Acidic pH promotes intervertebral disc degeneration: Acid-sensing ion channel-3 as a potential therapeutic target

Scientific Reports

Volumn 6, Issue , 2016, Pages

  Gilbert, Hamish T J ^a,b   Hodson, Nathan ^b   Baird, Pauline ^b   Richardson, Stephen M ^b   Hoyland, Judith A ^b,c  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL BLOCKING AGENT; APETX2 PROTEIN, ANTHOPLEURA ELEGANTISSIMA; ASIC3 PROTEIN, HUMAN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN-DERIVED NEUROTROPHIC FACTOR, HUMAN; COELENTERATE VENOM; CYTOKINE; NERVE GROWTH FACTOR;

BIOSYNTHESIS; CELL CULTURE; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; GENETICS; HUMAN; INTERVERTEBRAL DISK DEGENERATION; MALE; METABOLISM; MIDDLE AGED; MOLECULARLY TARGETED THERAPY; NUCLEUS PULPOSUS; PATHOLOGY; PH; PRECLINICAL STUDY; TRANSCRIPTION INITIATION;

ACID SENSING ION CHANNEL BLOCKERS; ACID SENSING ION CHANNELS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL PROLIFERATION; CELL SURVIVAL; CELLS, CULTURED; CNIDARIAN VENOMS; CYTOKINES; DRUG EVALUATION, PRECLINICAL; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; INTERVERTEBRAL DISC DEGENERATION; MALE; MIDDLE AGED; MOLECULAR TARGETED THERAPY; NERVE GROWTH FACTOR; NUCLEUS PULPOSUS; TRANSCRIPTIONAL ACTIVATION;

EID: 84997498737     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep37360     Document Type: Article

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