Drug interventions for the treatment of obesity in children and adolescents

Cochrane Database of Systematic Reviews

Volumn 2016, Issue 11, 2016, Pages

  Mead, Emma ^a   Atkinson, Greg ^a   Richter, Bernd ^b   Metzendorf, Maria Inti ^b   Baur, Louise ^c   Finer, Nicholas ^d   Corpeleijn, Eva ^e   O'Malley, Claire ^f   Ells, Louisa J ^a  

^a TEESSIDE UNIVERSITY   (United Kingdom)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF SYDNEY   (Australia)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f DURHAM UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYANOCOBALAMIN; FECES LIPID; FLUOXETINE; HEMOGLOBIN; METFORMIN; SIBUTRAMINE; TETRAHYDROLIPSTATIN; VITAMIN D; ANTIOBESITY AGENT; CYCLOBUTANE DERIVATIVE; LACTONE;

ABDOMINAL CRAMP; ABDOMINAL DISCOMFORT; ABDOMINAL PAIN; ABNORMAL FECES COMPOSITION; ADOLESCENT; ADOLESCENT BEHAVIOR; ADOLESCENT OBESITY; ALANINE AMINOTRANSFERASE BLOOD LEVEL; APPENDICITIS; ASEPTIC MENINGITIS; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ASTHMA; BEHAVIOR CHANGE; BLOATING; BODY FAT DISTRIBUTION; BODY MASS; BODY WEIGHT; CHILD; CHILD BEHAVIOR; CHILDHOOD MORTALITY; CHILDHOOD OBESITY; CHOLELITHIASIS; CONSTIPATION; DEPRESSION; DIARRHEA; DISEASE EXACERBATION; DIZZINESS; DRUG EFFICACY; ECG ABNORMALITY; ENCEPHALOMYELITIS; FACIAL NERVE PARALYSIS; FATIGUE; FECES INCONTINENCE; FOLLOW UP; GALLBLADDER DISEASE; GALLSTONE; GASTROINTESTINAL SYMPTOM; HEADACHE; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTENSION; HYPERTROPHY; HYPOGLYCEMIA; INSOMNIA; INTESTINE MOTILITY; LEG THROMBOSIS; LOOSE FECES; LOWER ABDOMINAL PAIN; MIGRAINE; MORBIDITY; MUSCULOSKELETAL DISEASE; NAUSEA; NAUSEA AND VOMITING; PAIN; PHARMACEUTICAL CARE; PILONIDAL SINUS; PNEUMONIA; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SEIZURE; SIDE EFFECT; SOCIOECONOMICS; STOMACH PAIN; SUICIDE; SUICIDE ATTEMPT; SYSTEMATIC REVIEW; TACHYCARDIA; TREATMENT OUTCOME; UPPER RESPIRATORY TRACT INFECTION; VITAMIN BLOOD LEVEL; VOMITING; XEROSTOMIA; META ANALYSIS; PEDIATRIC OBESITY;

ADOLESCENT; ANTI-OBESITY AGENTS; BODY MASS INDEX; CHILD; CYCLOBUTANES; FLUOXETINE; HUMANS; LACTONES; METFORMIN; PEDIATRIC OBESITY; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 85000936750     PISSN: None     EISSN: 1469493X     Source Type: Journal    
DOI: 10.1002/14651858.CD012436     Document Type: Review

References (303)

1. Atabek ME, Pirgon O. Use of metformin in obese adolescents with hyperinsulinemia: a 6-month, randomized, double-blind, placebo-controlled clinical trial. Journal of Pediatric Endocrinology and Metabolism 2008;21(4):339-48. [4450719]
2. Berkowitz RI, Wadden TA, Tershakovec AM, Cronquist JL. Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trial. JAMA 2003;289(14):1805-12. [4450721]
3. Bishop-Gilyard CT, Berkowitz RI, Wadden TA, Gehrman CA, Cronquist JL, Moore RH. Weight reduction in obese adolescents with and without binge eating. Obesity (Silver Spring) 2011;19(5):982-7. [4450722]
4. Budd GM, Hayman LL, Crump E, Pollydore C, Hawley K, Cronquist JL, et al. Weight loss in obese African American and Caucasian adolescents. Journal of Cardiovascular Nursing 2007;22(4):288-96. [4450723]
5. Parks EP, Zemel B, Moore RH, Berkowitz RI. Change in body composition during a weight loss trial in obese adolescents. Pediatric Obesity 2014;9:26-35. [4450724]
6. Berkowitz RI, Fujioka K, Daniels SR, Hoppin AG, Owen S, Perry AC, et al. Effects of sibutramine treatment in obese adolescents: a randomized trial. Annals of Internal Medicine 2006;145(2):81-90. [4450726]
7. Daniels SR, Long B, Crow S, Styne D, Sothern M, Vargas-Rodriguez I, et al. Cardiovascular effects of sibutramine in the treatment of obese adolescents: results of a randomized, double-blind, placebo-controlled study. Pediatrics 2007;120:e147-57. [4450727; DOI: 10.1542/peds.2006-2137]
8. Chanoine J, Hampl S, Jensen C, Boldrin M, Hauptman J. Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial. JAMA 2005;293(23):2873-83. [4450729]
9. Chanoine JP, Richard M. Early weight loss and outcome at one year in obese adolescents treated with orlistat or placebo. International Journal of Pediatric Obesity 2010;6(2):95-101. [4450730; DOI: 10.3109/17477166.2010.519387]
10. Clarson CL, Mahmud FH, Baker JE, Clark HE, Mckay WM, Schauteet VD, et al. Metformin in combination with structured lifestyle intervention improved body mass index in obese adolescents, but did not improve insulin resistance. Endocrine 2009;36(1):141-6. [4450732; DOI: 10.1007/s12020-009-9196-9]
11. Franco RR, Cominato L, Damiani D. The effect of sibutramine on weight loss in obese adolescents [O efeito da sibutramina na perda de peso de adolescentes obesos]. Arquivos Brasileiros de Endocrinologia e Metabologia 2014;58:243-50. [4450734]
12. Freemark M. Liver dysfunction in paediatric obesity: a randomized, controlled trial of metformin. Acta Paediatrica 2007;96:1326-32. [4450737; DOI: 10.1111/j.1651-2227.2007.00429.x]
13. Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics 2001;107(4):e55. [4450736]
14. García-Morales LM, Berber A, Macias-Lara CC, Lucio-Ortiz C, Del-Rio-Navarro BE, Dorantes-Alvárez LM. Use of sibutramine in obese Mexican adolescents: a 6-month, randomized, double-blind, placebo-controlled, parallel-group trial. Clinical Therapeutics 2006;28(5):770-82. [4450739; DOI: 10.1016/j.clinthera.2006.05.008]
15. Correa LL, Platt MW, Carraro L, Moreira RO, Junior RF, Godoy-Matos AF, et al. Evaluation of the sibutramine effect on satiety with a visual analogue scale in obese adolescents [Avaliação do efeito da sibutramina sobre a saciedade por escala visual analógica em adolescentes obesos]. Arquivos Brasileiros de Endocrinologia & Metabologia 2005;49(2):286-90. [4450741]
16. Godoy-Matos A, Carraro L, Vieira A, Oliveira J, Guedes EP, Mattos L, et al. Treatment of obese adolescents with sibutramine: a randomized, double-blind, controlled study. Journal of Clinical Endocrinology & Metabolism 2005;90(3):1460-5. [4450742]
17. Kendall D, Vail A, Amin R, Barrett T, Dimitri P, Ivison F, et al. Metformin in obese children and adolescents: the MOCA trial. Journal of Clinical Endocrinology & Metabolism 2013;98(1):322-9. [4450744; DOI: 10.1210/jc.2012-2710]
18. Maahs D, de Serna DG, Kolotkin RL, Ralston S, Sandate J, Qualls C, et al. Randomized, double-blind, placebo-controlled trial of orlistat for weight loss in adolescents. Endocrine Practice 2006;12(1):18-28. [4450746]
19. Benson M, Hossain J, Caulfield MP, Damaso L, Gidding S, Mauras N. Lipoprotein subfractions by ion mobility in lean and obese children. Journal of Pediatrics 2012;161:997-1003. [4450748]
20. Mauras N, DelGiorno C, Hossain J, Bird K, Killen K, Merinbaum D, et al. Metformin use in children with obesity and normal glucose tolerance - effects on cardiovascular markers and intrahepatic fat. Journal of Pediatric Endocrinology and Metabolism 2012;25(1-2):33-40. [4450749]
21. Rynders C, Weltman A, Delgiorno C, Balagopal P, Damaso L, Killen K, et al. Lifestyle intervention improves fitness independent of metformin in obese adolescents. Medicine & Science in Sports & Exercise 2012;44(5):786-92. [4450750; DOI: 10.1249/MSS.0b013e31823cef5e]
22. Condarco TA, Sherafat-Kazemzadeh R, McDuffie JR, Brady S, Salaita C, Sebring NG, et al. Long-term follow-up of a randomized, placebo-controlled trial of orlistat in African-American and Caucasian adolescents with obesity-related comorbid conditions. Endocrine Reviews 2013. [4450752]
23. Radin RM, Tanofsky-Kraff M, Shomaker LB, Kelly NR, Pickworth CK, Shank LM, et al. Metabolic characteristics of youth with loss of control eating. Eating Behaviors 2015;19:86-9. [4450753]
24. Ozkan B, Bereket A, Turan S, Keskin S. Addition of orlistat to conventional treatment in adolescents with severe obesity. European Journal of Pediatrics 2004;163(12):738-41. [4450755]
25. Prado B, Gaete V, Corona F, Peralta E, Donoso P, Raimann X. Metabolic effects of metformin in obese adolescents at risk for type 2 diabetes mellitus [Efecto metabólico de la metformina en adolescentes obesas con riesgo de diabetes mellitus tipo 2]. Revista Chilena de Pediatría 2012;83(1):48-57. [4450757]
26. Rezvanian H, Hashemipour M, Kelishadi R, Tavakoli N, Poursafa P. A randomized, triple masked, placebo-controlled clinical trial for controlling childhood obesity. World Journal of Pediatrics 2010;6(4):317-22. [4450759; DOI: 10.1007/s12519-010-0232-x]
