Stress Kinase GCN2 Controls the Proliferative Fitness and Trafficking of Cytotoxic T Cells Independent of Environmental Amino Acid Sensing

Cell Reports

Volumn 17, Issue 9, 2016, Pages 2247-2258

  Van de Velde, Lee Ann ^a   Guo, Xi Zhi J ^a   Barbaric, Lidija ^a   Smith, Amber M ^a   Oguin, Thomas H ^a   Thomas, Paul G ^a   Murray, Peter J ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

amino acid; cytotoxic T cell; GCN2; stress response; T cell; tryptophan

Indexed keywords

AMINO ACID; ASPARAGINE; INDOLEAMINE 2,3 DIOXYGENASE; INITIATION FACTOR 2ALPHA; LEUCINE; LYSINE; PROTEIN GCN2; PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TRANSFER RNA; TRYPTOPHAN; UNCLASSIFIED DRUG; CCR7 PROTEIN, MOUSE; CHEMOKINE RECEPTOR CCR7; EIF2AK4 PROTEIN, MOUSE; EPITOPE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN SERINE THREONINE KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CD8+ T LYMPHOCYTE; CELL CYCLE; CELL ISOLATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENETIC PROCEDURES; IMMUNIZATION; IN VITRO STUDY; IN VIVO STUDY; LYMPH NODE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA ISOLATION; T LYMPHOCYTE; ANIMAL; C57BL MOUSE; CD4+ T LYMPHOCYTE; CYTOLOGY; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION REGULATION; KNOCKOUT MOUSE; METABOLISM; PHYSIOLOGICAL STRESS; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; CELL CYCLE; CELL PROLIFERATION; EPITOPES; GENE EXPRESSION REGULATION; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, CCR7; SIGNAL TRANSDUCTION; SPLEEN; STRESS, PHYSIOLOGICAL; T-LYMPHOCYTES, CYTOTOXIC; TRANSCRIPTION FACTOR CHOP; TRYPTOPHAN;

EID: 84996644473     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.10.079     Document Type: Article

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