Nod2 deficiency leads to a specific and transmissible mucosa-associated microbial dysbiosis which is independent of the mucosal barrier defect

Journal of Crohn's and Colitis

Volumn 10, Issue 12, 2016, Pages 1428-1436

  Al Nabhani, Ziad ^a,b,c   Lepage, Patricia ^c   Mauny, Pascal ^d   Montcuquet, Nicolas ^a,e   Roy, Maryline ^a,b   Roux, Karine Le ^c   Dussaillant, Monique ^a,b   Berrebi, Dominique ^f,g   Hugot, Jean Pierre ^a,b,f   Barreau, Frédérick ^a,b,h  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b CENTRE DE RECHERCHE SUR L INFLAMMATION   (France)

^c UMR1319 MICALIS   (France)

^d CNRS   (France)

^e INSERM   (France)

^f HÔPITAL ROBERT DEBRÉ   (France)

^g Universite Paris Sud   (France)

^h UMR 1220 TCEM (INRA ENITAB)   (France)

Author keywords

Crohn's disease; Gut barrier dysfunction; Intestinal microbiota; Nod like

Indexed keywords

CASPASE RECRUITMENT DOMAIN PROTEIN 15; MUCIN; POLYPEPTIDE ANTIBIOTIC AGENT; RNA 16S; ANTIMICROBIAL CATIONIC PEPTIDE; CARD15 PROTEIN, MOUSE;

ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL TRANSLOCATION; C57BL 6 MOUSE; CELL INFILTRATION; CONTROLLED STUDY; CROHN DISEASE; DISEASE ASSOCIATION; DYSBIOSIS; EMBRYO TRANSFER; FEMALE; FLOW CYTOMETRY; GENE MUTATION; INTESTINE FLORA; INTESTINE MUCOSA PERMEABILITY; KNOCKOUT MOUSE; MOUSE; MUCOSAL DISEASE; NONHUMAN; OLIGOMERIZATION; PEYER PATCH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PYROSEQUENCING; REAL TIME POLYMERASE CHAIN REACTION; RISK FACTOR; SPECIES COMPOSITION; STOMACH MUCOSA; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; DEFICIENCY; GENETICS; INTESTINE MUCOSA; METABOLISM; MICROBIOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DYSBIOSIS; FEMALE; GASTROINTESTINAL MICROBIOME; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUCINS; NOD2 SIGNALING ADAPTOR PROTEIN; PEYER'S PATCHES; REAL-TIME POLYMERASE CHAIN REACTION; RNA, RIBOSOMAL, 16S;

EID: 84997263395     PISSN: 18739946     EISSN: 18764479     Source Type: Journal    
DOI: 10.1093/ecco-jcc/jjw095     Document Type: Article

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