메뉴 건너뛰기




Volumn 12, Issue 11, 2016, Pages

Deep Learning Automates the Quantitative Analysis of Individual Cells in Live-Cell Imaging Experiments

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CONVOLUTION; CYTOLOGY; DEEP NEURAL NETWORKS; FLUORESCENCE; IMAGE SEGMENTATION; SUPERVISED LEARNING;

EID: 84999836246     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1005177     Document Type: Article
Times cited : (437)

References (66)
  • 1
    • 15544371346 scopus 로고    scopus 로고
    • Gene regulation at the single-cell level
    • 15790856,.; (): –
    • Rosenfeld N, Young JW, Alon U, Swain PS, Elowitz MB, Gene regulation at the single-cell level. Science. 2005;307(5717):1962–5. doi: 10.1126/science.110691415790856
    • (2005) Science , vol.307 , Issue.5717 , pp. 1962-1965
    • Rosenfeld, N.1    Young, J.W.2    Alon, U.3    Swain, P.S.4    Elowitz, M.B.5
  • 2
    • 84919742411 scopus 로고    scopus 로고
    • Scaling of gene expression with transcription-factor fugacity
    • 25554908,.; ():
    • Weinert FM, Brewster RC, Rydenfelt M, Phillips R, Kegel WK, Scaling of gene expression with transcription-factor fugacity. Physical review letters. 2014;113(25):258101. doi: 10.1103/PhysRevLett.113.25810125554908
    • (2014) Physical review letters , vol.113 , Issue.25 , pp. 258101
    • Weinert, F.M.1    Brewster, R.C.2    Rydenfelt, M.3    Phillips, R.4    Kegel, W.K.5
  • 3
    • 84918571678 scopus 로고    scopus 로고
    • Accurate information transmission through dynamic biochemical signaling networks
    • 25504722,..; (): –
    • Selimkhanov J, Taylor B, Yao J, Pilko A, Albeck J, Hoffmann A, et al. Accurate information transmission through dynamic biochemical signaling networks. Science. 2014;346(6215):1370–3. doi: 10.1126/science.125493325504722
    • (2014) Science , vol.346 , Issue.6215 , pp. 1370-1373
    • Selimkhanov, J.1    Taylor, B.2    Yao, J.3    Pilko, A.4    Albeck, J.5    Hoffmann, A.6
  • 4
    • 77954541844 scopus 로고    scopus 로고
    • Single-cell NF-[kgr] B dynamics reveal digital activation and analogue information processing
    • 20581820,.; (): –
    • Tay S, Hughey JJ, Lee TK, Lipniacki T, Quake SR, Covert MW, Single-cell NF-[kgr] B dynamics reveal digital activation and analogue information processing. Nature. 2010;466(7303):267–71. doi: 10.1038/nature0914520581820
    • (2010) Nature , vol.466 , Issue.7303 , pp. 267-271
    • Tay, S.1    Hughey, J.J.2    Lee, T.K.3    Lipniacki, T.4    Quake, S.R.5    Covert, M.W.6
  • 5
    • 77951187551 scopus 로고    scopus 로고
    • A noisy paracrine signal determines the cellular NF-κB response to lipopolysaccharide
    • 19843957,..; ():
    • Lee TK, Denny EM, Sanghvi JC, Gaston JE, Maynard ND, Hughey JJ, et al. A noisy paracrine signal determines the cellular NF-κB response to lipopolysaccharide. Science signaling. 2009;2(93):ra65. doi: 10.1126/scisignal.200059919843957
    • (2009) Science signaling , vol.2 , Issue.93 , pp. ra65
    • Lee, T.K.1    Denny, E.M.2    Sanghvi, J.C.3    Gaston, J.E.4    Maynard, N.D.5    Hughey, J.J.6
  • 6
    • 84903217674 scopus 로고    scopus 로고
    • High-sensitivity measurements of multiple kinase activities in live single cells
    • 24949979,.; (): –
    • Regot S, Hughey JJ, Bajar BT, Carrasco S, Covert MW, High-sensitivity measurements of multiple kinase activities in live single cells. Cell. 2014;157(7):1724–34. doi: 10.1016/j.cell.2014.04.03924949979
    • (2014) Cell , vol.157 , Issue.7 , pp. 1724-1734
