메뉴 건너뛰기




Volumn 6, Issue , 2016, Pages

Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; IL23R PROTEIN, HUMAN; INTERLEUKIN 23; INTERLEUKIN RECEPTOR; MEMBRANE PROTEIN; PHOSPHOPEPTIDE; PHOSPHOPROTEIN; STAT3 PROTEIN; THYROID HORMONE; THYROID HORMONE-BINDING PROTEINS;

EID: 84964211524     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep24491     Document Type: Article
Times cited : (25)

References (62)
  • 2
    • 79952197291 scopus 로고    scopus 로고
    • Phosphoproteomics. Wiley interdisciplinary reviews
    • Ozlu, N. et al. Phosphoproteomics. Wiley interdisciplinary reviews. Systems biology and medicine 2, 255-276, doi: 10.1002/wsbm.41 (2010).
    • (2010) Systems Biology and Medicine , vol.2 , pp. 255-276
    • Ozlu, N.1
  • 3
    • 65249137629 scopus 로고    scopus 로고
    • Global and site-specific quantitative phosphoproteomics: Principles and applications
    • Macek, B., Mann, M. & Olsen, J. V. Global and site-specific quantitative phosphoproteomics: principles and applications. Annual review of pharmacology and toxicology 49, 199-221, doi: 10.1146/annurev.pharmtox.011008.145606 (2009).
    • (2009) Annual Review of Pharmacology and Toxicology , vol.49 , pp. 199-221
    • Macek, B.1    Mann, M.2    Olsen, J.V.3
  • 4
    • 84920450766 scopus 로고    scopus 로고
    • Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns
    • Ruprecht, B. et al. Comprehensive and reproducible phosphopeptide enrichment using iron immobilized metal ion affinity chromatography (Fe-IMAC) columns. Molecular & cellular proteomics: MCP 14, 205-215, doi: 10.1074/mcp.M114.043109 (2015).
    • (2015) Molecular & Cellular Proteomics: MCP , vol.14 , pp. 205-215
    • Ruprecht, B.1
  • 5
    • 0033565503 scopus 로고    scopus 로고
    • Immobilized gallium(III) affinity chromatography of phosphopeptides
    • Posewitz, M. C. & Tempst, P. Immobilized gallium(III) affinity chromatography of phosphopeptides. Analytical chemistry 71, 2883-2892 (1999).
    • (1999) Analytical Chemistry , vol.71 , pp. 2883-2892
    • Posewitz, M.C.1    Tempst, P.2
  • 6
    • 0030667705 scopus 로고    scopus 로고
    • Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry
    • Neville, D. C. et al. Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry. Protein science: a publication of the Protein Society 6, 2436-2445, doi: 10.1002/pro.5560061117 (1997).
    • (1997) Protein Science: A Publication of the Protein Society , vol.6 , pp. 2436-2445
    • Neville, D.C.1
  • 7
    • 3242688830 scopus 로고    scopus 로고
    • Selective isolation at the femtomole level of phosphopeptides from proteolytic digests using 2D-NanoLC-ESI-MS/MS and titanium oxide precolumns
    • Pinkse, M. W., Uitto, P. M., Hilhorst, M. J., Ooms, B. & Heck, A. J. Selective isolation at the femtomole level of phosphopeptides from proteolytic digests using 2D-NanoLC-ESI-MS/MS and titanium oxide precolumns. Analytical chemistry 76, 3935-3943, doi: 10.1021/ac0498617 (2004).
    • (2004) Analytical Chemistry , vol.76 , pp. 3935-3943
    • Pinkse, M.W.1    Uitto, P.M.2    Hilhorst, M.J.3    Ooms, B.4    Heck, A.J.5
  • 8
    • 3042575877 scopus 로고    scopus 로고
    • Titania as a chemo-affinity support for the column-switching HPLC analysis of phosphopeptides: Application to the characterization of phosphorylation sites in proteins by combination with protease digestion and electrospray ionization mass spectrometry
    • Sano, A. & Nakamura, H. Titania as a chemo-affinity support for the column-switching HPLC analysis of phosphopeptides: application to the characterization of phosphorylation sites in proteins by combination with protease digestion and electrospray ionization mass spectrometry. Analytical sciences: the international journal of the Japan Society for Analytical Chemistry 20, 861-864 (2004).
