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Volumn 16, Issue 7, 2015, Pages 538-545

Metformin treatment to reduce central adiposity after prenatal growth restraint: A placebo-controlled pilot study in prepubertal children

Author keywords

Adipose tissue; Body composition; Catch up; IGF I; Insulin; Metformin; Small for gestational age; Visceral fat

Indexed keywords

ADIPONECTIN; ANDROGEN; GLUCOSE; INSULIN; LIPID; METFORMIN; PLACEBO; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN C; TRIACYLGLYCEROL; ANTIDIABETIC AGENT; ANTIOBESITY AGENT; BIOLOGICAL MARKER;

EID: 84942903902     PISSN: 1399543X     EISSN: 13995448     Source Type: Journal    
DOI: 10.1111/pedi.12220     Document Type: Article
Times cited : (25)

References (40)
  • 1
    • 10744228850 scopus 로고    scopus 로고
    • Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood
    • Bhargava SK, Sachdev HS, Fall CH et al. Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N Engl J Med 2004: 350: 865-875.
    • (2004) N Engl J Med , vol.350 , pp. 865-875
    • Bhargava, S.K.1    Sachdev, H.S.2    Fall, C.H.3
  • 2
  • 5
    • 33744952660 scopus 로고    scopus 로고
    • Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children
    • Ibáñez L, Ong K, Dunger DB, de Zegher F. Early development of adiposity and insulin resistance after catch-up weight gain in small-for-gestational-age children. J Clin Endocrinol Metab 2006: 91: 2153-2158.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2153-2158
    • Ibáñez, L.1    Ong, K.2    Dunger, D.B.3    de Zegher, F.4
  • 6
    • 40849113046 scopus 로고    scopus 로고
    • Early development of visceral fat excess after spontaneous catch-up growth in children with low birth weight
    • Ibáñez L, Suarez L, López-Bermejo A, Díaz M, Valls C, de Zegher F. Early development of visceral fat excess after spontaneous catch-up growth in children with low birth weight. J Clin Endocrinol Metab 2008: 93: 925-928.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 925-928
    • Ibáñez, L.1    Suarez, L.2    López-Bermejo, A.3    Díaz, M.4    Valls, C.5    de Zegher, F.6
  • 8
    • 2942633569 scopus 로고    scopus 로고
    • Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls
    • Ong KK, Potau N, Petry CJ et al. Opposing influences of prenatal and postnatal weight gain on adrenarche in normal boys and girls. J Clin Endocrinol Metab 2004: 89: 2647-2651.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2647-2651
    • Ong, K.K.1    Potau, N.2    Petry, C.J.3
  • 9
    • 70349912072 scopus 로고    scopus 로고
    • Low-birth weight children develop lower sex hormone binding globulin and higher dehydroepiandrosterone sulfate levels and aggravate their visceral adiposity and hypoadiponectinemia between six and eight years of age
    • Ibáñez L, López-Bermejo A, Díaz M, Suárez L, de Zegher F. Low-birth weight children develop lower sex hormone binding globulin and higher dehydroepiandrosterone sulfate levels and aggravate their visceral adiposity and hypoadiponectinemia between six and eight years of age. J Clin Endocrinol Metab 2009: 94: 3696-3699.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 3696-3699
    • Ibáñez, L.1    López-Bermejo, A.2    Díaz, M.3    Suárez, L.4    de Zegher, F.5
  • 10
    • 33644839552 scopus 로고    scopus 로고
    • Early puberty-menarche after precocious pubarche: relation to prenatal growth
    • Ibáñez L, Jimenez R, de Zegher F. Early puberty-menarche after precocious pubarche: relation to prenatal growth. Pediatrics 2006: 117: 117-121.
    • (2006) Pediatrics , vol.117 , pp. 117-121
    • Ibáñez, L.1    Jimenez, R.2    de Zegher, F.3
  • 12
    • 72149102470 scopus 로고    scopus 로고
    • Pubertal metformin therapy to reduce total, visceral, and hepatic adiposity
