Adipose tissue heterogeneity: Implication of depot differences in adipose tissue for obesity complications

Molecular Aspects of Medicine

Volumn 34, Issue 1, 2013, Pages 1-11

  Lee, Mi Jeong ^a   Wu, Yuanyuan ^a   Fried, Susan K ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

C reactive protein; CLS; crown like structures; CRP; FFA; free fatty acids; glucose transporter 4; GLUT4; GM CSF; granulocyte macrophage colony stimulating factor; IL 6; interleukin 6; lipoprotein lipase; LPL; macrophage chemoattractant protein 1; MCP 1; RBP4; retinol binding protein 4; SAA; SAT; sc; serum amyloid A; stromal vascular cells; subcutaneous; subcutaneous adipose tissue; SVC; TG; thrombospondin 1; TNF ; triacylglyeride; TSP 1; tumor necrosis factor alpha; VAT; very low density lipoprotein; visceral adipose tissue; VLDL

Indexed keywords

ADIPOCYTOKINE; CYTOKINE; FATTY ACID; TRIACYLGLYCEROL;

ADIPOCYTE; AGING; ANATOMICAL VARIATION; BODY FAT DISTRIBUTION; CELL COMPOSITION; CELL DEATH; CELL DIFFERENTIATION; CELL KINETICS; CELL MIGRATION; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; FATTY ACID TRANSPORT; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIPECTOMY; LIPID STORAGE; LIPOGENESIS; LIPOLYSIS; METABOLIC DISORDER; NONHUMAN; OBESITY; PHENOTYPE; PROADIPOCYTE; RACE DIFFERENCE; REVIEW; SEX DIFFERENCE; TISSUE GROWTH; TISSUE TRANSPLANTATION;

ADIPOCYTES; ADIPOKINES; ADIPOSE TISSUE; BODY FAT DISTRIBUTION; CARDIOVASCULAR DISEASES; DIABETES MELLITUS, TYPE 2; FATTY ACIDS; FEMALE; HUMANS; MALE; OBESITY;

SPRING VIREMIA OF CARP VIRUS;

EID: 84872144478     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2012.10.001     Document Type: Review

References (110)

1. K.G. Alberti, R.H. Eckel, S.M. Grundy, P.Z. Zimmet, J.I. Cleeman, K.A. Donato, J.C. Fruchart, W.P. James, C.M. Loria, and S.C. Smith Jr. Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity Circulation 120 2009 1640 1645
2. C.A. Allan, and R.I. McLachlan Androgens and obesity Curr. Opin. Endocrinol. Diabetes Obes. 17 2010 224 232
3. S.S. Anand, M.A. Tarnopolsky, S. Rashid, K.M. Schulze, D. Desai, A. Mente, S. Rao, S. Yusuf, H.C. Gerstein, and A.M. Sharma Adipocyte hypertrophy, fatty liver and metabolic risk factors in South Asians: the molecular study of health and risk in ethnic groups (mol-SHARE) PLoS ONE 6 2011 e22112
4. C.M. Apovian, S. Bigornia, M. Mott, M.R. Meyers, J. Ulloor, M. Gagua, M. McDonnell, D. Hess, L. Joseph, and N. Gokce Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects Arterioscler. Thromb. Vasc. Biol. 28 2008 1654 1659
5. P. Arner Differences in lipolysis between human subcutaneous and omental adipose tissues Ann. Med. 27 1995 435 438
6. K. Azuma, L.K. Heilbronn, J.B. Albu, S.R. Smith, E. Ravussin, and D.E. Kelley Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus Am. J. Physiol. Endocrinol. Metab. 293 2007 E435 E442
7. T.J. Bartness, and C.K. Song Thematic review series: Adipocyte biology. Sympathetic and sensory innervation of white adipose tissue J. Lipid Res. 48 2007 1655 1672 (Pubitemid 47311983)