    • (2004) Analytical Sciences: The International Journal of the Japan Society for Analytical Chemistry , vol.20 , pp. 861-864
    • Sano, A.1    Nakamura, H.2
  • 9
    • 24944519450 scopus 로고    scopus 로고
    • Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns
    • Larsen, M. R., Thingholm, T. E., Jensen, O. N., Roepstorff, P. & Jorgensen, T. J. Highly selective enrichment of phosphorylated peptides from peptide mixtures using titanium dioxide microcolumns. Molecular & cellular proteomics:MCP 4, 873-886, doi: 10.1074/mcp.T500007-MCP200 (2005).
    • (2005) Molecular & Cellular Proteomics:MCP , vol.4 , pp. 873-886
    • Larsen, M.R.1    Thingholm, T.E.2    Jensen, O.N.3    Roepstorff, P.4    Jorgensen, T.J.5
  • 10
    • 84874093507 scopus 로고    scopus 로고
    • Toward a comprehensive characterization of a human cancer cell phosphoproteome
    • Zhou, H. et al. Toward a comprehensive characterization of a human cancer cell phosphoproteome. Journal of proteome research 12, 260-271, doi: 10.1021/pr300630k (2013).
    • (2013) Journal of Proteome Research , vol.12 , pp. 260-271
    • Zhou, H.1
  • 11
    • 84866093349 scopus 로고    scopus 로고
    • TiSH-A robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC
    • Engholm-Keller, K. et al. TiSH-a robust and sensitive global phosphoproteomics strategy employing a combination of TiO2, SIMAC, and HILIC. Journal of proteomics 75, 5749-5761, doi: 10.1016/j.jprot.2012.08.007 (2012).
    • (2012) Journal of Proteomics , vol.75 , pp. 5749-5761
    • Engholm-Keller, K.1
  • 12
    • 43849091451 scopus 로고    scopus 로고
    • Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection
    • McNulty, D. E. & Annan, R. S. Hydrophilic interaction chromatography reduces the complexity of the phosphoproteome and improves global phosphopeptide isolation and detection. Molecular & cellular proteomics: MCP 7, 971-980, doi: 10.1074/mcp.M700543-MCP200 (2008).
    • (2008) Molecular & Cellular Proteomics: MCP , vol.7 , pp. 971-980
    • McNulty, D.E.1    Annan, R.S.2
  • 13
    • 84926631409 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics of cytotoxic T cells to reveal protein kinase d 2 regulated networks
    • Navarro, M. N., Goebel, J., Hukelmann, J. L. & Cantrell, D. A. Quantitative phosphoproteomics of cytotoxic T cells to reveal protein kinase d 2 regulated networks. Molecular & cellular proteomics: MCP 13, 3544-3557, doi: 10.1074/mcp.M113.037242 (2014).
    • (2014) Molecular & Cellular Proteomics: MCP , vol.13 , pp. 3544-3557
    • Navarro, M.N.1    Goebel, J.2    Hukelmann, J.L.3    Cantrell, D.A.4
  • 14
    • 84908461433 scopus 로고    scopus 로고
    • Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naive CD8(+) T cells
    • Navarro, M. N., Feijoo-Carnero, C., Arandilla, A. G., Trost, M. & Cantrell, D. A. Protein kinase D2 is a digital amplifier of T cell receptor-stimulated diacylglycerol signaling in naive CD8(+) T cells. Science signaling 7, ra99, doi: 10.1126/scisignal.2005477 (2014).