    • Regot, S.1    Hughey, J.J.2    Bajar, B.T.3    Carrasco, S.4    Covert, M.W.5
  • 7
    • 80054841161 scopus 로고    scopus 로고
    • Information transduction capacity of noisy biochemical signaling networks
    • 21921160,.; (): –
    • Cheong R, Rhee A, Wang CJ, Nemenman I, Levchenko A, Information transduction capacity of noisy biochemical signaling networks. Science. 2011;334(6054):354–8. doi: 10.1126/science.120455321921160
    • (2011) Science , vol.334 , Issue.6054 , pp. 354-358
    • Cheong, R.1    Rhee, A.2    Wang, C.J.3    Nemenman, I.4    Levchenko, A.5
  • 10
    • 79955024764 scopus 로고    scopus 로고
    • High-throughput, subpixel precision analysis of bacterial morphogenesis and intracellular spatio-temporal dynamics
    • 21414037,.; (): –
    • Sliusarenko O, Heinritz J, Emonet T, Jacobs-Wagner C, High-throughput, subpixel precision analysis of bacterial morphogenesis and intracellular spatio-temporal dynamics. Molecular microbiology. 2011;80(3):612–27. doi: 10.1111/j.1365-2958.2011.07579.x21414037
    • (2011) Molecular microbiology , vol.80 , Issue.3 , pp. 612-627
    • Sliusarenko, O.1    Heinritz, J.2    Emonet, T.3    Jacobs-Wagner, C.4
  • 11
    • 84860653367 scopus 로고    scopus 로고
    • Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy
    • Young JW, Locke JC, Altinok A, Rosenfeld N, Bacarian T, Swain PS, et al. Measuring single-cell gene expression dynamics in bacteria using fluorescence time-lapse microscopy. Nature protocols. 2012;7(1):80–8.
    • (2012) Nature protocols , vol.7 , Issue.1 , pp. 80-88
    • Young, J.W.1    Locke, J.C.2    Altinok, A.3    Rosenfeld, N.4    Bacarian, T.5    Swain, P.S.6
  • 12
    • 33845792555 scopus 로고    scopus 로고
    • CellProfiler: image analysis software for identifying and quantifying cell phenotypes
    • 17076895,..; ():
    • Carpenter AE, Jones TR, Lamprecht MR, Clarke C, Kang IH, Friman O, et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome biology. 2006;7(10):R100. doi: 10.1186/gb-2006-7-10-r10017076895
    • (2006) Genome biology , vol.7 , Issue.10 , pp. R100
    • Carpenter, A.E.1    Jones, T.R.2    Lamprecht, M.R.3    Clarke, C.4    Kang, I.H.5    Friman, O.6
  • 14
    • 3042525106 scopus 로고    scopus 로고
    • Learning to detect natural image boundaries using local brightness, color, and texture cues
    • 15460277,.; (): –
    • Martin DR, Fowlkes CC, Malik J, Learning to detect natural image boundaries using local brightness, color, and texture cues. IEEE transactions on pattern analysis and machine intelligence. 2004;26(5):530–49. doi: 10.1109/TPAMI.2004.127391815460277
    • (2004) IEEE transactions on pattern analysis and machine intelligence , vol.26 , Issue.5 , pp. 530-549
    • Martin, D.R.1    Fowlkes, C.C.2    Malik, J.3
  • 15
    • 33744998910 scopus 로고    scopus 로고
    • Supervised learning-based cell image segmentation for p53 immunohistochemistry
    • 16761842,.; (): –
    • Mao KZ, Zhao P, Tan P-H, Supervised learning-based cell image segmentation for p53 immunohistochemistry. IEEE Transactions on Biomedical Engineering. 2006;53(6):1153–63. doi: 10.1109/TBME.2006.87353816761842
    • (2006) IEEE Transactions on Biomedical Engineering , vol.53 , Issue.6 , pp. 1153-1163
    • Mao, K.Z.1    Zhao, P.2    Tan, P.-H.3
  • 16
    • 80052894155 scopus 로고    scopus 로고
    • Bertelli L, Yu T, Vu D, Gokturk B, editors. Kernelized structural SVM learning for supervised object segmentation. Computer Vision and Pattern Recognition (CVPR), 2011 IEEE Conference on; 2011: IEEE.
