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Volumn 55, Issue 2, 2017, Pages 797-811

Aerosol Delivery of Curcumin Reduced Amyloid-β Deposition and Improved Cognitive Performance in a Transgenic Model of Alzheimer's Disease

Author keywords

Aerosol; amyloid ; curcumin; nebulization

Indexed keywords

AMYLOID BETA PROTEIN; CURCUMIN; AMYLOID PRECURSOR PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; PRESENILIN 1;

EID: 84999106787     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-160289     Document Type: Article
Times cited : (44)

References (46)
  • 2
    • 48149108245 scopus 로고    scopus 로고
    • Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases
    • Irvine GB, El-Agnaf OM, Shankar GM, Walsh DM (2008) Protein aggregation in the brain: The molecular basis for Alzheimer's and Parkinson's diseases. Mol Med 14, 451-464.
    • (2008) Mol Med , vol.14 , pp. 451-464
    • Irvine, G.B.1    El-Agnaf, O.M.2    Shankar, G.M.3    Walsh, D.M.4
  • 4
    • 69949149176 scopus 로고    scopus 로고
    • Alzheimer's disease drug development and the problem of the blood-brain barrier
    • Pardridge WM (2009) Alzheimer's disease drug development and the problem of the blood-brain barrier. Alzheimers Dement 5, 427-432.
    • (2009) Alzheimers Dement , vol.5 , pp. 427-432
    • Pardridge, W.M.1
  • 5
  • 6
    • 0023370041 scopus 로고
    • Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity
    • McMartin C, Hutchinson LE, Hyde R, Peters GE (1987) Analysis of structural requirements for the absorption of drugs and macromolecules from the nasal cavity. J Pharm Sci 76, 535-540.
    • (1987) J Pharm Sci , vol.76 , pp. 535-540
    • McMartin, C.1    Hutchinson, L.E.2    Hyde, R.3    Peters, G.E.4
  • 7
    • 84934969009 scopus 로고    scopus 로고
    • The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update
    • Ghosh S, Banerjee S, Sil PC (2015) The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food Chem Toxicol 83, 111-124.
    • (2015) Food Chem Toxicol , vol.83 , pp. 111-124
    • Ghosh, S.1    Banerjee, S.2    Sil, P.C.3
  • 8
    • 84942827395 scopus 로고    scopus 로고
    • Microglial HO-1 induction by curcumin provides antioxidant, anti-neuroinflammatory and glioprotective effects
    • Parada E, Buendia I, Navarro E, Avendano C, Egea J, Lopez MG (2015) Microglial HO-1 induction by curcumin provides antioxidant, anti-neuroinflammatory and glioprotective effects. Mol Nutr Food Res 59, 1690-1700.
    • (2015) Mol Nutr Food Res , vol.59 , pp. 1690-1700
    • Parada, E.1    Buendia, I.2    Navarro, E.3    Avendano, C.4    Egea, J.5    Lopez, M.G.6
  • 11
    • 84920038400 scopus 로고    scopus 로고
    • Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis
    • Galaly SR, Ahmed OM, Mahmoud AM (2014) Thymoquinone and curcumin prevent gentamicin-induced liver injury by attenuating oxidative stress, inflammation and apoptosis. J Physiol Pharmacol 65, 823-832.
    • (2014) J Physiol Pharmacol , vol.65 , pp. 823-832
    • Galaly, S.R.1    Ahmed, O.M.2    Mahmoud, A.M.3
  • 12
    • 84922737144 scopus 로고    scopus 로고
    • Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats
    • Rashid K, Sil PC (2015) Curcumin enhances recovery of pancreatic islets from cellular stress induced inflammation and apoptosis in diabetic rats. Toxicol Appl Pharmacol 282, 297-310.
    • (2015) Toxicol Appl Pharmacol , vol.282 , pp. 297-310
    • Rashid, K.1    Sil, P.C.2
  • 13
    • 84928911735 scopus 로고    scopus 로고
    • Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer
    • Das L, Vinayak M (2015) Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer. PLoS One 10, e0124000.
    • (2015) PLoS One , vol.10 , pp. e0124000
    • Das, L.1    Vinayak, M.2
  • 14
    • 84896366727 scopus 로고    scopus 로고
    • Curcumin attenuates carcinogenesis by down regulating proinflammatory cytokine interleukin-1 (IL-1alpha and IL-1beta) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice
    • Das L, Vinayak M (2014) Curcumin attenuates carcinogenesis by down regulating proinflammatory cytokine interleukin-1 (IL-1alpha and IL-1beta) via modulation of AP-1 and NF-IL6 in lymphoma bearing mice. Int Immunopharmacol 20, 141-147.
    • (2014) Immunopharmacol , vol.20 , pp. 141-147
    • Das, L.1    Vinayak, M.2
  • 15
    • 84856858059 scopus 로고    scopus 로고
    • Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-kappaB signalling in lymphoma-bearing mice
    • Das L, Vinayak M (2012) Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-kappaB signalling in lymphoma-bearing mice. Biosci Rep 32, 161-170.
    • (2012) Biosci Rep , vol.32 , pp. 161-170
    • Das, L.1    Vinayak, M.2
  • 18
    • 84931097532 scopus 로고    scopus 로고
    • Promoter methylationindependent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1
    • Parashar G, Capalash N (2016) Promoter methylationindependent reactivation of PAX1 by curcumin and resveratrol is mediated by UHRF1. Clin Exp Med 16, 471-478.
    • (2016) Clin Exp Med , vol.16 , pp. 471-478
    • Parashar, G.1    Capalash, N.2
  • 19
    • 84956805214 scopus 로고    scopus 로고
    • Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: Current stateof-The-art
    • Ahmad MZ, Alkahtani SA, Akhter S, Ahmad FJ, Ahmad J, Akhtar MS, Mohsin N, Abdel-Wahab BA (2016) Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: Current stateof-The-art. J Drug Target 24, 273-293.
    • (2016) J Drug Target , vol.24 , pp. 273-293
    • Ahmad, M.Z.1    Alkahtani, S.A.2    Akhter, S.3    Ahmad, F.J.4    Ahmad, J.5    Akhtar, M.S.6    Mohsin, N.7    Abdel-Wahab, B.A.8
  • 20
    • 84911872504 scopus 로고    scopus 로고
    • Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor
    • Endo H, Nikaido Y, Nakadate M, Ise S, Konno H (2014) Structure activity relationship study of curcumin analogues toward the amyloid-beta aggregation inhibitor. Bioorg Med Chem Lett 24, 5621-5626.
    • (2014) Bioorg Med Chem Lett , vol.24 , pp. 5621-5626
    • Endo, H.1    Nikaido, Y.2    Nakadate, M.3    Ise, S.4    Konno, H.5
  • 21
    • 84911191807 scopus 로고    scopus 로고
    • Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin
    • Maiti P, Manna J, Veleri S, Frautschy S (2014) Molecular chaperone dysfunction in neurodegenerative diseases and effects of curcumin. Biomed Res Int 2014, 495091.
    • (2014) Biomed Res Int 2014 , pp. 495091
    • Maiti, P.1    Manna, J.2    Veleri, S.3    Frautschy, S.4
  • 22
    • 84907361344 scopus 로고    scopus 로고
    • Dietary polyphenols for treatment of Alzheimer's disease-future research and development
    • Malar DS, Devi KP (2014) Dietary polyphenols for treatment of Alzheimer's disease-future research and development. Curr Pharm Biotechnol 15, 330-342.
    • (2014) Curr Pharm Biotechnol , vol.15 , pp. 330-342
    • Malar, D.S.1    Devi, K.P.2
  • 24
    • 84872142073 scopus 로고    scopus 로고
    • Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Abeta42 accumulation and Caspase-3 activation