    • (2014) Science Signaling , vol.7 , pp. ra99
    • Navarro, M.N.1    Feijoo-Carnero, C.2    Arandilla, A.G.3    Trost, M.4    Cantrell, D.A.5
  • 15
    • 84905206969 scopus 로고    scopus 로고
    • Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3zeta and ZAP-70 tyrosine phosphorylation
    • Salek, M. et al. Quantitative phosphoproteome analysis unveils LAT as a modulator of CD3zeta and ZAP-70 tyrosine phosphorylation. Plos one 8, e77423, doi: 10.1371/journal.pone.0077423 (2013).
    • (2013) Plos One , vol.8 , pp. e77423
    • Salek, M.1
  • 16
    • 79952384301 scopus 로고    scopus 로고
    • Quantitative phosphoproteomics studies using stable isotope dimethyl labeling coupled with IMAC-HILIC-nanoLC-MS/MS for estrogen-induced transcriptional regulation
    • Wu, C. J., Chen, Y. W., Tai, J. H. & Chen, S. H. Quantitative phosphoproteomics studies using stable isotope dimethyl labeling coupled with IMAC-HILIC-nanoLC-MS/MS for estrogen-induced transcriptional regulation. Journal of proteome research 10, 1088-1097, doi: 10.1021/pr100864b (2011).
    • (2011) Journal of Proteome Research , vol.10 , pp. 1088-1097
    • Wu, C.J.1    Chen, Y.W.2    Tai, J.H.3    Chen, S.H.4
  • 17
    • 84861136348 scopus 로고    scopus 로고
    • Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells
    • Ruperez, P., Gago-Martinez, A., Burlingame, A. L. & Oses-Prieto, J. A. Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells. Molecular & cellular proteomics: MCP 11, 171-186, doi: 10.1074/mcp.M112.017863 (2012).
    • (2012) Molecular & Cellular Proteomics: MCP , vol.11 , pp. 171-186
    • Ruperez, P.1    Gago-Martinez, A.2    Burlingame, A.L.3    Oses-Prieto, J.A.4
  • 19
    • 84921367335 scopus 로고    scopus 로고
    • Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics
    • Osinalde, N. et al. Simultaneous dissection and comparison of IL-2 and IL-15 signaling pathways by global quantitative phosphoproteomics. Proteomics 15, 520-531, doi: 10.1002/pmic.201400194 (2015).
    • (2015) Proteomics , vol.15 , pp. 520-531
    • Osinalde, N.1
  • 20
    • 84883197055 scopus 로고    scopus 로고
    • Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis
    • Storvold, G. L. et al. Quantitative profiling of tyrosine phosphorylation revealed changes in the activity of the T cell receptor signaling pathway upon cisplatin-induced apoptosis. Journal of proteomics 91, 344-357, doi: 10.1016/j.jprot.2013.07.019 (2013).
    • (2013) Journal of Proteomics , vol.91 , pp. 344-357
    • Storvold, G.L.1
  • 21
    • 84858727761 scopus 로고    scopus 로고
    • Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics
    • Osinalde, N. et al. Interleukin-2 signaling pathway analysis by quantitative phosphoproteomics. Journal of proteomics 75, 177-191, doi: 10.1016/j.jprot.2011.06.007 (2011).
    • (2011) Journal of Proteomics , vol.75 , pp. 177-191
    • Osinalde, N.1
  • 22
    • 79953010049 scopus 로고    scopus 로고
    • Proteomic characterization of plasma membrane-proximal T cell activation responses
    • de Wet, B., Zech, T., Salek, M., Acuto, O. & Harder, T. Proteomic characterization of plasma membrane-proximal T cell activation responses. The Journal of biological chemistry 286, 4072-4080, doi: 10.1074/jbc.M110.165415 (2011).
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 4072-4080
    • De Wet, B.1    Zech, T.2    Salek, M.3    Acuto, O.4    Harder, T.5
  • 23
    • 79953202189 scopus 로고    scopus 로고
    • T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component
    • Brockmeyer, C. et al. T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component. The Journal of biological chemistry 286, 7535-7547, doi: 10.1074/jbc.M110.201236 (2011).
    • (2011) The Journal of Biological Chemistry , vol.286 , pp. 7535-7547
    • Brockmeyer, C.1
  • 24
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue, S. et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. The Journal of experimental medicine 203, 2473-2483, doi: 10.1084/jem.20061099 (2006).