8. N. Barzilai, L. She, B.Q. Liu, P. Vuguin, P. Cohen, J. Wang, and L. Rossetti Surgical removal of visceral fat reverses hepatic insulin resistance Diabetes 48 1999 94 98 (Pubitemid 29019357)
9. N. Bashan, K. Dorfman, T. Tarnovscki, I. Harman-Boehm, I.F. Liberty, M. Bluher, S. Ovadia, T. Maymon-Zilberstein, R. Potashnik, M. Stumvoll, E. Avinoach, and A. Rudich Mitogen-activated protein kinases, inhibitory-kappaB kinase, and insulin signaling in human omental versus subcutaneous adipose tissue in obesity Endocrinology 148 2007 2955 2962 (Pubitemid 46984790)
10. P. Bjorntorp "Portal" adipose tissue as a generator of risk factors for cardiovascular disease and diabetes Arteriosclerosis 10 1990 493 496 (Pubitemid 20220571)
11. A. Boivin, G. Brochu, S. Marceau, P. Marceau, F.S. Hould, and A. Tchernof Regional differences in adipose tissue metabolism in obese men Metabolism 56 2007 533 540 (Pubitemid 46427852)
12. J.M. Bruun, A.S. Lihn, S.B. Pedersen, and B. Richelsen Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT J. Clin. Endocrinol. Metab. 90 2005 2282 2289 (Pubitemid 40586275)
13. R. Cancello, J. Tordjman, C. Poitou, G. Guilhem, J.L. Bouillot, D. Hugol, C. Coussieu, A. Basdevant, H.A. Bar, P. Bedossa, M. Guerre-Millo, and K. Clement Increased infiltration of macrophages in omental adipose tissue is associated with marked hepatic lesions in morbid human obesity Diabetes 55 2006 1554 1561 (Pubitemid 44324107)
14. J.F. Carroll, A.L. Chiapa, M. Rodriquez, D.R. Phelps, K.M. Cardarelli, J.K. Vishwanatha, S. Bae, and R. Cardarelli Visceral fat, waist circumference, and BMI: impact of race/ethnicity Obesity. (Silver.Spring) 16 2008 600 607 (Pubitemid 351337456)
15. I.M. Chapman Obesity paradox during aging Interdiscip. Top. Gerontol. 37 2010 20 36
16. T.B. Chaston, and J.B. Dixon Factors associated with percent change in visceral versus subcutaneous abdominal fat during weight loss: findings from a systematic review Int. J. Obes. (Lond) 32 2008 619 628 (Pubitemid 351536009)
17. S. Cinti The adipose organ: morphological perspectives of adipose tissues Proc. Nutr. Soc. 60 2001 319 328
18. S. Cinti, G. Mitchell, G. Barbatelli, I. Murano, E. Ceresi, E. Faloia, S. Wang, M. Fortier, A.S. Greenberg, and M.S. Obin Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans J. Lipid Res. 46 2005 2347 2355 (Pubitemid 41532523)
19. D.L. Crandall, B.M. Goldstein, F. Huggins, and P. Cervoni Adipocyte blood flow: influence of age, anatomic location, and dietary manipulation Am. J. Physiol. 247 1984 R46 R51
20. A. Csendes, F. Maluenda, and A.M. Burgos A prospective randomized study comparing patients with morbid obesity submitted to laparotomic gastric bypass with or without omentectomy Obes. Surg. 19 2009 490 494
21. E. Danforth Jr Failure of adipocyte differentiation causes type II diabetes mellitus? Nat. Genet. 26 2000 13
22. C. Darimont, O. Avanti, F. Blancher, S. Wagniere, R. Mansourian, I. Zbinden, P. Leone-Vautravers, A. Fuerholz, V. Giusti, and K. Mace Contribution of mesothelial cells in the expression of inflammatory-related factors in omental adipose tissue of obese subjects Int. J. Obes. (Lond.) 2007