    • (2011) , vol.2011
    • Bertelli, L.1    Yu, T.2    Vu, D.3    Gokturk, B.4
  • 17
    • 84958061161 scopus 로고    scopus 로고
    • Oufti: an integrated software package for high-accuracy, high-throughput quantitative microscopy analysis
    • Paintdakhi A, Parry B, Campos M, Irnov I, Elf J, Surovtsev I, et al. Oufti: an integrated software package for high-accuracy, high-throughput quantitative microscopy analysis. Molecular microbiology. 2016.
    • (2016) Molecular microbiology
    • Paintdakhi, A.1    Parry, B.2    Campos, M.3    Irnov, I.4    Elf, J.5    Surovtsev, I.6
  • 18
    • 79961198540 scopus 로고    scopus 로고
    • Sommer C, Straehle C, Koethe U, Hamprecht FA, editors. ilastik: Interactive learning and segmentation toolkit. Biomedical Imaging: From Nano to Macro, 2011 IEEE International Symposium on; 2011: IEEE.
    • (2011) , vol.2011
    • Sommer, C.1    Straehle, C.2    Koethe, U.3    Hamprecht, F.A.4
  • 19
    • 84961335080 scopus 로고    scopus 로고
    • Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets
    • 26727152,.; ():
    • Belevich I, Joensuu M, Kumar D, Vihinen H, Jokitalo E, Microscopy Image Browser: A Platform for Segmentation and Analysis of Multidimensional Datasets. PLoS Biol. 2016;14(1):e1002340. doi: 10.1371/journal.pbio.100234026727152
    • (2016) PLoS Biol , vol.14 , Issue.1 , pp. e1002340
    • Belevich, I.1    Joensuu, M.2    Kumar, D.3    Vihinen, H.4    Jokitalo, E.5
  • 20
    • 84937414579 scopus 로고    scopus 로고
    • A noisy linear map underlies oscillations in cell size and gene expression in bacteria
    • 26040722,..; (): –
    • Tanouchi Y, Pai A, Park H, Huang S, Stamatov R, Buchler NE, et al. A noisy linear map underlies oscillations in cell size and gene expression in bacteria. Nature. 2015;523(7560):357–60. doi: 10.1038/nature1456226040722
    • (2015) Nature , vol.523 , Issue.7560 , pp. 357-360
    • Tanouchi, Y.1    Pai, A.2    Park, H.3    Huang, S.4    Stamatov, R.5    Buchler, N.E.6
  • 21
    • 36348985016 scopus 로고    scopus 로고
    • Ali R, Gooding M, Christlieb M, Brady M, editors. Phase-based segmentation of cells from brightfield microscopy. Biomedical Imaging: From Nano to Macro, 2007 ISBI 2007 4th IEEE International Symposium on; 2007: IEEE
    • Ali R, Gooding M, Christlieb M, Brady M, editors. Phase-based segmentation of cells from brightfield microscopy. Biomedical Imaging: From Nano to Macro, 2007 ISBI 2007 4th IEEE International Symposium on; 2007: IEEE.
  • 23
    • 74049089035 scopus 로고    scopus 로고
    • Image segmentation and dynamic lineage analysis in single-cell fluorescence microscopy
    • Wang Q, Niemi J, Tan CM, You L, West M, Image segmentation and dynamic lineage analysis in single-cell fluorescence microscopy. Cytometry Part A. 2010;77(1):101–10.
    • (2010) Cytometry Part A , vol.77 , Issue.1 , pp. 101-110
    • Wang, Q.1    Niemi, J.2    Tan, C.M.3    You, L.4    West, M.5
  • 24
    • 84890335131 scopus 로고    scopus 로고
    • Automatic cell detection in bright-field microscope images using SIFT, random forests, and hierarchical clustering
    • Mualla F, Scholl S, Sommerfeldt B, Maier A, Hornegger J, Automatic cell detection in bright-field microscope images using SIFT, random forests, and hierarchical clustering. Medical Imaging, IEEE Transactions on. 2013;32(12):2274–86.