    • (2006) The Journal of Experimental Medicine , vol.203 , pp. 2473-2483
    • Hue, S.1
  • 26
    • 79958277385 scopus 로고    scopus 로고
    • IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease
    • Geremia, A. et al. IL-23-responsive innate lymphoid cells are increased in inflammatory bowel disease. The Journal of experimental medicine 208, 1127-1133, doi: 10.1084/jem.20101712 (2011).
    • (2011) The Journal of Experimental Medicine , vol.208 , pp. 1127-1133
    • Geremia, A.1
  • 27
    • 77951878587 scopus 로고    scopus 로고
    • Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology
    • Buonocore, S. et al. Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology. Nature 464, 1371-1375, doi: 10.1038/nature08949 (2010).
    • (2010) Nature , vol.464 , pp. 1371-1375
    • Buonocore, S.1
  • 28
    • 77955890952 scopus 로고    scopus 로고
    • Interleukin-23 drives intestinal inflammation through direct activity on T cells
    • Ahern, P. P. et al. Interleukin-23 drives intestinal inflammation through direct activity on T cells. Immunity 33, 279-288, doi: 10.1016/j.immuni.2010.08.010 (2010).
    • (2010) Immunity , vol.33 , pp. 279-288
    • Ahern, P.P.1
  • 29
    • 84906535154 scopus 로고    scopus 로고
    • The IL-23-IL-17 immune axis: From mechanisms to therapeutic testing
    • Gaffen, S. L., Jain, R., Garg, A. V. & Cua, D. J. The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing. Nat Rev Immunol 14, 585-600, doi: 10.1038/nri3707 (2014).
    • (2014) Nat Rev Immunol , vol.14 , pp. 585-600
    • Gaffen, S.L.1    Jain, R.2    Garg, A.V.3    Cua, D.J.4
  • 30
    • 84860914913 scopus 로고    scopus 로고
    • Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease
    • Polgar, N. et al. Investigation of JAK2, STAT3 and CCR6 polymorphisms and their gene-gene interactions in inflammatory bowel disease. Int J Immunogenet 39, 247-252, doi: 10.1111/j.1744-313X.2012.01084.x (2012).
    • (2012) Int J Immunogenet , vol.39 , pp. 247-252
    • Polgar, N.1
  • 31
    • 84957434789 scopus 로고    scopus 로고
    • Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3
    • Yang, L. et al. Impaired function of regulatory T cells in patients with psoriasis is mediated by phosphorylation of STAT3. J Dermatol Sci, doi: 10.1016/j.jdermsci.2015.11.007 (2015).
    • (2015) J Dermatol Sci
    • Yang, L.1
  • 32
    • 0021355340 scopus 로고
    • A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids
    • Wessel, D. & Flugge, U. I. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Analytical biochemistry 138, 141-143 (1984).
    • (1984) Analytical Biochemistry , vol.138 , pp. 141-143
    • Wessel, D.1    Flugge, U.I.2
  • 33
    • 64749108158 scopus 로고    scopus 로고
    • Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics
    • Boersema, P. J., Raijmakers, R., Lemeer, S., Mohammed, S. & Heck, A. J. Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics. Nature protocols 4, 484-494, doi: 10.1038/nprot.2009.21 (2009).
    • (2009) Nature Protocols , vol.4 , pp. 484-494
    • Boersema, P.J.1    Raijmakers, R.2    Lemeer, S.3    Mohammed, S.4    Heck, A.J.5
  • 34
    • 84883368399 scopus 로고    scopus 로고
    • Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated aurora-A
    • Hammond, D. et al. Melanoma-associated mutations in protein phosphatase 6 cause chromosome instability and DNA damage owing to dysregulated Aurora-A. Journal of cell science 126, 3429-3440, doi: 10.1242/jcs.128397 (2013).
