Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes

Nature Genetics

Volumn 37, Issue 8, 2005, Pages 889-893

  Spitz, François ^a   Herkenne, Carole ^a   Morris, Michael A ^a   Duboule, Denis ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

RNA;

ALLELE; ARTICLE; CHROMOSOME INVERSION; CHROMOSOME REARRANGEMENT; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CLUSTER; GENE CONTROL; GENETIC TRANSCRIPTION; HOX GENE; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RNA HYBRIDIZATION;

ANIMALS; EVOLUTION, MOLECULAR; GENE EXPRESSION REGULATION; GENES, HOMEOBOX; IN SITU HYBRIDIZATION, FLUORESCENCE; INVERSION, CHROMOSOME; MICE; MULTIGENE FAMILY;

VERTEBRATA;

EID: 23044477774     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1597     Document Type: Article

References (29)

1. Hurst, L.D., Pal, C. Lercher, M.J. The evolutionary dynamics of eukaryotic gene order. Nat. Rev. Genet. 5, 299-310 (2004).
2. Kleinjan, D.A. & van Heyningen, V. Long-range control of gene expression: emerging mechanisms and disruption in disease. Am. J. Hum. Genet. 76, 8-32 (2005).
3. Lettice, L.A. et al. A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly. Hum. Mol. Genet. 12, 1725-1735 (2003).
4. Spitz, F., Gonzalez, F. & Duboule, D. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Cell 113, 405-417 (2003).
5. Zuniga, A. et al. Mouse limb deformity mutations disrupt a global control region within the large regulatory landscape required for Gremlin expression. Genes Dev. 18, 1553-1564 (2004).
6. Spitz, F. et al. Large scale transgenic and cluster deletion analysis of the HoxD complex separate an ancestral regulatory module from evolutionary innovations. Genes Dev. 15, 2209-2214 (2001).
7. Duboule, D. Vertebrate Hox gene regulation: clustering and/or colinearity? Curr. Opin. Genet. Dev. 8, 514-518 (1998).
8. Akam, M. Hoxand HOM: homologous gene clusters in insects and vertebrates. Cell 57, 347-349 (1989).
9. Yu, Y. & Bradley, A. Engineering chromosomal rearrangements in mice. Nat. Rev. Genet. 2, 780-790 (2001).
10. Zakany, J., Gerard, M., Favier, B. & Duboule, D. Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J. 16, 4393-4402 (1997).
11. Gimond, C. et al. Cre-loxP-mediated inactivation of the alpha6A integrin splice variant in vivo: evidence for a specific functional role of alpha6A in lymphocyte migration but not in heart development. J. Cell Biol. 143, 253-266 (1998).
12. Wittig, B.M., Johansson, B., Zoller, M., Schwarzler, C. & Gunthert, U. Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7). J. Exp. Med 191, 2053-2064 (2000).
13. Kmita, M., Fraudeau, N., Herault, Y. & Duboule, D. Serial deletions and duplications suggest a mechanism for the collinearity of Hoxd genes in limbs. Nature 420, 145-150 (2002).
14. Kmita, M., Kondo, T. & Duboule, D. Targeted inversion of a polar silencer within the HoxD complex re-allocates domains of enhancer sharing. Nat. Genet. 26, 451-454 (2000).
15. Davis, A.P., Witte, D.P., Hsieh-Li, H.M., Potter, S.S. & Capecchi, M.R. Absence of radius and ulna in mice lacking Hoxa-11 and Hoxd-11. Nature 375, 791-795 (1995).
16. Sordino, P., van der Hoeven, F. & Duboule, D. Hoxgene expression in teleost fins and the origin of vertebrate digits. Nature 375, 678-681 (1995).
17. Duboule, D. & Dolle, P. The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 8, 1497-1505 (1989).
18. Graham, A., Papalopulu, N. & Krumlauf, R. The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell 57, 367-378 (1989).
19. Gaunt, S.J., Sharpe, P.T. & Duboule, D. Spatially restricted domains of homeo-gene transcripts in mouse embryos: relation to a segmented body plan. Development 104 Suppl, 169-179 (1988).
20. Gould, A., Morrison, A., Sproat, G., White, R.A. & Krumlauf, R. Positive cross-regulation and enhancer sharing: two mechanisms for specifying overlapping Hox expression patterns. Genes Dev. 11, 900-913 (1997).
21. Zhang, F. et al. Elements both 5′ and 3′ to the murine Hoxd4 gene establish anterior borders of expression in mesoderm and neurectoderm. Mech. Dev. 67, 49-58 (1997).
22. Vogels, R., Charite, J., de Graaff, W. & Deschamps, J. Proximal cis-acting elements cooperate to set Hoxb-7 (Hox-2.3) expression boundaries in transgenic mice. Development 118, 71-82 (1993).
23. Zheng, B., Sage, M., Sheppeard, E.A., Jurecic, V. & Bradley, A. Engineering mouse chromosomes with Cre-loxP: range, efficiency, and somatic applications. Mol. Cell. Biol. 20, 648-655 (2000).
24. Puech, A. et al. Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region. Proc. Natl. Acad. Sci. USA 97, 10090-10095 (2000).
25. Kondo, T., Zakany, J. & Duboule, D. Control of colinearity in AbdB genes of the mouse HoxD complex. Mol. Cell 1, 289-300 (1998).
26. Herault, Y., Rassoulzadegan, M., Cuzin, F. & Duboule, D. Engineering chromosomes in mice through targeted meiotic recombination (TAMERE). Nat. Genet. 20, 381-384 (1998).
27. Monge, I., Kondo, T. & Duboule, D. An enhancer-titration effect induces digit-specific regulatory alleles of the HoxD cluster. Dev. Biol. 256, 212-220 (2003).
28. Kulnane, L.S., Lehman, E.J.H., Hock, B.J., Tsuchiya, K.D. & Lamb, B.T. Rapid and efficient detection of transgene homozygosity by FISH of mouse fibroblasts. Mamm. Genome 13, 223-226 (2002).
29. Spitz, F. et al. A t(2;8) balanced translocation with breakpoints near the human HDXD complex causes mesomelic dysplasia and vertebral defects. Genomics 79, 493-498 (2002).