Tumour necrosis factor-alpha participates on the endothelin-1/nitric oxide imbalance in small arteries from obese patients: Role of perivascular adipose tissue

European Heart Journal

Volumn 36, Issue 13, 2015, Pages 784-794

  Virdis, Agostino ^a   Duranti, Emiliano ^a   Rossi, Chiara ^a   Dell'Agnello, Umberto ^a   Santini, Eleonora ^a   Anselmino, Marco ^b   Chiarugi, Massimo ^a   Taddei, Stefano ^a   Solini, Anna ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY HOSPITAL OF PISA   (Italy)

Author keywords

Endothelin 1; Nitric oxide; Perivascular adipose tissue; Small vessels; TNF

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; INFLIXIMAB; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; CYCLO(TRP-ASP-PRO-VAL-LEU); CYCLOPEPTIDE; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; ENZYME INHIBITOR; SUPEROXIDE; TUMOR NECROSIS FACTOR RECEPTOR;

ADIPOCYTE; ADIPOSE TISSUE; ADULT; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; MALE; MIDDLE AGED; OBESITY; PERIVASCULAR ADIPOSE TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASOCONSTRICTION; ANTAGONISTS AND INHIBITORS; CASE CONTROL STUDY; CELL CULTURE; DRUG EFFECTS; INTRAABDOMINAL FAT; METABOLISM; MICROVASCULATURE; MORBID OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

CASE-CONTROL STUDIES; CELLS, CULTURED; ENDOTHELIN A RECEPTOR ANTAGONISTS; ENDOTHELIN RECEPTOR ANTAGONISTS; ENDOTHELIN-1; ENZYME INHIBITORS; FEMALE; HUMANS; INFLIXIMAB; INTRA-ABDOMINAL FAT; MALE; MICROVESSELS; MIDDLE AGED; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; OBESITY, MORBID; PEPTIDES, CYCLIC; RECEPTOR, ENDOTHELIN A; RECEPTORS, TUMOR NECROSIS FACTOR; SUPEROXIDES; TUMOR NECROSIS FACTOR-ALPHA; VASOCONSTRICTION;

EID: 84926672252     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu072     Document Type: Article

References (30)