    • (2013) Journal of Cell Science , vol.126 , pp. 3429-3440
    • Hammond, D.1
  • 35
    • 36248934589 scopus 로고    scopus 로고
    • Evaluation of the impact of some experimental procedures on different phosphopeptide enrichment techniques
    • Jensen, S. S. & Larsen, M. R. Evaluation of the impact of some experimental procedures on different phosphopeptide enrichment techniques. Rapid Commun Mass Spectrom 21, 3635-3645, doi: 10.1002/rcm.3254 (2007).
    • (2007) Rapid Commun Mass Spectrom , vol.21 , pp. 3635-3645
    • Jensen, S.S.1    Larsen, M.R.2
  • 36
    • 34548183872 scopus 로고    scopus 로고
    • Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
    • Rappsilber, J., Mann, M. & Ishihama, Y. Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips. Nature protocols 2, 1896-1906, doi: 10.1038/nprot.2007.261 (2007).
    • (2007) Nature Protocols , vol.2 , pp. 1896-1906
    • Rappsilber, J.1    Mann, M.2    Ishihama, Y.3
  • 37
    • 84857938446 scopus 로고    scopus 로고
    • Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins
    • M111 014050
    • Geiger, T., Wehner, A., Schaab, C., Cox, J. & Mann, M. Comparative proteomic analysis of eleven common cell lines reveals ubiquitous but varying expression of most proteins. Molecular & cellular proteomics: MCP 11, M111 014050, doi: 10.1074/mcp.M111.014050 (2012).
    • (2012) Molecular & Cellular Proteomics: MCP , vol.11
    • Geiger, T.1    Wehner, A.2    Schaab, C.3    Cox, J.4    Mann, M.5
  • 38
    • 0029069946 scopus 로고
    • Synergistic effects of IL-7 and IL-12 on human T cell activation
    • Mehrotra, P. T., Grant, A. J. & Siegel, J. P. Synergistic effects of IL-7 and IL-12 on human T cell activation. Journal of immunology 154, 5093-5102 (1995).
    • (1995) Journal of Immunology , vol.154 , pp. 5093-5102
    • Mehrotra, P.T.1    Grant, A.J.2    Siegel, J.P.3
  • 39
    • 31644439146 scopus 로고    scopus 로고
    • Phosphorylation analysis by mass spectrometry: Myths, facts, and the consequences for qualitative and quantitative measurements
    • Steen, H., Jebanathirajah, J. A., Rush, J., Morrice, N. & Kirschner, M. W. Phosphorylation analysis by mass spectrometry: myths, facts, and the consequences for qualitative and quantitative measurements. Molecular & cellular proteomics: MCP 5, 172-181, doi: 10.1074/mcp.M500135-MCP200 (2006).
    • (2006) Molecular & Cellular Proteomics: MCP , vol.5 , pp. 172-181
    • Steen, H.1    Jebanathirajah, J.A.2    Rush, J.3    Morrice, N.4    Kirschner, M.W.5
  • 40
    • 84862776933 scopus 로고    scopus 로고
    • Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase
    • Gao, X., Wang, H., Yang, J. J., Liu, X. & Liu, Z. R. Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase. Molecular cell 45, 598-609, doi: 10.1016/j.molcel.2012.01.001 (2012).
    • (2012) Molecular Cell , vol.45 , pp. 598-609
    • Gao, X.1    Wang, H.2    Yang, J.J.3    Liu, X.4    Liu, Z.R.5
  • 41
    • 84920406385 scopus 로고    scopus 로고
    • Accurate protein complex retrieval by affinity enrichment mass spectrometry (AE-MS) rather than affinity purification mass spectrometry (AP-MS)
    • Keilhauer, E. C., Hein, M. Y. & Mann, M. Accurate protein complex retrieval by affinity enrichment mass spectrometry (AE-MS) rather than affinity purification mass spectrometry (AP-MS). Molecular & cellular proteomics: MCP 14, 120-135, doi: 10.1074/mcp.M114.041012 (2015).
