메뉴 건너뛰기




Volumn 9, Issue 2, 2012, Pages 297-314

A Progressive Mouse Model of Parkinson's Disease: The Thy1-aSyn ("Line 61") Mice

Author keywords

Alpha synuclein; Mouse model; Parkinson's disease; Progressive; Thy1 aSyn

Indexed keywords

ALPHA SYNUCLEIN; MESSENGER RNA; PROTEINASE K; THY 1 ANTIGEN;

EID: 84859712842     PISSN: 19337213     EISSN: 18787479     Source Type: Journal    
DOI: 10.1007/s13311-012-0104-2     Document Type: Review
Times cited : (238)

References (91)
  • 2
    • 65649135053 scopus 로고    scopus 로고
    • Parkinson's disease and other extrapyramidal movement disorders
    • A. S. Fauci (Ed.), New York: McGraw-Hill Medical
    • DeLong MR, Juncos JL. Parkinson's disease and other extrapyramidal movement disorders. In: Harrison's Principles of Internal Medicine. Fauci, AS McGraw-Hill Medical, New York, 2008: 2549-2559.
    • (2008) Harrison's Principles of Internal Medicine , pp. 2549-2559
    • Delong, M.R.1    Juncos, J.L.2
  • 4
    • 0030065255 scopus 로고    scopus 로고
    • Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus
    • Delfs JM, Ciaramitaro VM, Soghomonian JJ, Chesselet MF. Unilateral nigrostriatal lesions induce a bilateral increase in glutamate decarboxylase messenger RNA in the reticular thalamic nucleus. Neuroscience 1996; 71: 383-395.
    • (1996) Neuroscience , vol.71 , pp. 383-395
    • Delfs, J.M.1    Ciaramitaro, V.M.2    Soghomonian, J.J.3    Chesselet, M.F.4
  • 5
    • 77957232523 scopus 로고    scopus 로고
    • The challenge of non-motor symptoms in Parkinson's disease
    • Chaudhuri KR, Odin P. The challenge of non-motor symptoms in Parkinson's disease. Prog Brain Res 2010; 184: 325-341.
    • (2010) Prog Brain Res , vol.184 , pp. 325-341
    • Chaudhuri, K.R.1    Odin, P.2
  • 6
    • 66949117423 scopus 로고    scopus 로고
    • The scientific and clinical basis for the treatment of Parkinson disease
    • Olanow CW, Stern MB, Sethi K. The scientific and clinical basis for the treatment of Parkinson disease. Neurology 2009; 72: S1-136.
    • (2009) Neurology , vol.72 , pp. 1-136
    • Olanow, C.W.1    Stern, M.B.2    Sethi, K.3
  • 7
    • 74149088770 scopus 로고    scopus 로고
    • Clinical neuroprotection in Parkinson's disease - still waiting for the breakthrough
    • Lohle M, Reichmann H. Clinical neuroprotection in Parkinson's disease - still waiting for the breakthrough. J Neurol Sci 2010; 289: 104-114.
    • (2010) J Neurol Sci , vol.289 , pp. 104-114
    • Lohle, M.1    Reichmann, H.2
  • 8
    • 0031715849 scopus 로고    scopus 로고
    • Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate
    • Langston JW. Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate. Ann Neurol 1998; 44: S45-52.
    • (1998) Ann Neurol , vol.44
    • Langston, J.W.1
  • 9
    • 60749135286 scopus 로고    scopus 로고
    • Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference June 26-28, 2007
    • Bronstein J, Carvey P, Chen H, et al. Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference June 26-28, 2007. Environ Health Perspect 2009; 117: 117-121.
    • (2009) Environ Health Perspect , vol.117 , pp. 117-121
    • Bronstein, J.1    Carvey, P.2    Chen, H.3
  • 10
    • 80052328932 scopus 로고    scopus 로고
    • Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee
    • Hamza TH, Chen H, Hill-Burns EM, et al. Genome-wide gene-environment study identifies glutamate receptor gene GRIN2A as a Parkinson's disease modifier gene via interaction with coffee. PLoS Genet 2011; 7: e1002237.
    • (2011) PLoS Genet , vol.7
    • Hamza, T.H.1    Chen, H.2    Hill-Burns, E.M.3
  • 12
    • 78649394537 scopus 로고    scopus 로고
    • Balance is the challenge - the impact of mitochondrial dynamics in Parkinson's disease
    • Burbulla LF, Krebiehl G, Kruger R. Balance is the challenge - the impact of mitochondrial dynamics in Parkinson's disease. Eur J Clin Invest 2010; 40: 1048-1060.