27. Srinivasan S, Ambler GR, Baur LA, Garnett SP, Tepsa M, Yap F, et al. Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin. Journal of Clinical Endocrinology & Metabolism 2006;91(6):2074-80. [4450761; DOI: 10.1210/jc.2006-0241]
28. Van Mil EG, Westerterp KR, Kester AD, Delemarre-van de Waal HA, Gerver WJ, Saris WH. The effect of sibutramine on energy expenditure and body composition in obese adolescents. Journal of Clinical Endocrinology & Metabolism 2007;92(4):1409-14. [4450763]
29. Hübel H. Prospective randomised controlled study for the prevention of type 2 diabetes mellitus in obese children and adolescents, 2012 [Prospektive, randomisierte, kontrollierte Studie zur Prävention des Typ 2 Diabetes mellitus bei adipösen Kindern und Jugendlichen (Dissertation)]. www.diss.fu-berlin.de/diss/servlets/MCRFileNodeServlet/FUDISS_derivate_000000010572/2012.01.01.HHuebel.e_version_diss.pdf (last accessed 20 May 2016). [4450765]
30. Wiegand S, l'Allemand D, Hübel H, Krude H, Bürmann M, Martus P, et al. Metformin and placebo therapy both improve weight management and fasting insulin in obese insulin-resistant adolescents: a prospective, placebo-controlled, randomized study. European Journal of Endocrinology 2010;163(4):585-92. [4450766]
31. Wilson DM, Abrams SH, Aye T, Lee PD, Lenders C, Lustig RH, et al. Metformin extended release treatment of adolescent obesity: a 48-week randomized, double-blind, placebo-controlled trial with 48-week follow-up. Archives of Pediatrics & Adolescent Medicine 2010;164(2):116-23. [4450768; DOI: 10.1001/archpediatrics.2009.264]
32. Adeyemo MA, McDuffie JR, Kozlosky M, Krakoff J, Calis KA, Brady SM, et al. Effects of metformin on energy intake and satiety in obese children. Diabetes, Obesity and Metabolism 2015;17(4):363-70. [4450770; DOI: 10.1111/dom.12426]
33. Yanovski JA, Krakoff J, Salaita CG, McDuffie JR, Kozlosky M, Sebring NG, et al. Effects of metformin on body weight and body composition in obese insulin-resistant children a randomized clinical trial. Diabetes 2011;60(2):477-85. [4450771]
34. Andelman MB, Jones C, Nathan S. Treatment of obesity in underprivileged adolescents. Comparison of diethylpropion hydrochloride with placebo in a double-blind study. Clinical Pediatrics 1967;6:327-30. [4450773]
35. Ardizzi A, Grugni G, Guzzaloni G, Moro D, Morabito F. Effects of protracted rhGH administration on body composition and intermediate metabolism in juvenile obesity. Acta Medica Auxologica 1996;28:103-9. [4450775]
36. Arman S, Sadramely MR, Nadi M, Koleini N. A randomized, double-blind, placebo-controlled trial of metformin treatment for weight gain associated with initiation of risperidone in children and adolescents. Saudi Medical Journal 2008;29:1130-4. [4450777]
37. Bacon GE, Lowrey GH. A clinical trial of fenfluramine in obese children. Current therapeutic research. Clinical and Experimental 1967;9:626-30. [4450779]
38. Beyer G, Huth K, Muller GM, Niemoller H, Raisp I, Vorberg G. The treatment of obesity with the appetite curbing agent mefenorex [Zur Behandlung Von Übergewicht mit dem Appetitzügler Mefenorex]. Medizinische Welt 1980;31:306-9. [4450781]
39. Burgert TS, Duran EJ, Goldberg-Gell R, Dziura J, Yeckel CW, Katz S, et al. Short-term metabolic and cardiovascular effects of metformin in markedly obese adolescents with normal glucose tolerance. Pediatric Diabetes 2008;9:567-76. [4450783]
40. Canlorbe P, Borniche P, Toublanc JE. Controlled trial of an anorectic (An 448) in the treatment of childhood obesity [Essai controle d'un anorexigene (An 448) dans le traitment de l'obesite de l'enfant]. La Nouvelle Presse Médicale 1976;5:1061-2. [4450785]
41. Cannella M, Scarpelli PT, Vailati G. The role of anorexic drugs in the treatment of obesity. Clinical data on the use of a new anorexic drug (Ro 6-1343) [Il ruolo dei farmaci antioressici nel trattamento delle obesità. Rilievi clinici sull'impiego di un nuovo antioressico (Ro 6-1343)]. Minerva Medica 1968;59:3472-83. [4450787]
42. Casteels K, Fieuws S, Van Helvoirt M, Verpoorten C, Goemans N, Coudyzer W, et al. Metformin therapy to reduce weight gain and visceral adiposity in children and adolescents with neurogenic or myogenic motor deficit. Pediatric Diabetes 2010;11:61-9. [4450789]
43. Cayir A, Turan MI, Gurbuz F, Kurt N, Yildirim A. The effect of lifestyle change and metformin therapy on serum arylesterase and paraoxonase activity in obese children. Journal of Pediatric Endocrinology and Metabolism 2015;28(5-6):551-6. [4450791]
44. Biju KR, Patel KS. A clinical trial to study the effect of an Ayurvedic drug, Thriphalaguduchyadi Vati, in children with obesity. Clinical Trial Registry - India 2011. [4450793]
45. Danielsson P, Janson A, Norgren S, Marcus C. Impact sibutramine therapy in children with hypothalamic obesity or obesity with aggravating syndromes. Journal of Clinical Endocrinology and Metabolism 2007;92:4101-6. [4450795]
46. Danilovich N, Mastrandrea LD, Cataldi L, Quattrin T. Methylphenidate decreases fat and carbohydrate intake in obese teenagers. Obesity (Silver Spring, Md.) 2014;22:781-5. [4450797]
47. De Bock M, Derraik JGB, Brennan CM, Biggs JB, Smith GC, Cameron-Smith D, et al. Psyllium supplementation in adolescents improves fat distribution & lipid profile: a randomized, participant-blinded, placebo-controlled, crossover trial. PLoS One 2012;7(7):e41735. [4450799]
48. Delitala G, Alagna S, Masala A. Mazindol (AN-448): a new non-amphetamine anorectic in the treatment of exogenous obesity [Il mazindolo (AN-448): un nuovo anoressante non amfetaminico nel trattamento dell'obesita esogena]. Clinica Terapeutica 1977;81:547-54. [4450801]
49. Diaz M, Bassols J, Lopez-Bermejo A, De Zegher F, Ibanez L. Metformin treatment to reduce central adiposity after prenatal growth restraint: a placebo-controlled pilot study in prepubertal children. Pediatric Diabetes. 2015;16(7):538-45. [4450803]
50. Diaz M, Ibanez L, Lopez-Bermejo A, Sanchez-Infantes D, Bassols J, De Zegher F. Growth restraint before birth, weight catch-up in infancy, and central adiposity in childhood: a placebo-controlled pilot study of early metformin intervention. Hormone Research in Paediatrics 2013;80:116. [4450804]
51. Di Natale B, Devetta M, Rossi L, Garlaschi C, Caccamo A, Del Guercia MJ, et al. Arginine infusion in obese children. Helvetica Paediatrica Acta 1973;28:331-9. [4450806]
52. Doggrell SA. Sibutramine for obesity in adolescents. Expert Opinion on Pharmacotherapy 2006;7:2435-8. [4450808]
53. Fundació Sant Joan de Déu. A phase II, randomized, double-blind, placebo-controlled, in parallel groups clinical trial to assess the safety and efficacy of dietary supplementation with tryptophan to achieve weight loss, and its neuropsychological effects in adolescents with obesity. clinicaltrials.gov/ct2/show/NCT02612259 Date first received: 17 November 2015. [4450810; NCT02612259]
54. Novo Nordisk A/S. A randomised, double-blind, placebo-controlled trial to assess safety, tolerability and pharmacokinetics of liraglutide in obese adolescent subjects aged 12 to 17 years. clinicaltrials.gov/ct2/show/NCT01789086 Date first received: 8 February 2013. [4450812]
55. Fanghänel G, Cortinas L, Sánchez-Reyes L, Berber A. Second phase of a double-blind study clinical trial on sibutramine for the treatment of patients suffering essential obesity: 6 months after treatment cross-over. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 2001;25:741-7. [4450814]
56. Faria AN, Ribeiro Filho FF, Lerário DDG, Kohlmann N, Ferreira SRG, Zanella MT. Effects of sibutramine on the treatment of obesity in patients with arterial hypertension [Efeitos da sibutramina no tratamento da obesidade em pacientes com hipertensão arterial]. Arquivos Brasileiros de Cardiologia 2002;78:172-80. [4450816]
57. Ferguson JM. Fluoxetine-induced weight loss in overweight, nondepressed subjects. American Journal of Psychiatry 1986;143:1496. [4450818]
58. Ferrara P, Del Bufalo F, Ianniello F, Franceschini A, Paolini Paoletti F, Massart F, et al. Diet and physical activity "defeated" Tuberil in treatment of childhood obesity. Minerva Endocrinologica 2013;38:181-5. [4450820]
