Forkhead Box O-1 Modulation Improves Endothelial Insulin Resistance in Human Obesity

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 6, 2015, Pages 1498-1506

  Karki, Shakun ^a   Farb, Melissa G ^a   Ngo, Doan T M ^a   Myers, Samantha ^a   Puri, Vishwajeet ^a   Hamburg, Naomi M ^a   Carmine, Brian ^b   Hess, Donald T ^b   Gokce, Noyan ^a  

^a BOSTON MEDICAL CENTER   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

FOXO1 protein, human; insulin; nitric oxide synthase type III; obesity

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHR; 5-AMINO-7-(CYCLOHEXYLAMINO)-1-ETHYL-6-FLUORO-4-OXO-1,4-DIHYDROQUINOLINE-3-CARBOXYLIC ACID; DELAYED RELEASE FORMULATION; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; QUINOLONE DERIVATIVE;

ADULT; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; IMMUNOFLUORESCENCE; INSULIN RESISTANCE; INSULIN RESPONSE; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; OBESITY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SUBCUTANEOUS FAT; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; DELAYED RELEASE FORMULATION; DRUG EFFECTS; ENZYME ACTIVATION; METABOLISM; MIDDLE AGED; PHOSPHORYLATION; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADULT; DELAYED-ACTION PREPARATIONS; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; FEMALE; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; OBESITY; PHOSPHORYLATION; QUINOLONES;

EID: 84933051523     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.305139     Document Type: Article

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