    • (2015) Molecular & Cellular Proteomics: MCP , vol.14 , pp. 120-135
    • Keilhauer, E.C.1    Hein, M.Y.2    Mann, M.3
  • 42
    • 57449099865 scopus 로고    scopus 로고
    • MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteomewide protein quantification
    • Cox, J. & Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteomewide protein quantification. Nat Biotechnol 26, 1367-1372, doi: 10.1038/nbt.1511 (2008).
    • (2008) Nat Biotechnol , vol.26 , pp. 1367-1372
    • Cox, J.1    Mann, M.2
  • 43
    • 84928225301 scopus 로고    scopus 로고
    • Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at ser16 to trigger its nuclear localization
    • Herhaus, L. et al. Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Science signaling 8, ra35, doi: 10.1126/scisignal.aaa0441 (2015).
    • (2015) Science Signaling , vol.8 , pp. ra35
    • Herhaus, L.1
  • 44
    • 84876677570 scopus 로고    scopus 로고
    • Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions
    • Mihlan, S. et al. Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions. Oncogene 32, 2107-2113, doi: 10.1038/onc.2012.216 (2013).
    • (2013) Oncogene , vol.32 , pp. 2107-2113
    • Mihlan, S.1
  • 45
    • 84894037589 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-kappaB-dependent gene expression
    • Handschick, K. et al. Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-kappaB-dependent gene expression. Molecular cell 53, 193-208, doi: 10.1016/j.molcel.2013.12.002 (2014).
    • (2014) Molecular Cell , vol.53 , pp. 193-208
    • Handschick, K.1
  • 46
    • 84901707773 scopus 로고    scopus 로고
    • Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent bcl3 activation
    • Gringhuis, S. I., Kaptein, T. M., Wevers, B. A., Mesman, A. W. & Geijtenbeek, T. B. Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKepsilon- and CYLD-dependent Bcl3 activation. Nature communications 5, 3898, doi: 10.1038/ncomms4898 (2014).
    • (2014) Nature Communications , vol.5 , pp. 3898
    • Gringhuis, S.I.1    Kaptein, T.M.2    Wevers, B.A.3    Mesman, A.W.4    Geijtenbeek, T.B.5
  • 47
    • 84871569843 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 6 phosphorylates NF-kappaB P65 at serine 536 and contributes to the regulation of inflammatory gene expression
    • Buss, H. et al. Cyclin-dependent kinase 6 phosphorylates NF-kappaB P65 at serine 536 and contributes to the regulation of inflammatory gene expression. Plos one 7, e51847, doi: 10.1371/journal.pone.0051847 (2012).
    • (2012) Plos One , vol.7 , pp. e51847
    • Buss, H.1
  • 48
    • 69749120549 scopus 로고    scopus 로고
    • Distinct subcellular distribution of cyclin dependent kinase 6
    • Kohrt, D. M., Crary, J. I., Gocheva, V., Hinds, P. W. & Grossel, M. J. Distinct subcellular distribution of cyclin dependent kinase 6. Cell cycle 8, 2837-2843 (2009).
    • (2009) Cell Cycle , vol.8 , pp. 2837-2843
    • Kohrt, D.M.1    Crary, J.I.2    Gocheva, V.3    Hinds, P.W.4    Grossel, M.J.5
  • 49
    • 0028596154 scopus 로고
    • Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes
    • Nielsen, M., Svejgaard, A., Skov, S. & Odum, N. Interleukin-2 induces tyrosine phosphorylation and nuclear translocation of stat3 in human T lymphocytes. Eur J Immunol 24, 3082-3086, doi: 10.1002/eji.1830241225 (1994).
    • (1994) Eur J Immunol , vol.24 , pp. 3082-3086
    • Nielsen, M.1    Svejgaard, A.2    Skov, S.3    Odum, N.4
  • 51
    • 84886845190 scopus 로고    scopus 로고
    • Analysis of the STAT3 interactome using in-situ biotinylation and SILAC
    • Blumert, C. et al. Analysis of the STAT3 interactome using in-situ biotinylation and SILAC. Journal of proteomics 94, 370-386, doi: 10.1016/j.jprot.2013.08.021 (2013).