59. Fox CK, Marlatt KL, Rudser KD, Kelly AS. Topiramate for weight reduction in adolescents with severe obesity. Clinical Pediatrics 2015;54:19-24. [4450822]
60. Freemark M. Pharmacotherapy of childhood obesity: an evidence-based, conceptual approach. Diabetes Care 2007;30:395-402. [4450824]
61. Galloway DB, Logie AW, Petrie JC. Prolonged-action fenfluramine in non-diabetic patients with refractory obesity. Postgraduate Medical Journal 1975;51(Suppl 1):155-7. [4450826]
62. Gamski M, Komarnicka R. Regulation of appetite in obese subjects by means of neutrotropic drugs [Regulacja łaknienia u osób otyłych za pomoca leków neutrotropowych]. Polski Tygodnik Lekarski 1968;23:1688-90. [4450828]
63. Garnett SP, Baur LA, Noakes M, Steinbeck K, Woodhead HJ, Burrell S, et al. Researching effective strategies to improve insulin sensitivity in children and teenagers - RESIST. A randomised control trial investigating the effects of two different diets on insulin sensitivity in young people with insulin resistance and/or pre-diabetes. BMC Public Health 2010;10:575. [4450830]
64. Garnett SP, Dunkley M, Ho M, Baur LA, Noakes M, Cowell CT. Optimum macronutrient content of the diet for adolescents with pre-diabetes: RESIST, a randomised control trial (ACTRN12608000416392). Pediatric Diabetes 2012;13:23-4. [4450831]
65. Garnett SP, Gow M, Ho M, Baur LA, Noakes M, Woodhead HJ, et al. Improved insulin sensitivity and body composition, irrespective of macronutrient intake, after a 12 month intervention in adolescents with pre-diabetes; RESIST a randomised control trial. BMC Pediatrics 2014;14:289. [4450832]
66. Tam C, Lu J, Gow M, Ho M, Cowell C, Baur L, et al. Changes in systemic inflammation in obese children with prediabetes after a 12 month lifestyle intervention; RESIST, a randomised control trial. Obesity Research and Clinical Practice 2013;7:e80. [4450833]
67. Genova R, Massolo F, Venturelli, D The lipolytic action of ACTH. 3. comparison of the lipolytic and corticoadrenal response to extrative and synthetic corticotropin in obese children [L'azione lipopolitica dell'ACTH. 3. Confronto tra la riposta lipopolitica e corticosurrenalica alla corticotropina estrattiva ed a quella sintetica nei bambini obesi]. Clinica Pediatrica 1967;49(6):277-87. [4450835]
68. Gill E. Long-term treatment of obesity with the anorectic agent tenuate as an adjuvant to reducing diet [Langzeitbehandlung der Adipositas mit dem anorektikum tenuate als adjuvans der reduktionsdiät]. Medizinische Welt 1977;28:2080-1. [4450837]
69. Giovannini C, Ciucci E, Facchinetti F. Plasma levels of beta-endorphin, ACTH and cortisol in obese patients subjected to several weight-loss treatments [Livelli Plasmatici Di Beta-Endorfinemia, Acth E Cortisolo In Pazienti Obesi Sottoposti A Differenti Trattamenti Dimagranti]. Recenti Progressi In Medicina 1990;81:301-5. [4450839]
70. Godefroy G, Napolier A, Andriambao-Damasy S. Study of the action of concentrated lucofen with prolonged effect [Etude de l'action du lucofène fort à effet prolongé]. Marseille Medical 1968;105:289-93. [4450841]
71. Goldrick RB, Havenstein N, Whyte HM. Effects of caloric restriction and fenfluramine on weight loss and personality profiles of patients with long standing obesity. Australian And New Zealand Journal of Medicine 1973;3:131-41. [4450843]
72. Goldstein DJ, Rampey AH, Dornseif BE, Levine LR, Potvin JH, Fludzinski LA. Fluoxetine: a randomized clinical trial in the maintenance of weight loss. Obesity Research 1993;1:92-8. [4450845]
73. González Barranco J, Rull JA, Lozano Castañeda O. L-Thyroxine propylhexedrine in the treatment of obesity. Crossed double blind study [Propilhexedrina L-tiroxina en el tratamiento de la obesidad. Estudio doble ciego gruzado]. La Prensa Médica Mexicana 1974;39:298-9. [4450847]
74. Griboff SI, Berman R. A double blind clinical evaluation of a phenylpropanolamine-caffeine-vitamine combination and a placebo in the treatment of exogenous obesity. Current Therapeutic Research, Clinical and Experimental 1975;17:535-43. [4450849]
75. Grube B, Chong WF, Chong PW, Riede L. Weight reduction and maintenance with Iqp-Pv-101: a 12-week randomized controlled study with a 24-week open label period. Obesity 2014;22:645-51. [4450851]
76. Guazzelli R, Piazzini M, Conti C, Papi L, Strazzulla G, Matassi L. Clinical use of mazindol in the treatment of essential obesity [Impiego clinico del mazindolo nel trattamento dell'obesità essenziale]. Clinica Terapeutica 1987;120:385-91. [4450853]
77. Gwinup G, Poucher R. A controlled study of thyroid analogs in the therapy of obesity. American Journal of the Medical Sciences 1967;254:416-20. [4450855]
78. Halpern A, Mancini MC, Cercato C, Villares SMF, Costa AP. Effects of growth hormone on anthropometric and metabolic parameters in android obesity [Efeito Do Hormônio De Crescimento Sobre Parâmetros Antropométricos E Metabólicos Na Obesidade Andróide]. Arquivos Brasileiros de Endocrinologia & Metabologia 2006;50:68-73. [4450857]
79. Hamilton J, Cummings E, Zdravkovic V, Finegood D, Daneman D. Metformin as an adjunct therapy in adolescents with type 1 diabetes and insulin resistance: a randomized controlled trial. Diabetes Care 2003;26:138-43. [4450859]
80. Hansen D, Astrup A, Toubro S, Finer N, Kopelman P, Hilsted J, et al. Predictors of weight loss and maintenance during 2 years of treatment by sibutramine in obesity. Results from the European multi-centre Storm trial (Sibutramine Trial of Obesity Reduction and Maintenance). International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 2001;25:496-501. [4450861]
81. Haug E, Myklebust R. The therapeutic effect of fenfluramine on body weight in overweight patients. A controlled clinical study [Den terapeutiske effekt av fenfluramin på kroppsvekten hos overvektige. En kontrollert klinisk undersøkelse]. Tidsskrift For Den Norske Lægeforening: Tidsskrift For Praktisk Medicin, Ny Række 1973;93(35):2545-9. [4450863]
82. Hawkins FP. Metformin and placebo therapy in adjunct with lifestyle intervention both improve weight loss and insulin resistance in obese adolescents. Archives of Disease in Childhood - Education and Practice 2012;97:79-80. [4450865]
83. Honzak R, Rath R, Vondra K. Effect of cafilon in the treatment of obesity (author's translation). Ceskoslovenska Gastroenterologie A Vyziva 1976;30:155-61. [4450867]
84. Hooper AC. Comparison of fenfluramine (with ad libitum food intake) with 1, 000 calorie diet in obesity. Journal of the Irish Medical Association 1972;65:35-7. [4450869]
85. Huston JR. Obesity: phenmetrazine effect without dietary restriction. Ohio State Medical Journal 1966;62:805-7. [4450871]
86. Shiasi Arani K, Taghavi Ardakani A, Moazami Goudarzi R, Talari HR, Hami K, Akbari H, et al. Effect of vitamin E and metformin on fatty liver disease in obese children - randomized clinical trial. Iranian Journal of Public Health 2014;43(10):1417-23. [4450873]
87. Shahrekord University of Medical Sciences. The effect of folic acid on homocysteine and plasma insulin levels in weight gain and obesity in children and adolescents. en.search.irct.ir/view/16869 Date first received: 23 May 2014. [4450875]
88. Israsena T, Israngkura M, Srivuthana S. Treatment of childhood obesity. Journal of the Medical Association of Thailand 1980;63:433-7. [4450877]
89. James WP, Astrup A, Finer N, Hilsted J, Kopelman P, Rössner S, et al. Effect of sibutramine on weight maintenance after weight loss: a randomised trial. Storm study group. Sibutramine trial of obesity reduction and maintenance. Lancet 2000;356:2119-25. [4450879]
90. Kasa-Vubu JZ. Metformin as a weight-loss tool in "at-risk" obese adolescents: a magic bullet?. Journal of Pediatrics 2008;152(6):750-2. [4450881]
91. Kay JP, Alemzadeh R, Langley G, D'angelo L, Smith P, Holshouser S. Beneficial effects of metformin in normoglycemic morbidly obese adolescents. Metabolism: Clinical and Experimental 2001;50:1457-61. [4450883]
92. Kelly AS, Metzig AM, Rudser KD, Fitch AK, Fox CK, Nathan BM, et al. Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study. Obesity 2012;20:364-70. [4450885]
93. Kelly AS. The role of glucagon-like peptide-1 receptor agonists for the treatment of adolescent obesity. Expert Review of Endocrinology and Metabolism 2013;8:315-7. [4450887]
