC FINGERS;

EID: 85002639397     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-09-672337     Document Type: Article

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