    • Ibáñez L, Lopez-Bermejo A, Diaz M, Marcos MV, de Zegher F. Pubertal metformin therapy to reduce total, visceral, and hepatic adiposity. J Pediatr 2010: 156: e10198-e101102.
    • (2010) J Pediatr , vol.156 , pp. e10198-e101102
    • Ibáñez, L.1    Lopez-Bermejo, A.2    Diaz, M.3    Marcos, M.V.4    de Zegher, F.5
  • 13
    • 78751581706 scopus 로고    scopus 로고
    • Early metformin therapy to delay menarche and augment height in girls with precocious pubarche
    • Ibáñez L, Lopez-Bermejo A, Diaz M, Marcos MV, de Zegher F. Early metformin therapy to delay menarche and augment height in girls with precocious pubarche. Fertil Steril 2011: 95: 727-730.
    • (2011) Fertil Steril , vol.95 , pp. 727-730
    • Ibáñez, L.1    Lopez-Bermejo, A.2    Diaz, M.3    Marcos, M.V.4    de Zegher, F.5
  • 14
    • 67049089270 scopus 로고    scopus 로고
    • Estudio longitudinal de crecimiento y desarrollo. Centro Andrea Prader. Zaragoza 1980-2002
    • In: Garcia-Dihinx A, Romo A, Ferrandez-Longas A, eds. . Madrid: Ergon
    • Ferrández-Longas A, Mayayo E, Labarta JI et al. Estudio longitudinal de crecimiento y desarrollo. Centro Andrea Prader. Zaragoza 1980-2002. In: Garcia-Dihinx A, Romo A, Ferrandez-Longas A, eds. Patrones de crecimiento y desarrollo en España. Madrid: Ergon, 2004: 61-115.
    • (2004) Patrones de crecimiento y desarrollo en España , pp. 61-115
    • Ferrández-Longas, A.1    Mayayo, E.2    Labarta, J.I.3
  • 15
    • 33947501922 scopus 로고    scopus 로고
    • Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society
    • Clayton PE, Cianfarani S, Czernichow P, Johannsson G, Rapaport R, Rogol A. Management of the child born small for gestational age through to adulthood: a consensus statement of the International Societies of Pediatric Endocrinology and the Growth Hormone Research Society. J Clin Endocrinol Metab 2007: 92: 804-810.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 804-810
    • Clayton, P.E.1    Cianfarani, S.2    Czernichow, P.3    Johannsson, G.4    Rapaport, R.5    Rogol, A.6
  • 16
    • 0014524644 scopus 로고
    • Variations in pattern of pubertal changes in girls
    • Marshall WA, Tanner JM. Variations in pattern of pubertal changes in girls. Arch Dis Child 1969: 44: 291-303.
    • (1969) Arch Dis Child , vol.44 , pp. 291-303
    • Marshall, W.A.1    Tanner, J.M.2
  • 17
    • 0014736650 scopus 로고
    • Variations in the pattern of pubertal changes in boys
    • Marshall WA, Tanner JM. Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970: 45: 13-23.
    • (1970) Arch Dis Child , vol.45 , pp. 13-23
    • Marshall, W.A.1    Tanner, J.M.2
  • 18
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program
    • Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998: 21: 2191-2192.
    • (1998) Diabetes Care , vol.21 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3
  • 19
    • 84855695613 scopus 로고    scopus 로고
    • Carotid intima-media thickness at 7 years of age: relationship to C-reactive protein rather than adiposity
    • Osiniri I, Sitjar C, Soriano-Rodriguez P et al. Carotid intima-media thickness at 7 years of age: relationship to C-reactive protein rather than adiposity. J Pediatr 2012: 160: e271276-e271280.
    • (2012) J Pediatr , vol.160 , pp. e271276-e271280
    • Osiniri, I.1    Sitjar, C.2    Soriano-Rodriguez, P.3
  • 20
    • 0036313839 scopus 로고    scopus 로고
    • Adjustment of fat-free mass and fat mass for height in children aged 8 y
    • Wells JC, Cole TJ. Adjustment of fat-free mass and fat mass for height in children aged 8 y. Int J Obes Relat Metab Disord 2002: 26: 947-952.
    • (2002) Int J Obes Relat Metab Disord , vol.26 , pp. 947-952
    • Wells, J.C.1    Cole, T.J.2
  • 21
    • 84878757912 scopus 로고    scopus 로고
