β-amyloid plaques induce neuritic dystrophy of nitric oxide-producing neurons in a transgenic mouse model of Alzheimer's disease

Experimental Neurology

Volumn 168, Issue 2, 2001, Pages 203-212

  Quinn, Joseph ^a   Davis, Forrest ^b   Woodward, William R ^b   Eckenstein, Felix ^b  

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

Animal; Disease models; Free radicals; Oxidative; Stress

Indexed keywords

AMYLOID BETA PROTEIN; FREE RADICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MOUSE; NERVE DEGENERATION; NEURITE; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENILE PLAQUE; TRANSGENIC MOUSE;

EID: 0035072272     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.2000.7598     Document Type: Article

References (58)

1. Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism
2. Neuropeptides in neurological disease
3. β-amyloid activates the O-2 forming NADPH oxidase in microglia, monocytes, and neutrophils. A possible inflammatory mechanism of neuronal damage in Alzheimer's disease
4. Neuron loss in APP transgenic mice
5. Nitric oxide synthases: Targets for therapeutic strategies in neurological diseases
6. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice
7. β-amyloid neurotoxicity: A discussion of in vitro findings
8. Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues
9. Nitric oxide neurotoxicity
10. The importance of inflammatory mechanisms for the development of Alzheimer's disease
11. Nitric oxide-producing neurons in the neocortex: Morphological and functional relationship with intraparenchymal microvasculature
12. Microglial response to amyloid plaques in APPsw transgenic mice
13. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
14. Aging renders the brain vulnerable to amyloid beta-protein neurotoxicity
15. Evidence for neuronal oxidative damage in Alzheimer's disease
16. Integrin Mac-1 and β-amyloid in microglial release of nitric oxide
17. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations
18. Nitric oxide as a retrograde messenger during long-term potentiation in hippocampus
19. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
20. Transgenic mice expressing Alzheimer amyloid precursor proteins
21. Correlative memory deficits, A beta elevation, and amyloid plaques in transgenic mice
22. Amyloid-beta peptide activates cultured astrocytes: Morphological alterations, cytokine induction and nitric oxide release
23. β-amyloid 25-35 activates nitric oxide synthase in a neuronal clone
24. β-amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity
25. APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1
26. Cortical somatostatin, neuropeptide Y, and NADPH diaphorase neurons: Normal anatomy and alterations in Alzheimer's disease
27. Three distinct sub-populations of GABAergic neurons in rat frontal agranular cortex
28. Three classes of GABAergic interneurons in neocortex and neostriatum
29. The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F
30. β-amyloid neurotoxicity requires fibril formation and is inhibited by congo red
31. Oxidative alterations in Alzheimer's disease
32. Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration
33. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
34. The Consortium to Establish a Registry for Alzheimer's Disease 'CERAD', Part II: Standardization of the Neuropathologic Assessment of Alzheimer's Disease
35. Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients
36. Alzheimer's disease: A re-examination of the amyloid hypothesis
37. Neuronal nitric oxide synthase (nNOS) mRNA expression and NADPH-diaphorase staining in the frontal cortex, visual cortex and hippocampus of control and Alzheimer's disease brains
38. Evidence of oxidative stress and in vivo neurotoxicity of β-amyloid in a transgenic mouse model of Alzheimer's disease: A chronic oxidative paradigm for testing antioxidant therapies in vivo
39. Alzheimer's disease: Genetic studies and transgenic models
40. Inhibition of age-induced β-amyloid neurotoxicity in rat hippocampal cells
41. Synergistic induction of nitric oxide by β-amyloid and cytokines in astrocytes
42. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study
43. Demonstration of a unique population of neurons with NADPH-diaphorase histochemistry
44. Translating cell biology into therapeutic advances in Alzheimer's disease
45. Widespread peroxynitrite-mediated damage in Alzheimer's disease
46. Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress
47. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain
48. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology
49. nNOS expressing neurons in the entorhinal cortex and hippocampus are affected in patients with Alzheimer's disease
50. Regional cholinergic denervation of cortical microvessels and nitric oxide synthase-containing neurons in Alzheimer's disease
51. NADPH-diaphorase-positive cell populations in the human amygdala and temporal cortex: Neuroanatomy, peptidergic characteristics and aspects of aging and Alzheimer's disease
52. Fibrillar β-amyloid induces microglial phagocytosis, expression of inducible nitric oxide synthase, and loss of a select population of neurons in the rat CNS in vivo
53. Protective effects of idebenone and alpha-tocopherol on β-amyloid-(1-42)-induced learning and memory deficits in rats: Implication of oxidative stress in β-amyloid-induced neurotoxicity in vivo
54. Commentary and perspective on studies of β-amyloid neurotoxicity
55. The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: Implications for the free radical hypothesis of Alzheimer's disease
56. Temporal relations among amyloid beta-peptide-induced free-radical oxidative stress, neuronal toxicity, and neuronal defensive responses
57. Nitric oxide synthase neurons in different areas of normal aged and Alzheimer's brains
58. The role of A beta 42 in Alzheimer's disease