94. Kelly AS, Rudser KD, Nathan BM, Fox CK, Metzig AM, Coombes BJ, et al. The effect of glucagon-like peptide-1 receptor agonist therapy on body mass index in adolescents with severe obesity: a randomized, placebo-controlled, clinical trial. JAMA Pediatrics 2013;167:355-60. [4450889]
95. Kendall DL, Amin R, Clayton PE. Metformin in the treatment of obese children and adolescents at risk of type 2 diabetes. Paediatric Drugs 2014;16:13-20. [4450891]
96. Klein DJ, Cottingham EM, Sorter M, Barton BA, Morrison JA. A randomized, double-blind, placebo-controlled trial of metformin treatment of weight gain associated with initiation of atypical antipsychotic therapy in children and adolescents. American Journal of Psychiatry 2006;163:2072-9. [4450893]
97. Kneebone GM. Fenfluramine in the treatment of obesity. Medical Journal of Australia 1968;2:833-5. [4450895]
98. Knoll G, Spahn U, Plenert W. Therapy of obesity in childhood. Kinderarztliche Praxis 1975;43:412-26. [4450897]
99. Komarnicka R, Gorzko M. Results of treatment of obesity with low calorie diet and additional drugs (author's translation) [Wyniki leczenia otyłości dieta niskokaloryczna i lekami wspomagajacymi]. Przeglad Lekarski 1975;32:814-7. [4450899]
100. Komorowski JM, Zwaigzne-Raczynska J, Owczarczyk I, Golebiowska M, Zarzycki J. Effect of mazindol (Teronac) on various hormonal indicators in children with simple obesity. Pediatria Polska 1982;57:241-6. [4450901]
101. Kreze A, Kiselá J. Biguanides and the treatment of obesity [Biguanidy a terapia obezity]. Bratislavské Lekárske Listy 1967;48:184-9. [4450903]
102. Lamberto M, Novi RF, Mantovan M. Fluoxetine and obesity [Fluoxetina ed obesità]. Minerva Endocrinologica 1993;18:41-3. [4450905]
103. Leite AC, Liepen LL, Costa VP. Clinical trial of stimsem thozalinone in the treatment of obese patients [Ensaio clĩnico com o stimsem thozalinone no tratamento de pacientes obesos]. Revista Brasileira De Medicina 1971;28:475-8. [4450907]
104. Lewis EA, Adeleye GI, Ukponmwan OO. Comparison of fenfluramine and placebo on obese Nigerians. Nigerian Medical Journal 1978;8:104-7. [4450909]
105. Libman IM, Miller KM, Dimeglio LA, Bethin KE, Katz ML, Shah A, et al. Effect of metformin added to insulin on glycemic control among overweight/obese adolescents with type 1 diabetes a randomized clinical trial. JAMA 2015;314:2241-50. [4450911]
106. Liebermeister H, Probst G, Jahnke K. Experience with the appetite depressant, fenfluramine hydrochloride, in adiposity [Erfahrungen mit dem Appetithemmer Fenfluraminhydrochlorid bei der Adipositas]. Medizinische Klinik 1969;64:1201-7. [4450913]
107. Liu AG, Smith SR, Fujioka K, Greenway FL. The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss. Obesity 2013;21:1991-6. [4450915]
108. Lorber J. Obesity in childhood. A controlled trial of anorectic drugs. Archives of Disease in Childhood 1966;41:309-12. [4450917]
109. Love-Osborne K, Sheeder J, Zeitler P. Addition of metformin to a lifestyle modification program in adolescents with insulin resistance. Journal of Pediatrics 2008;152:817-22. [4450919]
110. Maclay WP, Wallace MG. A multi-centre general practice trial of mazindol in the treatment of obesity. Practitioner 1977;218:431-4. [4450921]
111. Malchow-Møller A, Larsen S, Hey H, Stokholm KH, Juhl E, Quaade F. Effect of elsinore tablets in the treatment of obesity. A controlled clinical trial. Ugeskrift For Laeger 1980;142:1496-9. [4450923]
112. Marques P, Limbert C, Oliveira L, Santos MI, Lopes L. Metformin effectiveness and safety in the management of overweight/obese nondiabetic children and adolescents: metabolic benefits of the continuous exposure to metformin at 12 and 24 months. International Journal of Adolescent Medicine and Health 2016 Feb 19;[Epub ahead of print]. [4450925]
113. McDuffie JR, Calis KA, Uwaifo GI, Sebring NG, Fallon EM, Hubbard VS, et al. Three-month tolerability of orlistat in adolescents with obesity-related comorbid conditions. Obesity Research 2002;10:642-50. [4450927]
114. Molnár D, Török K, Erhardt E, Jeges S. Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents. International Journal of Obesity and Related Metabolic Disorders 2000;24:1573-8. [4450929]
115. Muls E, Kolanowski J, Scheen A, Van Gaal L, Obelhyx Study Group. The effects of orlistat on weight and on serum lipids in obese patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled, multicentre study. International Journal of Obesity and Related Metabolic Disorders 2001;25:1713-21. [4450931]
116. Nadeau KJ, Chow K, Alam S, Lindquist K, Campbell S, Mcfann K, et al. Effects of low dose metformin in adolescents with type I diabetes mellitus: a randomized, double-blinded placebo-controlled study. Pediatric Diabetes 2015;16:196-203. [4450933]
117. Nathan BM, Rudser KD, Abuzzahab MJ, Fox CK, Coombes BJ, Bomberg EM, et al. Predictors of weight-loss response with glucagon-like peptide-1 receptor agonist treatment among adolescents with severe obesity. Clinical Obesity 2016;6:73-8. [4450935]
118. Novartis Pharmaceuticals. Pediatric hypothalamic obesity. clinicaltrials.gov/ct2/show/NCT00076362 Date first received: 21 January 2004. [4450937]
119. Emory University. A primary care behavioral approach for addressing childhood overweight. clinicaltrials.gov/ct2/show/NCT00284557 Date first received: 30 January 2006. [4450939]
120. University of Minnesota - Clinical and Translational Science Institute. Pioglitazone therapy in obese children with insulin resistance: a randomized, controlled pilot study. clinicaltrials.gov/ct2/show/NCT00775164 Date first received: 16 October 2008. [4450941]
121. Yale University. The effects of exenatide on post-meal sugar peaks and vascular health in obese/pre-diabetic young adults. clinicaltrials.gov/ct2/show/NCT00845559 Date first received: 16 February 2009. [4450943]
122. Brooke Army Medical Center. "Efficacy in adolescents of continued behavior modification following a six month sibutramine-based weight management intervention" (AOS). clinicaltrials.gov/ct2/show/NCT01023139 Date first received: 1 December 2009. [4450945]
123. Children's Hospitals and Clinics of Minnesota. Effects of exenatide on hypothalamic obesity. clinicaltrials.gov/ct2/show/NCT01061775 Date first received: 2 February 2010. [4450947]
124. University of Alabama at Birmingham. Calcium, vitamin D and metformin to treat insulin resistance in obese African American adolescent females. clinicaltrials.gov/ct2/show/NCT01107808 Date first received: 1 April 2010. [4450949]
125. NCT01169103 Effect of recombinant human growth hormone (rhGH) on abdominal fat and cardiovascular risk in obese girls. clinicaltrials.gov/ct2/show/NCT01169103 Date first received: 22 July 2010. [4450951]
126. Baylor College of Medicine. Propofol in obese children. clinicaltrials.gov/ct2/show/NCT01242241 Date first received: 15 November 2010. [4450953]
127. Clinica Universidad de Navarra, Universidad de Navarra. Nutrigenomics and children obesity: a moderate weight loss intervention study (NUGENOI). clinicaltrials.gov/ct2/show/NCT01329367 Date first received: 20 January 2011. [4450955]
128. GlaxoSmithKline Meta-analysis of orlistat laboratory data from placebo-controlled clinical trials. clinicaltrials.gov/ct2/show/NCT01332448 Date first received: 7 April 2011. [4450957]
129. Hospital Regional de Alta Especialidad del Bajio. Adipokines in obese adolescents with insulin resistance. clinicaltrials.gov/ct2/show/NCT01410604 Date first received: 4 August 2011. [4450959]
130. Coordinación de Investigación en Salud, Mexico Intervention study with omega-3 fatty acids for weight loss and insulin resistance in adolescents (O3WLIRADOL). clinicaltrials.gov/ct2/show/NCT01456221 Date first received: 12 October 2011. [4450961]
131. University of California, San Francisco. Cardiovascular effects of metformin on obesity. clinicaltrials.gov/ct2/show/NCT01910246 Date first received: 22 April 2013. [4450963]
132. Arena Pharmaceuticals. Single dose study to determine the safety, tolerability, and pharmacokinetic properties of lorcaserin hydrochloride (BELVIQ) in obese adolescents from 12 to 17 years of age. clinicaltrials.gov/ct2/show/NCT02022956 Date first received: 23 December 2013. [4450965]