    • (2010) Eur J Clin Invest , vol.40 , pp. 1048-1060
    • Burbulla, L.F.1    Krebiehl, G.2    Kruger, R.3
  • 13
    • 0034531475 scopus 로고    scopus 로고
    • The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy
    • Spillantini MG, Goedert M. The alpha-synucleinopathies: Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy. Ann N Y Acad Sci 2000; 920: 16-27.
    • (2000) Ann N Y Acad Sci , vol.920 , pp. 16-27
    • Spillantini, M.G.1    Goedert, M.2
  • 14
    • 77951185469 scopus 로고    scopus 로고
    • Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease
    • Edwards TL, Scott WK, Almonte C, et al. Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. Ann Hum Genet 2010; 74: 97-109.
    • (2010) Ann Hum Genet , vol.74 , pp. 97-109
    • Edwards, T.L.1    Scott, W.K.2    Almonte, C.3
  • 15
    • 77954885006 scopus 로고    scopus 로고
    • alpha-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease
    • Gatto NM, Rhodes SL, Manthripragada AD, et al. alpha-Synuclein gene may interact with environmental factors in increasing risk of Parkinson's disease. Neuroepidemiology 2010; 35: 191-195.
    • (2010) Neuroepidemiology , vol.35 , pp. 191-195
    • Gatto, N.M.1    Rhodes, S.L.2    Manthripragada, A.D.3
  • 16
    • 84863230106 scopus 로고    scopus 로고
    • Interaction between α-synuclein and tau genotypes and the progression of Parkinson's disease
    • Huang Y, Rowe DB, Halliday GM. Interaction between alpha-synuclein and tau genotypes and the progression of Parkinson's disease. J Parkinson's Dis 2011; 1: 271-276.
    • (2011) J Parkinson's Dis , vol.1 , pp. 271-276
    • Huang, Y.1    Rowe, D.B.2    Halliday, G.M.3
  • 17
    • 77957245642 scopus 로고    scopus 로고
    • Genetic mouse models of Parkinson's disease: the state of the art
    • Magen I, Chesselet MF. Genetic mouse models of Parkinson's disease: the state of the art. Prog Brain Res 2010; 184: 53-87.
    • (2010) Prog Brain Res , vol.184 , pp. 53-87
    • Magen, I.1    Chesselet, M.F.2
  • 18
    • 81255210997 scopus 로고    scopus 로고
    • Modelling of Parkinson's disease in mice
    • Chesselet MF, Richter F. Modelling of Parkinson's disease in mice. Lancet Neurol 2011; 10: 1108-1118.
    • (2011) Lancet Neurol , vol.10 , pp. 1108-1118
    • Chesselet, M.F.1    Richter, F.2
  • 19
    • 77953666105 scopus 로고    scopus 로고
    • Genetic animal models of Parkinson's disease
    • Dawson TM, Ko HS, Dawson VL. Genetic animal models of Parkinson's disease. Neuron 2010; 66: 646-661.
    • (2010) Neuron , vol.66 , pp. 646-661
    • Dawson, T.M.1    Ko, H.S.2    Dawson, V.L.3
  • 20
    • 79951674097 scopus 로고    scopus 로고
    • Transgenic animal models of neurodegeneration based on human genetic studies
    • Harvey BK, Richie CT, Hoffer BJ, Airavaara M. Transgenic animal models of neurodegeneration based on human genetic studies. J Neural Transm 2011; 118: 27-45.
    • (2011) J Neural Transm , vol.118 , pp. 27-45
    • Harvey, B.K.1    Richie, C.T.2    Hoffer, B.J.3    Airavaara, M.4
  • 21
    • 0036605566 scopus 로고    scopus 로고
    • Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters
    • Rockenstein E, Mallory M, Hashimoto M, et al. Differential neuropathological alterations in transgenic mice expressing alpha-synuclein from the platelet-derived growth factor and Thy-1 promoters. J Neurosci Res 2002; 68: 568-578.
    • (2002) J Neurosci Res , vol.68 , pp. 568-578
    • Rockenstein, E.1    Mallory, M.2    Hashimoto, M.3
  • 22
    • 0034681471 scopus 로고    scopus 로고
    • Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders
    • Masliah E, Rockenstein E, Veinbergs I, et al. Dopaminergic loss and inclusion body formation in alpha-synuclein mice: implications for neurodegenerative disorders. Science 2000; 287: 1265-1269.
    • (2000) Science , vol.287 , pp. 1265-1269
    • Masliah, E.1    Rockenstein, E.2    Veinbergs, I.3
  • 23
    • 0038389601 scopus 로고    scopus 로고
    • Transgenic models of alpha-synuclein pathology: past, present, and future
    • Hashimoto M, Rockenstein E, Masliah E. Transgenic models of alpha-synuclein pathology: past, present, and future. Ann N Y Acad Sci 2003; 991: 171-188.