23. C.M. de Souza Batista, R.Z. Yang, M.J. Lee, N.M. Glynn, D.Z. Yu, J. Pray, K. Ndubuizu, S. Patil, A. Schwartz, M. Kligman, S.K. Fried, D.W. Gong, A.R. Shuldiner, T.I. Pollin, and J.C. McLenithan Omentin plasma levels and gene expression are decreased in obesity Diabetes 56 2007 1655 1661 (Pubitemid 46842600)
24. J.P. Despres, and I. Lemieux Abdominal obesity and metabolic syndrome Nature 444 2006 881 887 (Pubitemid 46024995)
25. N.K. Edens, S.K. Fried, J.G. Kral, J. Hirsch, and R.L. Leibel In vitro lipid synthesis in human adipose tissue from three abdominal sites Am. J. Physiol. 265 1993 E374 E379
26. H.F. Escobar-Morreale, and J.L. San Millan Abdominal adiposity and the polycystic ovary syndrome Trends Endocrinol. Metab. 18 2007 266 272 (Pubitemid 47332217)
27. I.M. Faust, P.R. Johnson, J.S. Stern, and J. Hirsch Diet-induced adipocyte number increase in adult rats: A new model of obesity Am. J. Physiol. 235 1978 E279 E286
28. L. Fontana, J.C. Eagon, M.E. Trujillo, P.E. Scherer, and S. Klein Visceral fat adipokine secretion is associated with systemic inflammation in obese humans Diabetes 56 2007 1010 1013 (Pubitemid 46525079)
29. M.T. Foster, H. Shi, S. Softic, R. Kohli, R.J. Seeley, and S.C. Woods Transplantation of non-visceral fat to the visceral cavity improves glucose tolerance in mice. investigation of hepatic lipids and insulin sensitivity Diabetologia 2011
30. C.S. Fox, J.M. Massaro, U. Hoffmann, K.M. Pou, P. Maurovich-Horvat, C.Y. Liu, R.S. Vasan, J.M. Murabito, J.B. Meigs, L.A. Cupples, R.B. D'Agostino Sr., and C.J. O'Donnell Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study Circulation 116 2007 39 48 (Pubitemid 47016245)
31. S.K. Fried, and J.G. Kral Adipose tissue of morbidly obese patients: clinical implications of distribution, morphology, and metabolism Gastroenterol. Clin. North Am. 16 1987 207 213 (Pubitemid 18067870)
32. S.K. Fried, R.L. Leibel, N.K. Edens, and J.G. Kral Lipolysis in intraabdominal adipose tissues of obese women and men Obes. Res. 1 1993 443 448
33. S.K. Fried, T. Tittelbach, J. Blumenthal, U. Sreenivasan, L. Robey, J. Yi, S. Khan, C. Hollender, A.S. Ryan, and A.P. Goldberg Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women J. Lipid Res. 51 2010 1193 1200
34. B.G. Gabrielsson, J.M. Johansson, M. Lonn, M. Jernas, T. Olbers, M. Peltonen, I. Larsson, L. Lonn, L. Sjostrom, B. Carlsson, and L.M. Carlsson High expression of complement components in omental adipose tissue in obese men Obes. Res. 11 2003 699 708 (Pubitemid 41151596)
35. E.B. Geer, and W. Shen Gender differences in insulin resistance, body composition, and energy balance Gend. Med. 6 Suppl 1 2009 60 75
36. S. Gesta, M. Bluher, Y. Yamamoto, A.W. Norris, J. Berndt, S. Kralisch, J. Boucher, C. Lewis, and C.R. Kahn Evidence for a role of developmental genes in the origin of obesity and body fat distribution Proc. Natl. Acad. Sci. U.S.A. 103 2006 6676 6681
37. K.Y. Guo, P. Halo, R.L. Leibel, and Y. Zhang Effects of obesity on the relationship of leptin mRNA expression and adipocyte size in anatomically distinct fat depots in mice Am. J. Physiol. Regul. Integr. Comp. Physiol. 287 2004 R112 R119
