-
1
-
-
79955770162
-
Scaffold proteins: Hubs for controlling the flow of cellular information
-
Good, M. C., Zalatan, J. G., Lim, W. A. Scaffold proteins: hubs for controlling the flow of cellular information. Science 332, 680-6 (2011).
-
(2011)
Science
, vol.332
, pp. 680-686
-
-
Good, M.C.1
Zalatan, J.G.2
Lim, W.A.3
-
2
-
-
34248576576
-
KSR and CNK: Two scaffolds regulating RAS-mediated RAF activation
-
Clapéron, a., Therrien, M. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene 26, 3143-58 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 3143-3158
-
-
Clapéron, A.1
Therrien, M.2
-
4
-
-
0842325725
-
Linking rho and ras signal transduction pathways
-
Human CNK1 Acts as a Scaffold Protein
-
Jaffe, A. B., Aspenstro, P., Hall, A. Human CNK1 Acts as a Scaffold Protein, Linking Rho and Ras Signal Transduction Pathways. Mol. Cell Biol. 24, 1736-1746 (2004).
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 1736-1746
-
-
Jaffe, A.B.1
Aspenstro, P.2
Hall, A.3
-
5
-
-
14744276941
-
Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho
-
Jaffe, A. B., Hall, A., Schmidt, A. Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Curr. Biol. 15, 405-12 (2005).
-
(2005)
Curr. Biol.
, vol.15
, pp. 405-412
-
-
Jaffe, A.B.1
Hall, A.2
Schmidt, A.3
-
6
-
-
21244463565
-
CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation
-
Ziogas, A., Moelling, K., Radziwill, G. CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation. J. Biol. Chem. 280, 24205-11 (2005).
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 24205-24211
-
-
Ziogas, A.1
Moelling, K.2
Radziwill, G.3
-
7
-
-
77953809690
-
CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis
-
Fritz, R. D., Varga, Z., Radziwill, G. CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis. Oncogene 29, 3575-82 (2010).
-
(2010)
Oncogene
, vol.29
, pp. 3575-3582
-
-
Fritz, R.D.1
Varga, Z.2
Radziwill, G.3
-
8
-
-
77949721038
-
CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling
-
Fritz, R. D., Radziwill, G. CNK1 promotes invasion of cancer cells through NF-kappaB-dependent signaling. Mol. Cancer Res. 8, 395-406 (2010).
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 395-406
-
-
Fritz, R.D.1
Radziwill, G.2
-
9
-
-
77954852559
-
The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling
-
Lim, J., Zhou, M., Veenstra, T. D., Morrison, D. K. The CNK1 scaffold binds cytohesins and promotes insulin pathway signaling. Genes Dev. 1496-1506 (2010).
-
(2010)
Genes Dev.
, vol.1496-1506
-
-
Lim, J.1
Zhou, M.2
Veenstra, T.D.3
Morrison, D.K.4
-
10
-
-
84940828287
-
Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction
-
Fischer, A., Brummer, T., Warscheid, B., Radziwill, G. Differential tyrosine phosphorylation controls the function of CNK1 as a molecular switch in signal transduction. Biochim. Biophys. Acta-Mol. Cell Res. 1853, 2847-2855 (2015).
-
(2015)
Biochim. Biophys. Acta-Mol. Cell Res.
, vol.1853
, pp. 2847-2855
-
-
Fischer, A.1
Brummer, T.2
Warscheid, B.3
Radziwill, G.4
-
11
-
-
84904995490
-
Illuminating cell signalling with optogenetic tools
-
Tischer, D., Weiner, O. D. Illuminating cell signalling with optogenetic tools. Nat. Rev. Mol. Cell Biol. 15, 551-8 (2014).
-
(2014)
Nat. Rev. Mol. Cell Biol.
, vol.15
, pp. 551-558
-
-
Tischer, D.1
Weiner, O.D.2
-
12
-
-
84922638213
-
Optogenetic control of signaling in mammalian cells
-
Beyer, H. M., Naumann, S., Weber, W., Radziwill, G. Optogenetic control of signaling in mammalian cells. Biotechnol. J. 10, 273-83 (2015).
-
(2015)
Biotechnol. J.
, vol.10
, pp. 273-283
-
-
Beyer, H.M.1
Naumann, S.2
Weber, W.3
Radziwill, G.4
-
13
-
-
78649714869
-
Rapid blue light induction of protein interaction in living cells
-
Kennedy, M. J. et al. Rapid blue light induction of protein interaction in living cells. Nat. Methods 7, 973-975 (2010).