    • Birth weight, growth and feeding pattern in early infancy predict overweight/obesity status at two years of age: a birth cohort study of Chinese infants
    • Zhang J, Himes JH, Guo Y et al. Birth weight, growth and feeding pattern in early infancy predict overweight/obesity status at two years of age: a birth cohort study of Chinese infants. PLoS One 2013: 8: e64542.
    • (2013) PLoS One , vol.8 , pp. e64542
    • Zhang, J.1    Himes, J.H.2    Guo, Y.3
  • 22
    • 84878697753 scopus 로고    scopus 로고
    • Weight gain in infancy and vascular risk factors in later childhood
    • Skilton MR, Marks GB, Ayer JG et al. Weight gain in infancy and vascular risk factors in later childhood. Pediatrics 2013: 131: e1821-e1828.
    • (2013) Pediatrics , vol.131 , pp. e1821-e1828
    • Skilton, M.R.1    Marks, G.B.2    Ayer, J.G.3
  • 23
    • 64549107617 scopus 로고    scopus 로고
    • Small for gestational age status is associated with metabolic syndrome in overweight children
    • Reinehr T, Kleber M, Toschke AM. Small for gestational age status is associated with metabolic syndrome in overweight children. Eur J Endocrinol 2009: 160: 579-584.
    • (2009) Eur J Endocrinol , vol.160 , pp. 579-584
    • Reinehr, T.1    Kleber, M.2    Toschke, A.M.3
  • 25
    • 79956087497 scopus 로고    scopus 로고
    • Serum concentrations of insulin-like growth factor-I, insulin-like growth factor binding protein-3 and cardiovascular risk factors in adolescents
    • Kong AP, Choi KC, Wong GW et al. Serum concentrations of insulin-like growth factor-I, insulin-like growth factor binding protein-3 and cardiovascular risk factors in adolescents. Ann Clin Biochem 2011: 48: 263-269.
    • (2011) Ann Clin Biochem , vol.48 , pp. 263-269
    • Kong, A.P.1    Choi, K.C.2    Wong, G.W.3
  • 26
    • 84874317175 scopus 로고    scopus 로고
    • Clinical utility of visceral adipose tissue for the identification of cardiometabolic risk in white and African American adults
    • Katzmarzyk PT, Heymsfield SB, Bouchard C. Clinical utility of visceral adipose tissue for the identification of cardiometabolic risk in white and African American adults. Am J Clin Nutr 2013: 97: 480-486.
    • (2013) Am J Clin Nutr , vol.97 , pp. 480-486
    • Katzmarzyk, P.T.1    Heymsfield, S.B.2    Bouchard, C.3
  • 27
    • 0035321014 scopus 로고    scopus 로고
    • The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes
    • Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics 2001: 107: E55.
    • (2001) Pediatrics , vol.107 , pp. E55
    • Freemark, M.1    Bursey, D.2
  • 28
    • 84878254497 scopus 로고    scopus 로고
    • Safety and tolerability of the treatment of youth-onset type 2 diabetes: the TODAY experience
    • TODAY Study Group. Safety and tolerability of the treatment of youth-onset type 2 diabetes: the TODAY experience. Diabetes Care 2013: 36: 1765-1771.
    • (2013) Diabetes Care , vol.36 , pp. 1765-1771
  • 29
    • 84893470006 scopus 로고    scopus 로고
    • Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger
    • McDonagh MS, Selph S, Ozpinar A, Foley C. Systematic review of the benefits and risks of metformin in treating obesity in children aged 18 years and younger. JAMA Pediatr 2014: 168: 178-184.
    • (2014) JAMA Pediatr , vol.168 , pp. 178-184
    • McDonagh, M.S.1    Selph, S.2    Ozpinar, A.3    Foley, C.4
  • 30
    • 56949101509 scopus 로고    scopus 로고
    • Comparative associations of adiposity measures with cardiometabolic risk burden in asymptomatic subjects
    • Dervaux N, Wubuli M, Megnien JL, Chironi G, Simon A. Comparative associations of adiposity measures with cardiometabolic risk burden in asymptomatic subjects. Atherosclerosis 2008: 201: 413-417.
    • (2008) Atherosclerosis , vol.201 , pp. 413-417