133. Laboratorios Silanes S.A. de C.V. Metformin vs conjugated linoleic acid and an intervention program with healthy habits in obese children. clinicaltrials.gov/ct2/show/NCT02063802 Date first received: 12 February 2014. [4450967]
134. Duke University. PK study with pantoprazole in obese children and adolescents (PAN01). clinicaltrials.gov/ct2/show/NCT02186652 Date first received: 3 July 2014. [4450969]
135. NCT02378259 Randomized clinical trial; medical vs bariatric surgery for adolescents (13-16 y) with severe obesity. clinicaltrials.gov/ct2/show/NCT02378259 Date first received: 26 August 2014. [4450971]
136. Eisai Inc. A single dose pharmacokinetic study of lorcaserin hydrochloride in obese pediatric subjects 6 to 11 years of age. clinicaltrials.gov/ct2/show/NCT02398669 Date first received: 20 March 2015. [4450973]
137. Juan Pablo, C.-C, Hospital Central "Dr. Ignacio Morones, P, Universidad Autonoma De San Luis. P Study of efficacy of metformin in the treatment of acanthosis nigricans in children with obesity. clinicaltrials.gov/ct2/show/NCT02438020 Date first received: 3 May 2015. [4450975]
138. NCT02515773 Metformin for overweight & obese children and adolescents with BDS treated with SGAs. clinicaltrials.gov/ct2/show/NCT02515773 Date first received: 31 July 2015. [4450977]
139. Nwosu BU, Maranda L, Cullen K, Greenman L, Fleshman J, Mcshea N, et al. A randomized, double-blind, placebo-controlled trial of adjunctive metformin therapy in overweight/obese youth with type 1 diabetes. PLoS One 2015;10:e0137525. [4450979]
140. O'connor HT, Richman RM, Steinbeck KS, Caterson ID. Dexfenfluramine treatment of obesity: a double blind trial with post trial follow up. International Journal of Obesity and Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 1995;19:181-9. [4450981]
141. Park MH, Kinra S. Metformin treatment for adolescent obesity has limited long-term benefits. Journal of Pediatrics 2010;157:172. [4450983]
142. Pedrinola F, Cavaliere H, Lima N, Medeiros-Neto G. Is Dl-Fenfluramine a potentially helpful drug therapy in overweight adolescent subjects?. Obesity Research 1994;2:1-4. [4450985]
143. Persson I, Andersen U, Deckert T. Treatment of obesity with fenfluramine. European Journal of Clinical Pharmacology 1973;6:93-7. [4450987]
144. Plauchu M, De Montgolfier R, Noel P. Clinical study on a new appetite depressant Mg 559 [Etude clinique d'un anorexigène récent: le MG 559]. Lyon Medical 1967;217(15):1105-16. [4450989]
145. Plauchu M, Kofman J, Chapuy H. Clinical study of a new anorexigen: RD 354 (Hepatrol) [Etude clinique d'un nouvel anorexigène: le RD 354]. Lyon Medical 1967;217(17):1247-61. [4450991]
146. Plauchu M, Paffoy JC, Philippe LP, Nove-Josserand G, Chollet A, Valancogne C. Clinical study of a current anorexigenic agent: T.D [Etude clinique d'un anorexigène récent: le T.D]. Lyon Medical 1972;228(15):291-4. [4450993]
147. Pugnoli C, Bandini L, Caronna S, Ciarlini E, Magnati G, Strata A, et al. Clinical trial of a new long-acting fenfluramine in the treatment of obesity [Ricerca Clinica Controllata Su Un Nuovo Preparato Di Fenfluramina 'A Lenta Cessione' Nel Trattamento Dell'obesita]. Giornale Di Clinica Medica 1978;59:486-510. [4450995]
148. Rauh JL, Lipp R. Chlorphentermine as an anorexigenic agent in adolescent obesity. Report of its efficacy in a double-blind study of 30 teen-agers. Clinical Pediatrics 1968;7:138-40. [4450997]
149. Resnick M, Joubert L. A double-blind evaluation of an anorexiant, a placebo and diet alone in obese subjects. Canadian Medical Association Journal 1967;97:1011-5. [4450999]
150. Rodos JJ. The treatment of obesity with voranil (Su-10568), a new non-amphetamine anorexigenic agent. Journal of the American Osteopathic Association 1969;69:161-4. [4451001]
151. Rodriguez JE, Shearer B, Slawson DC. Metformin therapy and diabetes prevention in adolescents who are obese. American Family Physician 2007;76:1357-9. [4451003]
152. Roed P, Hansen PW, Bidstrup B, Kaern M, Helles A, Petersen KP. Elsinore banting tablets. A controlled clinical trial in general practice [Helsingor-slankepiller: En kontrolleret klinisk undersogelse i almen praksis]. Ugeskrift For Laeger 1980;142:1491-5. [4451005]
153. Roginsky MS, Barnett J. Double-blind study of phenethyldiguanide in weight control of obese nondiabetic subjects. American Journal of Clinical Nutrition 1966;19:223-6. [4451007]
154. Sabuncu T, Ucar E, Birden F, Yasar O. The effect of 1-yr sibutramine treatment on glucose tolerance, insulin sensitivity and serum lipid profiles in obese subjects. Diabetes, Nutrition & Metabolism - Clinical & Experimental 2004;17:103-7. [4451009]
155. Sainani GS, Fulambarkar AM, Khurana BK. A double-blind clinical trial of fenfluramine in the treatment of obesity. British Journal of Clinical Practice 1973;27:136-8. [4451011]
156. Scavo D, Giovannini C, Sellini M, Fierro A. Therapy of obesity in childhood and adolescence. Comparison of results obtained with dietary and drug treatment [La terapia dell'obesita nell'infanzia e nell'adolescenza]. Clinica Terapeutica 1976;79:205-18. [4451013]
157. Shutter L, Garell DC. Obesity in children and adolescents: a double-blind study with cross-over. Journal of School Health 1966;36:273-5. [4451015]
158. Spence AW, Medvei VC. Fenfluramine in the treatment of obesity. British Journal of Clinical Practice 1966;20:643-4. [4451017]
159. Spranger J. Anorexigenic drugs in the treatment of obesity in children. An enlarged double-blind study with chlorphentermin. Munchener Medizinische Wochenschrift (1950) 1963;105:1338-41. [4451019]
160. Spranger J. Phentermine resinate in obesity. Clinical trial of Mirapront in adipose children [Phentermin-Resinat bei Fettsucht. Klinische Prüfung von Mirapront bei adipösen Kindern]. Münchener medizinische Wochenschrift (1950) 1965;107:1833-4. [4451021]
161. Sproule BC. Double-blind trial of anorectic agents. Medical Journal of Australia 1969;1:394-5. [4451023]
162. Stewart DA, Bailey JD, Patell H. Tenuate dospan as an appetite suppressant in the treatment of obese children. Applied Therapeutics 1970;12:34-6. [4451025]
163. Sukkari SR, Sasich LD, Humaidan AS, Burikan O. Analysis of metformin treatment for adolescent obesity at 48 rather than 24 weeks after treatment cessation. Archives of Pediatrics & Adolescent Medicine 2010;164:678-9 (author reply). [4451027]
164. Arslanian SA, Pyle L, White NH, Bacha F, Caprio S, Haymond MW, et al. Racial disparity in maintenance of glycemic control in the TODAY trial: does insulin sensitivity, beta-cell function, or both play a role?. Diabetes 2013;62:A338. [4451029]
165. Copeland KC, Zeitler P, Geffner M, Guandalini C, Higgins J, Hirst K, et al. Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. Journal of Clinical Endocrinology and Metabolism 2011;96:159-67. [4451030]
166. Laffel L, Chang N, Grey M, Hale D, Higgins L, Hirst K, et al. Metformin monotherapy in youth with recent onset type 2 diabetes: experience from the prerandomization run-in phase of the TODAY study. Pediatric Diabetes 2012;13:369-75. [4451031]
167. TODAY Study Group. Treatment effects on measures of body composition in the TODAY clinical trial. Diabetes Care 2013;36(6):1742-8. [4451032]
168. TODAY study group. Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study. International Journal of Obesity 2010;34:217-26. [4451034]
169. TODAY study group. Treatment effects on measures of body composition in the TODAY clinical trial. Diabetes Care 2013;36:1742-8. [4451035]
170. TODAY study group, Zeitler P, Hirst K, Pyle L, Linder B, Copeland K, et al. A clinical trial to maintain glycemic control in youth with type 2 diabetes. New England Journal of Medicine 2012;366:2247-56. [4451033]
171. Tong NW, Ran XW, Li QF, Tang BD, Li R, Yang FY, et al. Effects of sibutramine on blood glucose and lipids, body fat mass and insulin resistance in obese patients: a multi-center clinical trial. Zhonghua Nei Ke Za Zhi 2005;44:659-63. [4451037]
172. Toubro S, Hansen DL, Hilsted JC, Porsborg PA, Astrup AV, James WPT, et al. The effect of sibutramine for the maintenance of weight loss: a randomised, clinical, controlled study [Effekt af sibutramin til vægttabsvedligeholdelse: en randomiseret klinisk kontrolleret undersøgelse]. Ugeskrift for Laeger 2001;163(21):2935-40. [4451039]