    • (2013) Journal of Proteomics , vol.94 , pp. 370-386
    • Blumert, C.1
  • 52
    • 84896490241 scopus 로고    scopus 로고
    • PKM2, STAT3 and HIF-1alpha: The Warburg's vicious circle
    • Demaria, M. & Poli, V. PKM2, STAT3 and HIF-1alpha: The Warburg's vicious circle. Jak-Stat 1, 194-196, doi: 10.4161/jkst.20662 (2012).
    • (2012) Jak-Stat , vol.1 , pp. 194-196
    • Demaria, M.1    Poli, V.2
  • 53
    • 84870598190 scopus 로고    scopus 로고
    • ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the warburg effect
    • Yang, W. et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nature cell biology 14, 1295-1304, doi: 10.1038/ncb2629 (2012).
    • (2012) Nature Cell Biology , vol.14 , pp. 1295-1304
    • Yang, W.1
  • 54
    • 0017153683 scopus 로고
    • Aerobic glycolysis during lymphocyte proliferation
    • Wang, T., Marquardt, C. & Foker, J. Aerobic glycolysis during lymphocyte proliferation. Nature 261, 702-705 (1976).
    • (1976) Nature , vol.261 , pp. 702-705
    • Wang, T.1    Marquardt, C.2    Foker, J.3
  • 55
    • 44449165597 scopus 로고    scopus 로고
    • Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways
    • Jacobs, S. R. et al. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. Journal of immunology 180, 4476-4486 (2008).
    • (2008) Journal of Immunology , vol.180 , pp. 4476-4486
    • Jacobs, S.R.1
  • 56
    • 0036069699 scopus 로고    scopus 로고
    • The CD28 signaling pathway regulates glucose metabolism
    • Frauwirth, K. A. et al. The CD28 signaling pathway regulates glucose metabolism. Immunity 16, 769-777 (2002).
    • (2002) Immunity , vol.16 , pp. 769-777
    • Frauwirth, K.A.1
  • 57
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and treg cells
    • Shi, L. Z. et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. The Journal of experimental medicine 208, 1367-1376, doi: 10.1084/jem.20110278 (2011).
    • (2011) The Journal of Experimental Medicine , vol.208 , pp. 1367-1376
    • Shi, L.Z.1
  • 59
    • 84964213889 scopus 로고    scopus 로고
    • HIF1a is induced by the pro-inflammatory IL-23 in dendritic cells but not macrophages
    • Spadaro, A. et al. HIF1a is Induced by the Pro-Inflammatory IL-23 in Dendritic Cells but Not Macrophages. J of Surgical Research 186, 688 (2014).
    • (2014) J of Surgical Research , vol.186 , pp. 688
    • Spadaro, A.1
  • 60
    • 79957567239 scopus 로고    scopus 로고
    • Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1
    • Luo, W. et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell 145, 732-744, doi: 10.1016/j.cell.2011.03.054 (2011).
    • (2011) Cell , vol.145 , pp. 732-744
    • Luo, W.1
  • 61
    • 84873684726 scopus 로고    scopus 로고
    • Metabolic control of the treg/Th17 axis
    • Barbi, J., Pardoll, D. & Pan, F. Metabolic control of the Treg/Th17 axis. Immunol Rev 252, 52-77, doi: 10.1111/imr.12029 (2013).
    • (2013) Immunol Rev , vol.252 , pp. 52-77
    • Barbi, J.1    Pardoll, D.2    Pan, F.3
  • 62
    • 0346101797 scopus 로고    scopus 로고
    • Constitutively active galpha16 stimulates STAT3 via a c-src/JAK- and ERK-dependent mechanism
    • Lo, R. K., Cheung, H. & Wong, Y. H. Constitutively active Galpha16 stimulates STAT3 via a c-Src/JAK- and ERK-dependent mechanism. The Journal of biological chemistry 278, 52154-52165, doi: 10.1074/jbc.M307299200 (2003).
    • (2003) The Journal of Biological Chemistry , vol.278 , pp. 52154-52165
    • Lo, R.K.1    Cheung, H.2    Wong, Y.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.