Acid-sensing ion channels in healthy and degenerated human intervertebral disc

Connective Tissue Research

Volumn 55, Issue 3, 2014, Pages 197-204

  Cuesta, Antonio ^a   Del Valle, Miguel E ^a,b   García Suárez, Olivia ^a   Viña, Eliseo ^a,c   Cabo, Roberto ^a   Vázquez, Gorka ^a   Cobo, Juan L ^a   Murcia, Antonio ^d   Alvarez Vega, Marco ^a,e   García Cosamalón, José ^f   Vega, José A ^a  

^a UNIVERSIDAD DE OVIEDO   (Spain)

^b UNIVERSITY OF OVIEDO   (Spain)

^c HOSPITAL DE CABUEÑES   (Spain)

^d Hospital Santa Lucia   (Spain)

^e HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

^f Gerencia Regional de Salud de Castilla y León   (Spain)

Author keywords

Acid sensing ion channels; Degenerated intervertebral disc; Healthy intervertebral disc; Human

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1; ACID SENSING ION CHANNEL 2; ACID SENSING ION CHANNEL 3; ACID SENSING ION CHANNEL 4; MESSENGER RNA; UNCLASSIFIED DRUG; CALCIUM; MEMBRANE PROTEIN; NERVE PROTEIN;

ADULT; ANNULUS FIBROSUS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INTERVERTEBRAL DISK DEGENERATION; MALE; MOLECULAR WEIGHT; NUCLEOTIDE SEQUENCE; NUCLEUS PULPOSUS; PATHOGENESIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; AGED; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISK; METABOLISM; MIDDLE AGED; PATHOLOGY; PROCEDURES;

ACID SENSING ION CHANNELS; ADULT; AGED; CALCIUM; EXTRACELLULAR MATRIX; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NERVE TISSUE PROTEINS;

EID: 84899868037     PISSN: 03008207     EISSN: 16078438     Source Type: Journal    
DOI: 10.3109/03008207.2014.884083     Document Type: Article

References (39)