38. C.Y. Han, S. Subramanian, C.K. Chan, M. Omer, T. Chiba, T.N. Wight, and A. Chait Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion Diabetes 2007
39. R.W. Hanson, and L. Reshef Glyceroneogenesis revisited Biochimie 85 2003 1199 1205 (Pubitemid 38096343)
40. I. Harman-Boehm, M. Bluher, H. Redel, N. Sion-Vardy, S. Ovadia, E. Avinoach, I. Shai, N. Kloting, M. Stumvoll, N. Bashan, and A. Rudich Macrophage infiltration into omental versus subcutaneous fat across different populations: effect of regional adiposity and the comorbidities of obesity J. Clin. Endocrinol. Metab. 92 2007 2240 2247 (Pubitemid 46997129)
41. A. Harte, P. McTernan, R. Chetty, S. Coppack, J. Katz, S. Smith, and S. Kumar Insulin-mediated upregulation of the renin angiotensin system in human subcutaneous adipocytes is reduced by rosiglitazone Circulation 111 2005 1954 1961 (Pubitemid 40570215)
42. H. Hauner, and G. Entenmann Regional variation of adipose differentiation in cultured stromal-vascular cells from the abdominal and femoral adipose tissue of obese women Int. J. Obes. 15 1991 121 126
43. H. Hauner, M. Wabitsch, and E.F. Pfeiffer Differentiation of adipocyte precursor cells from obese and nonobese adult women and from different adipose tissue sites Horm. Metab. Res. Suppl. 19 1988 35 39 (Pubitemid 19005619)
44. M.F. Herrera, J.P. Pantoja, D. Velazquez-Fernandez, J. Cabiedes, C. Aguilar-Salinas, E. Garcia-Garcia, A. Rivas, C. Villeda, D.F. Hernandez-Ramirez, A. Davila, and A. Zarain Potential additional effect of omentectomy on metabolic syndrome, acute-phase reactants, and inflammatory mediators in grade III obese patients undergoing laparoscopic Roux-en-Y gastric bypass: A randomized trial Diabetes Care 33 2010 1413 1418
45. E. Hijona, L. Hijona, J.I. Arenas, and L. Bujanda Inflammatory mediators of hepatic steatosis Mediators Inflamm. 2010 2010 837419
46. S.L. Hocking, D.J. Chisholm, and D.E. James Studies of regional adipose transplantation reveal a unique and beneficial interaction between subcutaneous adipose tissue and the intra-abdominal compartment Diabetologia 51 2008 900 902
47. M.D. Jensen Gender differences in regional fatty acid metabolism before and after meal ingestion J. Clin. Invest. 96 1995 2297 2303
48. M.D. Jensen, M.G. Sarr, D.A. Dumesic, P.A. Southorn, and J.A. Levine Regional uptake of meal fatty acids in humans Am. J. Physiol. Endocrinol. Metab. 285 2003 E1282 E1288
49. J.A. Johnson, S.K. Fried, F.X. Pi-Sunyer, and J.B. Albu Impaired insulin action in subcutaneous adipocytes from women with visceral obesity Am. J. Physiol. Endocrinol. Metab. 280 2001 E40 E49
50. S. Kajimura, P. Seale, and B.M. Spiegelman Transcriptional control of brown fat development Cell Metab. 11 2010 257 262
51. Karastergiou, K., Fried, S.K., Xie, H., Lee, M.-J., Divoux, A., Rosencrantz, M.A., Chang, J.R., Smith, S.R., 2013. Distinct developmental signatures of human abdominal and gluteal subcutaneous adipose tissue depots. J. Clin. Endocrinol. Metab. 98, in press.
