Treatment for 6 months with fish oil-derived n-3 polyunsaturated fatty acids has neutral effects on glycemic control but improves dyslipidemia in type 2 diabetic patients with abdominal obesity: a randomized, double-blind, placebo-controlled trial

European Journal of Nutrition

Volumn 56, Issue 7, 2017, Pages 2415-2422

  Wang, Feng ^a   Wang, Yanyan ^a   Zhu, Yan ^b   Liu, Xiaosong ^c   Xia, Hui ^a   Yang, Xian ^a   Sun, Guiju ^a  

^a SOUTHEAST UNIVERSITY   (China)

^b Food Nutrition and Safety Society in Yixing   (China)

^c Guanlin Hospital in Yixing   (China)

Author keywords

Abdominal obesity; Fish oil; Glycemic control; Lipid levels; n 3 polyunsaturated fatty acids; Type 2 diabetes

Indexed keywords

CORN OIL; DOCOSAHEXAENOIC ACID; ESSENTIAL FATTY ACID; FISH OIL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL; CHOLESTEROL; ICOSAPENTAENOIC ACID;

ABDOMINAL OBESITY; AGED; ARTICLE; BODY COMPOSITION; CHINESE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC PATIENT; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DYSLIPIDEMIA; FATTY ACID BLOOD LEVEL; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HEMOGLOBIN BLOOD LEVEL; HOMEOSTASIS MODEL ASSESSMENT; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; METABOLISM; MIDDLE AGED;

AGED; BLOOD GLUCOSE; BODY COMPOSITION; CHOLESTEROL; CORN OIL; DIABETES MELLITUS, TYPE 2; DOCOSAHEXAENOIC ACIDS; DOUBLE-BLIND METHOD; DYSLIPIDEMIAS; EICOSAPENTAENOIC ACID; FEMALE; FISH OILS; GLYCATED HEMOGLOBIN A; HUMANS; MALE; MIDDLE AGED; OBESITY, ABDOMINAL; TRIGLYCERIDES;

EID: 85000977893     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-016-1352-4     Document Type: Article

References (48)