    • (2003) Ann N Y Acad Sci , vol.991 , pp. 171-188
    • Hashimoto, M.1    Rockenstein, E.2    Masliah, E.3
  • 24
    • 79955629341 scopus 로고    scopus 로고
    • Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human alpha-synuclein
    • Lam HA, Wu N, Cely I, et al. Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human alpha-synuclein. J Neurosci Res 2011; 89: 1091-1102.
    • (2011) J Neurosci Res , vol.89 , pp. 1091-1102
    • Lam, H.A.1    Wu, N.2    Cely, I.3
  • 25
    • 0034663176 scopus 로고    scopus 로고
    • Neuropathology in mice expressing human alpha-synuclein
    • van der Putten H, Wiederhold KH, Probst A, et al. Neuropathology in mice expressing human alpha-synuclein. J Neurosci 2000; 20: 6021-6029.
    • (2000) J Neurosci , vol.20 , pp. 6021-6029
    • van der Putten, H.1    Wiederhold, K.H.2    Probst, A.3
  • 26
    • 7044270767 scopus 로고    scopus 로고
    • Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein
    • Fleming SM, Salcedo J, Fernagut PO, et al. Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein. J Neurosci 2004; 24: 9434-9440.
    • (2004) J Neurosci , vol.24 , pp. 9434-9440
    • Fleming, S.M.1    Salcedo, J.2    Fernagut, P.O.3
  • 27
    • 79960069979 scopus 로고    scopus 로고
    • α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies
    • Lim Y, Kehm VM, Lee EB, et al. alpha-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. J Neurosci 2011; 31: 10076-10087.
    • (2011) J Neurosci , vol.31 , pp. 10076-10087
    • Lim, Y.1    Kehm, V.M.2    Lee, E.B.3
  • 29
    • 37249011444 scopus 로고    scopus 로고
    • Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression
    • Fernagut PO, Hutson CB, Fleming SM, et al. Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression. Synapse 2007; 61: 991-1001.
    • (2007) Synapse , vol.61 , pp. 991-1001
    • Fernagut, P.O.1    Hutson, C.B.2    Fleming, S.M.3
  • 30
    • 10044242402 scopus 로고    scopus 로고
    • Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage
    • Neumann M, Muller V, Kretzschmar HA, Haass C, Kahle PJ. Regional distribution of proteinase K-resistant alpha-synuclein correlates with Lewy body disease stage. J Neuropathol Exp Neurol 2004; 63: 1225-1235.
    • (2004) J Neuropathol Exp Neurol , vol.63 , pp. 1225-1235
    • Neumann, M.1    Muller, V.2    Kretzschmar, H.A.3    Haass, C.4    Kahle, P.J.5
  • 31
    • 79960842310 scopus 로고    scopus 로고
    • Neuropathology underlying clinical variability in patients with synucleinopathies
    • Halliday GM, Holton JL, Revesz T, Dickson DW. Neuropathology underlying clinical variability in patients with synucleinopathies. Acta Neuropathol 2011; 122(2): 187-204.
    • (2011) Acta Neuropathol , vol.122 , Issue.2 , pp. 187-204
    • Halliday, G.M.1    Holton, J.L.2    Revesz, T.3    Dickson, D.W.4
  • 32
    • 32544442518 scopus 로고    scopus 로고
    • Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology
    • Braak H, de Vos RA, Bohl J, Del Tredici K. Gastric alpha-synuclein immunoreactive inclusions in Meissner's and Auerbach's plexuses in cases staged for Parkinson's disease-related brain pathology. Neurosci Lett 2006; 396: 67-72.
    • (2006) Neurosci Lett , vol.396 , pp. 67-72
    • Braak, H.1    de Vos, R.A.2    Bohl, J.3    del Tredici, K.4
  • 34
    • 77956217986 scopus 로고    scopus 로고
    • Parkinson's disease: a model dilemma
    • Beal MF. Parkinson's disease: a model dilemma. Nature 2010; 466: S8-S10.
    • (2010) Nature , vol.466
    • Beal, M.F.1
  • 35
    • 77952926102 scopus 로고    scopus 로고
    • Clinical progression in Parkinson disease and the neurobiology of axons
    • Cheng HC, Ulane CM, Burke RE. Clinical progression in Parkinson disease and the neurobiology of axons. Ann Neurol 2010; 67: 715-725.