    • Eimer WA, Vassar R (2013) Neuron loss in the 5XFAD mouse model of Alzheimer's disease correlates with intraneuronal Abeta42 accumulation and Caspase-3 activation. Mol Neurodegener 8, 2.
    • (2013) Mol Neurodegener , vol.8 , pp. 2
    • Eimer, W.A.1    Vassar, R.2
  • 25
    • 84877967931 scopus 로고    scopus 로고
    • Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry
    • McClure RA, Chumbley CW, Reyzer ML, Wilson K, Caprioli RM, Gore JC, Pham W (2013) Identification of promethazine as an amyloid-binding molecule using a fluorescence high-throughput assay and MALDI imaging mass spectrometry. Neuroimage Clin 2, 620-629.
    • (2013) Neuroimage Clin , vol.2 , pp. 620-629
    • McClure, R.A.1    Chumbley, C.W.2    Reyzer, M.L.3    Wilson, K.4    Caprioli, R.M.5    Gore, J.C.6    Pham, W.7
  • 26
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
    • Oakley H, Cole SL, Logan S, Maus E, Shao P, Craft J, Guillozet-Bongaarts A, Ohno M, Disterhoft J, Van Eldik L, Berry R, Vassar R (2006) Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation. J Neurosci 26, 10129-10140.
    • (2006) J Neurosci , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5    Craft, J.6    Guillozet-Bongaarts, A.7    Ohno, M.8    Disterhoft, J.9    Van Eldik, L.10    Berry, R.11    Vassar, R.12
  • 27
    • 25844460460 scopus 로고    scopus 로고
    • Crossing the blood-brain barrier:Apotential application of myristoylated polyarginine for in vivo neuroimaging
    • PhamW, Zhao BQ, Lo EH, Medarova Z, Rosen B, Moore A (2005) Crossing the blood-brain barrier:Apotential application of myristoylated polyarginine for in vivo neuroimaging. Neuroimage 28, 287-292.
    • (2005) Neuroimage , vol.28 , pp. 287-292
    • Pham, W.1    Zhao, B.Q.2    Lo, E.H.3    Medarova, Z.4    Rosen, B.5    Moore, A.6
  • 28
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • Lim GP, Chu T, Yang F, Beech W, Frautschy SA, Cole GM (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J Neurosci 21, 8370-8377.
    • (2001) J Neurosci , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 29
    • 0030444977 scopus 로고    scopus 로고
    • Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats
    • Tjalve H, Henriksson J, Tallkvist J, Larsson BS, Lindquist NG (1996) Uptake of manganese and cadmium from the nasal mucosa into the central nervous system via olfactory pathways in rats. Pharmacol Toxicol 79, 347-356.
    • (1996) Pharmacol Toxicol , vol.79 , pp. 347-356
    • Tjalve, H.1    Henriksson, J.2    Tallkvist, J.3    Larsson, B.S.4    Lindquist, N.G.5
  • 30
    • 0025733045 scopus 로고
    • Entorhinal cortex of the monkey: V Projections to the dentate gyrus, hippocampus, and subicular complex
    • WitterMP, AmaralDG(1991) Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex. J Comp Neurol 307, 437-459.
    • (1991) J Comp Neurol , vol.307 , pp. 437-459
    • Witter, M.P.1    Amaral, D.G.2
  • 31
    • 0015880386 scopus 로고
    • An autoradiographic study of complementary laminar patterns of termination of afferent fibers to the olfactory cortex
    • Price JL (1973) An autoradiographic study of complementary laminar patterns of termination of afferent fibers to the olfactory cortex. J Comp Neurol 150, 87-108.
    • (1973) J Comp Neurol , vol.150 , pp. 87-108
    • Price, J.L.1
  • 32
    • 0037012242 scopus 로고    scopus 로고
    • Comparative aspects of the olfactory portion of the entorhinal cortex and its projection to the hippocampus in rodents, nonhuman primates, and the human brain