1. NCD-RisC (2016) Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4.4 million participants. Lancet 387:1513–1530. doi:10.1016/s0140-6736(16)00618-8
2. Xu Y, Wang L, He J, Bi Y, Li M, Wang T, Wang L, Jiang Y, Dai M, Lu J, Xu M, Li Y, Hu N, Li J, Mi S, Chen CS, Li G, Mu Y, Zhao J, Kong L, Chen J, Lai S, Wang W, Zhao W, Ning G (2013) Prevalence and control of diabetes in Chinese adults. JAMA 310:948–959. doi:10.1001/jama.2013.168118
3. Kahn SE, Hull RL, Utzschneider KM (2006) Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 444:840–846. doi:10.1038/nature05482
4. Mouratoff GJ, Carroll NV, Scott EM (1967) Diabetes mellitus in Eskimos. JAMA 199:107–112
5. Bang HO, Dyerberg J, Sinclair HM (1980) The composition of the Eskimo food in north western Greenland. Am J Clin Nutr 33:2657–2661
6. Fumagalli M, Moltke I, Grarup N, Racimo F, Bjerregaard P, Jorgensen ME, Korneliussen TS, Gerbault P, Skotte L, Linneberg A, Christensen C, Brandslund I, Jorgensen T, Huerta-Sanchez E, Schmidt EB, Pedersen O, Hansen T, Albrechtsen A, Nielsen R (2015) Greenlandic Inuit show genetic signatures of diet and climate adaptation. Science 349:1343–1347. doi:10.1126/science.aab2319
7. Djousse L, Gaziano JM, Buring JE, Lee IM (2011) Dietary omega-3 fatty acids and fish consumption and risk of type 2 diabetes. Am J Clin Nutr 93:143–150. doi:10.3945/ajcn.110.005603
8. Kaushik M, Mozaffarian D, Spiegelman D, Manson JE, Willett WC, Hu FB (2009) Long-chain omega-3 fatty acids, fish intake, and the risk of type 2 diabetes mellitus. Am J Clin Nutr 90:613–620. doi:10.3945/ajcn.2008.27424
9. van Woudenbergh GJ, van Ballegooijen AJ, Kuijsten A, Sijbrands EJ, van Rooij FJ, Geleijnse JM, Hofman A, Witteman JC, Feskens EJ (2009) Eating fish and risk of type 2 diabetes: a population-based, prospective follow-up study. Diabetes Care 32:2021–2026. doi:10.2337/dc09-1042
10. Brostow DP, Odegaard AO, Koh WP, Duval S, Gross MD, Yuan JM, Pereira MA (2011) Omega-3 fatty acids and incident type 2 diabetes: the Singapore Chinese Health Study. Am J Clin Nutr 94:520–526. doi:10.3945/ajcn.110.009357
11. Nanri A, Mizoue T, Noda M, Takahashi Y, Matsushita Y, Poudel-Tandukar K, Kato M, Oba S, Inoue M, Tsugane S, Japan Public Health Center-based Prospective Study G (2011) Fish intake and type 2 diabetes in Japanese men and women: the Japan Public Health Center-based Prospective Study. Am J Clin Nutr 94:884–891. doi:10.3945/ajcn.111.012252
12. Villegas R, Xiang YB, Elasy T, Li HL, Yang G, Cai H, Ye F, Gao YT, Shyr Y, Zheng W, Shu XO (2011) Fish, shellfish, and long-chain n-3 fatty acid consumption and risk of incident type 2 diabetes in middle-aged Chinese men and women. Am J Clin Nutr 94:543–551. doi:10.3945/ajcn.111.013193
13. Zheng JS, Huang T, Yang J, Fu YQ, Li D (2012) Marine N-3 polyunsaturated fatty acids are inversely associated with risk of type 2 diabetes in Asians: a systematic review and meta-analysis. PLoS ONE 7:e44525. doi:10.1371/journal.pone.0044525
14. Chen C, Yu X, Shao S (2015) Effects of omega-3 fatty acid supplementation on glucose control and lipid levels in type 2 diabetes: a meta-analysis. PLoS ONE 10:e0139565. doi:10.1371/journal.pone.0139565
15. Glauber H, Wallace P, Griver K, Brechtel G (1988) Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. Ann Intern Med 108:663–668
16. Schectman G, Kaul S, Kissebah AH (1988) Effect of fish oil concentrate on lipoprotein composition in NIDDM. Diabetes 37:1567–1573
17. Borkman M, Chisholm DJ, Furler SM, Storlien LH, Kraegen EW, Simons LA, Chesterman CN (1989) Effects of fish oil supplementation on glucose and lipid metabolism in NIDDM. Diabetes 38:1314–1319
18. Mostad IL, Bjerve KS, Bjorgaas MR, Lydersen S, Grill V (2006) Effects of n-3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation. Am J Clin Nutr 84:540–550
19. Annuzzi G, Rivellese A, Capaldo B, Di Marino L, Iovine C, Marotta G, Riccardi G (1991) A controlled study on the effects of n-3 fatty acids on lipid and glucose metabolism in non-insulin-dependent diabetic patients. Atherosclerosis 87:65–73
20. Pelikanova T, Kohout M, Valek J, Kazdova L, Base J (1993) Metabolic effects of omega-3 fatty acids in type 2 (non-insulin-dependent) diabetic patients. Ann N Y Acad Sci 683:272–278
21. Morgan WA, Raskin P, Rosenstock J (1995) A comparison of fish oil or corn oil supplements in hyperlipidemic subjects with NIDDM. Diabetes Care 18:83–86
22. McManus RM, Jumpson J, Finegood DT, Clandinin MT, Ryan EA (1996) A comparison of the effects of n-3 fatty acids from linseed oil and fish oil in well-controlled type II diabetes. Diabetes Care 19:463–467
23. Luo J, Rizkalla SW, Vidal H, Oppert JM, Colas C, Boussairi A, Guerre-Millo M, Chapuis AS, Chevalier A, Durand G, Slama G (1998) Moderate intake of n-3 fatty acids for 2 months has no detrimental effect on glucose metabolism and could ameliorate the lipid profile in type 2 diabetic men. Results of a controlled study. Diabetes Care 21:717–724
24. Kabir M, Skurnik G, Naour N, Pechtner V, Meugnier E, Rome S, Quignard-Boulange A, Vidal H, Slama G, Clement K, Guerre-Millo M, Rizkalla SW (2007) Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study. Am J Clin Nutr 86:1670–1679