-
(2010)
Nat. Methods
, vol.7
, pp. 973-975
-
-
Kennedy, M.J.1
-
14
-
-
84874656353
-
Optogenetic protein clustering and signaling activation in mammalian cells
-
Bugaj, L. J., Choksi, A. T., Mesuda, C. K., Kane, R. S., Schaffer, D. V. Optogenetic protein clustering and signaling activation in mammalian cells. Nat. Methods 10, 249-252 (2013).
-
(2013)
Nat. Methods
, vol.10
, pp. 249-252
-
-
Bugaj, L.J.1
Choksi, A.T.2
Mesuda, C.K.3
Kane, R.S.4
Schaffer, D.V.5
-
15
-
-
84908520377
-
An optimized optogenetic clustering tool for probing protein interaction and function
-
Taslimi, A. et al. An optimized optogenetic clustering tool for probing protein interaction and function. Nat. Commun. 5, 4925 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 4925
-
-
Taslimi, A.1
-
16
-
-
84900874407
-
Optogenetic control of protein kinase activity in mammalian cells
-
Wend, S. et al. Optogenetic control of protein kinase activity in mammalian cells. ACS Synth. Biol. 3, 280-5 (2014).
-
(2014)
ACS Synth. Biol.
, vol.3
, pp. 280-285
-
-
Wend, S.1
-
17
-
-
84962449962
-
Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors
-
Chatelle, C. V. et al. Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors. Sci. Rep. 6, 23713 (2016).
-
(2016)
Sci. Rep.
, vol.6
, pp. 23713
-
-
Chatelle, C.V.1
-
18
-
-
84904568275
-
Spatiotemporal control of fibroblast growth factor receptor signals by blue light
-
Kim, N. et al. Spatiotemporal Control of Fibroblast Growth Factor Receptor Signals by Blue Light. Chem. Biol. 21, 903-912 (2014).
-
(2014)
Chem. Biol.
, vol.21
, pp. 903-912
-
-
Kim, N.1
-
19
-
-
84928807371
-
Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering
-
Bugaj, L. J. et al. Regulation of endogenous transmembrane receptors through optogenetic Cry2 clustering. Nat. Commun. 6, 6898 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 6898
-
-
Bugaj, L.J.1
-
20
-
-
0035816691
-
Differential usage of signal transduction pathways defines two types of serum response factor target gene
-
Gineitis, D., Treisman, R. Differential usage of signal transduction pathways defines two types of serum response factor target gene. J. Biol. Chem. 276, 24531-9 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 24531-24539
-
-
Gineitis, D.1
Treisman, R.2
-
21
-
-
84947023702
-
A positive feedback loop between Akt and mTORC2 via SIN1 phosphorylation
-
Yang, G., Murashige, D. S., Humphrey, S. J., James, D. E. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation. Cell Rep. 12, 937-43 (2015).
-
(2015)
Cell Rep.
, vol.12
, pp. 937-943
-
-
Yang, G.1
Murashige, D.S.2
Humphrey, S.J.3
James, D.E.4
-
22
-
-
33645520353
-
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila
-
Douziech, M., Sahmi, M., Laberge, G., Therrien, M. A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila. Genes Dev. 3, 807-819 (2006).
-
(2006)
Genes Dev.
, vol.3
, pp. 807-819
-
-
Douziech, M.1
Sahmi, M.2
Laberge, G.3
Therrien, M.4
-
23
-
-
33645521412
-
The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway
-
Roignant, J., Hamel, S., Janody, F., Treisman, J. E. The novel SAM domain protein Aveugle is required for Raf activation in the Drosophila EGF receptor signaling pathway. Genes Dev. 795-806 (2006).
-
(2006)
Genes Dev.
, pp. 795-806
-
-
Roignant, J.1
Hamel, S.2
Janody, F.3
Treisman, J.E.4
-
24
-
-
0033607633
-
Phosphorylation and regulation of Raf by Akt (protein kinase B)
-
Zimmermann, S., Moelling, K. Phosphorylation and regulation of Raf by Akt (protein kinase B). Science 286, 1741-1744 (1999).
-
(1999)
Science
, vol.286
, pp. 1741-1744
-
-
Zimmermann, S.1
Moelling, K.2
-
25
-
-
38049147787
-
MEF2: A central regulator of diverse developmental programs
-
Potthoff, M. J., Olson, E. N. MEF2: a central regulator of diverse developmental programs. Development 134, 4131-40 (2007).