    • (2010) Ann Neurol , vol.67 , pp. 715-725
    • Cheng, H.C.1    Ulane, C.M.2    Burke, R.E.3
  • 36
    • 0036245056 scopus 로고    scopus 로고
    • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice
    • Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, et al. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol 2002; 175: 35-48.
    • (2002) Exp Neurol , vol.175 , pp. 35-48
    • Richfield, E.K.1    Thiruchelvam, M.J.2    Cory-Slechta, D.A.3
  • 37
    • 39749196233 scopus 로고    scopus 로고
    • Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice
    • Wakamatsu M, Ishii A, Iwata S, et al. Selective loss of nigral dopamine neurons induced by overexpression of truncated human alpha-synuclein in mice. Neurobiol Aging 2008; 29: 574-585.
    • (2008) Neurobiol Aging , vol.29 , pp. 574-585
    • Wakamatsu, M.1    Ishii, A.2    Iwata, S.3
  • 38
    • 79952303794 scopus 로고    scopus 로고
    • PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease
    • Shin JH, Ko HS, Kang H, et al. PARIS (ZNF746) repression of PGC-1alpha contributes to neurodegeneration in Parkinson's disease. Cell 2011; 144: 689-702.
    • (2011) Cell , vol.144 , pp. 689-702
    • Shin, J.H.1    Ko, H.S.2    Kang, H.3
  • 39
    • 34247631275 scopus 로고    scopus 로고
    • Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
    • Sulzer D. Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease. Trends Neurosci 2007; 30: 244-250.
    • (2007) Trends Neurosci , vol.30 , pp. 244-250
    • Sulzer, D.1
  • 41
    • 78650958600 scopus 로고    scopus 로고
    • Mice overexpressing human alpha synuclein (Thy1-aSyn) show dopamine loss, catalepsy and severe motor deficits partially rescued by L-DOPA at 14 months of age
    • Hean S, Richter F, Torres ES, et al. Mice overexpressing human alpha synuclein (Thy1-aSyn) show dopamine loss, catalepsy and severe motor deficits partially rescued by L-DOPA at 14 months of age. Neurosci Abstr 2010; 750. 27/H20:.
    • (2010) Neurosci Abstr , pp. 750
    • Hean, S.1    Richter, F.2    Torres, E.S.3
  • 42
    • 78650209340 scopus 로고    scopus 로고
    • Dopamine turnover increases in asymptomatic LRRK2 mutations carriers
    • Sossi V, de la Fuente-Fernandez R, Nandhagopal R, et al. Dopamine turnover increases in asymptomatic LRRK2 mutations carriers. Mov Disord 2010; 25: 2717-2723.
    • (2010) Mov Disord , vol.25 , pp. 2717-2723
    • Sossi, V.1    de la Fuente-Fernandez, R.2    Nandhagopal, R.3
  • 43
    • 0037615219 scopus 로고    scopus 로고
    • Dopamine and Parkinson's disease: is the killer in the house?
    • Chesselet MF. Dopamine and Parkinson's disease: is the killer in the house? Mol Psychiatry 2003; 8: 369-370.
    • (2003) Mol Psychiatry , vol.8 , pp. 369-370
    • Chesselet, M.F.1
  • 44
    • 58149141576 scopus 로고    scopus 로고
    • Toxic effects of dopamine metabolism in Parkinson's disease
    • Hattoria N, Wanga M, Taka H, et al. Toxic effects of dopamine metabolism in Parkinson's disease. Parkinsonism Relat Disord 2009; 15(suppl 1): S35-S38.
    • (2009) Parkinsonism Relat Disord , vol.15 , Issue.SUPPL. 1
    • Hattoria, N.1    Wanga, M.2    Taka, H.3
  • 45
    • 77955846610 scopus 로고    scopus 로고
    • The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons
    • Lawal HO, Chang HY, Terrell AN, et al. The Drosophila vesicular monoamine transporter reduces pesticide-induced loss of dopaminergic neurons. Neurobiol Dis 2010; 40: 102-112.
    • (2010) Neurobiol Dis , vol.40 , pp. 102-112
    • Lawal, H.O.1    Chang, H.Y.2    Terrell, A.N.3
  • 46
    • 67449159281 scopus 로고    scopus 로고
    • Dopamine transporter genetic variants and pesticides in Parkinson's disease
    • Ritz BR, Manthripragada AD, Costello S, et al. Dopamine transporter genetic variants and pesticides in Parkinson's disease. Environ Health Perspect 2009; 117: 964-969.