    • (2013) Medical Imaging, IEEE Transactions on , vol.32 , Issue.12 , pp. 2274-2286
    • Mualla, F.1    Scholl, S.2    Sommerfeldt, B.3    Maier, A.4    Hornegger, J.5
  • 26
    • 84870950897 scopus 로고    scopus 로고
    • Segmenting time-lapse phase contrast images of adjacent NIH 3T3 cells
    • 23126432,..; (): –
    • Chalfoun J, Kociolek M, Dima A, Halter M, Cardone A, Peskin A, et al. Segmenting time-lapse phase contrast images of adjacent NIH 3T3 cells. Journal of microscopy. 2013;249(1):41–52. doi: 10.1111/j.1365-2818.2012.03678.x23126432
    • (2013) Journal of microscopy , vol.249 , Issue.1 , pp. 41-52
    • Chalfoun, J.1    Kociolek, M.2    Dima, A.3    Halter, M.4    Cardone, A.5    Peskin, A.6
  • 27
    • 84908602693 scopus 로고    scopus 로고
    • Nanoparticle vesicle encoding for imaging and tracking cell populations
    • 25218182,..; (): –
    • Rees P, Wills JW, Brown MR, Tonkin J, Holton MD, Hondow N, et al. Nanoparticle vesicle encoding for imaging and tracking cell populations. Nature methods. 2014;11(11):1177–81. doi: 10.1038/nmeth.310525218182
    • (2014) Nature methods , vol.11 , Issue.11 , pp. 1177-1181
    • Rees, P.1    Wills, J.W.2    Brown, M.R.3    Tonkin, J.4    Holton, M.D.5    Hondow, N.6
  • 28
    • 84855973755 scopus 로고    scopus 로고
    • Proteome-wide screens in Saccharomyces cerevisiae using the yeast GFP collection
    • .;. p. –
    • Chong YT, Cox MJ, Andrews B, Proteome-wide screens in Saccharomyces cerevisiae using the yeast GFP collection. Advances in Systems Biology: Springer; 2012. p. 169–78.
    • (2012) Advances in Systems Biology: Springer , pp. 169-178
    • Chong, Y.T.1    Cox, M.J.2    Andrews, B.3
  • 29
    • 66449100042 scopus 로고    scopus 로고
    • Machine vision-assisted analysis of structure-localization relationships in a combinatorial library of prospective bioimaging probes
    • Shedden K, Li Q, Liu F, Chang YT, Rosania GR, Machine vision-assisted analysis of structure-localization relationships in a combinatorial library of prospective bioimaging probes. Cytometry Part A. 2009;75(6):482–93.
    • (2009) Cytometry Part A , vol.75 , Issue.6 , pp. 482-493
    • Shedden, K.1    Li, Q.2    Liu, F.3    Chang, Y.T.4    Rosania, G.R.5
  • 30
    • 84941600785 scopus 로고    scopus 로고
    • Empirical gradient threshold technique for automated segmentation across image modalities and cell lines
    • 26046924,.; (): –
    • Chalfoun J, Majurski M, Peskin A, Breen C, Bajcsy P, Brady M, Empirical gradient threshold technique for automated segmentation across image modalities and cell lines. Journal of microscopy. 2015;260(1):86–99. doi: 10.1111/jmi.1226926046924
    • (2015) Journal of microscopy , vol.260 , Issue.1 , pp. 86-99
    • Chalfoun, J.1    Majurski, M.2    Peskin, A.3    Breen, C.4    Bajcsy, P.5    Brady, M.6
  • 32
    • 84930630277 scopus 로고    scopus 로고
    • Deep learning
    • 26017442,.; (): –
    • LeCun Y, Bengio Y, Hinton G, Deep learning. Nature. 2015;521(7553):436–44. doi: 10.1038/nature1453926017442
    • (2015) Nature , vol.521 , Issue.7553 , pp. 436-444
    • LeCun, Y.1    Bengio, Y.2    Hinton, G.3
  • 38
    • 84877789057 scopus 로고    scopus 로고
    • Ciresan D, Giusti A, Gambardella LM, Schmidhuber J, editors. Deep neural networks segment neuronal membranes in electron microscopy images. Advances in neural information processing systems; 2012.