173. Tsai AG, Wadden TA, Berkowitz RI. Pharmacotherapy for overweight adolescents. Obesity Management 2006;2:98-102. [4451041]
174. Van Seters AP, Bouwhuis-Hoogerwerf ML, Goslings BM, Van Nieuwkoop L, Van Slooten H, Struijk-Wielinga T. Long-term treatment of patients with obesity using mazindol and a reducing diet. Nederlands Tijdschrift Voor Geneeskunde 1982;126:990-4. [4451043]
175. Warren-Ulanch J. Metformin may aid weight loss in overweight teenage girls. Journal of Pediatrics 2008;153:725-6. [4451045]
176. Weintraub M, Hasday JD, Mushlin AI, Lockwood DH. Double-blind clinical trial in weight control. Use of fenfluramine and phentermine alone and in combination. Archives of Internal Medicine 1984;144:1143-8. [4451047]
177. Adeyemo MA, McDuffie JR, Kozlosky M, Krakoff J, Calis KA, Brady SM, et al. Effects of metformin on energy intake and satiety in obese children. Diabetes, Obesity & Metabolism 2015;17(4):363-70. [4451049]
178. Yanovski JA, Yanovski SZ. Treatment of pediatric and adolescent obesity. JAMA 2003;289:1851-3. [4451050]
179. Yu CC, Li AM, Chan KO, Chook P, Kam JT, Au CT, et al. Orlistat improves endothelial function in obese adolescents: a randomised trial. Journal of Paediatrics and Child Health 2013;49:969-72. [4451052]
180. Golebiowska M, Chlebna-Sokol D, Kobierska I, Konopinska A, Malek M, Mastalska A, et al. Clinical evaluation of teronac (mazindol) in the treatment of obesity in children. Part II. Anorectic properties and side effects (author's translation). Przeglad Lekarski 1981;38:355-8. [4451054]
181. Linquette A, Fossati, P Hunger control with benzphetamine hydrochloride in the treatment of obesity [Le contrôle de la faim par le chlorydrate de benzphétamine dans le traitement de l'obésité]. Lille Medical 1971;16(Suppl 2):620-4. [4451057]
182. Clarson CL, Brown H, Dejesus S, Jackman M, Mahmud FH, Prapavessis H, et al. Structured lifestyle intervention with metformin extended release or placebo in obese adolescents. Diabetes. 2013; Vol. 62:A337-8. [4451059]
183. Wilson AJ, Prapavessis H, Jung ME, Cramp AG, Vascotto J, Lenhardt L, et al. Lifestyle modification and metformin as long-term treatment options for obese adolescents: study protocol. BMC Public Health 2009;9:434. [4451060]
184. van der Aa MP, Elst MA, van Mil EG, Knibbe CA, van der Vorst MM. Metformin: an efficacy, safety and pharmacokinetic study on the short-term and long-term use in obese children and adolescents - study protocol of a randomized controlled study. Trials 2014;15:207. [4451063]
185. van der Aa MP, Elst MA, van de Garde EM, van Mil EG, Knibbe CA, van der Vorst MM. Long-term treatment with metformin in obese, insulin-resistant adolescents: results of a randomized double-blinded placebo-controlled trial. Nutrition & Diabetes 2016;6(8):e228. [4451064; DOI: 10.1038/nutd.2016.37]
186. Smetanina N, Seibokaite A, Valickas R, Kuprionis G, Grigoniene JJ, Rokaite R, et. al. Metformin in combination with lifestyle changes effectively reduces BMI and waist circumference in overweight/obese children and adolescents. Hormone Research in Paediatrics 2015;84:229. [4451066]
187. Pastor MB, Canete MD, Hoyos R, Latorre M, Vazquez-Cobela R, Rangel-Huerta OD, et al. Metformin in the treatment of obese children shows differential response according to pubertal stage. Acta Physiologica. 2014; Vol. 212:36-7. [4451068]
188. A study with lifestyle intervention and study medication once weekly or lifestyle intervention and placebo in adolescents with obesity to explore differences between groups with regard to change in BMI. Ongoing study Trial start date: not givenTrial completion date: not given.
189. Effect of exercise or metformin on nocturnal blood pressure and other risk factors for CVD among obese adolescents. Ongoing study Trial start date: February 2009Trial completion date: December 2012 (estimated).
190. Obesity in children and adolescents: associated risks and early intervention (OCA). Ongoing study Trial start date: May 2013Trial completion date: December 2015.
191. Topiramate in Adolescents with Severe Obesity. Ongoing study Trial start date: June 2013Trial completion date: December 2015.
192. Topiramate and Severe Obesity (TOBI). Ongoing study Trial start date: June 2015Trial completion date: December 2020.
193. Use of Metformin in Treatment of Childhood Obesity. Ongoing study Trial start date: July 2014Trial completion date: February 2016.
194. Enhancing Weight Loss Maintenance With GLP-1RA (BYDUREON™) in Adolescents with Severe Obesity. Ongoing study Trial start date: December 2015Trial completion date: July 2020.
195. Aggarwal A, Puri K, Thangada S, Zein N, Alkhouri N. Nonalcoholic fatty liver disease in children: recent practice guidelines, where do they take us?. Current Pediatric Reviews 2014;10(2):151-61.
196. Alonso J, Prieto L, Anto JM. The Spanish version of the SF 36 Health Survey (the SF 36 health questionnaire): an instrument for measuring clinical results. Medicina Clinica 1995;104:771-6.
197. Barlow SE, Dietz WH. Maternal and Child Health Resources and Services Administration and Department of Health and Human Services. Obesity evaluation and treatment: expert committee recommendations. Pediatrics 1998;102:E29.
198. Bayer O, Krüger H, Kries R, Toschke AM. Factors associated with tracking of BMI: a meta-regression analysis on BMI tracking. Obesity 2011;19(5):1069-76.
199. Berardis S, Sokal E. Pediatric non-alcoholic fatty liver disease: an increasing public health issue. European Journal of Pediatrics 2014;173(2):131-9.
200. Bocca G, Ongering EC, Stolk RP, Sauer PJ. Insulin resistance and cardiovascular risk factors in 3- to 5-year-old overweight or obese children. Hormone Research in Paediatrics 2013;80(3):201-6.
201. Boland CL, Brock Harris J, Harris, KB Pharmacological management of obesity in pediatric patients. Annals of Pharmacotherapy 2015;49(2):220-32. [DOI: 10.1177/1060028014557859]
202. Borkan GA, Gerzof SG, Robbins AH, Hults DE, Silbert CK, Silbert JE. Assessment of abdominal fat content by computed tomography. American Journal of Clinical Nutrition 1982;36(1):172-7.
203. Bouza C, Lopez-Cuadrado T, Gutierrez-Torres LF, Amate J. Efficacy and safety of metformin for treatment of overweight and obesity in adolescents: an updated systematic review and meta-analysis. Obesity Facts 2012;5:753-65.
204. Calloway CW, Chumlea WC, Bouchard C. Circumferences. In: Lohman TC, Roche AR, Martorell R editor(s). Anthropometric Standardization Manual. Campaign, III. Champaign, IL: Human Kinetics Publishers, 1988:39-64.
205. Catoira N, Nagel M, Di Girolamo G, Gonzalez CD. Pharmacological treatment of obesity in children and adolescents: current status and perspectives. Expert Opinion on Pharmacotherapy 2010;11(18):2973-83.
206. Cheung BM, Cheung TT, Samaranayake NR. Safety of antiobesity drugs. Therapeutic Advances in Drug Safety 2013;4(4):171-81. [DOI: 10.1177/2042098613489721]
207. Chief Medical Officer. Chief Medical Officer annual report: surveillance volume 2012. www.gov.uk/government/publications/chief-medicalofficer-annual-report-surveillance-volume-2012 27 March 2014.
208. Cole TJ, Freeman JV, Preece MA. Body mass index reference curves for the UK, 1990. Archives of Disease in Childhood 1995;73:25-9.
209. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000;320:1240-53.
210. Cole TJ, Faith MS, Pietrobelli A, Heo M. What is the best measure of adiposity change in growing children: BMI, BMI %, BMI z-score or BMI centile?. European Journal of Clinical Nutrition 2005;59:419-25.
211. Cole TJ, Lobstein T. Extended international (IOTF) body mass index cut offs for thinness, overweight and obesity. Pediatric Obesity 2012;7:284-94.
212. Colquitt JL, Loveman E, O'Malley C, Azevedo LB, Mead E, Al-Khudairy L, et al. Diet, physical activity, and behavioural interventions for the treatment of overweight or obesity in preschool children up to the age of 6 years. Cochrane Database of Systematic Reviews 2016, Issue 3. [DOI: 10.1002/14651858.CD012105]
213. Czernichow S, Lee CM, Barzi F, Green F. Efficacy of weight loss drugs on obesity and cardiovascular risk factors in obese adolescents: a meta-analysis of randomized controlled trials. Obesity Reviews 2010;11(2):150-8.