52. P.T. Katzmarzyk, G.A. Bray, F.L. Greenway, W.D. Johnson, R.L. Newton Jr., E. Ravussin, D.H. Ryan, S.R. Smith, and C. Bouchard Racial differences in abdominal depot-specific adiposity in white and African American adults Am. J. Clin. Nutr. 91 2010 7 15
53. S.P. Kim, K.J. Catalano, I.R. Hsu, J.D. Chiu, J.M. Richey, and R.N. Bergman Nocturnal free fatty acids are uniquely elevated in the longitudinal development of diet-induced insulin resistance and hyperinsulinemia Am. J. Physiol. Endocrinol. Metab. 292 2007 E1590 E1598
54. S. Klein, L. Fontana, V.L. Young, A.R. Coggan, C. Kilo, B.W. Patterson, and B.S. Mohammed Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease N. Engl. J. Med. 350 2004 2549 2557 (Pubitemid 38758542)
55. M. Kolak, J. Westerbacka, V.R. Velagapudi, D. Wagsater, L. Yetukuri, J. Makkonen, A. Rissanen, A.M. Hakkinen, M. Lindell, R. Bergholm, A. Hamsten, P. Eriksson, R.M. Fisher, M. Oresic, and H. Yki-Jarvinen Adipose tissue inflammation and increased ceramide content characterize subjects with high liver fat content independent of obesity Diabetes 56 2007 1960 1968 (Pubitemid 47195815)
56. C. Koutsari, A.H. Ali, M.S. Mundi, and M.D. Jensen Storage of circulating free fatty acid in adipose tissue of postabsorptive humans: quantitative measures and implications for body fat distribution Diabetes 60 2011 2032 2040
57. J.L. Kuk, T.J. Saunders, L.E. Davidson, and R. Ross Age-related changes in total and regional fat distribution Ageing Res. Rev. 8 2009 339 348
58. Lee, M.J., Fried, S.K., 2010. Adipose Tissue in Health and Disease (Chapter 15). Depot-Specific Biology of Adipose Tissues: Links to Fat Distribution and Metabolic Risk.
59. R.L. Leibel, N.K. Edens, and S.K. Fried Physiologic basis for the control of body fat distribution in humans Annu. Rev. Nutr. 9 1989 417 443
60. R.L. Leibel, N.K. Edens, and S.K. Fried Physiologic basis for the control of body fat distribution in humans Annu. Rev. Nutr. 9 417-43 1989 417 443
61. N.O. Litbarg, K.P. Gudehithlu, P. Sethupathi, J.A. Arruda, G. Dunea, and A.K. Singh Activated omentum becomes rich in factors that promote healing and tissue regeneration Cell Tissue Res. 328 2007 487 497 (Pubitemid 46684496)
62. F. Lonnqvist, A. Thorne, V. Large, and P. Arner Sex differences in visceral fat lipolysis and metabolic complications of obesity Arterioscler. Thromb. Vasc. Biol. 17 1997 1472 1480 (Pubitemid 27329875)
63. R. Madani, K. Karastergiou, N.C. Ogston, N. Miheisi, R. Bhome, N. Haloob, G.D. Tan, F. Karpe, J. Malone-Lee, M. Hashemi, M. Jahangiri, and V. Mohamed-Ali RANTES release by human adipose tissue in vivo and evidence for depot-specific differences Am. J. Physiol. Endocrinol. Metab. 296 2009 E1262 E1268
64. P. Marin, L. Lonn, B. Andersson, B. Oden, L. Olbe, B.A. Bengtsson, and P. Bjorntorp Assimilation of triglycerides in subcutaneous and intraabdominal adipose tissues in vivo in men: effects of testosterone J. Clin. Endocrinol. Metab. 81 1996 1018 1022 (Pubitemid 26083964)
65. P. Marin, B. Oden, and P. Bjorntorp Assimilation and mobilization of triglycerides in subcutaneous abdominal and femoral adipose tissue in vivo in men: effects of androgens J. Clin. Endocrinol. Metab. 80 1995 239 243
66. P. Marin, M. Rebuffe-Scrive, U. Smith, and P. Bjorntorp Glucose uptake in human adipose tissue Metabolism 36 1987 1154 1160