    • (2009) Environ Health Perspect , vol.117 , pp. 964-969
    • Ritz, B.R.1    Manthripragada, A.D.2    Costello, S.3
  • 47
    • 34547467082 scopus 로고    scopus 로고
    • Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration
    • Caudle WM, Richardson JR, Wang MZ, et al. Reduced vesicular storage of dopamine causes progressive nigrostriatal neurodegeneration. J Neurosci 2007; 27: 8138-8148.
    • (2007) J Neurosci , vol.27 , pp. 8138-8148
    • Caudle, W.M.1    Richardson, J.R.2    Wang, M.Z.3
  • 48
    • 84859699540 scopus 로고    scopus 로고
    • Animal models of the non-motor features of Parkinson's disease
    • (in press)
    • McDowell K, Chesselet MF. Animal models of the non-motor features of Parkinson's disease. Neurobiol Dis 2012;(in press).
    • (2012) Neurobiol Dis
    • McDowell, K.1    Chesselet, M.F.2
  • 49
    • 2542612292 scopus 로고    scopus 로고
    • Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease
    • Lang AE, Obeso JA. Time to move beyond nigrostriatal dopamine deficiency in Parkinson's disease. Ann Neurol 2004; 55: 761-765.
    • (2004) Ann Neurol , vol.55 , pp. 761-765
    • Lang, A.E.1    Obeso, J.A.2
  • 50
    • 40449083312 scopus 로고    scopus 로고
    • Association of olfactory dysfunction with risk for future Parkinson's disease
    • Ross GW, Petrovitch H, Abbott RD, et al. Association of olfactory dysfunction with risk for future Parkinson's disease. Ann Neurol 2008; 63: 167-173.
    • (2008) Ann Neurol , vol.63 , pp. 167-173
    • Ross, G.W.1    Petrovitch, H.2    Abbott, R.D.3
  • 52
    • 61449087466 scopus 로고    scopus 로고
    • Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein
    • Marxreiter F, Nuber S, Kandasamy M, et al. Changes in adult olfactory bulb neurogenesis in mice expressing the A30P mutant form of alpha-synuclein. Eur J Neurosci 2009; 29: 879-890.
    • (2009) Eur J Neurosci , vol.29 , pp. 879-890
    • Marxreiter, F.1    Nuber, S.2    Kandasamy, M.3
  • 53
    • 43249106066 scopus 로고    scopus 로고
    • Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein
    • Wang L, Fleming SM, Chesselet MF, Tache Y. Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein. Neuroreport 2008; 19: 873-876.
    • (2008) Neuroreport , vol.19 , pp. 873-876
    • Wang, L.1    Fleming, S.M.2    Chesselet, M.F.3    Tache, Y.4
  • 54
    • 0035859865 scopus 로고    scopus 로고
    • Frequency of bowel movements and the future risk of Parkinson's disease
    • Abbott RD, Petrovitch H, White LR, et al. Frequency of bowel movements and the future risk of Parkinson's disease. Neurology 2001; 57: 456-462.
    • (2001) Neurology , vol.57 , pp. 456-462
    • Abbott, R.D.1    Petrovitch, H.2    White, L.R.3
  • 55
    • 73349092154 scopus 로고    scopus 로고
    • Medical records documentation of constipation preceding Parkinson disease: a case-control study
    • Savica R, Carlin JM, Grossardt BR, et al. Medical records documentation of constipation preceding Parkinson disease: a case-control study. Neurology 2009; 73: 1752-1758.
    • (2009) Neurology , vol.73 , pp. 1752-1758
    • Savica, R.1    Carlin, J.M.2    Grossardt, B.R.3
  • 56
    • 77952478217 scopus 로고    scopus 로고
    • Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes
    • Kuo YM, Li Z, Jiao Y, et al. Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes. Hum Mol Genet 2010; 19: 1633-1650.
    • (2010) Hum Mol Genet , vol.19 , pp. 1633-1650
    • Kuo, Y.M.1    Li, Z.2    Jiao, Y.3
  • 57
    • 27644439093 scopus 로고    scopus 로고
    • Excessive daytime sleepiness and subsequent development of Parkinson disease
    • Abbott RD, Ross GW, White LR, et al. Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology 2005; 65: 1442-1446.
    • (2005) Neurology , vol.65 , pp. 1442-1446
    • Abbott, R.D.1    Ross, G.W.2    White, L.R.3
  • 58
    • 80053932171 scopus 로고    scopus 로고
    • Circadian dysfunction in a mouse model of Parkinson's disease
    • Kudo T, Loh DH, Truong D, Wu Y, Colwell CS. Circadian dysfunction in a mouse model of Parkinson's disease. Exp Neurol 2011; 232(1): 66-75.
