CNK1 is a novel Akt interaction partner that promotes cell proliferation through the Akt-FoxO signalling axis

Oncogene

Volumn 29, Issue 24, 2010, Pages 3575-3582

  Fritz, R D ^a   Varga, Z ^b   Radziwill, G ^a,c  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Akt; Breast cancer; CNK1; FoxO; Oncogenic signalling; Proliferation

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CONNECTOR ENHANCER OF KSR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SCAFFOLD PROTEIN; TRANSCRIPTION FACTOR FOXO; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANCHORAGE INDEPENDENT GROWTH; ARTICLE; BREAST; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL; CANCER INVASION; CELL MEMBRANE; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; EMBRYO CELL; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EPITHELIUM CELL; GENE INACTIVATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; INTRADUCTAL CARCINOMA; KIDNEY CELL; ONCOGENE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ONCOGENES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 77953809690     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.104     Document Type: Article

References (33)

1. Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P et al. (1996). Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15: 6541-6551.
2. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJ, Frech M et al. (1997). Role of translocation in the activation and function of protein kinase B. J Biol Chem 272: 31515-31524.
3. Baldwin AS. (2001). Control of oncogenesis and cancer therapy resistance by the transcription factor NF-kappaB. J Clin Invest 107: 241-246.
4. Barnett SF, Defeo-Jones D, Fu S, Hancock PJ, Haskell KM, Jones RE et al. (2005). Identification and characterization of pleckstrin-homology-domain- dependent and isoenzyme-specific Akt inhibitors. Biochem J 385: 399-408.
5. Bellacosa A, Chan TO, Ahmed NN, Datta K, Malstrom S, Stokoe D et al. (1998). Akt activation by growth factors is a multiple-step process: the role of the PH domain. Oncogene 17: 313-325.
6. Bumeister R, Rosse C, Anselmo A, Camonis J, White MA. (2004). CNK2 couples NGF signal propagation to multiple regulatory cascades driving cell differentiation. Curr Biol 14: 439-445.
7. Calnan DR, Brunet A. (2008). The FoxO code. Oncogene 27: 2276-2288.
8. Claperon A, Therrien M. (2007). KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene 26: 3143-3158.
9. Dhillon AS, Hagan S, Rath O, Kolch W. (2007). MAP kinase signalling pathways in cancer. Oncogene 26: 3279-3290.
10. Douziech M, Roy F, Laberge G, Lefrancois M, Armengod AV, Therrien M. (2003). Bimodal regulation of RAF by CNK in Drosophila. EMBO J 22: 5068-5078.
11. Fritz RD, Radziwill G. (2005). The scaffold protein CNK1 interacts with the angiotensin II type 2 receptor. Biochem Biophys Res Commun 338: 1906-1912.
12. Fritz RD, Radziwill G. (2010). CNK1 promotes invasion of cancer cells through NF-kB-dependent signaling. Mol Cancer Res 8: 395-406.
13. Fritzius T, Moelling K. (2008). Akt-and Foxo1-interacting WD-repeat-FYVE protein promotes adipogenesis. EMBO J 27: 1399-1410.
14. Huang H, Tindall DJ. (2007). Dynamic FoxO transcription factors. J Cell Sci 120: 2479-2487.
15. Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY et al. (2006). SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127: 125-137.
16. Jaffe AB, Aspenstrom P, Hall A. (2004). Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol Cell Biol 24: 1736-1746.
17. Jaffe AB, Hall A, Schmidt A. (2005). Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Curr Biol 15: 405-412.
18. Karin M, Cao Y, Greten FR, Li ZW. (2002). NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2: 301-310.
19. Kasper G, Reule M, Tschirschmann M, Dankert N, Stout-Weider K, Lauster R et al. (2007). Stromelysin-3 over-expression enhances tumourigenesis in MCF-7 and MDA-MB-231 breast cancer cell lines: involvement of the IGF-1 signalling pathway. BMC Cancer 7: 12.
20. Laberge G, Douziech M, Therrien M. (2005). Src42 binding activity regulates Drosophila RAF by a novel CNK-dependent derepression mechanism. EMBO J 24: 487-498.
21. Lanigan TM, Liu A, Huang YZ, Mei L, Margolis B, Guan KL. (2003). Human homologue of Drosophila CNK interacts with Ras effector proteins Raf and Rlf. FASEB J 17: 2048-2060.
22. Lopez-Ilasaca MA, Bernabe-Ortiz JC, Na SY, Dzau VJ, Xavier RJ. (2005). Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. FEBS Lett 579: 648-654.
23. Manning BD, Cantley LC. (2007). AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
24. Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. (2002). Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 10: 151-162.
25. Rabizadeh S, Xavier RJ, Ishiguro K, Bernabeortiz J, Lopez-Ilasaca M, Khokhlatchev A et al. (2004). The scaffold protein CNK1 interacts with the tumor suppressor RASSF1A and augments RASSF1A-induced cell death. J Biol Chem 279: 29247-29254.
26. Rocheleau CE, Ronnlund A, Tuck S, Sundaram MV. (2005). Caenorhabditis elegans CNK-1 promotes Raf activation but is not essential for Ras/Raf signaling. Proc Natl Acad Sci USA 102: 11757-11762.
27. Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E et al. (2007). PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 25: 903-915.
28. Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307: 1098-1101.
29. Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. (2002). Tuberous sclerosis complex-1 and-2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 99: 13571-13576.
30. Therrien M, Wong AM, Rubin GM. (1998). CNK, a RAF-binding multidomain protein required for RAS signaling. Cell 95: 343-353.
31. Theurillat JP, Zurrer-Hardi U, Varga Z, Storz M, Probst-Hensch NM, Seifert B et al. (2007). NY-BR-1 protein expression in breast carcinoma: a mammary gland differentiation antigen as target for cancer immunotherapy. Cancer Immunol Immunother 56: 1723-1731.
32. Vivanco I, Sawyers CL. (2002). The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501.
33. Ziogas A, Moelling K, Radziwill G. (2005). CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation. J Biol Chem 280: 24205-24211.