    • Dervaux, N.1    Wubuli, M.2    Megnien, J.L.3    Chironi, G.4    Simon, A.5
  • 31
    • 84885206896 scopus 로고    scopus 로고
    • Waist circumference measurement site does not affect relationships with visceral adiposity and cardiometabolic risk factors in children
    • Harrington DM, Staiano AE, Broyles ST, Gupta AK, Katzmarzyk PT. Waist circumference measurement site does not affect relationships with visceral adiposity and cardiometabolic risk factors in children. Pediatr Obes 2013: 8: 199-206.
    • (2013) Pediatr Obes , vol.8 , pp. 199-206
    • Harrington, D.M.1    Staiano, A.E.2    Broyles, S.T.3    Gupta, A.K.4    Katzmarzyk, P.T.5
  • 33
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001: 108: 1167-1174.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 34
    • 44649139278 scopus 로고    scopus 로고
    • Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents
    • Hoffman RP. Indices of insulin action calculated from fasting glucose and insulin reflect hepatic, not peripheral, insulin sensitivity in African-American and Caucasian adolescents. Pediatr Diabetes 2008: 9: 57-61.
    • (2008) Pediatr Diabetes , vol.9 , pp. 57-61
    • Hoffman, R.P.1
  • 35
    • 84878224394 scopus 로고    scopus 로고
    • Lipid and inflammatory cardiovascular risk worsens over 3 years in youth with type 2 diabetes: the TODAY clinical trial
    • TODAY Study Group. Lipid and inflammatory cardiovascular risk worsens over 3 years in youth with type 2 diabetes: the TODAY clinical trial. Diabetes Care 2013: 36: 1758-1764.
    • (2013) Diabetes Care , vol.36 , pp. 1758-1764
  • 36
    • 84894900806 scopus 로고    scopus 로고
    • Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial
    • Preiss D, Lloyd SM, Ford I et al. Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial. Lancet Diabetes Endocrinol 2014: 2: 116-124.
    • (2014) Lancet Diabetes Endocrinol , vol.2 , pp. 116-124
    • Preiss, D.1    Lloyd, S.M.2    Ford, I.3
  • 37
    • 77956596784 scopus 로고    scopus 로고
    • Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: the Coronary Artery Risk Development in Young Adults women's study
    • Calderon-Margalit R, Schwartz SM, Wellons MF et al. Prospective association of serum androgens and sex hormone-binding globulin with subclinical cardiovascular disease in young adult women: the Coronary Artery Risk Development in Young Adults women's study. J Clin Endocrinol Metab 2010: 95: 4424-4431.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 4424-4431
    • Calderon-Margalit, R.1    Schwartz, S.M.2    Wellons, M.F.3
  • 38
    • 84902578977 scopus 로고    scopus 로고
    • Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study
    • Epub ahead of print].
    • Canoy D, Barber TM, Pouta A et al. Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study. Eur J Endocrinol 2014[Epub ahead of print].
    • (2014) Eur J Endocrinol
    • Canoy, D.1    Barber, T.M.2    Pouta, A.3
  • 39
    • 65949090518 scopus 로고    scopus 로고
    • Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty
    • Sørensen K, Aksglaede L, Munch-Andersen T et al. Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty. Diabetes Care 2009: 32: 909-914.
    • (2009) Diabetes Care , vol.32 , pp. 909-914
    • Sørensen, K.1    Aksglaede, L.2    Munch-Andersen, T.3
  • 40
    • 33744956288 scopus 로고    scopus 로고
    • Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty
    • Ibáñez L, Valls C, Ong K, Dunger DB, de Zegher F. Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty. J Clin Endocrinol Metab 2006: 91: 2068-2073.
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 2068-2073
    • Ibáñez, L.1    Valls, C.2    Ong, K.3    Dunger, D.B.4    de Zegher, F.5


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