    • Insausti R, Marcos P, Arroyo-Jimenez MM, Blaizot X, Martinez-Marcos A (2002) Comparative aspects of the olfactory portion of the entorhinal cortex and its projection to the hippocampus in rodents, nonhuman primates, and the human brain. Brain Res Bull 57, 557-560.
    • (2002) Brain Res Bull , vol.57 , pp. 557-560
    • Insausti, R.1    Marcos, P.2    Arroyo-Jimenez, M.M.3    Blaizot, X.4    Martinez-Marcos, A.5
  • 33
    • 0037222946 scopus 로고    scopus 로고
    • The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation
    • van Groen T, Miettinen P, Kadish I (2003) The entorhinal cortex of the mouse: Organization of the projection to the hippocampal formation. Hippocampus 13, 133-149.
    • (2003) Hippocampus , vol.13 , pp. 133-149
    • Van Groen, T.1    Miettinen, P.2    Kadish, I.3
  • 35
    • 84886664610 scopus 로고    scopus 로고
    • Comparative anatomy of the prosubiculum, subiculum, presubiculum, postsubiculum, and parasubiculum in human, monkey, and roden
    • Ding SL (2013) Comparative anatomy of the prosubiculum, subiculum, presubiculum, postsubiculum, and parasubiculum in human, monkey, and roden. J Comp Neurol 521, 4145-4162.
    • (2013) J Comp Neurol , vol.521 , pp. 4145-4162
    • Ding, S.L.1
  • 36
    • 0023106967 scopus 로고
    • A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
    • Davies CA, Mann DM, Sumpter PQ, Yates PO (1987) A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neurol Sci 78, 151-164.
    • (1987) J Neurol Sci , vol.78 , pp. 151-164
    • Davies, C.A.1    Mann, D.M.2    Sumpter, P.Q.3    Yates, P.O.4
  • 37
    • 0031046970 scopus 로고    scopus 로고
    • Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease
    • Simic G, Kostovic I,Winblad B, Bogdanovic N (1997) Volume and number of neurons of the human hippocampal formation in normal aging and Alzheimer's disease. J Comp Neurol 379, 482-494.
    • (1997) J Comp Neurol , vol.379 , pp. 482-494
    • Simic, G.1    Kostovic, I.2    Winblad, B.3    Bogdanovic, N.4
  • 38
    • 0035072272 scopus 로고    scopus 로고
    • Beta-amyloid plaques induce neuritic dystrophy of nitric oxide-producing neurons in a transgenic mouse model of Alzheimer's disease
    • Quinn J, Davis F, Woodward WR, Eckenstein F (2001) Beta-amyloid plaques induce neuritic dystrophy of nitric oxide-producing neurons in a transgenic mouse model of Alzheimer's disease. Exp Neurol 168, 203-212.
    • (2001) Exp Neurol , vol.168 , pp. 203-212
    • Quinn, J.1    Davis, F.2    Woodward, W.R.3    Eckenstein, F.4
  • 41
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • Kitazawa M, Oddo S,Yamasaki TR, Green KN, LaFerlaFM (2005) Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25, 8843-8853.
    • (2005) J Neurosci , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 42
    • 0032146978 scopus 로고    scopus 로고
    • The importance of inflammatory mechanisms in Alzheimer disease
    • McGeer EG, McGeer PL (1998) The importance of inflammatory mechanisms in Alzheimer disease. Exp Gerontol 33, 371-378.
    • (1998) Exp Gerontol , vol.33 , pp. 371-378
    • McGeer, E.G.1    McGeer, P.L.2
  • 43
    • 0035696167 scopus 로고    scopus 로고
    • Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated with inflamation
    • Mackenzie IR (2001) Postmortem studies of the effect of anti-inflammatory drugs on Alzheimer-type pathology and associated with inflamation. Neurobiol Aging 22, 819-822.
    • (2001) Neurobiol Aging , vol.22 , pp. 819-822
    • Mackenzie, I.R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.