-
(2007)
Development
, vol.134
, pp. 4131-4140
-
-
Potthoff, M.J.1
Olson, E.N.2
-
26
-
-
23944498100
-
The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells
-
Sanchez-Rodriguez, J., Kaninda-Tshilumbu, J. P., Santos, A., Perez-Castillo, A. The spot 14 protein inhibits growth and induces differentiation and cell death of human MCF-7 breast cancer cells. Biochem. J. 390, 57-65 (2005).
-
(2005)
Biochem. J.
, vol.390
, pp. 57-65
-
-
Sanchez-Rodriguez, J.1
Kaninda-Tshilumbu, J.P.2
Santos, A.3
Perez-Castillo, A.4
-
27
-
-
0021923858
-
Nile red: A selective fluorescent stain for intracellular lipid droplets
-
Greenspan, P. Nile red: a selective fluorescent stain for intracellular lipid droplets. J. Cell Biol. 100, 965-973 (1985).
-
(1985)
J. Cell Biol.
, vol.100
, pp. 965-973
-
-
Greenspan, P.1
-
28
-
-
84887040380
-
Transforming growth factor-? Signalling controls human breast cancer metastasis in a zebrafish xenograft model
-
Drabsch, Y. et al. Transforming growth factor-? signalling controls human breast cancer metastasis in a zebrafish xenograft model. Breast Cancer Res. 15, 10-16 (2013).
-
(2013)
Breast Cancer Res.
, vol.15
, pp. 10-16
-
-
Drabsch, Y.1
-
29
-
-
0037163050
-
Regulation of raf-akt cross-talk
-
Moelling, K., Schad, K., Bosse, M., Zimmermann, S., Schweneker, M. Regulation of Raf-Akt Cross-talk. J. Biol. Chem. 277, 31099-106 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31099-31106
-
-
Moelling, K.1
Schad, K.2
Bosse, M.3
Zimmermann, S.4
Schweneker, M.5
-
30
-
-
0035823542
-
Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells
-
Reusch, H. P., Zimmermann, S., Schaefer, M., Paul, M., Moelling, K. Regulation of Raf by Akt controls growth and differentiation in vascular smooth muscle cells. J. Biol. Chem. 276, 33630-7 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 33630-33637
-
-
Reusch, H.P.1
Zimmermann, S.2
Schaefer, M.3
Paul, M.4
Moelling, K.5
-
31
-
-
84863241921
-
Signaling network crosstalk in human pluripotent cells: A Smad2/3-regulated switch that controls the balance between self-renewal and differentiation
-
Singh, A. M. et al. Signaling network crosstalk in human pluripotent cells: a Smad2/3-regulated switch that controls the balance between self-renewal and differentiation. Cell Stem Cell 10, 312-26 (2012).
-
(2012)
Cell Stem Cell
, vol.10
, pp. 312-326
-
-
Singh, A.M.1
-
32
-
-
0033607784
-
Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt
-
Rommel, C. et al. Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science 286, 1738-41 (1999).
-
(1999)
Science
, vol.286
, pp. 1738-1741
-
-
Rommel, C.1
-
33
-
-
84863895262
-
Building muscle: Molecular regulation of myogenesis
-
Bentzinger, C. F., Wang, Y. X., Rudnicki, M. A. Building muscle: Molecular regulation of myogenesis. Cold Spring Harb. Perspect. Biol. 4, 1-16 (2012).
-
(2012)
Cold Spring Harb. Perspect. Biol.
, vol.4
, pp. 1-16
-
-
Bentzinger, C.F.1
Wang, Y.X.2
Rudnicki, M.A.3
-
34
-
-
84874915869
-
It takes two to tango-signalling by dimeric Raf kinases
-
Baljuls, A., Kholodenko, B. N., Kolch, W. It takes two to tango-signalling by dimeric Raf kinases. Mol. Biosyst. 9, 551-8 (2013).
-
(2013)
Mol. Biosyst.
, vol.9
, pp. 551-558
-
-
Baljuls, A.1
Kholodenko, B.N.2
Kolch, W.3
-
35
-
-
84929077789
-
Regulation of RAF protein kinases in ERK signalling
-
Lavoie, H., Therrien, M. Regulation of RAF protein kinases in ERK signalling. Nat. Rev. Mol. Cell Biol. 16, 281-298 (2015).
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 281-298
-
-
Lavoie, H.1
Therrien, M.2
-
36
-
-
0034282892
-
Negative regulation of the serine/threonine kinase B-Raf by Akt
-
Guan, K. L. et al. Negative regulation of the serine/threonine kinase B-Raf by Akt. J. Biol. Chem. 275, 27354-9 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 27354-27359
-
-
Guan, K.L.1
-
37
-
-
84947023702
-
A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
-
Yang, G., Murashige, D. S., Humphrey, S. J., James, D. E. A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation. Cell Rep. 12, 937-43 (2015).