1. Pattappa G, Li Z, Peroglio M, Wismer N, Alini M, Grad S. Diversity of intervertebral disc cells: Phenotype and function. J Anat 2012;221:480-96.
2. Grunhagen T, Wilde G, Soukane DM, Shirazi-Adl SA, Urban JP. Nutrient supply and intervertebral disc metabolism. J Bone Joint Surg Am 2006;88:30-5.
3. Wu QQ, Chen Q. Mechanoregulation of chondrocyte proliferation, maturation, and hypertrophy: Ion-channel dependent transduction of matrix deformation signals. Exp Cell Res 2000;256:383-91.
4. Urban JP. The chondrocyte: A cell under pressure. Br J Rheumatol 1994;33:901-8.
5. Feng H, Danfelter M, Strömqvist B, Heinegard D. Extracellular matrix in disc degeneration. J Bone Joint Surg Am 2006;88 (Suppl. 2):25-9.
6. Colombini A, Lombardi G, Corsi MM, Banfi G. Pathophysiology of the human intervertebral disc. Int J Biochem Cell Biol 2008;40: 837-42.
7. Adams MA, Dolan P. Intervertebral disc degeneration: Evidence for two distinct phenotypes. J Anat 2012;221:497-506.
8. Barrett-Jolley R, Lewis R, Fallman R, Mobasheri A. The emerging chondrocyte channelome. Front Physiol 2010;1:135. doi: 10.3389/ fphys.2010.00135.
9. Holzer P. Acid-sensitive ion channels and receptors. Handb Exp Pharmacol 2009:283-332.
10. Holzer P. Acid sensing by visceral afferent neurons. Acta Physiol 2011;201:63-75.
11. Sherwood TW, Frey EN, Askwith CC. Structure and activity of the acid-sensing ion channels. Am J Physiol Cell Physiol 2012;303: C699-C710.
12. Wemmie JA, Price MP, Welsh MJ. Acid-sensing ion channels: Advances, questions and therapeutic opportunities. Trends Neurosci 2006;29:578-86.
13. Kress M, Waldmann R. Acid sensing ionic channels. Curr Top Membr 2006;57:241-76.
14. Lumpkin EA, Caterina MJ. Mechanisms of sensory transduction in the skin. Nature 2007;445:858-65.
15. Del Valle ME, Cobo T, Cobo JL, Vega JA. Mechanosensory neurons, cutaneous mechanoreceptors, and putative mechanoproteins. Microsc Res Tech 2012;75:1033-43.
16. Jahr H, van Driel M, van Osch GJ, Weinans H, van Leeuwen JP. Identification of acid-sensing ion channels in bone. Biochem Biophys Res Commun 2005;337:349-54.
17. Kolker SJ, Walder RY, Usachev Y, Hillman J, Boyle DL, Firestein GS, Sluka KA. Acid-sensing ion channel 3 expressed in type B synoviocytes and chondrocytes modulates hyaluronan expression and release. Ann Rheum Dis 2010;69:903-9.
18. Yuan FL, Chen FH, Lu WG, Li X, Li JP, Li CW, Xu RS, Wu FR, Hu W, Zhang TY. Inhibition of acid-sensing ion channels in articular chondrocytes by amiloride attenuates articular cartilage destruction in rats with adjuvant arthritis. Inflamm Res 2010;59: 939-47.
19. Uchiyama Y, Cheng CC, Danielson KG, Mochida J, Albert TJ, Shapiro IM, Risbud MV. Expression of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc is regulated by p75NTR and ERK signaling. J Bone Miner Res 2007; 22:1996-2006.
20. Uchiyama Y, Guttapalli A, Gajghate S, Mochida J, Shapiro IM, Risbud MV. SMAD3 functions as a transcriptional repressor of acid-sensing ion channel 3 (ASIC3) in nucleus pulposus cells of the intervertebral disc. J Bone Miner Res 2008;23:1619-28.
21. Hughes SP, Freemont AJ, Hukins DW, McGregor AH, Roberts S. The pathogenesis of degeneration of the intervertebral disc and emerging therapies in the management of back pain. J Bone Joint Surg Br 2012;94:1298-304.
22. Thompson JP, Pearce RH, Schechter MT, Adams ME, Tsang IK, Bishop PB. Preliminary evaluation of a scheme for grading the gross morphology of the human intervertebral disc. Spine (Phila Pa 1976) 1990;15:411-15.
23. Rose J, Söder S, Skhirtladze C, Schmitz N, Gebhard PM, Sesselmann S, Aigner T. DNA damage, discoordinated gene expression and cellular senescence in osteoarthritic chondrocytes. Osteoarthritis Cartilage 2012;20:1020-8.
24. Gottschalk D, Fehn M, Patt S, Saeger W, Kirchner T, Aigner T. Matrix gene expression analysis and cellular phenotyping in chordoma reveals focal differentiation pattern of neoplastic cells mimicking nucleus pulposus development. Am J Pathol 2001;158: 1571-8.
25. Neidlinger-Wilke C, Galbusera F, Pratsinis H, Mavrogonatou E, Mietsch A, Kletsas D, Wilke HJ. Mechanical loading of the intervertebral disc: From the macroscopic to the cellular level. Eur Spine J 2013. [Epub ahead of print]. DOI: 10.1007/s00586-013-2855-9.
26. Ikeuchi M, Kolker SJ, Sluka KA. Acid-sensing ion channel 3 expression in mouse knee joint afferents and affects of carrageenan-induced arthritis. J Pain 2009;10:336-42.
27. Hung CT. Transient receptor potential vanilloid 4 channel as an important modulator of chondrocyte mechanotransduction of osmotic loading. Arthritis Rheum 2010;62:2850-1.
28. Yuan FL, Chen FH, Lu WG, Li X, Wu FR, Li JP, Li CW, Wang Y, Zhang TY, Hu W. Acid-sensing ion channel 1a mediates acidinduced increases in intracellular calcium in rat articular chondrocytes. Mol Cell Biochem 2010;340:153-9.
29. Yuan LF, Chen FH, Lu WG, Li X. Acid-sensing ion channels 3: A potential therapeutic target for pain treatment in arthritis. Mol Biol Rep 2010;37:3233-8.
30. Hu W, Chen FH, Yuan FL, Zhang TY, Wu FR, Rong C, Jiang S, Tang J, Zhang CC, Lin MY. Blockade of acid-sensing ion channels protects articular chondrocytes from acid-induced apoptotic injury. Inflamm Res 2012;61:327-35.
31. Rong C, Chen FH, Jiang S, Hu W, Wu FR, Chen TY, Yuan FL. Inhibition of acid-sensing ion channels by amiloride protects rat articular chondrocytes from acid-induced apoptosis via a mitochondrial-mediated pathway. Cell Biol Int 2012;36:635-41.
32. Sharma P, Hughes S, El Haj A, Maffulli N. Expression of the two pore domain potassium channel TREK-1 in human intervertebral disc cells. Curr Stem Cell Res Ther 2012;7:266-71.
33. Kitano T, Zerwekh JE, Usui Y, Edwards ML, Flicker PL, Mooney V. Biochemical changes associated with the symptomatic human intervertebral disc. Clin Orthop Relat Res 1993;293:372-7.
34. Wu MH, Urban JP, Cui ZF, Cui Z, Xu X. Effect of extracellular pH on matrix synthesis by chondrocytes in 3D agarose gel. Biotechnol Prog 2007;23:430-4.
35. Wohlrab D, Vocke M, Klapperstück T, Hein W. The influence of lidocaine and verapamil on the proliferation, CD44 expression and apoptosis behavior of human chondrocytes. Int J Mol Med 2005;16: 149-57.
36. Wohlrab D, Wohlrab J, Reichel H, Hein W. Is the proliferation of human chondrocytes regulated by ionic channels? J Orthop Sci 2001;6:155-9.
37. Grishko V, Xu M, Wilson G, Pearsall 4th AW. Apoptosis and mitochondrial dysfunction in human chondrocytes following exposure to lidocaine, bupivacaine, and ropivacaine. J Bone Joint Surg Am 2010;92:609-18.
38. Hsieh AH, Twomey JD. Cellular mechanobiology of the intervertebral disc: New directions and approaches. J Biomech 2010;43: 137-45.
39. Sowa GA, Coelho JP, Vo NV, Pacek C, Westrick E, Kang JD. Cells from degenerative intervertebral discs demonstrate unfavorable responses to mechanical and inflammatory stimuli: A pilot study. Am J Phys Med Rehabil 2012;91:846-55.