    • (2011) Exp Neurol , vol.232 , Issue.1 , pp. 66-75
    • Kudo, T.1    Loh, D.H.2    Truong, D.3    Wu, Y.4    Colwell, C.S.5
  • 59
    • 24644434376 scopus 로고    scopus 로고
    • Cognitive predictors of dementia in Parkinson's disease: a community-based, 4-year longitudinal study
    • Janvin CC, Aarsland D, Larsen JP. Cognitive predictors of dementia in Parkinson's disease: a community-based, 4-year longitudinal study. J Geriatr Psychiatry Neurol 2005; 18: 149-154.
    • (2005) J Geriatr Psychiatry Neurol , vol.18 , pp. 149-154
    • Janvin, C.C.1    Aarsland, D.2    Larsen, J.P.3
  • 60
    • 84858860243 scopus 로고    scopus 로고
    • Cognitive deficits in a mouse model of pre-manifest Parkinson's disease
    • (in press)
    • Magen I, Fleming S, Garcia E, et al. Cognitive deficits in a mouse model of pre-manifest Parkinson's disease. Eur J Neurosci 2011 (in press).
    • (2011) Eur J Neurosci
    • Magen, I.1    Fleming, S.2    Garcia, E.3
  • 61
    • 77951092321 scopus 로고    scopus 로고
    • A flexible sequential learning deficit in patients with Parkinson's disease: a 2 x 8 button-press task
    • Mochizuki-Kawai H, Mochizuki S, Kawamura M. A flexible sequential learning deficit in patients with Parkinson's disease: a 2 x 8 button-press task. Exp Brain Res 2010; 202: 147-153.
    • (2010) Exp Brain Res , vol.202 , pp. 147-153
    • Mochizuki-Kawai, H.1    Mochizuki, S.2    Kawamura, M.3
  • 62
    • 84858173709 scopus 로고    scopus 로고
    • Mouse Models of Cognitive Deficits Due to Alpha-Synuclein Pathology
    • Magen I, Chesselet MF. Mouse Models of Cognitive Deficits Due to Alpha-Synuclein Pathology. J Parkinsons Dis 2011; 1: 217-227.
    • (2011) J Parkinsons Dis , vol.1 , pp. 217-227
    • Magen, I.1    Chesselet, M.F.2
  • 63
    • 84877048978 scopus 로고    scopus 로고
    • Mice overexpressing human alpha synuclein under the Thy1-promotor show increased fear conditioning and altered responses in anxiety related behavior
    • Torres ES, Zelikowsky M, Richter F, et al. Mice overexpressing human alpha synuclein under the Thy1-promotor show increased fear conditioning and altered responses in anxiety related behavior. Neurosci Abstr 2010; 750. 25/H18.
    • (2010) Neurosci Abstr , pp. 750
    • Torres, E.S.1    Zelikowsky, M.2    Richter, F.3
  • 64
    • 77957241788 scopus 로고    scopus 로고
    • Mice overexpressing human wildtype alpha-synuclein under the Thy-1 promoter exhibit anomalies in behavioral tests of anxiety
    • Mulligan CK, Fleming SM, Dorriz P, Masliah E, Chesselet MF. Mice overexpressing human wildtype alpha-synuclein under the Thy-1 promoter exhibit anomalies in behavioral tests of anxiety. Neurosci Abstr 2008; 742. 19/U28.
    • (2008) Neurosci Abstr , pp. 742
    • Mulligan, C.K.1    Fleming, S.M.2    Dorriz, P.3    Masliah, E.4    Chesselet, M.F.5
  • 66
    • 33750300797 scopus 로고    scopus 로고
    • Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein
    • Fleming SM, Salcedo J, Hutson CB, et al. Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein. Neuroscience 2006; 142: 1245-1253.
    • (2006) Neuroscience , vol.142 , pp. 1245-1253
    • Fleming, S.M.1    Salcedo, J.2    Hutson, C.B.3
  • 68
    • 58749112730 scopus 로고    scopus 로고
    • Behavioural and neurochemical response of alpha-synuclein A30P transgenic mice to the effects of L-DOPA
    • Oksman M, Tanila H, Yavich L. Behavioural and neurochemical response of alpha-synuclein A30P transgenic mice to the effects of L-DOPA. Neuropharmacology 2009; 56: 647-652.
    • (2009) Neuropharmacology , vol.56 , pp. 647-652
    • Oksman, M.1    Tanila, H.2    Yavich, L.3
  • 69
    • 28844448732 scopus 로고    scopus 로고
    • Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease
    • Cools R. Dopaminergic modulation of cognitive function-implications for L-DOPA treatment in Parkinson's disease. Neurosci Biobehav Rev 2006; 30: 1-23.