-
(2015)
Cell Rep.
, vol.12
, pp. 937-943
-
-
Yang, G.1
Murashige, D.S.2
Humphrey, S.J.3
James, D.E.4
-
38
-
-
72949093349
-
The nuts and bolts of AGC protein kinases
-
Pearce, L. R., Komander, D., Alessi, D. R. The nuts and bolts of AGC protein kinases. Nat. Rev. Mol. Cell Biol. 11, 9-22 (2010).
-
(2010)
Nat. Rev. Mol. Cell Biol.
, vol.11
, pp. 9-22
-
-
Pearce, L.R.1
Komander, D.2
Alessi, D.R.3
-
39
-
-
15644381754
-
Role of translocation in the activation and function of protein kinase B
-
Andjelkovi?, M. et al. Role of translocation in the activation and function of protein kinase B. J. Biol. Chem. 272, 31515-24 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 31515-31524
-
-
Andjelkovi, M.1
-
40
-
-
0035914338
-
Insulin-like Growth Factor-mediated Muscle Differentiation: Collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogenein
-
Tureckova, J., Wilson, E. M., Cappalonga, J. L., Rotwein, P. Insulin-like Growth Factor-mediated Muscle Differentiation: collaboration between phosphatidylinositol 3-kinase-Akt-signaling pathways and myogenein. J. Biol. Chem. 276, 39264-39270 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39264-39270
-
-
Tureckova, J.1
Wilson, E.M.2
Cappalonga, J.L.3
Rotwein, P.4
-
41
-
-
30344442873
-
The many faces of SAM
-
Qiao, F., Bowie, J. U. The many faces of SAM. Sci. STKE 2005, re7 (2005).
-
(2005)
Sci. STKE
, vol.2005
, pp. 7
-
-
Qiao, F.1
Bowie, J.U.2
-
42
-
-
84999752561
-
AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1
-
In press
-
Fischer, A., Weber, W., Warscheid, B., Radziwill, G. AKT-dependent phosphorylation of the SAM domain induces oligomerization and activation of the scaffold protein CNK1. Biochim. Biophys. Acta In press (2016).
-
(2016)
Biochim. Biophys. Acta
-
-
Fischer, A.1
Weber, W.2
Warscheid, B.3
Radziwill, G.4
-
43
-
-
0035943615
-
Serum-and glucocorticoid-inducible kinase SGK phosphorylates and negatively regulates B-Raf
-
Zhang, B. H. et al. Serum-and Glucocorticoid-inducible Kinase SGK Phosphorylates and Negatively Regulates B-Raf. J. Biol. Chem. 276, 31620-31626 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 31620-31626
-
-
Zhang, B.H.1
-
44
-
-
61849087361
-
Regulation of human myoblast differentiation by PEBP4
-
Garcia, R., Grindlay, J., Rath, O., Fee, F., Kolch, W. Regulation of human myoblast differentiation by PEBP4. EMBO Rep. 10, 278-84 (2009).
-
(2009)
EMBO Rep.
, vol.10
, pp. 278-284
-
-
Garcia, R.1
Grindlay, J.2
Rath, O.3
Fee, F.4
Kolch, W.5
-
45
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
Kolch, W. Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat. Rev. Mol. Cell Biol. 6, 827-37 (2005).
-
(2005)
Nat. Rev. Mol. Cell Biol.
, vol.6
, pp. 827-837
-
-
Kolch, W.1
-
46
-
-
84943595596
-
Crosstalk between MAPK/ERK and PI3K/AKT signal pathways during brain ischemia/reperfusion
-
Zhou, J. et al. Crosstalk Between MAPK/ERK and PI3K/AKT Signal Pathways During Brain Ischemia/Reperfusion. ASN Neuro 7 (2015).
-
(2015)
ASN Neuro
, vol.7
-
-
Zhou, J.1
-
47
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi, D. R. et al. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15, 6541-51 (1996).
-
(1996)
EMBO J.
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
-
48
-
-
67349270900
-
Enzymatic assembly of DNA molecules up to several hundred kilobases
-
Gibson, D. G. et al. Enzymatic assembly of DNA molecules up to several hundred kilobases. Nat. Methods 6, 343-5 (2009).
-
(2009)
Nat. Methods
, vol.6
, pp. 343-345
-
-
Gibson, D.G.1
|