214. De Onis M, Blossner M. Borghi, E Global prevalence and trends of overweight and obesity among preschool children. American Journal of Clinical Nutrition 2010;92:1257-64.
215. Derogatis LR, Melisaratos N. The Brief Symptom Inventory: an introductory report. Psychological Medicine 1983;13:595-605.
216. Dietz, WH Health consequences of obesity in youth: childhood predictors of adult disease. Paediatrics 1998;101(3S):518-25.
217. Ebbeling CB, Pawlak DB, Ludwig DS. Childhood obesity: public-health crisis, common sense cure. Lancet 2002;360(9331):473-82.
218. Ells L, Hancock C, Copley VR, Mead E, Dinsdale H, Kinra S, et al. Prevalence of severe childhood obesity in England: 2006-2013. Archives of Disease in Childhood 2015;100(7):631-6. [DOI: 10.1136/archdischild-2014-307036]
219. Ells LJ, Mead E, Atkinson G, Corpeleijn E, Roberts K, Viner R, et al. Surgery for the treatment of obesity in children and adolescents. Cochrane Database of Systematic Reviews 2015, Issue 6. [DOI: 10.1002/14651858.CD011740]
220. Falaschetti E, Hingorani AD, Jones A, Charakida M, Finer N, Whincup P, et al. Adiposity and cardiovascular risk factors in a large contemporary population of pre-pubertal children. European Heart Journal 2010;173(2):131-9.
221. Fernandez JR, Redden DT, Pietrobelli A, Allison DB. Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescent. Journal of Pediatrics 2004;145:439-44.
222. Fishbein MH, Stevens WR. Rapid MRI using a modified Dixon technique: a non-invasive and effective method for detection and monitoring of fatty metamorphosis of the liver. Pediatric Radiology 2001;31(11):806-9.
223. Fishbein MH, Miner M, Mogren C, Chalekson J. The spectrum of fatty liver in obese children and the relationship of serum aminotransferases to severity of steatosis. Journal of Pediatric Gastroenterology and Nutrition 2003;36(1):54-61.
224. Freedman DS, Dietz WH, Srinivasan SR, Berenson GS. The relation of overweight to cardiovascular risk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 1999;103(6 Pt 1):1175-82.
225. Freedman DS, Khan LK, Serdula MK, Ogden CL, Dietz WH. Racial and ethnic differences in secular trends for childhood BMI, weight, and height. Obesity 2006;14:301-8.
226. Fuller NJ, Jebb SA, Laskey MA, Coward WA, Elia M. Four-component model for the assessment of body composition in humans: comparison with alternative methods, and evaluation of the density and hydration of fat-free mass. Clinical Science (London) 1992;82:687-93.
227. Glenny A M. O'Meara S, Melville A, sheldon TA, Wilson C. The treatment and prevention of obesity: a systematic review of the literature. International Journal of Obesity & Related Metabolic Disorders: Journal of the International Association for the Study of Obesity 1997;21(9):715-37.
228. Halford JC, Boyland EJ, Blundell JE, Kirkham TC, Harrold JA. Pharmacological management of appetite expression in obesity. Nature Reviews. Endocrinology 2010;6(5):255-69.
229. Halpern A, Mancini MC, Magalhães ME, Fisberg M, Radominski R, Bertolami MC, et al. Metabolic syndrome, dyslipidemia, hypertension and type 2 diabetes in youth: from diagnosis to treatment. Diabetology & Metabolic Syndrome 2010;2:55. [PUBMED: 20718958]
230. Hansen DL, Toubro S, Stock MJ, Macdonald IA, Astrup A. Thermogenic effects of sibutramine in humans. American Journal of Clinical Nutrition 1998;68:1180-6.
231. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Statistics in Medicine 2002;21(11):1539-58.
232. Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003;327(7414):557-60.
233. Higgins JPT, Thompson SG, Spiegelhalter DJ. A re-evaluation of random-effects meta-analysis. Journal of the Royal Statistical Society. Series A, (Statistics in Society) 2009;172(1):137-59.
234. Higgins JPT, Green S (editors). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 (updated March 2011). The Cochrane Collaboration, 2011. Available from www.cochrane-handbook.org.
235. Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ 2011;343:d5928.
236. Hróbjartsson A, Thomsen AS, Emanuelsson F, Tendal B, Hilden J, Boutron I, et al. Observer bias in randomized clinical trials with measurement scale outcomes: a systematic review of trials with both blinded and nonblinded assessors. Canadian Medical Association Journal 2013;185(4):E201-11.
237. Health and Social Care Information Centre. National Child Measurement Programme - England, 2013-14 school year. www.hscic.gov.uk/ (22 October 2016).
238. Hsia Y, Dawoud D, Sutcliffe AG, Viner RM, Kinra S, Wong ICK. Unlicensed use of metformin in children and adolescents in the UK. British Journal of Clinical Pharmacology 2011;73(1):135-9. [DOI: 10.1111/j.1365-2125.2011.04063.x]
239. Imperatore G, Boyle JP, Thompson TJ, Case D, Dabelea D, Hamman RF, et al. Projections of type 1 and type 2 diabetes burden in the U.S. population aged <20 years through 2050: dynamic modeling of incidence, mortality, and population growth. Diabetes Care 2012;35(12):2515-20.
240. James WP, Caterson ID, Coutinho W, Finer N, Van Gaal LF, Maggioni AP, et al. Effect of sibutramine on cardiovascular outcomes in overweight and obese subjects. New England Journal of Medicine 2010;363(10):905-17.
241. Kakinami L, Henderson M, Chiolero A, Cole TJ, Paradis G. Identifying the best body mass index metric to assess adiposity change in children. Archives of Disease in Childhood 2014;99:1020-4.
242. Kelly AS, Barlow SE, Rao G, Inge TH, Hayman LL, Steinberger J, et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement From the American Heart Association. Circulation 2013;128:1689-712.
243. Kirkham JJ, Dwan KM, Altman DG, Gamble C, Dodd S, Smyth R, et al. The impact of outcome reporting bias in randomised controlled trials on a cohort of systematic reviews. BMJ 2010;340:c365. [DOI: 10.1136/bmj.c365]
244. Knai C, Lobstein T, Darmon N, Rutter H, McKee M. Socioeconomic patterning of childhood overweight status in Europe. International Journal of Environmental Research and Public Health 2012;9(4):1472-89.
245. Kolotkin RL, Head S, Brookhart A. Construct validity of the Impact of Weight on Quality of Life Questionnaire. Obesity Research 1997;5(5):434-41.
246. Kolotkin RL, Crosby RD, Williams GR, Hartley GG, Nicol S. The relationship between health-related quality of life and weight loss. Obesity Research 2001;9(9):564-71.
247. Kromeyer-Hausschild K, Wabitsch M, Kunze D. Perzentile fur den Body-mass-Index fr das Kindes-und Jugendalterunter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilkd 2001;149:807-18. [DOI: 10.1007/s001120170107]
248. Kuczmarski RJ, Ogden CL, Grummer-Strawn LM, Flegal KM, Guo SS, Wei R, et al. CDC growth charts: United States. Advance Data 2000;314:1-27.
249. Leclercq E, Leeflang MM, van Dalen EC, Kremer LC. Validation of search filters for identifying pediatric studies in PubMed. Journal of Pediatrics 2013;162(3):629-34.
250. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic and meta-analyses of studies that evaluate interventions: explanation and elaboration. PLoS Medicine 2009;6(7):1-28. [DOI: 10.1371/journal.pmed.1000100]
251. Lobstein T, Baur L, Uauy R. Obesity in children and young people: a crisis in public health. Obesity Review 2004;5(Suppl 1):4-104.
252. Loveman E, Al-Khudairy L, Johnson RE, Robertson W, Colquitt JL, Mead EL, et al. Parent-only interventions for childhood overweight or obesity in children aged 5 to 11 years. Cochrane Database of Systematic Reviews 2015, Issue 12. [DOI: 10.1002/14651858.CD012008]
253. Maahs DM, Daniels SR, de Ferranti SD, Dichek HL, Flynn J, Goldstein BI, et al. Cardiovascular disease risk factors in youth with diabetes mellitus: a scientific statement from the American Heart Association. Circulation 2014;130(17):1532-58.
254. Matson KL, Fallon RM. Treatment of obesity in children and adolescents. Journal of Pediatric Pharmacology and Therapeutics 2012;17(1):45-57.
255. McCreight LJ, Bailey CJ, Pearson ER. Metformin and the gastrointestinal tract. Diabetologia 2016;59(3):426-35.
256. McDonagh M, Selph S, Ozpinar A, Foley C. Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger. JAMA Pediatrics 2014;168(2):178-84. [DOI: 10.1001/jamapediatrics.2013.4200]
257. McGovern L, Johnson JN, Paulo R, Hettinger A, Singhal V, Kamath C, et al. Treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials. Journal of Clinical Endocrinology and Metabolism 2008;93(12):4600-5.