    • (2006) Neurosci Biobehav Rev , vol.30 , pp. 1-23
    • Cools, R.1
  • 71
    • 77952327983 scopus 로고    scopus 로고
    • Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway
    • Wu N, Joshi PR, Cepeda C, Masliah E, Levine MS. Alpha-synuclein overexpression in mice alters synaptic communication in the corticostriatal pathway. J Neurosci Res 2010; 88: 1764-1776.
    • (2010) J Neurosci Res , vol.88 , pp. 1764-1776
    • Wu, N.1    Joshi, P.R.2    Cepeda, C.3    Masliah, E.4    Levine, M.S.5
  • 72
    • 60849116119 scopus 로고    scopus 로고
    • Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein
    • Watson JB, Hatami A, David H, et al. Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein. Neuroscience 2009; 159: 501-513.
    • (2009) Neuroscience , vol.159 , pp. 501-513
    • Watson, J.B.1    Hatami, A.2    David, H.3
  • 73
    • 0023740773 scopus 로고
    • Rate of cell death in parkinsonism indicates active neuropathological process
    • McGeer PL, Itagaki S, Akiyama H, McGeer EG. Rate of cell death in parkinsonism indicates active neuropathological process. Ann Neurol 1988; 24: 574-576.
    • (1988) Ann Neurol , vol.24 , pp. 574-576
    • McGeer, P.L.1    Itagaki, S.2    Akiyama, H.3    McGeer, E.G.4
  • 74
    • 0032602163 scopus 로고    scopus 로고
    • Neurotrophins and cytokines in Parkinson's disease
    • Mogi M, Nagatsu T. Neurotrophins and cytokines in Parkinson's disease. Adv Neurol 1999; 80: 135-139.
    • (1999) Adv Neurol , vol.80 , pp. 135-139
    • Mogi, M.1    Nagatsu, T.2
  • 75
    • 71849087424 scopus 로고    scopus 로고
    • Neuroinflammation in the living brain of Parkinson's disease
    • Ouchi Y, Yagi S, Yokokura M, Sakamoto M. Neuroinflammation in the living brain of Parkinson's disease. Parkinsonism Relat Disord 2009;(15 suppl 3): S200-S204.
    • (2009) Parkinsonism Relat Disord , vol.15 , Issue.SUPPL. 3
    • Ouchi, Y.1    Yagi, S.2    Yokokura, M.3    Sakamoto, M.4
  • 76
    • 84859726025 scopus 로고    scopus 로고
    • Regionally specific microglial activation precedes neuropathology and peripheral immune response in mice over-expressing wildtype alpha synuclein
    • Watson MB, Lee SK, Richter F, Masliah E, Chesselet MF. Regionally specific microglial activation precedes neuropathology and peripheral immune response in mice over-expressing wildtype alpha synuclein. Neurosci Abstr 2011; 357. 12/AA31.
    • (2011) Neurosci Abstr , pp. 357
    • Watson, M.B.1    Lee, S.K.2    Richter, F.3    Masliah, E.4    Chesselet, M.F.5
  • 77
    • 0035255035 scopus 로고    scopus 로고
    • Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism
    • Bas J, Calopa M, Mestre M, et al. Lymphocyte populations in Parkinson's disease and in rat models of parkinsonism. J Neuroimmunol 2001; 113: 146-152.
    • (2001) J Neuroimmunol , vol.113 , pp. 146-152
    • Bas, J.1    Calopa, M.2    Mestre, M.3
  • 79
    • 58849107919 scopus 로고    scopus 로고
    • Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease
    • Brochard V, Combadiere B, Prigent A, et al. Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 2009; 119: 182-192.
    • (2009) J Clin Invest , vol.119 , pp. 182-192
    • Brochard, V.1    Combadiere, B.2    Prigent, A.3
  • 80
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG. Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 1988; 38: 1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 81
    • 1542617769 scopus 로고    scopus 로고
    • Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP
    • Song DD, Shults CW, Sisk A, Rockenstein E, Masliah E. Enhanced substantia nigra mitochondrial pathology in human alpha-synuclein transgenic mice after treatment with MPTP. Exp Neurol 2004; 186: 158-172.
    • (2004) Exp Neurol , vol.186 , pp. 158-172
    • Song, D.D.1    Shults, C.W.2    Sisk, A.3    Rockenstein, E.4    Masliah, E.5
  • 82
    • 84877083298 scopus 로고    scopus 로고
    • Transcriptome network and pathway analyses reveal early alterations in dopaminergic neurons of mice overexpressing human wild-type alpha-synuclein (Thy1-aSyn)
    • Richter F, Gao F, Bove N, et al. Transcriptome network and pathway analyses reveal early alterations in dopaminergic neurons of mice overexpressing human wild-type alpha-synuclein (Thy1-aSyn). Neurosci Abstr 2011; 357. 07/AA26.
