Protein kinase C-β contributes to impaired endothelial insulin signaling in humans with diabetes mellitus

Circulation

Volumn 127, Issue 1, 2013, Pages 86-95

  Tabit, Corey E ^a   Shenouda, Sherene M ^a   Holbrook, Monica ^a   Fetterman, Jessica L ^a   Kiani, Soroosh ^a   Frame, Alissa A ^a   Kluge, Matthew A ^a   Held, Aaron ^a   Dohadwala, Mustali M ^a   Gokce, Noyan ^a   Farb, Melissa G ^a   Rosenzweig, James ^a   Ruderman, Neil ^a   Vita, Joseph A ^a   Hamburg, Naomi M ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

diabetes mellitus; endothelium; insulin resistance; nitric oxide

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 3 NITROTYROSINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INSULIN; LY 379196; METFORMIN; PROTEIN KINASE C BETA; SERINE; SULFONYLUREA;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INSULIN RESPONSE; INSULIN TREATMENT; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADULT; CELLS, CULTURED; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; ENDOTHELIAL CELLS; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; MALE; MESYLATES; MIDDLE AGED; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PROTEIN KINASE C; PYRROLES; SIGNAL TRANSDUCTION;

EID: 84872081425     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.112.127514     Document Type: Article

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