1. Dhaun N, Goddard J, Kohan DE, Pollock DM, Schiffrin EL, Webb DJ. Role of endothelin-1 in clinical hypertension: 20 years on. Hypertension 2008;52:452-459.
2. Cardillo C, Kilcoyne CM, Cannon RO, Panza JA. Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo. Hypertension 2000;35:1237-1241.
3. Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/ insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996;97:2601-2610.
4. Al Suwaidi J, Higano ST, HolmesDRJr, Lennon R, Lerman A.Obesity is independently associated with coronary endothelial dysfunction in patients with normal or mildly diseased coronary arteries. J Am Coll Cardiol 2001;37:1523-1528.
5. Grassi G, Seravalle G, Scopelliti F, Dell'Oro R, Fattori L, Quarti-Trevano F, Brambilla G, Schiffrin EL, Mancia G. Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity. Obesity (Silver Spring) 2010; 18:92-98.
6. Virdis A, Santini F, Colucci R, Duranti E, Salvetti G, Rugani I, SegnaniC, Anselmino M, Bernardini N, Blandizzi C, Salvetti A, Pinchera A, Taddei S. Vascular generation of tumor necrosis factor-alpha reduces nitric oxide availability in small arteries from visceral fat of obese patients. J Am Coll Cardiol 2011;58:238-247.
7. De Ciuceis C, Porteri E, Rizzoni D, Corbellini C, La Boria E, Boari GE, Pilu A, Mittempergher F, Di Betta E, Casella C, Nascimbeni R, Rosei CA, Ruggeri G, Caimi L, Rosei EA. Effects of weight loss on structural and functional alterations of subcutaneous small arteries in obese patients. Hypertension 2011;58: 29-36.
8. Cardillo C, Campia U, IantornoM, Panza JA. Enhanced vascular activity of endogenous endothelin-1 in obese hypertensive patients. Hypertension 2004;43:36-40.
9. Tesauro M, Schinzari F, Rovella V, Di Daniele N, Lauro D, Mores N, Veneziani A, Cardillo C. Ghrelin restores the endothelin 1/nitric oxide balance in patients with obesity-related metabolic syndrome. Hypertension 2009;54:995-1000.
10. Dandona P, Aljada A, Chaudhuri A, Mohanty P, Garg R. Metabolic syndrome: a comprehensive perspective based on interactions between obesity, diabetes, and inflammation. Circulation 2005;111:1448-1454.
11. Virdis A, Neves MF, Duranti E, Bernini G, Taddei S. Microvascular endothelial dysfunction in obesity and hypertension. Curr Pharm Des 2013;19:2382-2389.
12. Greenstein AS, Khavandi K, Withers SB, Sonoyama K, Clancy O, Jeziorska M, Laing I, Yates AP, PembertonPW, Malik RA, Heagerty AM. Local inflammation and hypoxia abolish the protective anticontractile properties of perivascular fat in obese patients. Circulation 2009;119:1661-1670.
13. Dandona P, Ghanim H, Chaudhuri A. An inflammatory tale from 3 fatty depots. J Am Coll Cardiol 2011;58:256-257.
14. Kahler J, Ewert A, Weckmuller J, Stobbe S, Mittmann C, Koster R, Paul M, Meinertz T, Munzel T. Oxidative stress increases endothelin-1 synthesis in human coronary artery smooth muscle cells. J Cardiovasc Pharmacol 2001;38:49-57.
15. Pollock DM, Pollock JS. Endothelin and oxidative stress in the vascular system. Curr Vasc Pharmacol 2005;3:365-367.
16. Endemann DH, Pu Q, De Ciuceis C, Savoia C, Virdis A, Neves MF, Touyz RM, Schiffrin EL. Persistent remodeling of resistance arteries in type 2 diabetic patients on antihypertensive treatment. Hypertension 2004;43:399-404.
17. Virdis A, Bacca A, Colucci R, Duranti E, Fornai M, Materazzi G, Ippolito C, Bernardini N, Blandizzi C, Bernini G, Taddei S. Endothelial dysfunction in small arteries of essential hypertensive patients: role of cyclooxygenase-2 in oxidative stress generation. Hypertension 2013;62:337-344.
18. Jimenez-Altayo F, Briones AM, Giraldo J, Planas AM, Salaices M, Vila E. Increased superoxide anion production by interleukin-1beta impairs nitric oxide-mediated relaxation in resistance arteries. J Pharmacol Exp Ther 2006;316:42-52.
19. Rodbell M. Localization of lipoprotein lipase in fat cells of rat adipose tissue. J Biol Chem 1964;239:753-755.
20. Johnstrom P, Fryer TD, Richards HK, Harris NG, Barret O, Clark JC, Pickard JD, Davenport AP. Positron emission tomography using 18F-labelled endothelin-1 reveals prevention of binding to cardiac receptors owing to tissue-specific clearance by ET B receptors in vivo. Br J Pharmacol 2005;144:115-122.
21. MazzucaMQ, Khalil RA. Vascular endothelin receptor typeB: structure, function and dysregulation in vascular disease. Biochem Pharmacol 2012;84:147-162.
22. Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006;113:1708-1714.
23. Munzel T, Gori T, Bruno RM, Taddei S. Is oxidative stress a therapeutic target in cardiovascular disease? Eur Heart J 2010;31:2741-2748.
24. Chen CA, Wang TY, Varadharaj S, Reyes LA, Hemann C, Talukder MA, Chen YR, Druhan LJ, Zweier JL. S-glutathionylation uncouples eNOS and regulates its cellular and vascular function. Nature 2010;468:1115-1118.
25. Yang WS, Chang JW, Han NJ, Park SK. Darbepoetin alfa suppresses tumor necrosis factor-alpha-induced endothelin-1 production through antioxidant action in human aortic endothelial cells: role of sialic acid residues. Free Radic Biol Med 2011;50: 1242-1251.
26. Levin ER. Endothelins. N Engl J Med 1995;333:356-363.
27. Eringa EC, BakkerW, van Hinsbergh VW. Paracrine regulation of vascular tone, inflammation and insulin sensitivity by perivascular adipose tissue. Vascul Pharmacol 2012;56:204-209.
28. Eringa EC, Stehouwer CD, Walburg K, Clark AD, van Nieuw Amerongen GP, Westerhof N, Sipkema P. Physiological concentrations of insulin induce endothelindependent vasoconstriction of skeletal muscle resistance arteries in the presence of tumor necrosis factor-alpha dependence on c-Jun N-terminal kinase. Arterioscler Thromb Vasc Biol 2006;26:274-280.
29. Merial-Kieny C, Lonchampt M, Coge F, Verwaerde P, Galizzi JP, Boutin JA, Lafontan M, Levens N, Galitzky J, Feletou M. Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes. Br J Pharmacol 2003; 139:935-944.
30. Bergh N, Ulfhammer E, Glise K, Jern S, Karlsson L. Influence of TNF-alpha and biomechanical stress on endothelial anti- and prothrombotic genes. Biochem Biophys Res Commun 2009;385:314-318.