67. S.E. Meek, K.S. Nair, and M.D. Jensen Insulin regulation of regional free fatty acid metabolism Diabetes 48 1999 10 14 (Pubitemid 29019346)
68. V. Mohamed-Ali, S. Goodrick, A. Rawesh, D.R. Katz, J.M. Miles, J.S. Yudkin, S. Klein, and S.W. Coppack Subcutaneous adipose tissue releases interleukin-6, but not tumor necrosis factor-alpha, in vivo J. Clin. Endocrinol. Metab. 82 1997 4196 4200 (Pubitemid 27525539)
69. S. Nielsen, Z. Guo, C.M. Johnson, D.D. Hensrud, and M.D. Jensen Splanchnic lipolysis in human obesity J. Clin. Invest. 113 2004 1582 1588 (Pubitemid 39071681)
70. C.U. Niesler, K. Siddle, and J.B. Prins Human preadipocytes display a depot-specific susceptibility to apoptosis Diabetes 47 1998 1365 1368 (Pubitemid 28357020)
71. S. Nishimura, I. Manabe, M. Nagasaki, K. Seo, H. Yamashita, Y. Hosoya, M. Ohsugi, K. Tobe, T. Kadowaki, R. Nagai, and S. Sugiura In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue J. Clin. Invest. 118 2008 710 721 (Pubitemid 351206559)
72. M. Pasarica, O.R. Sereda, L.M. Redman, D.C. Albarado, D.T. Hymel, L.E. Roan, J.C. Rood, D.H. Burk, and S.R. Smith Reduced adipose tissue oxygenation in human obesity: evidence for rarefaction, macrophage chemotaxis, and inflammation without an angiogenic response Diabetes 58 2009 718 725
73. C.M. Pond Adipose tissue and the immune system Prostaglandins Leukot. Essent. Fatty Acids 73 2005 17 30 (Pubitemid 40826924)
74. E. Ravussin, and J.E. Galgani The implication of brown adipose tissue for humans Annu. Rev. Nutr. 31 2011 33 47
75. M. Rebuffe-Scrive, B. Anderson, L. Olbe, and P. Bjorntorp Metabolism of adipose tissue in intraabdominal depots in severely obese men and women Metabolism 39 1990 1021 1025 (Pubitemid 20351258)
76. M. Rebuffe-Scrive, P. Marin, and P. Bjorntorp Effect of testosterone on abdominal adipose tissue in men Int. J. Obes. 15 1991 791 795
77. S.A. Romanski, R.M. Nelson, and M.D. Jensen Meal fatty acid uptake in adipose tissue: gender effects in nonobese humans Am. J. Physiol. Endocrinol. Metab. 279 2000 E455 E462
78. H.S. Sacks, and J.N. Fain Human epicardial adipose tissue: A review Am. Heart J. 153 2007 907 917 (Pubitemid 46809849)
79. S. Shadid, C. Koutsari, and M.D. Jensen Direct free fatty acid uptake into human adipocytes in vivo: relation to body fat distribution Diabetes 56 2007 1369 1375 (Pubitemid 46715629)
80. A. Shahparaki, L. Grunder, and A. Sorisky Comparison of human abdominal subcutaneous versus omental preadipocyte differentiation in primary culture Metabolism 51 2002 1211 1215
81. W. Shen, Z. Wang, M. Punyanita, J. Lei, A. Sinav, J.G. Kral, C. Imielinska, R. Ross, and S.B. Heymsfield Adipose tissue quantification by imaging methods: A proposed classification Obes. Res. 11 2003 5 16 (Pubitemid 41137532)
82. H. Shi, A. Strader, S.C. Woods, and R.J. Seeley The Effect of Fat Removal on Glucose Tolerance is Depot Specific in Male and Female Mice Am. J. Physiol. Endocrinol. Metab 2007
83. K. Sjoholm, J. Palming, L.E. Olofsson, A. Gummesson, P.A. Svensson, T.C. Lystig, E. Jennische, J. Brandberg, J.S. Torgerson, B. Carlsson, and L.M. Carlsson A microarray search for genes predominantly expressed in human omental adipocytes: Adipose tissue as a major production site of serum amyloid A J. Clin. Endocrinol. Metab. 90 2005 2233 2239 (Pubitemid 40586267)