258. Meader N, King K, Llewellyn A, Norman G, Brown J, Rodgers M, et al. A checklist designed to aid consistency and reproducibility of GRADE assessments: development and pilot validation. Systematic Reviews 2014;3:82.
259. Nespoli L, Caprioglio A, Brunetti L, Nosetti L. Obstructive sleep apnea syndrome in childhood. Early Human Development 2013;89(Suppl 3):S33-7.
260. Ng M, Fleming T, Robinson M, Thomson B, Graetz N, Margono C, et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis of the Global Burden of Disease Study 2013. Lancet 2014;384(9945):766-81.
261. National Institute for Health and Care Excellence. Obesity: identification, assessment and management of overweight and obesity in children, young people and adults. www.nice.org.uk/guidance/cg189/chapter/1-recommendations#pharmacological-interventions (accessed 5 August 2015).
262. Olds T, Maher C, Zumin S, Peneau S, Lioret S, Castetbon K, et al. Evidence that the prevalence of childhood overweight is plateauing: data from nine countries. International Journal of Pediatric Obesity 2011;6:342-60. [DOI: 10.3109/17477166.2011.605895]
263. Padwal RS, Rucker D, Li SK, Curioni C, Lau DCW. Long-term pharmacotherapy for obesity and overweight. Cochrane Database of Systematic Reviews 2003, Issue 4. [DOI: 10.1002/14651858.CD004094.pub2]
264. Pandey A, Chawla S, Guchhait P. Type-2 diabetes: current understanding and future perspectives. IUBMB Life 2015;67(7):506-13.
265. Park MH, Kinra S, Ward KJ, White B, Viner RM. Metformin for obesity in children and adolescents: a systematic review. Diabetes Care 2009;32(9):1743-5.
266. Parsons TJ, Power C, Logan S, Summerbell CD. Childhood predictors of adult obesity: a systematic review. International Journal of Obesity 1999;23(Suppl 8):S1-107.
267. Petkar R, Wright N. Pharmacological management of obese child. Archives of Disease in Childhood - Education and Practice 2013;98:108-12. [DOI: 10.1136/archdischild-2011-301127]
268. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. Journal of Pediatrics 2005;146:693-700.
269. Power C, Pinto Pereira SM, Law C, Ki M. Obesity and risk factors for cardiovascular disease and type 2 diabetes: investigating the role of physical activity and sedentary behaviour in mid-life in the 1958 British cohort. Atherosclerosis. 2014;233(2):363-9.
270. Puhl RM, Latner JD. Stigma, obesity, and the health of the nation's children. Psychology Bulletin 2007;133(4):557-80.
271. Rajput N, Tuohy P, Mishra S, Smith A, Taylor B. Overweight and obesity in 4-5-year-old children in New Zealand: results from the first 4 years (2009-2012) of the B4School Check programme. Journal of Paediatrics and Child Health 2014;51(3):334-43. [DOI: 10.1111/jpc.12716]
272. Ravens-Sieberer U, Redegeld M, Bullinger M. Quality of life after in-patient rehabilitation in children with obesity. International Journal of Obesity and Related Metabolic Disorders 2001;25 Suppl 1:S63-5.
273. Reilly JJ, Methven E, McDowell ZC, Hacking B, Alexander D, Stewart L, et al. Health consequences of obesity. Archives of Disease in Childhood 2003;88(9):748-52.
274. Reilly JJ, Kelly J. Long-term impact of overweight and obesity in childhood and adolescence on morbidity and premature mortality in adulthood: systematic review. International Journal of Obesity 2011;35:891-8.
275. The Nordic Cochrane Centre, The Cochrane Collaboration. Review Manager (RevMan). Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2014.
276. Riley RD, Higgins JP, Deeks JJ. Interpretation of random effects meta-analyses. BMJ 2011;342:d549.
277. Rokholm B, Baker JL, Sørenson TIA. The levelling off of the obesity epidemic since the year 1999 - a review of evidence and perspectives. Obesity Reviews 2010;11:835-46.
278. Rosner B, Prineas R, Loggie J, Daniels SR. Percentiles for body mass index in U.S. children 5 to 17 years of age. Journal of Pediatrics 1998;132:211-22.
279. Sherafat-Kazemzadeh R, Yanovski SZ, Yanovski JA. Pharmacotherapy for childhood obesity: present and future prospects. International Journal of Obesity (London) 2013;37(1):1-15. [DOI: 10.1038/ijo.2012.144]
280. Shrewsbury V, Wardle J. Socioeconomic status and adiposity in childhood: a systematic review of cross-sectional studies 1990-2005. Obesity (Silver Spring) 2008;16(2):275-84.
281. Singh AS, Mulder C, Twisk JW, vanMechelen W, Chinapaw MJ. Tracking of childhood overweight into adulthood: a systematic review of the literature. Obesity Reviews 2008;9(5):474-88.
282. Skinner AC, Skelton JA. Prevalence and trends in obesity and severe obesity among children in the United States, 1999-2012. JAMA Pediatrics 2014;168(6):561-6. [DOI: 10.1001/jamapediatrics.2014.21]
283. Sterne JA, Sutton AJ, Ioannidis JP, Terrin N, Jones DR, Lau J, et al. Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ 2011;343:d4002.
284. Stunkard AJ, Messick S. The three-factor eating questionnaire to measure dietary restraint, disinhibition and hunger. Journal of Psychosomatic Research 1985;29:71-83.
285. Tang-Peronard JL, Heitmann BL. Stigmatization of obese children and adolescents, the importance of gender. Obesity Reviews 2008;9:1467-89.
286. Van Marken Lichtenbelt W, Fogelholm M. Body composition. In: Westerterp-Plantenga MS, Steffens AB, Tremblay A, eds editor(s). Regulation of Food Intake and Energy Expenditure. Milan: EDRA, 1999:383-404.
287. Viner RM, Hsia Y, Tomsic T, Wong IC. Efficacy and safety of anti-obesity drugs in children and adolescents: systematic review and meta-analysis. Obesity Reviews 2010;11(8):593-602.
288. von Scheven E, Gordon CM, Wypij D, Wertz M, Gallagher KT, Bachrach L. Variable deficits of bone mineral despite chronic glucocorticoid therapy in pediatric patients with inflammatory diseases: a Glaser Pediatric Research Network study. Journal of Pediatric Endocrinology & Metabolism 2006;19(6):821-30.
289. Wang J, Thornton JC, Bari S, Williamson B, Gallagher D, Heymsfield SB, et al. Comparisons of waist circumferences measured at 4 sites. American Journal of Clinical Nutrition 2003;77(2):379-84.
290. Wang Y, Lim H. The global childhood obesity epidemic and the association between socio-economic status and childhood obesity. International Review of Psychiatry 2012;24(3):176-88.
291. Weiss R, Dziura J, Burgert TS, Tamborlane WV, Taksali SE, Yeckel CW, et al. Obesity and the metabolic syndrome in children and adolescents. New England Journal of Medicine 2004;350(23):2362-74.
292. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. New England Journal of Medicine 1997;337(13):869-73. [MEDLINE: 97433004]
293. World Health Organization. The Use and Interpretation of Antropometry. Geneva: WHO 1995.
294. World Health Organization. The WHO Child Growth Standards. www.who.int/childgrowth/standards/Technical_report.pdf 2006 (accessed 08/11/2016).
295. World Health Organization. Fact sheet on overweight and obesity. www.who.int/mediacentre/factsheets/fs311/en/ (accessed 24 February 2015).
296. Widhalm HK, Seemann R, Hamboeck M, Mittlboeck M, Neuhold A, Friedrich K, et al. Osteoarthritis in morbidly obese children and adolescents, an age-matched controlled study. Knee Surgery, Sports Traumatology, Arthroscopy 2016;24(3):644-52.
297. Wong SS, Wilczynski NL, Haynes RB. Developing optimal search strategies for detecting clinically sound treatment studies in EMBASE. Journal of the Medical Library Association 2006;94(1):41-7.
298. Wood L, Egger M, Gluud LL, Schulz KF, Juni P, Altman DG, et al. Empirical evidence of bias in treatment effect estimates in controlled trials with different interventions and outcomes: meta-epidemiological study. BMJ 2008;336(7644):601-5.
299. The World Bank. Country and Lending Groups. data.worldbank.org/about/country-and-lending-groups (accessed 5 August 2015).
300. Yanovski SZ, Yanovski JA. Long-term drug treatment of obesity: a systematic and clinical review. JAMA 2014;311(1):74-86. [DOI: 10.1001/jama.2013.281361]
301. Ye Z, Chen L, Yang Z, Li Q, Huang Y, He M, et al. Metabolic effects of fluoxetine in adults with type 2 diabetes mellitus: a meta-analysis of randomized placebo-controlled trials. PLoS One 2011;6(7):e21551.
302. Oude Luttikhuis H, Baur L, Jansen H, Shrewsbury VA, O'Malley C, Stolk RP, et al. Interventions for treating obesity in children. Cochrane Database of Systematic Reviews 2009, Issue 1. [DOI: 10.1002/14651858.CD001872.pub2]
303. Summerbell CD, Ashton V, Campbell KJ, Edmunds L, Kelly S, Waters E. Interventions for treating obesity in children. Cochrane Database of Systematic Reviews 2003, Issue 3. [DOI: 10.1002/14651858.CD001872]