25. WGOC (2004) Guidelines for the prevention and control of overweight and obesity among Chinese adults (Excerpt). Acta Nutrimenta Sinica 26:1–4. doi:10.3321/j.issn:0512-7955.2004.01.001
26. Popp-Snijders C, Bilo HJ, Heine RJ (1990) Fish oil and glycemic control: importance of dose. Diabetes Care 13:80–81
27. McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW, Hayes JR (1993) Dietary fish oil augments nitric oxide production or release in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 36:33–38
28. Neil HA, Ceglarek U, Thiery J, Paul S, Farmer A, Holman RR (2010) Impact of atorvastatin and omega-3 ethyl esters 90 on plasma plant sterol concentrations and cholesterol synthesis in type 2 diabetes: a randomised placebo controlled factorial trial. Atherosclerosis 213:512–517. doi:10.1016/j.atherosclerosis.2010.09.013
29. Sirtori CR, Paoletti R, Mancini M, Crepaldi G, Manzato E, Rivellese A, Pamparana F, Stragliotto E (1997) N-3 fatty acids do not lead to an increased diabetic risk in patients with hyperlipidemia and abnormal glucose tolerance. Italian Fish Oil Multicenter Study. Am J Clin Nutr 65:1874–1881
30. Vessby B, Boberg M (1990) Dietary supplementation with n-3 fatty acids may impair glucose homeostasis in patients with non-insulin-dependent diabetes mellitus. J Intern Med 228:165–171
31. Puhakainen I, Ahola I, Yki-Jarvinen H (1995) Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus. Am J Clin Nutr 61:121–126
32. Shidfar F, Keshavarz A, Hosseyni S, Ameri A, Yarahmadi S (2008) Effects of omega-3 fatty acid supplements on serum lipids, apolipoproteins and malondialdehyde in type 2 diabetes patients. East Mediterr Health J 14:305–313
33. Pooya S, Jalali MD, Jazayery AD, Saedisomeolia A, Eshraghian MR, Toorang F (2010) The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr Metab Cardiovasc Dis 20:326–331. doi:10.1016/j.numecd.2009.04.002
34. Wong CY, Yiu KH, Li SW, Lee S, Tam S, Lau CP, Tse HF (2010) Fish-oil supplement has neutral effects on vascular and metabolic function but improves renal function in patients with Type 2 diabetes mellitus. Diabet Med 27:54–60. doi:10.1111/j.1464-5491.2009.02869.x
35. Clark LF, Thivierge MC, Kidd CA, McGeoch SC, Abraham P, Pearson DW, Horgan GW, Holtrop G, Thies F, Lobley GE (2016) Fish oil supplemented for 9 months does not improve glycaemic control or insulin sensitivity in subjects with impaired glucose regulation: a parallel randomised controlled trial. Br J Nutr 115:75–86. doi:10.1017/s0007114515004274
36. Marsh JB (2003) Lipoprotein metabolism in obesity and diabetes: insights from stable isotope kinetic studies in humans. Nutr Rev 61:363–375
37. Nestel PJ (1990) Effects of N-3 fatty acids on lipid metabolism. Annu Rev Nutr 10:149–167. doi:10.1146/annurev.nu.10.070190.001053
38. Woodman RJ, Mori TA, Burke V, Puddey IB, Watts GF, Beilin LJ (2002) Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr 76:1007–1015
39. Yang ZH, Miyahara H, Takemura S, Hatanaka A (2011) Dietary saury oil reduces hyperglycemia and hyperlipidemia in diabetic KKAy mice and in diet-induced obese C57BL/6J mice by altering gene expression. Lipids 46:425–434. doi:10.1007/s11745-011-3553-1
40. Song Z, Yang L, Shu G, Lu H, Sun G (2013) Effects of the n-6/n-3 polyunsaturated fatty acids ratio on postprandial metabolism in hypertriacylglycerolemia patients. Lipids Health Dis 12:181. doi:10.1186/1476-511X-12-181
41. Yang LG, Song ZX, Yin H, Wang YY, Shu GF, Lu HX, Wang SK, Sun GJ (2016) Low n-6/n-3 PUFA ratio improves lipid metabolism, inflammation, oxidative stress and endothelial function in rats using plant oils as n-3 fatty acid source. Lipids 51:49–59. doi:10.1007/s11745-015-4091-z
42. Jain S, Gaiha M, Bhattacharjee J, Anuradha S (2002) Effects of low-dose omega-3 fatty acid substitution in type-2 diabetes mellitus with special reference to oxidative stress—a prospective preliminary study. J Assoc Physicians India 50:1028–1033
43. Kesavulu MM, Kameswararao B, Apparao C, Kumar EG, Harinarayan CV (2002) Effect of omega-3 fatty acids on lipid peroxidation and antioxidant enzyme status in type 2 diabetic patients. Diabetes Metab 28:20–26
44. Pedersen H, Petersen M, Major-Pedersen A, Jensen T, Nielsen NS, Lauridsen ST, Marckmann P (2003) Influence of fish oil supplementation on in vivo and in vitro oxidation resistance of low-density lipoprotein in type 2 diabetes. Eur J Clin Nutr 57:713–720. doi:10.1038/sj.ejcn.1601602
45. Pascot A, Lemieux I, Prud’homme D, Tremblay A, Nadeau A, Couillard C, Bergeron J, Lamarche B, Despres JP (2001) Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity. J Lipid Res 42:2007–2014
46. Petersen M, Pedersen H, Major-Pedersen A, Jensen T, Marckmann P (2002) Effect of fish oil versus corn oil supplementation on LDL and HDL subclasses in type 2 diabetic patients. Diabetes Care 25:1704–1708
47. Mocking RJ, Assies J, Bot M, Jansen EH, Schene AH, Pouwer F (2012) Biological effects of add-on eicosapentaenoic acid supplementation in diabetes mellitus and co-morbid depression: a randomized controlled trial. PLoS ONE 7:e49431. doi:10.1371/journal.pone.0049431
48. Haffner SM (2006) Abdominal obesity, insulin resistance, and cardiovascular risk in pre-diabetes and type 2 diabetes. Eur. Heart J. Suppl. 8:B20–B25