84. S.R. Smith, J.C. Lovejoy, F. Greenway, D. Ryan, L. deJonge, B.J. de la, J. Volafova, and G.A. Bray Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity Metabolism 50 2001 425 435 (Pubitemid 32321951)
85. M.B. Snijder, M. Visser, J.M. Dekker, B.H. Goodpaster, T.B. Harris, S.B. Kritchevsky, R.N. De, A.M. Kanaya, A.B. Newman, F.A. Tylavsky, and J.C. Seidell Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study Diabetologia 48 2005 301 308 (Pubitemid 40543303)
86. K.L. Spalding, E. Arner, P.O. Westermark, S. Bernard, B.A. Buchholz, O. Bergmann, L. Blomqvist, J. Hoffstedt, E. Naslund, T. Britton, H. Concha, M. Hassan, M. Ryden, J. Frisen, and P. Arner Dynamics of fat cell turnover in humans Nature 453 2008 783 787 (Pubitemid 351793777)
87. J. St-Pierre, I. Lemieux, P. Perron, D. Brisson, M. Santure, M.C. Vohl, J.P. Despres, and D. Gaudet Relation of the "hypertriglyceridemic waist" phenotype to earlier manifestations of coronary artery disease in patients with glucose intolerance and type 2 diabetes mellitus Am. J. Cardiol. 99 2007 369 373 (Pubitemid 46157216)
88. K.J. Strissel, Z. Stancheva, H. Miyoshi, J.W. Perfield, J. DeFuria, Z. Jick, A.S. Greenberg, and M.S. Obin Adipocyte death, adipose tissue remodeling, and obesity complications Diabetes 56 2007 2910 2918 (Pubitemid 350223625)
89. W. Tang, D. Zeve, J.M. Suh, D. Bosnakovski, M. Kyba, R.E. Hammer, M.D. Tallquist, and J.M. Graff White fat progenitor cells reside in the adipose vasculature Science 322 2008 583 586
90. A. Tchernof, C. Belanger, A.S. Morisset, C. Richard, J. Mailloux, P. Laberge, and P. Dupont Regional differences in adipose tissue metabolism in women: minor effect of obesity and body fat distribution Diabetes 55 2006 1353 1360 (Pubitemid 44195374)
91. T. Tchkonia, N. Giorgadze, T. Pirtskhalava, T. Thomou, M. DePonte, A. Koo, R.A. Forse, D. Chinnappan, C. Martin-Ruiz, Z.T. von, and J.L. Kirkland Fat depot-specific characteristics are retained in strains derived from single human preadipocytes Diabetes 55 2006 2571 2578 (Pubitemid 44871158)
92. T. Tchkonia, M. Lenburg, T. Thomou, N. Giorgadze, G. Frampton, T. Pirtskhalava, A. Cartwright, M. Cartwright, J. Flanagan, I. Karagiannides, N. Gerry, R.A. Forse, Y. Tchoukalova, M.D. Jensen, C. Pothoulakis, and J.L. Kirkland Identification of depot-specific human fat cell progenitors through distinct expression profiles and developmental gene patterns Am. J. Physiol. Endocrinol. Metab. 292 2007 E298 E307
93. T. Tchkonia, Y.D. Tchoukalova, N. Giorgadze, T. Pirtskhalava, I. Karagiannides, R.A. Forse, A. Koo, M. Stevenson, D. Chinnappan, A. Cartwright, M.D. Jensen, and J.L. Kirkland Abundance of two human preadipocyte subtypes with distinct capacities for replication, adipogenesis, and apoptosis varies among fat depots Am. J. Physiol. Endocrinol. Metab. 288 2005 E267 E277
94. Y.D. Tchoukalova, C. Koutsari, S.B. Votruba, T. Tchkonia, N. Giorgadze, T. Thomou, J.L. Kirkland, and M.D. Jensen Sex- and depot-dependent differences in adipogenesis in normal-weight humans Obesity. (Silver. Spring) 18 2010 1875 1880
95. Y.D. Tchoukalova, S.B. Votruba, T. Tchkonia, N. Giorgadze, J.L. Kirkland, and M.D. Jensen Regional differences in cellular mechanisms of adipose tissue gain with overfeeding Proc. Natl. Acad. Sci. U.S.A. 107 2010 18226 18231
96. A. Thorne, F. Lonnqvist, J. Apelman, G. Hellers, and P. Arner A pilot study of long-term effects of a novel obesity treatment: omentectomy in connection with adjustable gastric banding Int. J. Obes. Relat. Metab. Disord. 26 2002 193 199 (Pubitemid 34151196)