    • (2011) Neurosci Abstr , pp. 357
    • Richter, F.1    Gao, F.2    Bove, N.3
  • 83
    • 60549111634 scopus 로고    scopus 로고
    • WGCNA: an R package for weighted correlation network analysis
    • Langfelder P, Horvath S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 2008; 9: 559.
    • (2008) BMC Bioinformatics , vol.9 , pp. 559
    • Langfelder, P.1    Horvath, S.2
  • 84
    • 79951852318 scopus 로고    scopus 로고
    • A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions
    • Fleming SM, Mulligan CK, Richter F, et al. A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions. Mol Cell Neurosci 2011; 46: 597-606.
    • (2011) Mol Cell Neurosci , vol.46 , pp. 597-606
    • Fleming, S.M.1    Mulligan, C.K.2    Richter, F.3
  • 85
    • 79956317900 scopus 로고    scopus 로고
    • Enhanced phosphatase activity attenuates alpha-Synucleinopathy in a mouse model
    • Lee KW, Chen W, Junn E, et al. Enhanced phosphatase activity attenuates alpha-Synucleinopathy in a mouse model. J Neurosci 2011; 31: 6963-6971.
    • (2011) J Neurosci , vol.31 , pp. 6963-6971
    • Lee, K.W.1    Chen, W.2    Junn, E.3
  • 86
    • 73949132010 scopus 로고    scopus 로고
    • Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies
    • Koob AO, Ubhi K, Paulsson JF, et al. Lovastatin ameliorates alpha-synuclein accumulation and oxidation in transgenic mouse models of alpha-synucleinopathies. Exp Neurol 2010; 221: 267-274.
    • (2010) Exp Neurol , vol.221 , pp. 267-274
    • Koob, A.O.1    Ubhi, K.2    Paulsson, J.F.3
  • 87
    • 34547123812 scopus 로고    scopus 로고
    • Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis
    • Bordet T, Buisson B, Michaud M, et al. Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis. J Pharmacol Exp Ther 2007; 322: 709-720.
    • (2007) J Pharmacol Exp Ther , vol.322 , pp. 709-720
    • Bordet, T.1    Buisson, B.2    Michaud, M.3
  • 88
    • 70349446343 scopus 로고    scopus 로고
    • Targeting neuroprotection as an alternative approach to preventing and treating neuropathic pain
    • Bordet T, Pruss RM. Targeting neuroprotection as an alternative approach to preventing and treating neuropathic pain. Neurotherapeutics 2009; 6: 648-662.
    • (2009) Neurotherapeutics , vol.6 , pp. 648-662
    • Bordet, T.1    Pruss, R.M.2
  • 89
    • 77952368170 scopus 로고    scopus 로고
    • TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition
    • Schaller S, Paradis S, Ngoh GA, et al. TRO40303, a new cardioprotective compound, inhibits mitochondrial permeability transition. J Pharmacol Exp Ther 2010; 333: 696-706.
    • (2010) J Pharmacol Exp Ther , vol.333 , pp. 696-706
    • Schaller, S.1    Paradis, S.2    Ngoh, G.A.3
  • 90
    • 84877043292 scopus 로고    scopus 로고
    • The cholesterol-oximes TRO19622 and TRO40303 affect motor function, olfaction, and alpha synuclein aggregation in mice overexpressing human alpha synuclein under the Thy1 promoter
    • Richter F, Fleming SM, Michaud M, et al. The cholesterol-oximes TRO19622 and TRO40303 affect motor function, olfaction, and alpha synuclein aggregation in mice overexpressing human alpha synuclein under the Thy1 promoter. Neurosci Abstr 2010; 750. 28/H21.
    • (2010) Neurosci Abstr , pp. 750
    • Richter, F.1    Fleming, S.M.2    Michaud, M.3
  • 91
    • 84877038653 scopus 로고    scopus 로고
    • The glucocerebrosidase pharmacological chaperone afegostat-tartrate (AT2101) partially improves motor and olfactory function and alters the size of alpha-synuclein inclusions in mice overexpressing alpha-synuclein
    • Lemesre V, Richter F, Fleming SM, et al. The glucocerebrosidase pharmacological chaperone afegostat-tartrate (AT2101) partially improves motor and olfactory function and alters the size of alpha-synuclein inclusions in mice overexpressing alpha-synuclein. Neurosci Abstr 2010; 750. 29/H22.
    • (2010) Neurosci Abstr , vol.750
    • Lemesre, V.1    Richter, F.2    Fleming, S.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.