    • (2012)
    • Ciresan, D.1    Giusti, A.2    Gambardella, L.M.3    Schmidhuber, J.4
  • 44
    • 84893343292 scopus 로고    scopus 로고
    • Lecture 6.5-rmsprop: Divide the gradient by a running average of its recent magnitude
    • Tieleman T, Hinton G, Lecture 6.5-rmsprop: Divide the gradient by a running average of its recent magnitude. COURSERA: Neural Networks for Machine Learning. 2012;4:2.
    • (2012) COURSERA: Neural Networks for Machine Learning , vol.4 , pp. 2
    • Tieleman, T.1    Hinton, G.2
  • 45
    • 84973911419 scopus 로고    scopus 로고
    • He K, Zhang X, Ren S, Sun J, editors. Delving deep into rectifiers: Surpassing human-level performance on imagenet classification. Proceedings of the IEEE International Conference on Computer Vision; 2015.
    • (2015)
    • He, K.1    Zhang, X.2    Ren, S.3    Sun, J.4
  • 46
    • 0022471098 scopus 로고
    • Learning representations by back-propagating errors
    • Rumelhart DE, Hinton GE, Williams RJ, Learning representations by back-propagating errors. Nature. 1986;323(6088):533–6.
    • (1986) Nature , vol.323 , Issue.6088 , pp. 533-536
    • Rumelhart, D.E.1    Hinton, G.E.2    Williams, R.J.3
  • 49
    • 84999621197 scopus 로고    scopus 로고
    • Chollet F. Keras. GitHub repository: GitHub; 2015.
    • (2015)
    • Chollet, F.1
  • 50
    • 84999687721 scopus 로고    scopus 로고
    • Jones E, Oliphant T, Peterson P. SciPy: Open source scientific tools for Python, 2001. 2015
    • Jones E, Oliphant T, Peterson P. SciPy: Open source scientific tools for Python, 2001. http://www.scipy.org. 2015.
  • 53
    • 84944402905 scopus 로고    scopus 로고
    • Survey statistics of automated segmentations applied to optical imaging of mammalian cells
    • Bajcsy P, Cardone A, Chalfoun J, Halter M, Juba D, Kociolek M, et al. Survey statistics of automated segmentations applied to optical imaging of mammalian cells. BMC bioinformatics. 2015;16(1):1.
    • (2015) BMC bioinformatics , vol.16 , Issue.1 , pp. 1
    • Bajcsy, P.1    Cardone, A.2    Chalfoun, J.3    Halter, M.4    Juba, D.5    Kociolek, M.6
  • 54
    • 48449087576 scopus 로고    scopus 로고
    • Robust single-particle tracking in live-cell time-lapse sequences
    • 18641657,..; (): –
    • Jaqaman K, Loerke D, Mettlen M, Kuwata H, Grinstein S, Schmid SL, et al. Robust single-particle tracking in live-cell time-lapse sequences. Nature methods. 2008;5(8):695–702. doi: 10.1038/nmeth.123718641657
    • (2008) Nature methods , vol.5 , Issue.8 , pp. 695-702
    • Jaqaman, K.1    Loerke, D.2    Mettlen, M.3    Kuwata, H.4    Grinstein, S.5    Schmid, S.L.6
  • 57
    • 84922359470 scopus 로고    scopus 로고
    • A constant size extension drives bacterial cell size homeostasis
    • 25480302,..; (): –
    • Campos M, Surovtsev IV, Kato S, Paintdakhi A, Beltran B, Ebmeier SE, et al. A constant size extension drives bacterial cell size homeostasis. Cell. 2014;159(6):1433–46. doi: 10.1016/j.cell.2014.11.02225480302
    • (2014) Cell , vol.159 , Issue.6 , pp. 1433-1446
    • Campos, M.1    Surovtsev, I.V.2    Kato, S.3    Paintdakhi, A.4    Beltran, B.5    Ebmeier, S.E.6
  • 58
    • 84938503781 scopus 로고    scopus 로고
    • Metabolic co-dependence gives rise to collective oscillations within biofilms
    • 26200335,..; (): –
    • Liu J, Prindle A, Humphries J, Gabalda-Sagarra M, Asally M, Dong-yeon DL, et al. Metabolic co-dependence gives rise to collective oscillations within biofilms. Nature. 2015;523(7562):550–4. doi: 10.1038/nature1466026200335