97. T.T. Tran, Y. Yamamoto, S. Gesta, and C.R. Kahn Transplantation of subcutaneous fat to the visceral cavity induced protective metabolic effects: Evidence for intrinsic properties of subcutaneous fat Diabetes 56 2007 A5 A6
98. M.E. Trujillo, and P.E. Scherer Adipose tissue-derived factors: impact on health and disease Endocr. Rev. 27 2006 762 778 (Pubitemid 44936059)
99. H.V. van, K. Rohrig, and H. Hauner Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects Metabolism 53 2004 632 637 (Pubitemid 38596537)
100. V. Varma, A. Yao-Borengasser, N. Rasouli, A.M. Bodles, B. Phanavanh, M.J. Lee, T. Starks, L.M. Kern, H.J. Spencer III, R.E. McGehee Jr., S.K. Fried, and P.A. Kern Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation J. Clin. Endocrinol. Metab. 92 2007 666 672
101. G.L. Vega, B. ms-Huet, R. Peshock, D. Willett, B. Shah, and S.M. Grundy Influence of body fat content and distribution on variation in metabolic risk J. Clin. Endocrinol. Metab. 91 2006 4459 4466 (Pubitemid 44833423)
102. A. Veilleux, K. Blouin, C. Rheaume, M. Daris, A. Marette, and A. Tchernof Glucose transporter 4 and insulin receptor substrate-1 messenger RNA expression in omental and subcutaneous adipose tissue in women Metabolism 58 2009 624 631
103. K.A. Virtanen, P. Lonnroth, R. Parkkola, P. Peltoniemi, M. Asola, T. Viljanen, T. Tolvanen, J. Knuuti, T. Ronnemaa, R. Huupponen, and P. Nuutila Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans J. Clin. Endocrinol. Metab. 87 2002 3902 3910 (Pubitemid 34879546)
104. M.C. Vohl, R. Sladek, J. Robitaille, S. Gurd, P. Marceau, D. Richard, T.J. Hudson, and A. Tchernof A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men Obes. Res. 12 2004 1217 1222 (Pubitemid 41137463)
105. Y. Wang, S. Sullivan, M. Trujillo, M.J. Lee, S.H. Schneider, R.E. Brolin, Y.H. Kang, Y. Werber, A.S. Greenberg, and S.K. Fried Perilipin expression in human adipose tissues: effects of severe obesity, gender, and depot Obes. Res. 11 2003 930 936 (Pubitemid 41137503)
106. S.P. Weisberg, D. Hunter, R. Huber, J. Lemieux, S. Slaymaker, K. Vaddi, I. Charo, R.L. Leibel, and A.W. Ferrante Jr. CCR2 modulates inflammatory and metabolic effects of high-fat feeding J. Clin. Invest. 116 2006 115 124 (Pubitemid 43121796)
107. D.B. West, W.A. Prinz, and M.R. Greenwood Regional changes in adipose tissue blood flow and metabolism in rats after a meal Am. J. Physiol. 257 1989 R711 R716
108. Q. Yang, T.E. Graham, N. Mody, F. Preitner, O.D. Peroni, J.M. Zabolotny, K. Kotani, L. Quadro, and B.B. Kahn Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes Nature 436 2005 356 362 (Pubitemid 41065039)
109. R.Z. Yang, M.J. Lee, H. Hu, T.I. Pollin, A.S. Ryan, B.J. Nicklas, S. Snitker, R.B. Horenstein, K. Hull, N.H. Goldberg, A.P. Goldberg, A.R. Shuldiner, S.K. Fried, and D.W. Gong Acute-phase serum amyloid A: An inflammatory adipokine and potential link between obesity and its metabolic complications PLoS Med. 3 2006 287
110. R.Z. Yang, M.J. Lee, H. Hu, J. Pray, H.B. Wu, B.C. Hansen, A.R. Shuldiner, S.K. Fried, J.C. McLenithan, and D.W. Gong Identification of omentin as a novel depot-specific adipokine in human adipose tissue: possible role in modulating insulin action Am. J. Physiol. Endocrinol. Metab. 290 2006 E1253 E1261