    • (2015) Nature , vol.523 , Issue.7562 , pp. 550-554
    • Liu, J.1    Prindle, A.2    Humphries, J.3    Gabalda-Sagarra, M.4    Asally, M.5    Dong-yeon, D.L.6
  • 59
    • 84884552341 scopus 로고    scopus 로고
    • Microfabricated polyacrylamide devices for the controlled culture of growing cells and developing organisms
    • 24086559,.; ():
    • Nghe P, Boulineau S, Gude S, Recouvreux P, van Zon JS, Tans SJ, Microfabricated polyacrylamide devices for the controlled culture of growing cells and developing organisms. PloS one. 2013;8(9):e75537. doi: 10.1371/journal.pone.007553724086559
    • (2013) PloS one , vol.8 , Issue.9 , pp. e75537
    • Nghe, P.1    Boulineau, S.2    Gude, S.3    Recouvreux, P.4    van Zon, J.S.5    Tans, S.J.6
  • 60
    • 84876989674 scopus 로고    scopus 로고
    • Single-cell dynamics reveals sustained growth during diauxic shifts
    • 23637881,.; ():
    • Boulineau S, Tostevin F, Kiviet DJ, ten Wolde PR, Nghe P, Tans SJ, Single-cell dynamics reveals sustained growth during diauxic shifts. PLoS One. 2013;8(4):e61686. doi: 10.1371/journal.pone.006168623637881
    • (2013) PLoS One , vol.8 , Issue.4 , pp. e61686
    • Boulineau, S.1    Tostevin, F.2    Kiviet, D.J.3    ten Wolde, P.R.4    Nghe, P.5    Tans, S.J.6
  • 61
    • 84908191393 scopus 로고    scopus 로고
    • Stochasticity of metabolism and growth at the single-cell level
    • 25186725,.; (): –
    • Kiviet DJ, Nghe P, Walker N, Boulineau S, Sunderlikova V, Tans SJ, Stochasticity of metabolism and growth at the single-cell level. Nature. 2014;514(7522):376–9. doi: 10.1038/nature1358225186725
    • (2014) Nature , vol.514 , Issue.7522 , pp. 376-379
    • Kiviet, D.J.1    Nghe, P.2    Walker, N.3    Boulineau, S.4    Sunderlikova, V.5    Tans, S.J.6
  • 64
    • 84892181925 scopus 로고    scopus 로고
    • Internalization of Salmonella by macrophages induces formation of nonreplicating persisters
    • 24408438,.; (): –
    • Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW, Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science. 2014;343(6167):204–8. doi: 10.1126/science.124470524408438
    • (2014) Science , vol.343 , Issue.6167 , pp. 204-208
    • Helaine, S.1    Cheverton, A.M.2    Watson, K.G.3    Faure, L.M.4    Matthews, S.A.5    Holden, D.W.6
  • 65
    • 33748994704 scopus 로고    scopus 로고
    • Stochastic mRNA Synthesis in Mammalian Cells
    • 17048983,.; ():
    • Raj A, Peskin CS, Tranchina D, Vargas DY, Tyagi S, Stochastic mRNA Synthesis in Mammalian Cells. PLoS Biol. 2006;4(10):e309. doi: 10.1371/journal.pbio.004030917048983
    • (2006) PLoS Biol , vol.4 , Issue.10 , pp. e309
    • Raj, A.1    Peskin, C.S.2    Tranchina, D.3    Vargas, D.Y.4    Tyagi, S.5
  • 66
    • 36749101359 scopus 로고    scopus 로고
    • Dynamics of Escherichia coli chromosome segregation during multifork replication
    • 17905986,.; (): –
    • Nielsen HJ, Youngren B, Hansen FG, Austin S, Dynamics of Escherichia coli chromosome segregation during multifork replication. Journal of bacteriology. 2007;189(23):8660–6. doi: 10.1128/JB.01212-0717905986
    • (2007) Journal of bacteriology , vol.189 , Issue.23 , pp. 8660-8666
    • Nielsen, H.J.1    Youngren, B.2    Hansen, F.G.3    Austin, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.